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HLA class II histocompatibility antigen, DQ beta 1 chain (MHC class II antigen DQB1)

 DQB1_HUMAN              Reviewed;         261 AA.
P01920; A1KR27; A2RPH3; A4Q9R4; A4USG2; A4USG5; A6N8I7; A9YQA0;
B0S7Y7; B1A0K6; B1GXI3; B3VLT3; B5BLN7; B7VU69; C0MQ34; C0MQ35;
C8ZL52; C8ZLJ8; C8ZLJ9; C9DRQ3; O19708; O19713; O19724; O62861;
O78046; O78221; O78223; O98034; O98201; P01917; P01918; P01919;
P03992; P05537; P79482; P79526; P79544; P79551; Q08GC8; Q09035;
Q0E4V9; Q1M312; Q29731; Q29877; Q29884; Q29915; Q29966; Q2P9N3;
Q2QK85; Q30061; Q30075; Q30076; Q30080; Q30081; Q30082; Q30083;
Q30084; Q30089; Q30095; Q31633; Q38I47; Q45UE3; Q4QZB5; Q53I44;
Q564J6; Q5G841; Q5ISH1; Q5ISH3; Q5W1E1; Q5Y7G8; Q643R4; Q6B9X1;
Q70VH8; Q7YP69; Q8HWH0; Q8MH58; Q8SNB4; Q8SND1; Q8SP70; Q8WMA3;
Q9BD17; Q9MYH2; Q9TPA9; Q9XRY6; Q9XRY7; Q9XRZ2;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
02-MAR-2010, sequence version 2.
23-MAY-2018, entry version 174.
RecName: Full=HLA class II histocompatibility antigen, DQ beta 1 chain;
AltName: Full=MHC class II antigen DQB1;
Flags: Precursor;
Name=HLA-DQB1; Synonyms=HLA-DQB;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01), AND NUCLEOTIDE
SEQUENCE [MRNA] OF 33-261 (CLONE PII-BETA-2) (ALLELE DQB1*05:01).
PubMed=6415003; DOI=10.1016/0198-8859(83)90087-3;
Larhammar D., Andersson G., Andersson M., Bill P., Boehme J.,
Claesson L., Denaro M., Emmoth E., Gustafsson K., Hammarling U.,
Heldin E., Hyldig-Nielsen J.-J., Lind P., Schenning L., Servenius B.,
Widmark E., Rask L., Peterson P.A.;
"Molecular analysis of human class II transplantation antigens and
their genes.";
Hum. Immunol. 8:95-103(1983).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01).
PubMed=6954511; DOI=10.1073/pnas.79.12.3687;
Larhammar D., Schenning L., Gustafsson K., Wiman K., Claesson L.,
Rask L., Peterson P.A.;
"Complete amino acid sequence of an HLA-DR antigen-like beta chain as
predicted from the nucleotide sequence: similarities with
immunoglobulins and HLA-A, -B, and -C antigens.";
Proc. Natl. Acad. Sci. U.S.A. 79:3687-3691(1982).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02).
PubMed=6316358; DOI=10.1073/pnas.80.23.7313;
Larhammar D., Hyldig-Nielsen J.-J., Servenius B., Andersson G.,
Rask L., Peterson P.A.;
"Exon-intron organization and complete nucleotide sequence of a human
major histocompatibility antigen DC beta gene.";
Proc. Natl. Acad. Sci. U.S.A. 80:7313-7317(1983).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01).
PubMed=6206493; DOI=10.1073/pnas.81.16.5199;
Boss J.M., Strominger J.L.;
"Cloning and sequence analysis of the human major histocompatibility
complex gene DC-3 beta.";
Proc. Natl. Acad. Sci. U.S.A. 81:5199-5203(1984).
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01).
PubMed=2998758;
Tonnelle C., Demars R., Long E.O.;
"DO beta: a new beta chain gene in HLA-D with a distinct regulation of
expression.";
EMBO J. 4:2839-2847(1985).
[6]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01).
PubMed=2888727; DOI=10.1007/BF00346523;
Turco E., Care A., Compagnone-Post P., Robinson C., Cascino I.,
Trucco M.;
"Allelic forms of the alpha- and beta-chain genes encoding DQw1-
positive heterodimers.";
Immunogenetics 26:282-290(1987).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02).
PubMed=3036828;
Jonsson A.-K., Hyldig-Nielsen J.-J., Servenius B., Larhammar D.,
Andersson G., Joergensen F., Peterson P.A., Rask L.;
"Class II genes of the human major histocompatibility complex.
Comparisons of the DQ and DX alpha and beta genes.";
J. Biol. Chem. 262:8767-8777(1987).
[8]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-15; SER-28; GLY-45;
LEU-58; GLY-77; GLY-102 AND ARG-199.
PubMed=3584986;
Schiffenbauer J., Didier D.K., Klearman M., Rice K., Shuman S.,
Tieber V.L., Kittlesen D.J., Schwartz B.D.;
"Complete sequence of the HLA DQ alpha and DQ beta cDNA from a
DR5/DQw3 cell line.";
J. Immunol. 139:228-233(1987).
[9]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:02).
PubMed=3259543; DOI=10.1007/BF00364432;
Lock C.B., So A.K., Welsh K.I., Parkes J.D., Trowsdale J.;
"MHC class II sequences of an HLA-DR2 narcoleptic.";
Immunogenetics 27:449-455(1988).
[10]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*03:03).
PubMed=2050393; DOI=10.1007/BF00216702;
Giorda R., Turco E., Trucco M.;
"Full length beta chain cDNAs of DQw9 and DQw8 molecules encode
proteins that differ only at amino acid 57.";
Immunogenetics 33:404-408(1991).
[11]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:12).
PubMed=8988543; DOI=10.1111/j.1399-0039.1996.tb02674.x;
Vilches C., Garcia-Pacheco J.M., de Pablo R., Puente S., Kreisler M.;
"Complete coding region of the new HLA-DQB1*0612 allele, obtained by
RT-PCR.";
Tissue Antigens 48:589-592(1996).
[12]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01).
PubMed=9271631; DOI=10.1007/s002510050295;
Ellis M.C., Hetisimer A.H., Ruddy D.A., Hansen S.L., Kronmal G.S.,
McClelland E., Quintana L., Drayna D.T., Aldrich M.S., Mignot E.;
"HLA class II haplotype and sequence analysis support a role for DQ in
narcolepsy.";
Immunogenetics 46:410-417(1997).
[13]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQB1*03:01 AND DQB1*03:03).
PubMed=16140993; DOI=10.1101/gr.3554305;
Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S.,
Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V.;
"Ancient haplotypes of the HLA Class II region.";
Genome Res. 15:1250-1257(2005).
[14]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DQB1*03:01; DQB1*04:01 AND
DQB1*05:02).
Kim E., Lee E., Kwack K.;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[15]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DQB1*02:02;
DQB1*03:01 AND DQB1*03:03).
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[16]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DQB1*03:02).
TISSUE=B-cell;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[17]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-126 (ALLELE DQB1*06:02).
PubMed=2925231; DOI=10.1007/BF00373644;
Hiraiwa A., Seyfried C.E., Nepom G.T., Milner E.C.;
"Sequence analysis of HLA class II domains: characterization of the
DQw3 family of DQB genes.";
Immunogenetics 29:186-190(1989).
[18]
NUCLEOTIDE SEQUENCE [MRNA] OF 2-261 (ALLELE DQB1*03:01), AND
NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:09).
White J.M., Baxter-Lowe L.A.;
"Nucleotide Deletions in a DQB1*0301 variant.";
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
[19]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-126 (ALLELE DQB1*06:02).
PubMed=2494138; DOI=10.1016/0198-8859(89)90058-X;
Uryu N., Maeda M., Nagata Y., Matsuki K., Juji T., Honda Y., Kawai J.,
Ando A., Tsuji K., Inoko H.;
"No difference in the nucleotide sequence of the DQ beta beta 1 domain
between narcoleptic and healthy individuals with DR2,Dw2.";
Hum. Immunol. 24:175-181(1989).
[20]
NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*04:02).
PubMed=2777341; DOI=10.1007/BF02421214;
Jonsson A.-K., Andersson L., Rask L.;
"Complete sequences of DQA1 and DQB1 cDNA clones corresponding to the
DQw4 specificity.";
Immunogenetics 30:232-234(1989).
[21]
NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELES DQB1*03:03; DQB1*05:01;
DQB1*05:03; DQB1*06:01; DQB1*06:02; DQB1*06:03 AND DQB1*06:04), AND
NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*03:01).
PubMed=8929711; DOI=10.1111/j.1399-0039.1996.tb02512.x;
Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.;
"Different contribution of HLA-DR and -DQ genes in susceptibility and
resistance to insulin-dependent diabetes mellitus (IDDM).";
Tissue Antigens 47:37-48(1996).
[22]
NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:10).
PubMed=11098940; DOI=10.1034/j.1399-0039.2000.560412.x;
Balas A., Santos S., Aviles M.J., Garcia-Sanchez F., Lillo R.,
Vicario J.L.;
"Identification by sequencing based typing and complete coding region
analysis of three new HLA class II alleles: DRB3*0210, DRB3*0211 and
DQB1*0310.";
Tissue Antigens 56:380-384(2000).
[23]
NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*06:09).
Yasunaga S.;
Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
[24]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-231 (ALLELES DQB1*03:04 AND
DQB1*03:05).
PubMed=7928445; DOI=10.1016/0198-8859(94)90060-4;
Cucca F., Frau F., Lampis R., Floris M., Argiolas L., Macis D.,
Cao A., De Virgiliis S., Congia M.;
"HLA-DQB1*0305 and -DQB1*0304 alleles among Sardinians. Evolutionary
and practical implications for oligotyping.";
Hum. Immunol. 40:143-149(1994).
[25]
PROTEIN SEQUENCE OF 33-181 AND 200-230 (ALLELE DQB1*06:02).
PubMed=6576979;
Goetz H., Kratzin H., Thinnes F.P., Yang C.-Y., Kruse T., Pauly E.,
Koelbel S., Egert G., Wernet P., Hilschmann N.;
"Primary structure of human class II histocompatibility antigens 3rd
communication. Amino acid sequence comparison between DR and DC
subclass antigens derived from a lymphoblastoid B cell line homozygous
at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1).";
Hoppe-Seyler's Z. Physiol. Chem. 364:749-755(1983).
[26]
NUCLEOTIDE SEQUENCE [MRNA] OF 33-140 (ALLELE DQB1*06:05).
PubMed=2212675;
Lee K.W., Johnson A.H., Hurley C.K.;
"Two divergent routes of evolution gave rise to the DRw13
haplotypes.";
J. Immunol. 145:3119-3125(1990).
[27]
NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*02:01).
PubMed=3020127;
Karr R.W., Gregersen P.K., Obata F., Goldberg D., Maccari J.,
Alber C., Silver J.;
"Analysis of DR-beta and DQ-beta chain cDNA clones from a DR7
haplotype.";
J. Immunol. 137:2886-2890(1986).
[28]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-126 (ALLELE DQB1*06:22).
PubMed=17868257; DOI=10.1111/j.1399-0039.2007.00927.x;
Chang Y., Fan T.X., Santana Z., Day N.K.;
"Identification of a novel allele HLA-DQB1*0622.";
Tissue Antigens 70:442-444(2007).
[29]
NUCLEOTIDE SEQUENCE [MRNA] OF 33-122 (ALLELE DQB1*06:02).
PubMed=2886427; DOI=10.1007/BF00345460;
Lee B.S., Bell J.I., Rust N.A., McDevitt H.O.;
"Structural and functional variability among DQ beta alleles of DR2
subtypes.";
Immunogenetics 26:85-91(1987).
[30]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-107 (ALLELE DQB1*03:07).
PubMed=9174147; DOI=10.1111/j.1399-0039.1997.tb02789.x;
Thye T., Muntau B., Stelma F.F., Horstmann R.D.;
"A novel allele, DQB1*0307, in a West African family.";
Tissue Antigens 49:517-518(1997).
[31]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:18).
PubMed=11782280; DOI=10.1034/j.1399-0039.2001.580409.x;
Casamitjana N., Gil J., Campos E., Santos M., Nogues N., Ribera A.,
Palou E.;
"Identification of a novel HLA-DQB1*06 allele, DQB1*0618.";
Tissue Antigens 58:269-271(2001).
[32]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:19).
Bowman S., Diviney M., Dunckley H., Holdsworth R., Varney M.;
"A new DQB1*0602 variant found in Australian Caucasian.";
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
[33]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DQB1*06:13).
PubMed=9458130; DOI=10.1111/j.1399-0039.1997.tb02935.x;
Hsu S.H., Robbins F.M., Modelo R.B., Brunner J., Flomenberg N.;
"Identification of a new DQB1*0613 allele in a family.";
Tissue Antigens 50:685-687(1997).
[34]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-257 (ALLELE DQB1*06:36).
TISSUE=Peripheral blood;
Skrablin P.S., Richter R., Seidl C., Seifried E.;
"New HLA-DQB1*06 allele found in a voluntary blood stem cell donor.";
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[35]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:19).
PubMed=17559588; DOI=10.1111/j.1399-0039.2007.00848.x;
Witter K., Mautner J., Albert T., Zahn R., Kauke T.;
"HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype
association to HLA-DRB1*1102.";
Tissue Antigens 70:73-75(2007).
[36]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*06:34).
PubMed=18331527; DOI=10.1111/j.1399-0039.2008.01021.x;
Witter K., Albert T., Zahn R., Kauke T.;
"HLA-DQB1*0634, a novel DQB1 allele found by high-resolution HLA
typing of a sibling pair for potential bone marrow transplantation.";
Tissue Antigens 71:486-488(2008).
[37]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:21), AND
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELES DQB1*02:05 AND
DQB1*03:20).
PubMed=18588576; DOI=10.1111/j.1399-0039.2008.01070.x;
Lazaro A.M., Xiao Y., Masaberg C., Lebeck L., Ng J., Hurley C.K.,
Posch P.E.;
"Novel alleles at the HLA-DRB1 and -DQB1 loci.";
Tissue Antigens 72:72-74(2008).
[38]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:22).
TISSUE=Peripheral blood;
PubMed=19254265; DOI=10.1111/j.1399-0039.2008.01201.x;
Witter K., Lochmann E., Vecchiato C., Albert T., Zahn R., Kauke T.;
"Sequence-based HLA high-resolution retyping of a bone marrow
donor/recipient pair reveals the novel HLA allele DQB1*0322.";
Tissue Antigens 73:283-285(2009).
[39]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:23).
TISSUE=Peripheral blood;
PubMed=19493242; DOI=10.1111/j.1399-0039.2009.01231.x;
Wienzek S., Verboom M., Blasczyk R., Bein G., Horn P.A.;
"DQB1*0323 is the result of a gene conversion event between a DQB1*06
and a DQB1*030303 allele.";
Tissue Antigens 73:624-625(2009).
[40]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*02:04).
Gragg H., Cordovado S.K., Hendrix M.M., Mueller P.W.;
"Identification of a novel HLA-DQB1*02 allele.";
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[41]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:25).
Thompson E.M., Mehdizadeh Kashi Z., Martin R.K.;
"Homo sapiens novel MHC class II HLA-DQB1 gene HLA-DQB1*03 novel
allele, exons 2 and 3.";
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
[42]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:24).
Michaud C., Giannoli C., Favre Victoire I., Dubois V.;
"A new HLA-DQB allele, identified by routine sequencing.";
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
[43]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELES DQB1*06:38 AND
DQB1*06:39).
TISSUE=Blood;
Anholts J.D.H.;
"New alleles found during routine SBT HLA typing.";
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
[44]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:10).
PubMed=8896183; DOI=10.1111/j.1399-0039.1996.tb02633.x;
Mersch G., Semana G., De Canck I., Jannes G., Rombout A., Sterker G.,
Rossau R.;
"Characterization of a new DQB1 allele (DQB1*0610) which differs from
DQB1*0602 at the highly polymorphic 57-codon.";
Tissue Antigens 48:217-220(1996).
[45]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:06).
TISSUE=Blood;
PubMed=8988541; DOI=10.1111/j.1399-0039.1996.tb02672.x;
Saito S., Ota S., Hashizume K., Yamada E., Kaneshige T., Hashimoto M.,
Oguchi H., Ishii E., Fukushima H.;
"A new HLA-DQB1*0306 allele sharing motifs from DQB1*03032 and DQB1*04
sequences.";
Tissue Antigens 48:580-585(1996).
[46]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:11), AND
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-120 (ALLELE DQB1*06:20).
PubMed=15361133; DOI=10.1111/j.1399-0039.2004.00307.x;
Hogbin J.P., Greville W., Chapman G., Kennedy A., Velickovic Z.M.,
Dunckley H.;
"Identification of two novel HLA class II alleles, DQB1*0311 and
DQB1*0620.";
Tissue Antigens 64:515-517(2004).
[47]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:16).
Chen D.-F., DeOliveira A., Peplinski S., Herczyk W., Reinsmoen N.L.;
"A novel DQB1*03 allele revealed by rSSOP and identified by SBT.";
Hum. Immunol. 66:30-30(2005).
[48]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:14).
PubMed=15853909; DOI=10.1111/j.1399-0039.2005.00397.x;
Gu H., Kimm K., Lee J.K., Oh B.;
"Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-
based typing in the Korean population.";
Tissue Antigens 65:503-504(2005).
[49]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:28).
PubMed=17212715; DOI=10.1111/j.1399-0039.2006.00733.x;
Witter K., Albert T., Zahn R., Kauke T.;
"A novel HLA-DQB1*06 allele, DQB1*0628, found through routine
sequence-based HLA typing and confirmation of DQB1*060302.";
Tissue Antigens 69:102-103(2007).
[50]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:32).
TISSUE=Blood;
PubMed=17999653; DOI=10.1111/j.1399-0039.2007.00967.x;
Emmerich F., Schonemann C., Diederich G., Horn P.A., Salama A.;
"Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632.";
Tissue Antigens 71:94-95(2008).
[51]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*05:05).
PubMed=19392794; DOI=10.1111/j.1399-0039.2009.01248.x;
Giannoli C., Paturel L., Favre-Victoire I., Bera O., Dubois V.;
"Two new HLA-DQB alleles routinely identified by sequence-based
typing: DQB1*030103 and DQB1*0505.";
Tissue Antigens 73:622-623(2009).
[52]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*02:03).
Olerup O.H.;
"A novel DQB1*02 allele.";
Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
[53]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05).
Rugg J., Blanton M., Whitacre L., Balakrishnan K., Lebeer K.,
Van Reybroeck G., Mersch G.;
"Detection of a new DQB1 allele.";
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
[54]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:15).
Shah A., Ross J., Chenery P., Holman R., Madrigal A., Little A.M.;
"Two novel DQB1*06 alleles, identified by reverse line blot assay.";
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
[55]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05).
TISSUE=Peripheral blood;
Moine A.;
"A new variant form of the HLA DQB1*0305 allele.";
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
[56]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:12).
Schwarz K., Zenz C.;
"Homo sapiens HLA-DQB1*0312 allele, exon 2.";
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
[57]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:13).
Wu J., Bassinger S., Williams T.M.;
"Novel human HLA-DQB1 allele identified in potential bone marrow
donors.";
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
[58]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:21).
De Canck I.;
"Identification of a new HLA-DQB1*06 allele by INNO-LiPA.";
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
[59]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:17).
Bassinger S., Wu J., Zhang Q., Brinkema C., Smith A.G., Williams T.M.;
"Novel DQB1*06 alleles.";
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
[60]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:23).
Hirv K., Krauss A., Mytilineos J.;
"Characterization of a new HLA-DQB1 allele by direct sequencing.";
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
[61]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:15).
TISSUE=Peripheral blood;
Velickovic Z.M.;
"Novel HLA-DQB1*03 allele.";
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
[62]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:24).
Schranz P., Seelig R., Seelig H.P.;
"A new HLA-DQB1 allele.";
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[63]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:25).
Watabe K., Hashimoto M.;
"Homo sapiens HLA-DQ gene for MHC class2 antigen, partial cds, allele:
HLA-DQB1*060401V.";
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[64]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:17).
Chu C.-C.;
"A novel DQB1 allele found in Taiwan.";
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[65]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:18).
Hendrix M.M., Cordovado S.K., Mueller P.W.;
"High resolution genotyping of HLA-DQB1 exon 2 and 3.";
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[66]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:29).
Horn P.A., Blasczyk R.;
"A novel HLA-DRQ1*06 allele.";
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
[67]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:31).
Nieberle I., Hirschmann D., Woelpl A.;
"Identification of several new class I and II alleles in routine HLA-
testing.";
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
[68]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:33).
Yu M., Hall J.E., Hartman K.J., Caparelli E., Czech J., Smyth E.,
Jennings L.;
"A novel HLA-DQB1*06 allele identified by PCR-SBT in a caucasian NMDP
donor.";
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
[69]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*04:03).
Vigh A., Hirv K., Mytilineos J.;
"Characterization of a new HLA-Cw*07 allele.";
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
[70]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:37).
Fuerst D., Mytilineos J.;
"A new variant of HLA-DQB1*06.";
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
[71]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:26).
Yang K., Chen M.;
"Novel DQB1*03 found in CAP test sample.";
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
[72]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-122 (ALLELE DQB1*06:16).
PubMed=10323344; DOI=10.1034/j.1399-0039.1999.530410.x;
Luo M., Blanchard J., Maclean I., Brunham R.;
"Identification of a novel DQB1 allele DBQ1*0616.";
Tissue Antigens 53:381-382(1999).
[73]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-115 (ALLELE DQB1*06:30).
Rizzo M., Hurley C.K.;
"Novel HLA-DQB1 allele.";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
[74]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-126 (ALLELE DQB1*06:14).
TISSUE=Blood;
PubMed=9802612; DOI=10.1111/j.1399-0039.1998.tb03047.x;
Hashemi-tavoularis S., Ouellet S., Sengar D.P.S., Buyse I.M.;
"A novel DRB3 allele (DRB3*0208), a new allelic variant of DRB1*1502
(DRB1*15023) and two new DQB1 (DQB1*03012 and DQB1*0614) alleles.";
Tissue Antigens 52:294-299(1998).
[75]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:11).
PubMed=8896171; DOI=10.1111/j.1399-0039.1996.tb02621.x;
Williams T.M., Bassinger S., Moehlenkamp C., Wu J., Montoya G.D.,
Griffith B.B., McAuley J.D., Goldman S., Maurer D.H., Troup G.M.;
"Strategy for distinguishing a new DQB1 allele (DQB1*0611) from the
closely related DQB1*0602 allele via sequence specific PCR or direct
DNA sequencing.";
Tissue Antigens 48:143-147(1996).
[76]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:27).
PubMed=16441489; DOI=10.1111/j.1399-0039.2006.00515.x;
Brixner V., Mosebach M., Schmidt M., Hermann S., Seifried E.,
Martin H., Seidl C.;
"HLA-DRB1*0826 and HLA-DQB1*0627, two novel class II alleles
identified in blood stem cell donors of Caucasian origin.";
Tissue Antigens 67:160-162(2006).
[77]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-122 (ALLELES DQB1*06:07 AND
DQB1*06:08).
Dinauer D.M., Hessner M.J.;
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
[78]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-114 (ALLELE DQB1*05:04).
PubMed=1440562; DOI=10.1111/j.1399-0039.1992.tb01958.x;
Fenske T.S., Baxter-Lowe L.A.;
"Two novel HLA-DQB1*06 alleles reveal additional heterogeneity of HLA-
DQw1.";
Tissue Antigens 40:49-52(1992).
[79]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELE DQB1*02:01).
PubMed=2308943; DOI=10.1073/pnas.87.5.1835;
Gyllensten U.B., Lashkari D., Erlich H.A.;
"Allelic diversification at the class II DQB locus of the mammalian
major histocompatibility complex.";
Proc. Natl. Acad. Sci. U.S.A. 87:1835-1839(1990).
[80]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELES DQB1*02:01 AND
DQB1*06:02).
PubMed=2010218; DOI=10.1007/BF01719235;
Bugawan T.L., Erlich H.A.;
"Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive
oligonucleotide probes and amplified DNA.";
Immunogenetics 33:163-170(1991).
[81]
NUCLEOTIDE SEQUENCE [MRNA] OF 135-217 (ALLELE DQB1*02:01).
PubMed=6952552; DOI=10.1111/j.1365-3083.1981.tb00603.x;
Larhammar D., Wiman K., Schenning L., Claesson L., Gustafsson K.,
Peterson P.A., Rask L.;
"Evolutionary relationship between HLA-DR antigen beta-chains, HLA-A,
B, C antigen subunits and immunoglobulin chains.";
Scand. J. Immunol. 14:617-622(1981).
[82]
POLYMORPHISM.
PubMed=18565458; DOI=10.1016/S1474-4422(08)70140-6;
Bourgin P., Zeitzer J.M., Mignot E.;
"CSF hypocretin-1 assessment in sleep and neurological disorders.";
Lancet Neurol. 7:649-662(2008).
[83]
REVIEW.
PubMed=8598037; DOI=10.1016/S0092-8674(00)81025-9;
Cresswell P.;
"Invariant chain structure and MHC class II function.";
Cell 84:505-507(1996).
[84]
REVIEW.
PubMed=11684289; DOI=10.1016/S0161-5890(01)00069-4;
Villadangos J.A.;
"Presentation of antigens by MHC class II molecules: getting the most
out of them.";
Mol. Immunol. 38:329-346(2001).
[85]
REVIEW.
PubMed=18046453; DOI=10.1038/sj.emboj.7601945;
Rocha N., Neefjes J.;
"MHC class II molecules on the move for successful antigen
presentation.";
EMBO J. 27:1-5(2008).
[86]
REVIEW.
PubMed=17241953; DOI=10.1016/j.immuni.2007.01.005;
Menendez-Benito V., Neefjes J.;
"Autophagy in MHC class II presentation: sampling from within.";
Immunity 26:1-3(2007).
[87]
REVIEW.
PubMed=19092054; DOI=10.1242/jcs.035089;
Berger A.C., Roche P.A.;
"MHC class II transport at a glance.";
J. Cell Sci. 122:1-4(2009).
[88]
REVIEW.
PubMed=19533806; DOI=10.3748/wjg.15.2855;
Beswick E.J., Reyes V.E.;
"CD74 in antigen presentation, inflammation, and cancers of the
gastrointestinal tract.";
World J. Gastroenterol. 15:2855-2861(2009).
[89]
X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 35-224 OF HLA-DQA1/HLA-DQB1
HETERODIMER IN COMPLEX WITH INS PEPTIDE, SUBUNIT, AND DISULFIDE BONDS.
PubMed=11376336; DOI=10.1038/88694;
Lee K.H., Wucherpfennig K.W., Wiley D.C.;
"Structure of a human insulin peptide-HLA-DQ8 complex and
susceptibility to type 1 diabetes.";
Nat. Immunol. 2:501-507(2001).
[90]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 35-231 OF HLA-DQA1/HLA-DQB1
HETERODIMER (HLA-DQ0602) IN COMPLEX WITH HCRT PEPTIDE, POLYMORPHISM,
SUBUNIT, AND DISULFIDE BONDS.
PubMed=14769912; DOI=10.1073/pnas.0308458100;
Siebold C., Hansen B.E., Wyer J.R., Harlos K., Esnouf R.E.,
Svejgaard A., Bell J.I., Strominger J.L., Jones E.Y., Fugger L.;
"Crystal structure of HLA-DQ0602 that protects against type 1 diabetes
and confers strong susceptibility to narcolepsy.";
Proc. Natl. Acad. Sci. U.S.A. 101:1999-2004(2004).
[91]
X-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF 33-230 OF HLA-DQA1/HLA-DQB1
HETERODIMER (DQ2) IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN
PEPTIDE, SUBUNIT, AND POLYMORPHISM.
PubMed=15020763; DOI=10.1073/pnas.0306885101;
Kim C.Y., Quarsten H., Bergseng E., Khosla C., Sollid L.M.;
"Structural basis for HLA-DQ2-mediated presentation of gluten epitopes
in celiac disease.";
Proc. Natl. Acad. Sci. U.S.A. 101:4175-4179(2004).
[92]
X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 33-224 OF HLA-DQA1/HLA-DQB1
HETERODIMER IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN
PEPTIDE, POLYMORPHISM, SUBUNIT, AND DISULFIDE BONDS.
PubMed=17629515; DOI=10.1016/j.immuni.2007.05.015;
Henderson K.N., Tye-Din J.A., Reid H.H., Chen Z., Borg N.A.,
Beissbarth T., Tatham A., Mannering S.I., Purcell A.W., Dudek N.L.,
van Heel D.A., McCluskey J., Rossjohn J., Anderson R.P.;
"A structural and immunological basis for the role of human leukocyte
antigen DQ8 in celiac disease.";
Immunity 27:23-34(2007).
[93]
VARIANT [LARGE SCALE ANALYSIS] ALA-172, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
-!- FUNCTION: Binds peptides derived from antigens that access the
endocytic route of antigen presenting cells (APC) and presents
them on the cell surface for recognition by the CD4 T-cells. The
peptide binding cleft accommodates peptides of 10-30 residues. The
peptides presented by MHC class II molecules are generated mostly
by degradation of proteins that access the endocytic route, where
they are processed by lysosomal proteases and other hydrolases.
Exogenous antigens that have been endocytosed by the APC are thus
readily available for presentation via MHC II molecules, and for
this reason this antigen presentation pathway is usually referred
to as exogenous. As membrane proteins on their way to degradation
in lysosomes as part of their normal turn-over are also contained
in the endosomal/lysosomal compartments, exogenous antigens must
compete with those derived from endogenous components. Autophagy
is also a source of endogenous peptides, autophagosomes
constitutively fuse with MHC class II loading compartments. In
addition to APCs, other cells of the gastrointestinal tract, such
as epithelial cells, express MHC class II molecules and CD74 and
act as APCs, which is an unusual trait of the GI tract. To produce
a MHC class II molecule that presents an antigen, three MHC class
II molecules (heterodimers of an alpha and a beta chain) associate
with a CD74 trimer in the ER to form a heterononamer. Soon after
the entry of this complex into the endosomal/lysosomal system
where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving
a small fragment termed CLIP (class-II-associated invariant chain
peptide). The removal of CLIP is facilitated by HLA-DM via direct
binding to the alpha-beta-CLIP complex so that CLIP is released.
HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound
to a peptide is then transported to the cell membrane surface. In
B-cells, the interaction between HLA-DM and MHC class II molecules
is regulated by HLA-DO. Primary dendritic cells (DCs) also to
express HLA-DO. Lysosomal microenvironment has been implicated in
the regulation of antigen loading into MHC II molecules, increased
acidification produces increased proteolysis and efficient peptide
loading.
-!- SUBUNIT: Heterodimer of an alpha and a beta subunit; also referred
as MHC class II molecule. In the endoplasmic reticulum (ER) it
forms a heterononamer; 3 MHC class II molecules bind to a CD74
homotrimer (also known as invariant chain or HLA class II
histocompatibility antigen gamma chain). In the
endosomal/lysosomal system; CD74 undergoes sequential degradation
by various proteases; leaving a small fragment termed CLIP on each
MHC class II molecule. MHC class II molecule interacts with
HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides.
{ECO:0000269|PubMed:11376336, ECO:0000269|PubMed:14769912,
ECO:0000269|PubMed:15020763, ECO:0000269|PubMed:17629515}.
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein. Endoplasmic reticulum membrane; Single-pass type I
membrane protein. Golgi apparatus, trans-Golgi network membrane;
Single-pass type I membrane protein. Endosome membrane; Single-
pass type I membrane protein. Lysosome membrane; Single-pass type
I membrane protein. Note=The MHC class II complex transits through
a number of intracellular compartments in the endocytic pathway
until it reaches the cell membrane for antigen presentation.
-!- POLYMORPHISM: The following alleles of HLA-DQB1 are known:
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05,
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05,
DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10,
DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15,
DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20,
DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25,
DQB1*03:26, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*05:01,
DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*06:01,
DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06,
DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11,
DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16,
DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21,
DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27,
DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32,
DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37,
DQB1*06:38, and DQB1*06:39. The sequence shown is that of
DQB1*03:01.
-!- POLYMORPHISM: DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is
associated with more than 90% of celiac disease patients. A
minority displays DQ8 (heterodimer of DQA1*03/DQB1*03:02).
-!- POLYMORPHISM: DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02)
confers dominant protection against type 1 diabetes (T1D) and
strong susceptibility to narcolepsy. DQB1*06:02 has been found to
be present in most of the narcolepsy patients. As well 98% of the
patients with an HCRT deficiency are positive for DQB1*06:02.
-!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAC64403.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CAJ57391.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and
polymorphism database;
URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HLA-DQB1";
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EMBL; K01499; AAA98746.1; -; Genomic_DNA.
EMBL; K02405; AAA75521.1; -; Genomic_DNA.
EMBL; X03068; CAA26872.1; -; mRNA.
EMBL; M17564; AAA59765.1; -; mRNA.
EMBL; M29613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M29616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M16996; AAA59770.1; -; mRNA.
EMBL; M20432; AAA59769.1; -; mRNA.
EMBL; M60028; AAA59755.1; -; mRNA.
EMBL; X96420; CAA65280.1; -; mRNA.
EMBL; U92032; AAB91991.1; -; Genomic_DNA.
EMBL; AY663393; AAU87973.1; -; Genomic_DNA.
EMBL; AY663394; AAU87977.1; -; Genomic_DNA.
EMBL; AY663397; AAU87986.1; -; Genomic_DNA.
EMBL; AY663409; AAU88017.1; -; Genomic_DNA.
EMBL; AY663404; AAU88002.1; -; Genomic_DNA.
EMBL; AY663410; AAU88020.1; -; Genomic_DNA.
EMBL; AY663412; AAU88027.1; -; Genomic_DNA.
EMBL; AY656681; AAV71028.1; -; mRNA.
EMBL; AY656682; AAV71029.1; -; mRNA.
EMBL; AY656683; AAV71030.1; -; mRNA.
EMBL; BX927168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CR753846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CR933859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC012106; AAH12106.1; -; mRNA.
EMBL; M25327; AAA59677.1; -; mRNA.
EMBL; U66400; AAB51698.1; -; mRNA.
EMBL; U83582; AAB41231.1; -; mRNA.
EMBL; AH002887; AAA59762.1; -; Genomic_DNA.
EMBL; M26042; AAA36270.1; -; mRNA.
EMBL; M33907; AAA52672.1; -; mRNA.
EMBL; L34096; AAC41964.1; -; mRNA.
EMBL; L34098; AAC41966.1; -; mRNA.
EMBL; L34101; AAC41969.1; -; mRNA.
EMBL; L34103; AAC41971.1; -; mRNA.
EMBL; L34104; AAC41972.1; -; mRNA.
EMBL; L34105; AAC41973.1; -; mRNA.
EMBL; L34106; AAC41974.1; -; mRNA.
EMBL; L34107; AAC41975.1; -; mRNA.
EMBL; AF195245; AAF28315.1; -; mRNA.
EMBL; L42626; AAA85335.1; -; mRNA.
EMBL; X76553; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; X76554; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; M59800; AAA64235.1; -; mRNA.
EMBL; M14189; AAA36268.1; -; mRNA.
EMBL; AY672649; AAT77952.1; -; Genomic_DNA.
EMBL; M17207; AAA59697.1; -; mRNA.
EMBL; Z49215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AY026349; AAK01944.1; -; Genomic_DNA.
EMBL; AF091305; AAC64403.2; ALT_SEQ; Genomic_DNA.
EMBL; U77344; AAB19215.1; -; Genomic_DNA.
EMBL; FN256435; CAX62164.1; -; Genomic_DNA.
EMBL; FN256435; CAX62165.1; -; Genomic_DNA.
EMBL; AM400970; CAL47037.1; -; Genomic_DNA.
EMBL; AM421131; CAM07104.1; -; Genomic_DNA.
EMBL; EF484936; ABO87661.1; -; Genomic_DNA.
EMBL; EF484939; ABO87664.1; -; Genomic_DNA.
EMBL; EU275158; ABY26531.1; -; Genomic_DNA.
EMBL; AM944346; CAQ16179.1; -; Genomic_DNA.
EMBL; FM200854; CAR31119.1; -; Genomic_DNA.
EMBL; AH013029; AAP93137.1; -; Genomic_DNA.
EMBL; EU770203; ACF16333.1; -; Genomic_DNA.
EMBL; FM955320; CAW24712.1; -; Genomic_DNA.
EMBL; FN552709; CBF35736.1; -; Genomic_DNA.
EMBL; FN552710; CBF35739.1; -; Genomic_DNA.
EMBL; X86327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; D78569; BAA11413.1; -; Genomic_DNA.
EMBL; AF439338; AAL35222.1; -; Genomic_DNA.
EMBL; AF384556; AAM53072.1; -; Genomic_DNA.
EMBL; DQ026226; AAY89656.1; -; Genomic_DNA.
EMBL; AY762968; AAV97949.1; -; Genomic_DNA.
EMBL; AM181332; CAJ57391.1; ALT_SEQ; Genomic_DNA.
EMBL; AM691798; CAM88661.1; -; Genomic_DNA.
EMBL; AM259942; CAJ90956.1; -; Genomic_DNA.
EMBL; U39090; AAB02681.1; -; Genomic_DNA.
EMBL; AJ003005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AJ012156; CAA09929.1; -; Genomic_DNA.
EMBL; AJ290396; CAC27418.1; -; Genomic_DNA.
EMBL; AF469118; AAL77085.1; -; Genomic_DNA.
EMBL; AF479569; AAM09472.1; -; Genomic_DNA.
EMBL; AJ535315; CAD59445.2; -; Genomic_DNA.
EMBL; AF181983; AAD54423.2; -; Genomic_DNA.
EMBL; AY733062; AAU33811.1; -; Genomic_DNA.
EMBL; AJ854065; CAH69441.1; -; Genomic_DNA.
EMBL; AJ964903; CAI79639.1; -; Genomic_DNA.
EMBL; AB211231; BAD95610.1; -; Genomic_DNA.
EMBL; DQ114427; AAZ20753.1; -; Genomic_DNA.
EMBL; DQ227421; ABB05231.1; -; Genomic_DNA.
EMBL; AM403489; CAL48285.1; -; Genomic_DNA.
EMBL; AM490069; CAM32717.1; -; Genomic_DNA.
EMBL; EF622510; ABR24117.1; -; Genomic_DNA.
EMBL; EU410617; ABZ89500.1; -; Genomic_DNA.
EMBL; GQ422610; ACV66342.1; -; Genomic_DNA.
EMBL; FN550110; CBE66554.1; -; Genomic_DNA.
EMBL; AF087939; AAD39697.1; -; Genomic_DNA.
EMBL; AY094140; AAM14401.1; -; Genomic_DNA.
EMBL; AJ001257; CAA04631.1; -; Genomic_DNA.
EMBL; U39086; AAA93181.1; -; Genomic_DNA.
EMBL; AJ965439; CAI84643.1; -; Genomic_DNA.
EMBL; AF112463; AAD23990.1; -; Genomic_DNA.
EMBL; AF112464; AAD23991.1; -; Genomic_DNA.
EMBL; M94773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M65042; AAA36241.1; -; Genomic_DNA.
EMBL; M25025; AAA59793.1; -; mRNA.
PIR; A02234; HLHU1C.
PIR; A35055; A35055.
PIR; A94003; HLHUDB.
PIR; B32527; B32527.
PIR; B37044; B37044.
PIR; C24669; HLHU2C.
PIR; F30575; F30575.
PIR; I54480; I54480.
PIR; I68732; I68732.
PIR; I72482; I72482.
PIR; S46648; S46648.
RefSeq; NP_001230891.1; NM_001243962.1.
RefSeq; NP_002114.3; NM_002123.4.
UniGene; Hs.409934; -.
UniGene; Hs.534322; -.
PDB; 1JK8; X-ray; 2.40 A; B=35-224.
PDB; 1NBN; Model; -; B=35-224.
PDB; 1S9V; X-ray; 2.22 A; B/E=33-230.
PDB; 1UVQ; X-ray; 1.80 A; B=35-230.
PDB; 2NNA; X-ray; 2.10 A; B=33-224.
PDB; 4GG6; X-ray; 3.20 A; B/D=33-224.
PDB; 4OZF; X-ray; 2.70 A; B=33-224.
PDB; 4OZG; X-ray; 3.00 A; B/D=33-224.
PDB; 4OZH; X-ray; 2.80 A; B/D=33-224.
PDB; 4OZI; X-ray; 3.20 A; B/D=33-224.
PDBsum; 1JK8; -.
PDBsum; 1NBN; -.
PDBsum; 1S9V; -.
PDBsum; 1UVQ; -.
PDBsum; 2NNA; -.
PDBsum; 4GG6; -.
PDBsum; 4OZF; -.
PDBsum; 4OZG; -.
PDBsum; 4OZH; -.
PDBsum; 4OZI; -.
ProteinModelPortal; P01920; -.
SMR; P01920; -.
BioGrid; 109364; 11.
IntAct; P01920; 1.
MINT; P01920; -.
DrugBank; DB00071; Insulin Pork.
iPTMnet; P01920; -.
PhosphoSitePlus; P01920; -.
BioMuta; HLA-DQB1; -.
DMDM; 290457643; -.
PeptideAtlas; P01920; -.
PRIDE; P01920; -.
DNASU; 3119; -.
Ensembl; ENST00000399088; ENSP00000382038; ENSG00000231286.
Ensembl; ENST00000413089; ENSP00000396539; ENSG00000231286.
Ensembl; ENST00000416192; ENSP00000410107; ENSG00000233209.
Ensembl; ENST00000419914; ENSP00000402865; ENSG00000225824.
Ensembl; ENST00000422950; ENSP00000414079; ENSG00000233209.
Ensembl; ENST00000424806; ENSP00000410330; ENSG00000225824.
GeneID; 3119; -.
KEGG; hsa:3119; -.
UCSC; uc011hep.3; human.
CTD; 3119; -.
DisGeNET; 3119; -.
GeneCards; HLA-DQB1; -.
GeneReviews; HLA-DQB1; -.
HGNC; HGNC:4944; HLA-DQB1.
HPA; HPA013667; -.
MalaCards; HLA-DQB1; -.
MIM; 604305; gene.
neXtProt; NX_P01920; -.
Orphanet; 703; Bullous pemphigoid.
Orphanet; 555; Celiac disease.
Orphanet; 243377; Diabetes mellitus type 1.
Orphanet; 930; Idiopathic achalasia.
Orphanet; 802; Multiple sclerosis.
Orphanet; 83465; Narcolepsy without cataplexy.
Orphanet; 2073; Narcolepsy-cataplexy.
PharmGKB; PA35068; -.
HOVERGEN; HBG012730; -.
InParanoid; P01920; -.
KO; K06752; -.
PhylomeDB; P01920; -.
Reactome; R-HSA-202424; Downstream TCR signaling.
Reactome; R-HSA-202427; Phosphorylation of CD3 and TCR zeta chains.
Reactome; R-HSA-202430; Translocation of ZAP-70 to Immunological synapse.
Reactome; R-HSA-202433; Generation of second messenger molecules.
Reactome; R-HSA-2132295; MHC class II antigen presentation.
Reactome; R-HSA-389948; PD-1 signaling.
Reactome; R-HSA-877300; Interferon gamma signaling.
SIGNOR; P01920; -.
ChiTaRS; HLA-DQB1; human.
EvolutionaryTrace; P01920; -.
GeneWiki; HLA-DQB1; -.
GenomeRNAi; 3119; -.
PRO; PR:P01920; -.
Proteomes; UP000005640; Chromosome 6.
CleanEx; HS_HLA-DQB1; -.
GO; GO:0030669; C:clathrin-coated endocytic vesicle membrane; TAS:Reactome.
GO; GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0005765; C:lysosomal membrane; TAS:Reactome.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0042613; C:MHC class II protein complex; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO; GO:0030658; C:transport vesicle membrane; TAS:Reactome.
GO; GO:0032395; F:MHC class II receptor activity; NAS:UniProtKB.
GO; GO:0042605; F:peptide antigen binding; ISS:UniProtKB.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
GO; GO:0002455; P:humoral immune response mediated by circulating immunoglobulin; IDA:UniProtKB.
GO; GO:0006955; P:immune response; NAS:UniProtKB.
GO; GO:0002381; P:immunoglobulin production involved in immunoglobulin mediated immune response; IDA:UniProtKB.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
GO; GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 3.10.320.10; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003006; Ig/MHC_CS.
InterPro; IPR003597; Ig_C1-set.
InterPro; IPR011162; MHC_I/II-like_Ag-recog.
InterPro; IPR014745; MHC_II_a/b_N.
InterPro; IPR000353; MHC_II_b_N.
Pfam; PF07654; C1-set; 1.
Pfam; PF00969; MHC_II_beta; 1.
ProDom; PD000328; MHC_II_b_N; 1.
SMART; SM00407; IGc1; 1.
SMART; SM00921; MHC_II_beta; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF54452; SSF54452; 1.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS00290; IG_MHC; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Complete proteome;
Direct protein sequencing; Disulfide bond; Endoplasmic reticulum;
Endosome; Glycoprotein; Golgi apparatus; Immunity; Lysosome; Membrane;
MHC II; Polymorphism; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 32 {ECO:0000269|PubMed:6576979}.
CHAIN 33 261 HLA class II histocompatibility antigen,
DQ beta 1 chain.
/FTId=PRO_0000018989.
TOPO_DOM 33 230 Extracellular. {ECO:0000255}.
TRANSMEM 231 251 Helical. {ECO:0000255}.
TOPO_DOM 252 261 Cytoplasmic. {ECO:0000255}.
DOMAIN 129 217 Ig-like C1-type.
REGION 33 126 Beta-1.
REGION 127 220 Beta-2.
REGION 221 230 Connecting peptide.
CARBOHYD 51 51 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 47 111
DISULFID 149 205
VARIANT 6 6 A -> S (in allele DQB1*05:01 and allele
DQB1*05:02; dbSNP:rs1049056).
/FTId=VAR_056570.
VARIANT 12 12 G -> D (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*06:02 and allele
DQB1*06:12; dbSNP:rs1049057).
/FTId=VAR_062679.
VARIANT 15 15 A -> V (in allele DQB1*03:02, allele
DQB1*03:03, allele DQB1*04:01, allele
DQB1*05:01, allele DQB1*05:02, allele
DQB1*06:02 and allele DQB1*06:12;
dbSNP:rs3189152).
{ECO:0000269|PubMed:3584986}.
/FTId=VAR_062680.
VARIANT 23 23 A -> S (in allele DQB1*02:01 and allele
DQB1*02:02; dbSNP:rs3891176).
/FTId=VAR_062681.
VARIANT 24 24 M -> I (in allele DQB1*05:01 and allele
DQB1*05:02; dbSNP:rs1049059).
/FTId=VAR_062682.
VARIANT 27 27 T -> A (in allele DQB1*04:01;
dbSNP:rs1049060).
/FTId=VAR_062683.
VARIANT 27 27 T -> S (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*06:02 and allele
DQB1*06:12; dbSNP:rs1049060).
/FTId=VAR_062684.
VARIANT 28 28 P -> L (in allele DQB1*06:02 and allele
DQB1*06:12; dbSNP:rs1049062).
/FTId=VAR_062685.
VARIANT 28 28 P -> S (in allele DQB1*05:01 and allele
DQB1*05:02; dbSNP:rs1049061).
{ECO:0000269|PubMed:3584986}.
/FTId=VAR_062686.
VARIANT 29 29 V -> L (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*06:02 and allele
DQB1*06:12; dbSNP:rs1130366).
/FTId=VAR_062687.
VARIANT 35 35 S -> P (in allele DQB1*06:01;
dbSNP:rs12722106).
/FTId=VAR_062688.
VARIANT 41 41 Y -> F (in allele DQB1*04:01, allele
DQB1*04:02, allele DQB1*04:03, allele
DQB1*06:02, allele DQB1*06:10, allele
DQB1*06:13, allele DQB1*06:14, allele
DQB1*06:15, allele DQB1*06:16, allele
DQB1*06:19, allele DQB1*06:20, allele
DQB1*06:22, allele DQB1*06:23, allele
DQB1*06:24, allele DQB1*06:29, allele
DQB1*06:33 and allele DQB1*06:37;
dbSNP:rs9274407).
/FTId=VAR_062689.
VARIANT 41 41 Y -> L (in allele DQB1*06:01 and allele
DQB1*06:35; requires 2 nucleotide
substitutions).
/FTId=VAR_062690.
VARIANT 43 43 F -> L (in allele DQB1*06:33;
dbSNP:rs56173496).
/FTId=VAR_062691.
VARIANT 45 45 A -> G (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04, allele DQB1*02:05, allele
DQB1*03:02, allele DQB1*03:03, allele
DQB1*03:05, allele DQB1*03:06, allele
DQB1*03:07, allele DQB1*03:08, allele
DQB1*03:11, allele DQB1*03:15, allele
DQB1*03:17, allele DQB1*03:18, allele
DQB1*03:20, allele DQB1*03:23, allele
DQB1*03:25, allele DQB1*03:26, allele
DQB1*04:01, allele DQB1*04:02, allele
DQB1*04:03, allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:04, allele DQB1*05:05, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:05, allele
DQB1*06:07, allele DQB1*06:08, allele
DQB1*06:09, allele DQB1*06:10, allele
DQB1*06:11, allele DQB1*06:12, allele
DQB1*06:13, allele DQB1*06:14, allele
DQB1*06:15, allele DQB1*06:16, allele
DQB1*06:17, allele DQB1*06:18, allele
DQB1*06:19, allele DQB1*06:20, allele
DQB1*06:21, allele DQB1*06:22, allele
DQB1*06:23, allele DQB1*06:24, allele
DQB1*06:25, allele DQB1*06:27, allele
DQB1*06:28, allele DQB1*06:29, allele
DQB1*06:30, allele DQB1*06:31, allele
DQB1*06:32, allele DQB1*06:33, allele
DQB1*06:34, allele DQB1*06:36, allele
DQB1*06:37, allele DQB1*06:38 and allele
DQB1*06:39; dbSNP:rs1130375).
{ECO:0000269|PubMed:3584986}.
/FTId=VAR_061472.
VARIANT 46 46 M -> L (in allele DQB1*03:11, allele
DQB1*03:26, allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:04, allele DQB1*05:05, allele
DQB1*06:05, allele DQB1*06:20 and allele
DQB1*06:31; dbSNP:rs1130368).
/FTId=VAR_061473.
VARIANT 55 55 R -> L (in allele DQB1*04:01;
dbSNP:rs41540813).
/FTId=VAR_062692.
VARIANT 58 58 Y -> G (in allele DQB1*03:05, allele
DQB1*03:17, allele DQB1*04:01, allele
DQB1*04:02, allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:04, allele DQB1*05:05 and allele
DQB1*06:23; requires 2 nucleotide
substitutions).
/FTId=VAR_062693.
VARIANT 58 58 Y -> L (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04, allele DQB1*02:05, allele
DQB1*03:02, allele DQB1*03:03, allele
DQB1*03:06, allele DQB1*03:07, allele
DQB1*03:08, allele DQB1*03:11, allele
DQB1*03:12, allele DQB1*03:15, allele
DQB1*03:18, allele DQB1*03:20, allele
DQB1*03:23, allele DQB1*03:25, allele
DQB1*03:26, allele DQB1*04:03, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:05, allele
DQB1*06:06, allele DQB1*06:07, allele
DQB1*06:08, allele DQB1*06:09, allele
DQB1*06:10, allele DQB1*06:11, allele
DQB1*06:12, allele DQB1*06:13, allele
DQB1*06:14, allele DQB1*06:15, allele
DQB1*06:16, allele DQB1*06:17, allele
DQB1*06:18, allele DQB1*06:19, allele
DQB1*06:20, allele DQB1*06:21, allele
DQB1*06:22, allele DQB1*06:24, allele
DQB1*06:25, allele DQB1*06:27, allele
DQB1*06:28, allele DQB1*06:29, allele
DQB1*06:30, allele DQB1*06:31, allele
DQB1*06:32, allele DQB1*06:33, allele
DQB1*06:34, allele DQB1*06:36, allele
DQB1*06:37, allele DQB1*06:38 and allele
DQB1*06:39; requires 2 nucleotide
substitutions; dbSNP:rs766817072).
{ECO:0000269|PubMed:3584986}.
/FTId=VAR_062694.
VARIANT 59 59 V -> L (in allele DQB1*03:18;
dbSNP:rs41563539).
/FTId=VAR_062695.
VARIANT 60 60 T -> S (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04 and allele DQB1*02:05;
dbSNP:rs9274405).
/FTId=VAR_062696.
VARIANT 62 62 Y -> H (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:05, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:07, allele
DQB1*06:08, allele DQB1*06:14, allele
DQB1*06:17, allele DQB1*06:21, allele
DQB1*06:25, allele DQB1*06:27, allele
DQB1*06:28, allele DQB1*06:30, allele
DQB1*06:31, allele DQB1*06:32, allele
DQB1*06:34, allele DQB1*06:36, allele
DQB1*06:38 and allele DQB1*06:39;
dbSNP:rs281862065).
/FTId=VAR_062697.
VARIANT 62 62 Y -> S (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04 and allele DQB1*02:05).
/FTId=VAR_062698.
VARIANT 69 69 Y -> D (in allele DQB1*06:01 and allele
DQB1*06:35; dbSNP:rs281874782).
/FTId=VAR_062699.
VARIANT 69 69 Y -> I (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04 and allele DQB1*02:05;
requires 2 nucleotide substitutions).
/FTId=VAR_062700.
VARIANT 70 70 A -> T (in allele DQB1*03:20;
dbSNP:rs45519640).
/FTId=VAR_062701.
VARIANT 70 70 A -> V (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04, allele DQB1*02:05, allele
DQB1*05:01, allele DQB1*05:02, allele
DQB1*05:03, allele DQB1*05:04, allele
DQB1*06:01, allele DQB1*06:28 and allele
DQB1*06:35; dbSNP:rs1063318).
/FTId=VAR_062702.
VARIANT 77 77 E -> G (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04, allele DQB1*02:05, allele
DQB1*03:02, allele DQB1*03:03, allele
DQB1*03:05, allele DQB1*03:06, allele
DQB1*03:07, allele DQB1*03:08, allele
DQB1*03:10, allele DQB1*03:11, allele
DQB1*03:12, allele DQB1*03:14, allele
DQB1*03:15, allele DQB1*03:17, allele
DQB1*03:18, allele DQB1*03:20, allele
DQB1*03:23, allele DQB1*03:25, allele
DQB1*03:26, allele DQB1*04:01, allele
DQB1*04:02, allele DQB1*04:03, allele
DQB1*05:01, allele DQB1*05:02, allele
DQB1*05:03, allele DQB1*05:04, allele
DQB1*05:05, allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:05, allele
DQB1*06:06, allele DQB1*06:07, allele
DQB1*06:08, allele DQB1*06:09, allele
DQB1*06:10, allele DQB1*06:11, allele
DQB1*06:12, allele DQB1*06:13, allele
DQB1*06:14, allele DQB1*06:15, allele
DQB1*06:16, allele DQB1*06:17, allele
DQB1*06:18, allele DQB1*06:19, allele
DQB1*06:20, allele DQB1*06:21, allele
DQB1*06:22, allele DQB1*06:23, allele
DQB1*06:24, allele DQB1*06:25, allele
DQB1*06:27, allele DQB1*06:28, allele
DQB1*06:29, allele DQB1*06:30, allele
DQB1*06:31, allele DQB1*06:32, allele
DQB1*06:33, allele DQB1*06:34, allele
DQB1*06:36, allele DQB1*06:37, allele
DQB1*06:38 and allele DQB1*06:39;
dbSNP:rs1049083).
{ECO:0000269|PubMed:3584986}.
/FTId=VAR_062703.
VARIANT 78 78 V -> E (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04 and allele DQB1*02:05;
dbSNP:rs9274398).
/FTId=VAR_062704.
VARIANT 79 79 Y -> F (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04 and allele DQB1*02:05;
dbSNP:rs9274397).
/FTId=VAR_062705.
VARIANT 81 81 A -> V (in allele DQB1*03:07;
dbSNP:rs41558214).
/FTId=VAR_062706.
VARIANT 84 84 P -> L (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04 and allele DQB1*02:05;
dbSNP:rs9274395).
/FTId=VAR_062707.
VARIANT 85 85 L -> Q (in allele DQB1*03:23, allele
DQB1*05:01, allele DQB1*05:02, allele
DQB1*05:03, allele DQB1*05:04, allele
DQB1*05:05, allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:05, allele
DQB1*06:06, allele DQB1*06:07, allele
DQB1*06:08, allele DQB1*06:09, allele
DQB1*06:10, allele DQB1*06:11, allele
DQB1*06:12, allele DQB1*06:13, allele
DQB1*06:14, allele DQB1*06:15, allele
DQB1*06:16, allele DQB1*06:17, allele
DQB1*06:18, allele DQB1*06:20, allele
DQB1*06:22, allele DQB1*06:21, allele
DQB1*06:23, allele DQB1*06:24, allele
DQB1*06:25, allele DQB1*06:27, allele
DQB1*06:28, allele DQB1*06:29, allele
DQB1*06:30, allele DQB1*06:31, allele
DQB1*06:32, allele DQB1*06:33, allele
DQB1*06:34, allele DQB1*06:36, allele
DQB1*06:37, allele DQB1*06:38 and allele
DQB1*06:39; dbSNP:rs1140313).
/FTId=VAR_062708.
VARIANT 87 87 P -> L (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04 and allele DQB1*02:05;
dbSNP:rs1130380).
/FTId=VAR_062709.
VARIANT 87 87 P -> Q (in allele DQB1*03:16;
dbSNP:rs1130380).
/FTId=VAR_062710.
VARIANT 87 87 P -> R (in allele DQB1*03:23, allele
DQB1*03:25, allele DQB1*04:01, allele
DQB1*04:02, allele DQB1*04:03, allele
DQB1*05:01, allele DQB1*05:02, allele
DQB1*05:03, allele DQB1*05:04, allele
DQB1*05:05, allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:05, allele
DQB1*06:06, allele DQB1*06:07, allele
DQB1*06:08, allele DQB1*06:09, allele
DQB1*06:10, allele DQB1*06:11, allele
DQB1*06:12, allele DQB1*06:13, allele
DQB1*06:14, allele DQB1*06:15, allele
DQB1*06:16, allele DQB1*06:17, allele
DQB1*06:18, allele DQB1*06:19, allele
DQB1*06:20, allele DQB1*06:21, allele
DQB1*06:22, allele DQB1*06:23, allele
DQB1*06:24, allele DQB1*06:25, allele
DQB1*06:27, allele DQB1*06:28, allele
DQB1*06:30, allele DQB1*06:31, allele
DQB1*06:32, allele DQB1*06:33, allele
DQB1*06:34, allele DQB1*06:35, allele
DQB1*06:36, allele DQB1*06:37, allele
DQB1*06:38 and allele DQB1*06:39;
dbSNP:rs1130380).
/FTId=VAR_062711.
VARIANT 88 88 P -> L (in allele DQB1*03:25, allele
DQB1*04:01, allele DQB1*04:02 and allele
DQB1*04:03; dbSNP:rs1130381).
/FTId=VAR_062712.
VARIANT 89 89 D -> A (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:04, allele
DQB1*02:05, allele DQB1*03:02, allele
DQB1*03:04, allele DQB1*03:05, allele
DQB1*03:07, allele DQB1*03:08, allele
DQB1*03:11, allele DQB1*03:14, allele
DQB1*03:18 and allele DQB1*06:29;
dbSNP:rs1071637).
/FTId=VAR_062713.
VARIANT 89 89 D -> S (in allele DQB1*05:02, allele
DQB1*05:04, allele DQB1*05:05, allele
DQB1*06:10 and allele DQB1*06:25;
requires 2 nucleotide substitutions).
/FTId=VAR_062714.
VARIANT 89 89 D -> V (in allele DQB1*05:01, allele
DQB1*06:04, allele DQB1*06:05, allele
DQB1*06:06, allele DQB1*06:08, allele
DQB1*06:09, allele DQB1*06:12, allele
DQB1*06:13, allele DQB1*06:17, allele
DQB1*06:18, allele DQB1*06:21, allele
DQB1*06:22, allele DQB1*06:27, allele
DQB1*06:34, allele DQB1*06:36, allele
DQB1*06:38 and allele DQB1*06:39;
dbSNP:rs1071637).
/FTId=VAR_062715.
VARIANT 92 92 Y -> N (in allele DQB1*06:16;
dbSNP:rs41562414).
/FTId=VAR_062716.
VARIANT 94 94 N -> K (in allele DQB1*06:37;
dbSNP:rs1130382).
/FTId=VAR_062717.
VARIANT 95 95 S -> R (in allele DQB1*03:15;
dbSNP:rs41556215).
/FTId=VAR_062718.
VARIANT 98 98 E -> D (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04, allele DQB1*02:05, allele
DQB1*03:06, allele DQB1*03:25, allele
DQB1*04:01, allele DQB1*04:02, allele
DQB1*04:03, allele DQB1*05:04, allele
DQB1*06:01 and allele DQB1*06:35;
dbSNP:rs9274390).
/FTId=VAR_062719.
VARIANT 99 99 V -> D (in allele DQB1*03:13;
dbSNP:rs41563814).
/FTId=VAR_062720.
VARIANT 99 99 V -> I (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04, allele DQB1*02:05, allele
DQB1*03:06, allele DQB1*03:25, allele
DQB1*04:01, allele DQB1*04:02, allele
DQB1*04:03, allele DQB1*05:04, allele
DQB1*06:01 and allele DQB1*06:35;
dbSNP:rs9274390).
/FTId=VAR_062721.
VARIANT 102 102 R -> E (in allele DQB1*03:06, allele
DQB1*03:25, allele DQB1*04:01, allele
DQB1*04:02, allele DQB1*04:03 and allele
DQB1*05:04; requires 2 nucleotide
substitutions).
/FTId=VAR_062722.
VARIANT 102 102 R -> G (in allele DQB1*03:08, allele
DQB1*05:01, allele DQB1*05:02, allele
DQB1*05:03, allele DQB1*05:05, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:08, allele DQB1*06:10, allele
DQB1*06:11, allele DQB1*06:12, allele
DQB1*06:13, allele DQB1*06:14, allele
DQB1*06:16, allele DQB1*06:17, allele
DQB1*06:19, allele DQB1*06:20, allele
DQB1*06:21, allele DQB1*06:23, allele
DQB1*06:24, allele DQB1*06:28, allele
DQB1*06:29, allele DQB1*06:30, allele
DQB1*06:31 and allele DQB1*06:33;
dbSNP:rs1130386).
{ECO:0000269|PubMed:3584986}.
/FTId=VAR_062723.
VARIANT 103 103 T -> A (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:05, allele DQB1*06:17, allele
DQB1*06:24 and allele DQB1*06:30;
dbSNP:rs1130390).
/FTId=VAR_062724.
VARIANT 103 103 T -> D (in allele DQB1*03:06, allele
DQB1*03:25, allele DQB1*04:01, allele
DQB1*04:02, allele DQB1*04:03 and allele
DQB1*05:04; requires 2 nucleotide
substitutions).
/FTId=VAR_062725.
VARIANT 103 103 T -> K (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04 and allele DQB1*02:05).
/FTId=VAR_062726.
VARIANT 106 106 E -> A (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04, allele DQB1*02:05 and allele
DQB1*06:06; dbSNP:rs1130387).
/FTId=VAR_062727.
VARIANT 106 106 E -> S (in allele DQB1*03:06, allele
DQB1*03:25, allele DQB1*04:01, allele
DQB1*04:02, allele DQB1*04:03, allele
DQB1*05:01, allele DQB1*05:02, allele
DQB1*05:03, allele DQB1*05:04 and allele
DQB1*05:05; requires 2 nucleotide
substitutions).
/FTId=VAR_062728.
VARIANT 107 107 L -> V (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04, allele DQB1*02:05, allele
DQB1*03:06, allele DQB1*03:25, allele
DQB1*04:01, allele DQB1*04:02, allele
DQB1*04:03, allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:04, allele DQB1*05:05 and allele
DQB1*06:06; dbSNP:rs9274384).
/FTId=VAR_062729.
VARIANT 109 109 T -> R (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:03, allele
DQB1*02:04, allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:04, allele DQB1*05:05 and allele
DQB1*06:06; dbSNP:rs1130392).
/FTId=VAR_062730.
VARIANT 116 116 Q -> E (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:05, allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:05, allele
DQB1*06:07, allele DQB1*06:08, allele
DQB1*06:09, allele DQB1*06:10, allele
DQB1*06:11, allele DQB1*06:12, allele
DQB1*06:13, allele DQB1*06:14, allele
DQB1*06:15, allele DQB1*06:16, allele
DQB1*06:17, allele DQB1*06:18, allele
DQB1*06:19, allele DQB1*06:20, allele
DQB1*06:21, allele DQB1*06:22, allele
DQB1*06:23, allele DQB1*06:24, allele
DQB1*06:25, allele DQB1*06:27, allele
DQB1*06:28, allele DQB1*06:29, allele
DQB1*06:30, allele DQB1*06:31, allele
DQB1*06:32, allele DQB1*06:33, allele
DQB1*06:34, allele DQB1*06:35, allele
DQB1*06:36, allele DQB1*06:37, allele
DQB1*06:38, allele DQB1*06:39;
dbSNP:rs1140316).
/FTId=VAR_062731.
VARIANT 117 117 L -> V (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:05, allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:05, allele
DQB1*06:07, allele DQB1*06:08, allele
DQB1*06:09, allele DQB1*06:10, allele
DQB1*06:11, allele DQB1*06:12, allele
DQB1*06:13, allele DQB1*06:14, allele
DQB1*06:15, allele DQB1*06:16, allele
DQB1*06:17, allele DQB1*06:18, allele
DQB1*06:19, allele DQB1*06:20, allele
DQB1*06:21, allele DQB1*06:22, allele
DQB1*06:23, allele DQB1*06:24, allele
DQB1*06:25, allele DQB1*06:27, allele
DQB1*06:28, allele DQB1*06:29, allele
DQB1*06:30, allele DQB1*06:31, allele
DQB1*06:32, allele DQB1*06:33, allele
DQB1*06:34, allele DQB1*06:35, allele
DQB1*06:36, allele DQB1*06:37, allele
DQB1*06:38 and allele DQB1*06:39;
dbSNP:rs1140317).
/FTId=VAR_062732.
VARIANT 118 118 E -> A (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:05, allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:08, allele DQB1*06:10, allele
DQB1*06:11, allele DQB1*06:13, allele
DQB1*06:14, allele DQB1*06:16, allele
DQB1*06:18, allele DQB1*06:19, allele
DQB1*06:20, allele DQB1*06:23, allele
DQB1*06:24, allele DQB1*06:27, allele
DQB1*06:28, allele DQB1*06:29, allele
DQB1*06:30, allele DQB1*06:31, allele
DQB1*06:32, allele DQB1*06:33, allele
DQB1*06:35 and allele DQB1*06:37;
dbSNP:rs9274380).
/FTId=VAR_062733.
VARIANT 118 118 E -> G (in allele DQB1*06:04, allele
DQB1*06:05, allele DQB1*06:07, allele
DQB1*06:09, allele DQB1*06:12, allele
DQB1*06:15, allele DQB1*06:17, allele
DQB1*06:21, allele DQB1*06:22, allele
DQB1*06:25, allele DQB1*06:34, allele
DQB1*06:36, allele DQB1*06:38 and allele
DQB1*06:39; dbSNP:rs9274380).
/FTId=VAR_062734.
VARIANT 119 119 L -> F (in allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:08, allele DQB1*06:10, allele
DQB1*06:11, allele DQB1*06:13, allele
DQB1*06:14, allele DQB1*06:16, allele
DQB1*06:18, allele DQB1*06:19, allele
DQB1*06:20, allele DQB1*06:23, allele
DQB1*06:24, allele DQB1*06:27, allele
DQB1*06:28, allele DQB1*06:29, allele
DQB1*06:30, allele DQB1*06:31, allele
DQB1*06:32, allele DQB1*06:33, allele
DQB1*06:35 and allele DQB1*06:37;
dbSNP:rs9274379).
/FTId=VAR_062735.
VARIANT 119 119 L -> Y (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:05, allele DQB1*06:04, allele
DQB1*06:05, allele DQB1*06:07, allele
DQB1*06:09, allele DQB1*06:12, allele
DQB1*06:15, allele DQB1*06:17, allele
DQB1*06:21, allele DQB1*06:22, allele
DQB1*06:25, allele DQB1*06:34, allele
DQB1*06:36, allele DQB1*06:38 and allele
DQB1*06:39; requires 2 nucleotide
substitutions).
/FTId=VAR_062736.
VARIANT 121 121 T -> G (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:05, allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:05, allele
DQB1*06:07, allele DQB1*06:08, allele
DQB1*06:09, allele DQB1*06:10, allele
DQB1*06:11, allele DQB1*06:12, allele
DQB1*06:13, allele DQB1*06:14, allele
DQB1*06:15, allele DQB1*06:16, allele
DQB1*06:17, allele DQB1*06:18, allele
DQB1*06:19, allele DQB1*06:21, allele
DQB1*06:22, allele DQB1*06:23, allele
DQB1*06:24, allele DQB1*06:25, allele
DQB1*06:27, allele DQB1*06:28, allele
DQB1*06:29, allele DQB1*06:30, allele
DQB1*06:31, allele DQB1*06:32, allele
DQB1*06:33, allele DQB1*06:34, allele
DQB1*06:35, allele DQB1*06:36, allele
DQB1*06:37, allele DQB1*06:38 and allele
DQB1*06:39; requires 2 nucleotide
substitutions).
/FTId=VAR_062737.
VARIANT 122 122 T -> I (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*05:05, allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:05, allele
DQB1*06:07, allele DQB1*06:08, allele
DQB1*06:09, allele DQB1*06:10, allele
DQB1*06:11, allele DQB1*06:12, allele
DQB1*06:14, allele DQB1*06:15, allele
DQB1*06:16, allele DQB1*06:17, allele
DQB1*06:18, allele DQB1*06:19, allele
DQB1*06:21, allele DQB1*06:22, allele
DQB1*06:23, allele DQB1*06:24, allele
DQB1*06:25, allele DQB1*06:27, allele
DQB1*06:28, allele DQB1*06:29, allele
DQB1*06:30, allele DQB1*06:31, allele
DQB1*06:32, allele DQB1*06:33, allele
DQB1*06:34, allele DQB1*06:35, allele
DQB1*06:36, allele DQB1*06:37, allele
DQB1*06:38 and allele DQB1*06:39;
dbSNP:rs1140320).
/FTId=VAR_062738.
VARIANT 148 148 V -> I (in allele DQB1*05:01, allele
DQB1*05:02 and allele DQB1*05:03;
dbSNP:rs1049100).
/FTId=VAR_056571.
VARIANT 157 157 A -> G (in allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:09, allele
DQB1*06:12, allele DQB1*06:34, allele
DQB1*06:36, allele DQB1*06:38 and allele
DQB1*06:39; dbSNP:rs1063322).
/FTId=VAR_062739.
VARIANT 157 157 A -> S (in allele DQB1*05:01, allele
DQB1*05:02 and allele DQB1*05:03).
/FTId=VAR_062740.
VARIANT 158 158 Q -> H (in allele DQB1*05:02;
dbSNP:rs41542812).
/FTId=VAR_062741.
VARIANT 162 162 R -> Q (in allele DQB1*03:22, allele
DQB1*06:04, allele DQB1*06:09, allele
DQB1*06:12, allele DQB1*06:34, allele
DQB1*06:36 and allele DQB1*06:38;
dbSNP:rs41544112).
/FTId=VAR_062742.
VARIANT 165 165 R -> Q (in allele DQB1*06:38;
dbSNP:rs9273989).
/FTId=VAR_062744.
VARIANT 165 165 R -> W (in allele DQB1*03:21;
dbSNP:rs63626961).
/FTId=VAR_062743.
VARIANT 167 167 D -> G (in allele DQB1*02:02;
dbSNP:rs2647032).
/FTId=VAR_062745.
VARIANT 168 168 Q -> E (in allele DQB1*02:04;
dbSNP:rs9273981).
/FTId=VAR_062746.
VARIANT 172 172 T -> A (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:04, allele
DQB1*05:01, allele DQB1*05:02, allele
DQB1*05:03, allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:09, allele
DQB1*06:12, allele DQB1*06:34, allele
DQB1*06:36, allele DQB1*06:38 and allele
DQB1*06:39; dbSNP:rs1063323).
{ECO:0000244|PubMed:21269460}.
/FTId=VAR_062747.
VARIANT 194 194 E -> D (in dbSNP:rs9273952).
/FTId=VAR_056572.
VARIANT 197 197 P -> L (in dbSNP:rs9273948).
/FTId=VAR_059522.
VARIANT 199 199 H -> R (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:04, allele
DQB1*03:02, allele DQB1*03:03, allele
DQB1*03:05, allele DQB1*03:23, allele
DQB1*03:25, allele DQB1*04:01, allele
DQB1*04:02, allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:09, allele
DQB1*06:12, allele DQB1*06:34, allele
DQB1*06:36, allele DQB1*06:38 and allele
DQB1*06:39; dbSNP:rs701564).
{ECO:0000269|PubMed:3584986}.
/FTId=VAR_062748.
VARIANT 200 201 GD -> A (in allele DQB1*03:09).
/FTId=VAR_062749.
VARIANT 202 202 V -> I (in allele DQB1*03:24;
dbSNP:rs80255621).
/FTId=VAR_062750.
VARIANT 214 214 N -> S (in allele DQB1*02:01, allele
DQB1*02:02, allele DQB1*02:04, allele
DQB1*05:01, allele DQB1*05:02, allele
DQB1*05:03, allele DQB1*06:01, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:09, allele
DQB1*06:12, allele DQB1*06:34, allele
DQB1*06:36, allele DQB1*06:38 and allele
DQB1*06:39; dbSNP:rs1130398).
/FTId=VAR_062751.
VARIANT 217 217 T -> I (in allele DQB1*03:02, allele
DQB1*03:03, allele DQB1*03:05, allele
DQB1*03:19, allele DQB1*03:25, allele
DQB1*04:01 and allele DQB1*04:02;
dbSNP:rs1130399).
/FTId=VAR_062752.
VARIANT 218 218 V -> A (in allele DQB1*06:36;
dbSNP:rs281864132).
/FTId=VAR_062753.
VARIANT 229 229 S -> N (in allele DQB1*06:01;
dbSNP:rs1130429).
/FTId=VAR_062754.
VARIANT 235 235 I -> V (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*06:02, allele DQB1*06:03, allele
DQB1*06:04, allele DQB1*06:09, allele
DQB1*06:12 and allele DQB1*06:36;
dbSNP:rs1049163).
/FTId=VAR_062755.
VARIANT 252 252 H -> R (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*06:01, allele DQB1*06:02, allele
DQB1*06:03, allele DQB1*06:04, allele
DQB1*06:09, allele DQB1*06:12 and allele
DQB1*06:36; dbSNP:rs1140342).
/FTId=VAR_062756.
VARIANT 253 253 H -> Q (in allele DQB1*05:01, allele
DQB1*05:02, allele DQB1*05:03, allele
DQB1*06:01, allele DQB1*06:02, allele
DQB1*06:03, allele DQB1*06:04, allele
DQB1*06:09, allele DQB1*06:12 and allele
DQB1*06:36; dbSNP:rs1140343).
/FTId=VAR_062757.
VARIANT 256 256 Q -> R (in allele DQB1*05:01, allele
DQB1*05:02 and allele DQB1*05:03;
dbSNP:rs1130432).
/FTId=VAR_061474.
CONFLICT 111 111 C -> S (in Ref. 71; AAD39697).
{ECO:0000305}.
CONFLICT 113 113 H -> Q (in Ref. 22; AAF28315).
{ECO:0000305}.
CONFLICT 173 173 G -> A (in Ref. 24; X76553/X76554).
{ECO:0000305}.
CONFLICT 214 214 N -> T (in Ref. 8; AAA59770).
{ECO:0000305}.
STRAND 40 50 {ECO:0000244|PDB:1UVQ}.
TURN 51 54 {ECO:0000244|PDB:1UVQ}.
STRAND 55 64 {ECO:0000244|PDB:1UVQ}.
STRAND 67 73 {ECO:0000244|PDB:1UVQ}.
TURN 74 76 {ECO:0000244|PDB:1UVQ}.
STRAND 78 83 {ECO:0000244|PDB:1UVQ}.
HELIX 84 86 {ECO:0000244|PDB:1UVQ}.
HELIX 87 94 {ECO:0000244|PDB:1UVQ}.
HELIX 97 109 {ECO:0000244|PDB:1UVQ}.
HELIX 111 117 {ECO:0000244|PDB:1UVQ}.
HELIX 119 122 {ECO:0000244|PDB:1UVQ}.
STRAND 130 135 {ECO:0000244|PDB:1UVQ}.
STRAND 141 144 {ECO:0000244|PDB:1JK8}.
STRAND 146 157 {ECO:0000244|PDB:1UVQ}.
STRAND 160 165 {ECO:0000244|PDB:1UVQ}.
STRAND 168 170 {ECO:0000244|PDB:1UVQ}.
STRAND 174 176 {ECO:0000244|PDB:1UVQ}.
STRAND 183 185 {ECO:0000244|PDB:1UVQ}.
STRAND 187 194 {ECO:0000244|PDB:1UVQ}.
STRAND 203 208 {ECO:0000244|PDB:1UVQ}.
STRAND 216 220 {ECO:0000244|PDB:1UVQ}.
SEQUENCE 261 AA; 29991 MW; 79B1E571A628CF96 CRC64;
MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT NGTERVRYVT
RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL ERTRAELDTV CRHNYQLELR
TTLQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI
RNGDWTFQIL VMLEMTPQHG DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL
GLIFLGLGLI IHHRSQKGLL H


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