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HLA class II histocompatibility antigen, DRB1-14 beta chain (MHC class II antigen DRB1*14) (DR-14) (DR14)

 2B1E_HUMAN              Reviewed;         266 AA.
Q9GIY3; A0N0W1; A2TGX3; A4ZY86; A5H000; A5HKN8; A7DZP9; A7X5B1;
A7X5B7; A7X5E0; A7X5E6; A7X5H8; A9JPG0; B1GWE7; B2CR03; B2LVF9;
B2NJ29; B2ZCY1; B3VTP8; B5B8U0; B5B9V5; B5LZ25; B6VEL9; B9VRA4;
B9X248; O02876; O46793; O77969; O78210; Q0PQ39; Q155F7; Q1AP33;
Q1JRP3; Q27PR6; Q27PR7; Q29734; Q29770; Q29772; Q29800; Q2A120;
Q2HZE5; Q2LE76; Q2MJA6; Q2VQU1; Q307W5; Q31636; Q3LA87; Q3LA88;
Q3LA89; Q3LA90; Q3LA91; Q3LA92; Q3T919; Q4PRC3; Q4PRC5; Q4VZY7;
Q56FP1; Q5BM92; Q5U9W6; Q683P7; Q70GL2; Q7YNY9; Q7YQA5; Q860D8;
Q860D9; Q860S0; Q861H5; Q861H7; Q8MH59; Q8MH60; Q8WLU3; Q95348;
Q95HK1; Q95HL0; Q95IG2; Q9GIL5; Q9GIL6; Q9GIY0; Q9GIY1; Q9GIY2;
Q9GJ56; Q9GJ57; Q9GJ58; Q9TPB6; Q9TPW1; Q9XRY4; Q9Y4H7;
23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
27-SEP-2017, entry version 117.
RecName: Full=HLA class II histocompatibility antigen, DRB1-14 beta chain;
AltName: Full=MHC class II antigen DRB1*14;
Short=DR-14;
Short=DR14;
Flags: Precursor;
Name=HLA-DRB1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*14:05).
PubMed=12652907; DOI=10.1080/1042517021000041822;
Kohsaka H., Nasu K., Matsushita S., Miyasaka N.;
"Complete cDNA coding sequence of the HLA-DRB1*1405 allele.";
DNA Seq. 13:359-361(2002).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DRB1*14:01 AND DRB1*14:04),
AND NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-264 (ALLELES DRB1*14:02 AND
DRB1*14:03).
PubMed=11972886; DOI=10.1034/j.1399-0039.2002.590116.x;
Corell A., Cox S.T., Soteriou B., Ramon D., Madrigal J.A.,
Marsh S.G.E.;
"Complete cDNA sequences of the HLA-DRB1*14011, *1402, *1403 and *1404
alleles.";
Tissue Antigens 59:66-69(2002).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DRB1*14:05).
PubMed=16140993; DOI=10.1101/gr.3554305;
Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S.,
Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V.;
"Ancient haplotypes of the HLA Class II region.";
Genome Res. 15:1250-1257(2005).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*14:11), AND NUCLEOTIDE
SEQUENCE [MRNA] OF 1-265 (ALLELE DRB1*14:46).
PubMed=17174751; DOI=10.1016/j.humimm.2006.09.002;
Balas A., Vilches C., Rodriguez M.A., Fernandez B., Martinez M.P.,
de Pablo R., Garcia-Sanchez F., Vicario J.L.;
"Group-specific amplification of cDNA from DRB1 genes. Complete coding
sequences of partially defined alleles and identification of the new
alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113.";
Hum. Immunol. 67:1008-1016(2006).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-217 (ALLELE DRB1*14:57).
PubMed=17026471; DOI=10.1111/j.1399-0039.2006.00669.x;
Chen Q., Zou H., Xu X.H., Luo M., Wang J., Zuo Y.Q., Chen Y.H.,
Chen X.H., Chen X.L., Yao Z.Q., Song N., Zeng J., Mi X.Y., Sun S.X.,
Wang J.X., Zhao T.M.;
"Characterization of HLA-B*5516, -B*1313, -B*9512, and -DRB1*1457
alleles identified in a southwest Chinese population.";
Tissue Antigens 68:339-343(2006).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-208 (ALLELE DRB1*14:54).
PubMed=19284446; DOI=10.1111/j.1744-313X.2008.00826.x;
Yang K.L., Chen M.J., Lee S.K., Lin C.C., Tsai M.J., Chiu H.M.,
Jiang S., Chao Y.C., Chen S.P., Lin S., Shyr M.H., Lin P.Y.;
"New allele name of some HLA-DRB1*1401: HLA-DRB1*1454.";
Int. J. Immunogenet. 36:119-120(2009).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-123 (ALLELE DRB1*14:19).
PubMed=8560458; DOI=10.1111/j.1399-0039.1995.tb02506.x;
Loeffler D., Woelpl A., Kern P., Eiermann T.H.;
"A novel HLA-DR allele, DRB1*1419.";
Tissue Antigens 46:343-344(1995).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-217 (ALLELE DRB1*14:82).
Ogrzewalla K., Tillmann G., Scheibelhut N., Lauber J., Enczmann J.;
"A novel HLA-DRB1*14 allele identified by sequence-based typing.";
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-216 (ALLELES DRB1*14:06;
DRB1*14:07; DRB1*14:10; DRB1*14:13; DRB1*14:14 AND DRB1*14:21).
TISSUE=Peripheral blood;
PubMed=17767557; DOI=10.1111/j.1399-0039.2007.00918.x;
Horn P.A., Albis-Camps M., Verboom M., Bunce M., Yousaf K.,
Williams S., Blasczyk R.;
"The nature of diversity of HLA-DRB1 exon 3.";
Tissue Antigens 70:335-337(2007).
[10]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-124 (ALLELE DRB1*14:85).
Maruya E., Matsushita M., Saji H., Ounuma T., Futagami T., Kojima H.,
Tujino T., Hayashi K., Kusunoki Y., Yoshida T., Maekawajiri S.;
"HLA-DR new allele related with DRB1*1403.";
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:22).
PubMed=8575830; DOI=10.1007/s002510050058;
Adami N., Aubert V., Jeannet M., Tiercy J.M.;
"Sequencing of a new HLA-DR14 allele (DRB1(*)1422).";
Immunogenetics 43:248-249(1996).
[12]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:36).
PubMed=10321590; DOI=10.1034/j.1399-0039.1999.530421.x;
Bodmer J., Marsh S., Albert E., Bodmer W.;
"Nomenclature for factors of the HLA system, 1998.";
Tissue Antigens 53:407-446(1999).
[13]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:37).
TISSUE=Blood;
PubMed=11380954; DOI=10.1034/j.1399-0039.2001.057004384.x;
Wu S., Shiao Y.M., Lai C.Y., Lai S.M., Chen S.P., Sidebottom D.A.,
Hildebrand W.H., Tilanus M.G.J., Chou F.C., Tsai M.F.;
"Polymorphism of human HLA-DRB1 antigens generated by genetic exchange
between DR2 (DRB1*15011) and DR6 (DRB1*1405) alleles: a novel DRB1
allele (DRB1*1437) identified in a Paiwan tribe member of Taiwan.";
Tissue Antigens 57:384-387(2001).
[14]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:41), AND
NUCLEOTIDE SEQUENCE [MRNA] OF 35-123 (ALLELE DRB1*14:42).
PubMed=12144619; DOI=10.1034/j.1399-0039.2002.590502.x;
Gans C.P., Tang T.F., Slack R., Ng J., Hartzman R.J., Hurley C.K.;
"DRB1*14 diversity and DRB3 associations in four major population
groups in the United States.";
Tissue Antigens 59:364-369(2002).
[15]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:43).
PubMed=15304015; DOI=10.1111/j.0001-2815.2004.00275.x;
Chu C.C., Lee H.L., Hsieh N.K., Trejaut J., Lin M.;
"Two novel HLA-DRB1 alleles identified using a sequence-based typing:
HLA-DRB1*1443 and HLA-DRB1*1351*.";
Tissue Antigens 64:308-310(2004).
[16]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:47 AND
DRB1*14:48).
PubMed=16185331; DOI=10.1111/j.1399-0039.2005.00459.x;
Lazaro A.M., Steiner N.K., Moraes M.E., Moraes J.R., Ng J.,
Hartzman R.J., Hurley C.K.;
"Ten novel HLA-DRB1 alleles and one novel DRB3 allele.";
Tissue Antigens 66:327-329(2005).
[17]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:50).
TISSUE=Peripheral blood;
PubMed=16185333; DOI=10.1111/j.1399-0039.2005.00472a.x;
Tijssen H.J., Zeeuw van der S.C., Joosten I.;
"Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*1450.";
Tissue Antigens 66:332-333(2005).
[18]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:49).
PubMed=16426240; DOI=10.1111/j.1744-313X.2005.00557.x;
Miao K.R., Xue M., Zhou X.Y., Xu R., Fei X.M., Pan Q.Q., Zhang J.W.,
Zhao X., Fan S., Kukuruga D., Xu A.L., Wang C.Y.;
"Characterization of a novel DRB1*14 allele (DRB1*1449) in the Han-
Chinese population.";
Int. J. Immunogenet. 33:33-35(2006).
[19]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:56).
PubMed=16774552; DOI=10.1111/j.1399-0039.2006.00612.x;
Baek J.Y., Yun H.S., Hur S.S., Kwon O.J., Kwack K.;
"Identification of a novel HLA-DRB1*14 allele, DRB1*1456, in the cord
blood of a Korean baby.";
Tissue Antigens 68:97-98(2006).
[20]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:60).
TISSUE=Peripheral blood;
PubMed=17026474; DOI=10.1111/j.1399-0039.2006.00675.x;
Tijssen H.J., van den Dungen-Toet J.H.G., van Houwelingen K.P.,
Allebes W.A., Joosten I.;
"Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*1460.";
Tissue Antigens 68:346-347(2006).
[21]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:65).
PubMed=17498272; DOI=10.1111/j.1399-0039.2007.00835.x;
Abdeen H., McErlean C., Moraes M.E., Torres M., Campiotto S.,
Galvao S., Gouvea C., Middleton D.;
"Identification of three novel alleles of HLA-DRB1 and HLA-A in the
Brazilian population.";
Tissue Antigens 69:607-610(2007).
[22]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:74).
PubMed=18179646; DOI=10.1111/j.1399-0039.2007.00993.x;
Rahal M., Kervaire B., Villard J., Tiercy J.M.;
"DNA typing by microbead arrays and PCR-SSP: apparent false-negative
or -positive hybridization or amplification signals disclose new HLA-B
and -DRB1 alleles.";
Tissue Antigens 71:238-241(2008).
[23]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:67).
TISSUE=Blood;
PubMed=18643964; DOI=10.1111/j.1399-0039.2008.01089.x;
Yan L.N., Li S.Y., Dong Z., Dong L., Xie J.H., An S.P., Yuan Y.H.;
"Sequence-based typing reveals the novel HLA-DRB1*1467 allele in a
Chinese individual.";
Tissue Antigens 72:409-410(2008).
[24]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:75).
PubMed=18937796; DOI=10.1111/j.1399-0039.2008.01116.x;
Schuett S., Geflitter A., von Baehr V.;
"Sequence-based typing of a novel HLA-DRB1*14 allele, DRB1*1475, in a
Caucasian woman.";
Tissue Antigens 72:501-502(2008).
[25]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:61).
PubMed=19000132; DOI=10.1111/j.1399-0039.2008.01135.x;
Wang Z., Shan X., Zhang Z.;
"Identification of a novel HLA-DRB allele, HLA-DRB1*1461.";
Tissue Antigens 72:603-604(2008).
[26]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:78).
PubMed=19140840; DOI=10.1111/j.1399-0039.2008.01175.x;
Han S.H., Jung S.M., Park S.R., Chung S.Y., Han H.;
"Identification of a new HLA-DRB1*14 variant, HLA-DRB1*1478, in a
Korean individual.";
Tissue Antigens 73:81-83(2009).
[27]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:26;
DRB1*14:27 AND DRB1*14:29).
Kashiwase K., Tokunaga K., Akaza T., Tadokoro K., Juji T.;
"Sequence of new allele.";
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
[28]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:32).
Blasczyk R.;
"A new HLA-DRB1*14 variant.";
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
[29]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:34).
Whidborne R.S., Sayer D.C., Christiansen F.T.;
"Novel DRB1*14 and 15 alleles in the Western Australian population.";
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
[30]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:17).
Gervais T.G., Latinne D.;
"Confirmatory sequence for HLA-DRB1*1417 gene obtained by sequence
based typing.";
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
[31]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:18).
Rizzo M., Steiner N.K., Nichol L., Hurley C.K.;
"Complete exon 2 sequence for HLA-DRB1*1418.";
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
[32]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:15).
Kervaire B., Villard J., Tiercy J.M.;
"An unusual HLA-DR/DQ haplotype carrying a new DR8 variant and the
DRB3*0202 allele.";
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[33]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:23).
TISSUE=Blood;
Velickovic Z.M.;
"Novel HLA-DRB1*11 allele.";
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
[34]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:12).
Oh H.B., Byun E.K., Hong S.A., Lee M.N., Kwon O.J.;
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[35]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:01).
Lee T.D.;
"Identification of a novel HLA-DRB1*14 allele.";
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[36]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:53).
Dormoy A.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[37]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:55).
TISSUE=Leukocyte;
Hirv K., Krauss A., Mytilineos J.;
"Characterization of a new HLA-DRB1*14 allele.";
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
[38]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:58).
Karvunidis T., Jindra P., Fischer G., Koza V.;
"Identification of a new HLA-DRB1*14 allele by sequence-based
typing.";
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
[39]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:59).
Dormoy A., Weschler B., Leinsenbach R.;
"A new DRB1*14 allele close to the DRB1*1418 allele is different for 3
substitutions at nucleotide positions 84, 152 and 174 leading to the
change of 2 amino acids at positions 28 and 51.";
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
[40]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:63).
Ye S., Liu M., Qi J.;
"Identification a novel HLA-DRB1*14 new allele.";
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
[41]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:30).
Greville W.D., Dunckley H.;
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
[42]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:76).
TISSUE=Blood;
Tavoularis S., Rebeiro E., Sayer D.;
"Identification of a novel DRB1 allele.";
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
[43]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:77).
TISSUE=Blood;
Yan L.N., An S.P., Li S.Y., Xie J.H., Dong L., Dong Z., Yuan Y.H.;
"A new allele of HLA-DRB1*14 detected with SBT.";
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
[44]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:38;
DRB1*14:39; DRB1*14:40; DRB1*14:44; DRB1*14:45 AND DRB1*14:80).
Juji T., Shimizu M., Kashiwase K., Nakajima F., Tadokoro K.,
Tanaka H.;
"HLA-DRB1*1401V1M, HLA-DRB1*1401V2, HLA-DRB1*1403V2, HLA-DRB1*1405V1,
HLA-DRB1*1405V2, HLA-DRB1*1406V1.";
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
[45]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:51;
DRB1*14:52; DRB1*14:62; DRB1*14:64; DRB1*14:68; DRB1*14:69;
DRB1*14:70; DRB1*14:71; DRB1*14:72; DRB1*14:73; DRB1*14:79; DRB1*14:81
AND DRB1*14:83).
Lazaro A.M., Cao K., Xiao Y., Lebeck L., Hurley C.K.;
"Novel class II allele.";
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
[46]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:24).
Dormoy A., Weschler B.;
"The HLA-DRB1*14New allele has 3 nucleotide changes from the DRB1*1402
allele at positions 286, 298 and 299 of exon 2 where: C286->A286
(codon 72 (CTC->ATC)) resulting in a change of amino acid: Leu->Ile
A298->G298 + G299->C299 (codon 76 (AGG->GCG)) resulting in a change of
amino acid: Arg->Ala.";
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
[47]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:84).
TISSUE=Peripheral blood;
Lee T.-D., Chien W.-C.;
"A new DR14-related DRB1 allele, identified by sequence-based
typing.";
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
[48]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB1*14:35).
PubMed=11532019; DOI=10.1046/j.1365-2370.2001.00243.x;
Trejaut J., Kennedy A., Hobart D., Le T., Greville W.D., Ng G.,
Taverniti A., Dunckley H.;
"PCR-RFLP typing detects new HLA-DRB1 alleles: DRB1*13022, DRB1*1336
and DRB1*1435.";
Eur. J. Immunogenet. 28:441-447(2001).
[49]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB1*14:28).
TISSUE=Blood;
PubMed=9243765; DOI=10.1111/j.1399-0039.1997.tb02843.x;
Hashemi-Tavoularis S., Couture C., Buyse I.M.;
"Identification of new DRB1*01 (DRB1*01022), DRB1*14 (DRB1*1428) and
DRB3* (DRB3*0206) alleles.";
Tissue Antigens 50:89-93(1997).
[50]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB1*14:01).
TISSUE=Peripheral blood;
PubMed=15104685; DOI=10.1111/j.0001-2815.2004.00186.x;
Tavoularis S., Couture C., Ribeiro-Barros E.;
"Identification of three novel alleles: DRB3*0110, DRB1*1140, and
DRB1*140102.";
Tissue Antigens 63:496-500(2004).
[51]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-123 (ALLELES DRB1*14:09 AND
DRB1*14:25).
Vayntrub T., Lo B.;
"Confirmatory sequence of HLA class II DRB1*1409 and DRB1*1425.";
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
[52]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-122 (ALLELE DRB1*14:08).
TISSUE=Blood;
PubMed=1644450; DOI=10.1007/BF00215663;
Gao X., Veale A., Serjeantson S.W.;
"HLA class II diversity in Australian aborigines: unusual HLA-DRB1
alleles.";
Immunogenetics 36:333-337(1992).
[53]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-119 (ALLELE DRB1*14:31).
PubMed=10599892; DOI=10.1034/j.1399-0039.1999.540510.x;
Panigoro R., Greville W.D., Kennedy A., Trejaut J., Dunckley H.;
"New HLA class II alleles in the Indonesian population.";
Tissue Antigens 54:521-523(1999).
[54]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-122 (ALLELE DRB1*14:33).
Greville W.D., van Eijck A., Dunckley H.;
"New HLA class II (DRB1) alleles detected by sequencing-based
typing.";
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
[55]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB1*14:20).
PubMed=8883296; DOI=10.1111/j.1399-0039.1996.tb02611.x;
Verduyn W., Anholts J.D., Versluis L.F., Parlevliet J., Drabbels J.,
De Meester J., Tilanus M.G., Doxiadis I.I., Giphart M.J.,
Schreuder G.M.;
"Six newly identified HLA-DRB alleles: DRB1*1121, *1419, *1420, *1421,
DRB3*0203 and DRB5*0103.";
Tissue Antigens 48:80-86(1996).
[56]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-131 (ALLELE DRB1*14:24).
TISSUE=B-cell;
Hurley C.K.;
Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
[57]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-120 (ALLELE DRB1*14:16).
Gervais T.G., Latinne D.;
"Confirmatory typing for exon 2 of HLA-DRB1*1416 gene, obtained by
sequence-based typing.";
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
[58]
REVIEW.
PubMed=8598037; DOI=10.1016/S0092-8674(00)81025-9;
Cresswell P.;
"Invariant chain structure and MHC class II function.";
Cell 84:505-507(1996).
[59]
REVIEW.
PubMed=11684289; DOI=10.1016/S0161-5890(01)00069-4;
Villadangos J.A.;
"Presentation of antigens by MHC class II molecules: getting the most
out of them.";
Mol. Immunol. 38:329-346(2001).
[60]
REVIEW.
PubMed=17241953; DOI=10.1016/j.immuni.2007.01.005;
Menendez-Benito V., Neefjes J.;
"Autophagy in MHC class II presentation: sampling from within.";
Immunity 26:1-3(2007).
[61]
REVIEW.
PubMed=18046453; DOI=10.1038/sj.emboj.7601945;
Rocha N., Neefjes J.;
"MHC class II molecules on the move for successful antigen
presentation.";
EMBO J. 27:1-5(2008).
[62]
UBIQUITINATION BY MARCH1, AND SUBCELLULAR LOCATION.
PubMed=18305173; DOI=10.1073/pnas.0708874105;
De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N.,
Pierre P., Gatti E.;
"MHC class II stabilization at the surface of human dendritic cells is
the result of maturation-dependent MARCH I down-regulation.";
Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008).
[63]
REVIEW.
PubMed=19092054; DOI=10.1242/jcs.035089;
Berger A.C., Roche P.A.;
"MHC class II transport at a glance.";
J. Cell Sci. 122:1-4(2009).
[64]
REVIEW.
PubMed=19533806; DOI=10.3748/wjg.15.2855;
Beswick E.J., Reyes V.E.;
"CD74 in antigen presentation, inflammation, and cancers of the
gastrointestinal tract.";
World J. Gastroenterol. 15:2855-2861(2009).
-!- FUNCTION: Binds peptides derived from antigens that access the
endocytic route of antigen presenting cells (APC) and presents
them on the cell surface for recognition by the CD4 T-cells. The
peptide binding cleft accommodates peptides of 10-30 residues. The
peptides presented by MHC class II molecules are generated mostly
by degradation of proteins that access the endocytic route, where
they are processed by lysosomal proteases and other hydrolases.
Exogenous antigens that have been endocytosed by the APC are thus
readily available for presentation via MHC II molecules, and for
this reason this antigen presentation pathway is usually referred
to as exogenous. As membrane proteins on their way to degradation
in lysosomes as part of their normal turn-over are also contained
in the endosomal/lysosomal compartments, exogenous antigens must
compete with those derived from endogenous components. Autophagy
is also a source of endogenous peptides, autophagosomes
constitutively fuse with MHC class II loading compartments. In
addition to APCs, other cells of the gastrointestinal tract, such
as epithelial cells, express MHC class II molecules and CD74 and
act as APCs, which is an unusual trait of the GI tract. To produce
a MHC class II molecule that presents an antigen, three MHC class
II molecules (heterodimers of an alpha and a beta chain) associate
with a CD74 trimer in the ER to form a heterononamer. Soon after
the entry of this complex into the endosomal/lysosomal system
where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving
a small fragment termed CLIP (class-II-associated invariant chain
peptide). The removal of CLIP is facilitated by HLA-DM via direct
binding to the alpha-beta-CLIP complex so that CLIP is released.
HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound
to a peptide is then transported to the cell membrane surface. In
B-cells, the interaction between HLA-DM and MHC class II molecules
is regulated by HLA-DO. Primary dendritic cells (DCs) also to
express HLA-DO. Lysosomal microenvironment has been implicated in
the regulation of antigen loading into MHC II molecules, increased
acidification produces increased proteolysis and efficient peptide
loading.
-!- SUBUNIT: Heterodimer of an alpha and a beta subunit; also referred
as MHC class II molecule. In the endoplasmic reticulum (ER) it
forms a heterononamer; 3 MHC class II molecules bind to a CD74
homotrimer (also known as invariant chain or HLA class II
histocompatibility antigen gamma chain). In the
endosomal/lysosomal system; CD74 undergoes sequential degradation
by various proteases; leaving a small fragment termed CLIP on each
MHC class II molecule. MHC class II molecule interacts with
HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18305173};
Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}.
Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173};
Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}.
Golgi apparatus, trans-Golgi network membrane
{ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein
{ECO:0000269|PubMed:18305173}. Endosome membrane
{ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein
{ECO:0000269|PubMed:18305173}. Lysosome membrane
{ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein
{ECO:0000269|PubMed:18305173}. Late endosome membrane
{ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein
{ECO:0000269|PubMed:18305173}. Note=The MHC class II complex
transits through a number of intracellular compartments in the
endocytic pathway until it reaches the cell membrane for antigen
presentation.
-!- PTM: Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to
sorting into the endosome system and down-regulation of MHC class
II. {ECO:0000305|PubMed:18305173}.
-!- POLYMORPHISM: The following alleles of DRB1-14 are known:
DRB1*14:01, DRB1*14:02, DRB1*14:03, DRB1*14:04, DRB1*14:05,
DRB1*14:06, DRB1*14:07, DRB1*14:08, DRB1*14:09, DRB1*14:10,
DRB1*14:11, DRB1*14:12, DRB1*14:13, DRB1*14:14, DRB1*14:15,
DRB1*14:16, DRB1*14:17, DRB1*14:18, DRB1*14:19, DRB1*14:20,
DRB1*14:21, DRB1*14:22, DRB1*14:23, DRB1*14:24, DRB1*14:25,
DRB1*14:26, DRB1*14:27, DRB1*14:28, DRB1*14:29, DRB1*14:30,
DRB1*14:31, DRB1*14:32, DRB1*14:33, DRB1*14:34, DRB1*14:35,
DRB1*14:36, DRB1*14:37, DRB1*14:38, DRB1*14:39, DRB1*14:40,
DRB1*14:41, DRB1*14:42, DRB1*14:43, DRB1*14:44, DRB1*14:45,
DRB1*14:46, DRB1*14:47, DRB1*14:48, DRB1*14:49, DRB1*14:50,
DRB1*14:51, DRB1*14:52, DRB1*14:53, DRB1*14:54, DRB1*14:55,
DRB1*14:56, DRB1*14:57, DRB1*14:58, DRB1*14:59, DRB1*14:60,
DRB1*14:61, DRB1*14:62, DRB1*14:63, DRB1*14:64, DRB1*14:65,
DRB1*14:67, DRB1*14:68, DRB1*14:69, DRB1*14:70, DRB1*14:71,
DRB1*14:72, DRB1*14:73, DRB1*14:74, DRB1*14:75, DRB1*14:76,
DRB1*14:77, DRB1*14:78, DRB1*14:79, DRB1*14:80, DRB1*14:81,
DRB1*14:82, DRB1*14:83, DRB1*14:84 and DRB1*14:85. The sequence
shown is that of DRB1*14:01.
-!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAB45249.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB062112; BAB84521.2; -; mRNA.
EMBL; AJ297582; CAC08822.1; -; mRNA.
EMBL; AJ297583; CAC08823.1; -; mRNA.
EMBL; AJ297584; CAC08824.1; -; mRNA.
EMBL; AJ297585; CAC08825.1; -; mRNA.
EMBL; AY663408; AAU88014.1; -; Genomic_DNA.
EMBL; AY935719; AAX33315.1; -; mRNA.
EMBL; AY961071; AAX63459.2; -; mRNA.
EMBL; DQ235685; ABB52004.1; -; Genomic_DNA.
EMBL; DQ390459; ABD60300.1; -; Genomic_DNA.
EMBL; DQ390460; ABD60301.1; -; Genomic_DNA.
EMBL; FJ379259; ACJ06537.1; -; Genomic_DNA.
EMBL; Z38072; CAA86217.1; -; Genomic_DNA.
EMBL; FM196525; CAQ86516.1; -; Genomic_DNA.
EMBL; AM109998; CAJ33605.1; -; Genomic_DNA.
EMBL; AM109999; CAJ33606.1; -; Genomic_DNA.
EMBL; AM110000; CAJ33607.1; -; Genomic_DNA.
EMBL; AM110001; CAJ33608.1; -; Genomic_DNA.
EMBL; AM110002; CAJ33609.1; -; Genomic_DNA.
EMBL; AM110003; CAJ33610.1; -; Genomic_DNA.
EMBL; AB485773; BAH23562.1; -; Genomic_DNA.
EMBL; Z50730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AJ242985; CAB45249.1; ALT_SEQ; Genomic_DNA.
EMBL; AJ251985; CAC19086.1; -; Genomic_DNA.
EMBL; AY050186; AAL23547.1; -; Genomic_DNA.
EMBL; AY054375; AAL15169.1; -; mRNA.
EMBL; AF400066; AAK85431.1; -; Genomic_DNA.
EMBL; AY267905; AAP32696.1; -; Genomic_DNA.
EMBL; AY267906; AAP32697.1; -; Genomic_DNA.
EMBL; AJ969417; CAI94542.1; -; Genomic_DNA.
EMBL; AY912075; AAY17288.1; -; Genomic_DNA.
EMBL; DQ333353; ABC59115.1; -; Genomic_DNA.
EMBL; AM259285; CAJ90660.1; -; Genomic_DNA.
EMBL; EF199810; ABM90423.1; -; Genomic_DNA.
EMBL; AM774161; CAO81738.1; -; Genomic_DNA.
EMBL; EF495154; ABP38039.1; -; Genomic_DNA.
EMBL; AM922324; CAP58300.1; -; Genomic_DNA.
EMBL; DQ494324; ABF50050.1; -; Genomic_DNA.
EMBL; EU588391; ACB97664.1; -; Genomic_DNA.
EMBL; D86502; BAA13097.1; -; Genomic_DNA.
EMBL; D86504; BAA13099.1; -; Genomic_DNA.
EMBL; D88310; BAA13587.1; -; Genomic_DNA.
EMBL; AJ010982; CAA09450.1; -; Genomic_DNA.
EMBL; AF172071; AAD51970.1; -; Genomic_DNA.
EMBL; AJ543433; CAD65908.1; -; Genomic_DNA.
EMBL; AY277390; AAP34694.1; -; Genomic_DNA.
EMBL; AJ581744; CAE46451.1; -; Genomic_DNA.
EMBL; AJ812566; CAH23708.1; -; Genomic_DNA.
EMBL; AY770520; AAV37191.1; -; Genomic_DNA.
EMBL; DQ021915; AAY85747.1; -; Genomic_DNA.
EMBL; AM084908; CAJ29895.1; -; Genomic_DNA.
EMBL; DQ327711; ABC59293.1; -; Genomic_DNA.
EMBL; DQ358688; ABC84557.1; -; Genomic_DNA.
EMBL; AM233907; CAJ80873.1; -; Genomic_DNA.
EMBL; DQ643390; ABG25965.1; -; Genomic_DNA.
EMBL; U95115; AAB58397.2; -; Genomic_DNA.
EMBL; AM933133; CAP69806.1; -; Genomic_DNA.
EMBL; EU545181; ACB30275.1; -; Genomic_DNA.
EMBL; AB049830; BAB16682.1; -; Genomic_DNA.
EMBL; AB049831; BAB16683.1; -; Genomic_DNA.
EMBL; AB049832; BAB16684.1; -; Genomic_DNA.
EMBL; AB087875; BAC02938.1; -; Genomic_DNA.
EMBL; AB087876; BAC02939.1; -; Genomic_DNA.
EMBL; AB436778; BAG32234.1; -; Genomic_DNA.
EMBL; EF078986; ABK56696.1; -; Genomic_DNA.
EMBL; EF536016; ABQ08747.1; -; Genomic_DNA.
EMBL; EU029787; ABU86846.1; -; Genomic_DNA.
EMBL; EU029788; ABU86847.1; -; Genomic_DNA.
EMBL; EU029792; ABU86851.1; -; Genomic_DNA.
EMBL; EU029793; ABU86852.1; -; Genomic_DNA.
EMBL; EU029798; ABU86857.1; -; Genomic_DNA.
EMBL; EU643616; ACD01094.1; -; Genomic_DNA.
EMBL; EU812536; ACE88696.1; -; Genomic_DNA.
EMBL; EU924810; ACH57405.1; -; Genomic_DNA.
EMBL; DQ060439; AAY59541.1; -; Genomic_DNA.
EMBL; DQ060441; AAY59543.1; -; Genomic_DNA.
EMBL; DQ782331; ABG91054.1; -; Genomic_DNA.
EMBL; FM179681; CAQ77159.1; -; Genomic_DNA.
EMBL; FJ594768; ACM47962.1; -; Genomic_DNA.
EMBL; AF177215; AAD53910.1; -; Genomic_DNA.
EMBL; X99839; CAA68150.1; -; Genomic_DNA.
EMBL; AJ289123; CAC19015.1; -; Genomic_DNA.
EMBL; AY174092; AAO20089.1; -; Genomic_DNA.
EMBL; AY174181; AAO17053.1; -; Genomic_DNA.
EMBL; M77673; AAA73131.1; -; Genomic_DNA.
EMBL; AF028010; AAB94612.1; -; Genomic_DNA.
EMBL; AF112879; AAD29584.1; -; Genomic_DNA.
EMBL; X86974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; U41489; AAA86242.1; -; Genomic_DNA.
EMBL; AJ508388; CAD48196.1; -; Genomic_DNA.
PIR; B33287; B33287.
PIR; C33287; C33287.
PIR; C60748; C60748.
PIR; F60748; F60748.
PIR; PH0157; PH0157.
PIR; PH0158; PH0158.
PIR; S03440; S03440.
UniGene; Hs.485130; -.
UniGene; Hs.534322; -.
UniGene; Hs.696211; -.
UniGene; Hs.716081; -.
UniGene; Hs.723344; -.
UniGene; Hs.736560; -.
ProteinModelPortal; Q9GIY3; -.
SMR; Q9GIY3; -.
IntAct; Q9GIY3; 1.
DMDM; 74761361; -.
PeptideAtlas; Q9GIY3; -.
PRIDE; Q9GIY3; -.
Ensembl; ENST00000328980; ENSP00000331343; ENSG00000206306.
Ensembl; ENST00000360004; ENSP00000353099; ENSG00000196126.
Ensembl; ENST00000399450; ENSP00000382378; ENSG00000206240.
Ensembl; ENST00000412634; ENSP00000408795; ENSG00000228080.
Ensembl; ENST00000415796; ENSP00000412168; ENSG00000206306.
Ensembl; ENST00000419393; ENSP00000403458; ENSG00000228080.
Ensembl; ENST00000428566; ENSP00000392280; ENSG00000206240.
UCSC; uc063uqx.1; human.
DisGeNET; 3123; -.
EuPathDB; HostDB:ENSG00000196126.10; -.
GeneCards; HLA-DRB1; -.
HGNC; HGNC:4948; HLA-DRB1.
HPA; CAB015400; -.
HPA; CAB034021; -.
MalaCards; HLA-DRB1; -.
MIM; 142857; gene.
neXtProt; NX_Q9GIY3; -.
HOVERGEN; HBG012730; -.
Reactome; R-HSA-202424; Downstream TCR signaling.
Reactome; R-HSA-202427; Phosphorylation of CD3 and TCR zeta chains.
Reactome; R-HSA-202430; Translocation of ZAP-70 to Immunological synapse.
Reactome; R-HSA-202433; Generation of second messenger molecules.
Reactome; R-HSA-2132295; MHC class II antigen presentation.
Reactome; R-HSA-389948; PD-1 signaling.
Reactome; R-HSA-877300; Interferon gamma signaling.
ChiTaRS; HLA-DRB1; human.
Proteomes; UP000005640; Chromosome 6.
Bgee; ENSG00000196126; -.
ExpressionAtlas; Q9GIY3; baseline and differential.
Genevisible; Q9GIY3; HS.
GO; GO:0030669; C:clathrin-coated endocytic vesicle membrane; TAS:Reactome.
GO; GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0031902; C:late endosome membrane; IDA:UniProtKB.
GO; GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO; GO:0030658; C:transport vesicle membrane; TAS:Reactome.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
GO; GO:0031295; P:T cell costimulation; TAS:Reactome.
GO; GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 3.10.320.10; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003006; Ig/MHC_CS.
InterPro; IPR003597; Ig_C1-set.
InterPro; IPR011162; MHC_I/II-like_Ag-recog.
InterPro; IPR014745; MHC_II_a/b_N.
InterPro; IPR000353; MHC_II_b_N.
Pfam; PF07654; C1-set; 1.
Pfam; PF00969; MHC_II_beta; 1.
ProDom; PD000328; MHC_II_b_N; 1.
SMART; SM00407; IGc1; 1.
SMART; SM00921; MHC_II_beta; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF54452; SSF54452; 1.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS00290; IG_MHC; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond;
Endoplasmic reticulum; Endosome; Glycoprotein; Golgi apparatus;
Immunity; Isopeptide bond; Lysosome; Membrane; MHC II; Polymorphism;
Reference proteome; Signal; Transmembrane; Transmembrane helix;
Ubl conjugation.
SIGNAL 1 29 {ECO:0000255}.
CHAIN 30 266 HLA class II histocompatibility antigen,
DRB1-14 beta chain.
/FTId=PRO_5000066676.
TRANSMEM 228 248 Helical. {ECO:0000255}.
DOMAIN 126 214 Ig-like C1-type.
CARBOHYD 48 48 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 146 202 {ECO:0000255|PROSITE-ProRule:PRU00114}.
CROSSLNK 254 254 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000250|UniProtKB:P20039}.
VARIANT 39 39 Y -> L (in allele DRB1*14:46; requires 2
nucleotide substitutions).
/FTId=VAR_062907.
VARIANT 39 39 Y -> Q (in allele DRB1*14:10 and allele
DRB1*14:57; requires 2 nucleotide
substitutions).
/FTId=VAR_062906.
VARIANT 40 40 S -> P (in allele DRB1*14:39).
/FTId=VAR_062910.
VARIANT 40 40 S -> R (in allele DRB1*14:46).
/FTId=VAR_062908.
VARIANT 40 40 S -> V (in allele DRB1*14:10 and allele
DRB1*14:57; requires 2 nucleotide
substitutions).
/FTId=VAR_062909.
VARIANT 41 41 T -> K (in allele DRB1*14:10, allele
DRB1*14:46 and allele DRB1*14:57).
/FTId=VAR_062911.
VARIANT 42 42 S -> G (in allele DRB1*14:04, allele
DRB1*14:11, allele DRB1*14:15, allele
DRB1*14:28, allele DRB1*14:31, allele
DRB1*14:50, allele DRB1*14:52, allele
DRB1*14:61, allele DRB1*14:68, allele
DRB1*14:71, allele DRB1*14:73, allele
DRB1*14:76 and allele DRB1*14:79).
/FTId=VAR_062913.
VARIANT 42 42 S -> H (in allele DRB1*14:10 and allele
DRB1*14:57; requires 2 nucleotide
substitutions).
/FTId=VAR_062912.
VARIANT 45 45 H -> Q (in allele DRB1*14:05, allele
DRB1*14:37, allele DRB1*14:43, allele
DRB1*14:44, allele DRB1*14:45, allele
DRB1*14:56 and allele DRB1*14:84).
/FTId=VAR_062915.
VARIANT 45 45 H -> Y (in allele DRB1*14:04, allele
DRB1*14:11, allele DRB1*14:15, allele
DRB1*14:28, allele DRB1*14:31, allele
DRB1*14:50, allele DRB1*14:52, allele
DRB1*14:68, allele DRB1*14:71, allele
DRB1*14:73, allele DRB1*14:76 and allele
DRB1*14:79).
/FTId=VAR_062914.
VARIANT 54 54 R -> Q (in allele DRB1*14:26).
/FTId=VAR_062916.
VARIANT 55 55 F -> Y (in allele DRB1*14:82).
/FTId=VAR_062917.
VARIANT 56 56 L -> M (in allele DRB1*14:83).
/FTId=VAR_062918.
VARIANT 57 57 D -> E (in allele DRB1*14:02, allele
DRB1*14:03, allele DRB1*14:06, allele
DRB1*14:12, allele DRB1*14:13, allele
DRB1*14:18, allele DRB1*14:19, allele
DRB1*14:20, allele DRB1*14:24, allele
DRB1*14:27, allele DRB1*14:29, allele
DRB1*14:40, allele DRB1*14:41, allele
DRB1*14:46, allele DRB1*14:47, allele
DRB1*14:48, allele DRB1*14:49, allele
DRB1*14:51, allele DRB1*14:52, allele
DRB1*14:63, allele DRB1*14:67, allele
DRB1*14:77, allele DRB1*14:78, allele
DRB1*14:81, allele DRB1*14:83 and allele
DRB1*14:85).
/FTId=VAR_062919.
VARIANT 59 59 Y -> H (in allele DRB1*14:70).
/FTId=VAR_062920.
VARIANT 61 61 H -> Y (in allele DRB1*14:25, allele
DRB1*14:42, allele DRB1*14:53, allele
DRB1*14:58 and allele DRB1*14:69).
/FTId=VAR_062921.
VARIANT 66 66 F -> N (in allele DRB1*14:02, allele
DRB1*14:03, allele DRB1*14:06, allele
DRB1*14:09, allele DRB1*14:12, allele
DRB1*14:13, allele DRB1*14:17, allele
DRB1*14:18, allele DRB1*14:19, allele
DRB1*14:21, allele DRB1*14:24, allele
DRB1*14:27, allele DRB1*14:29, allele
DRB1*14:30, allele DRB1*14:33, allele
DRB1*14:46, allele DRB1*14:47, allele
DRB1*14:48, allele DRB1*14:51, allele
DRB1*14:52, allele DRB1*14:59, allele
DRB1*14:63, allele DRB1*14:64, allele
DRB1*14:67, allele DRB1*14:78, allele
DRB1*14:80, allele DRB1*14:81, allele
DRB1*14:83 and allele DRB1*14:85;
requires 2 nucleotide substitutions).
/FTId=VAR_062923.
VARIANT 66 66 F -> Y (in allele DRB1*14:25, allele
DRB1*14:42, allele DRB1*14:53, allele
DRB1*14:58 and allele DRB1*14:69).
/FTId=VAR_062922.
VARIANT 67 67 V -> L (in allele DRB1*14:41 and allele
DRB1*14:77).
/FTId=VAR_062924.
VARIANT 74 74 G -> R (in allele DRB1*14:36 and allele
DRB1*14:60).
/FTId=VAR_062925.
VARIANT 76 76 Y -> F (in allele DRB1*14:17, allele
DRB1*14:21, allele DRB1*14:30, allele
DRB1*14:33, allele DRB1*14:35, allele
DRB1*14:42, allele DRB1*14:53, allele
DRB1*14:64, allele DRB1*14:65 and allele
DRB1*14:72).
/FTId=VAR_062926.
VARIANT 80 80 T -> R (in allele DRB1*14:59).
/FTId=VAR_062927.
VARIANT 86 86 A -> D (in allele DRB1*14:02, allele
DRB1*14:03, allele DRB1*14:05, allele
DRB1*14:06, allele DRB1*14:08, allele
DRB1*14:09, allele DRB1*14:11, allele
DRB1*14:12, allele DRB1*14:14, allele
DRB1*14:15, allele DRB1*14:17, allele
DRB1*14:18, allele DRB1*14:19, allele
DRB1*14:20, allele DRB1*14:21, allele
DRB1*14:23, allele DRB1*14:24, allele
DRB1*14:27, allele DRB1*14:29, allele
DRB1*14:30, allele DRB1*14:33, allele
DRB1*14:34, allele DRB1*14:36, allele
DRB1*14:37, allele DRB1*14:40, allele
DRB1*14:41, allele DRB1*14:42, allele
DRB1*14:43, allele DRB1*14:44, allele
DRB1*14:45, allele DRB1*14:46, allele
DRB1*14:47, allele DRB1*14:51, allele
DRB1*14:52, allele DRB1*14:56, allele
DRB1*14:59, allele DRB1*14:64, allele
DRB1*14:67, allele DRB1*14:72, allele
DRB1*14:77, allele DRB1*14:80, allele
DRB1*14:81, allele DRB1*14:83 and allele
DRB1*14:84).
/FTId=VAR_062928.
VARIANT 86 86 A -> S (in allele DRB1*14:13, allele
DRB1*14:63, allele DRB1*14:65, allele
DRB1*14:78 and allele DRB1*14:85).
/FTId=VAR_062929.
VARIANT 86 86 A -> T (in allele DRB1*14:62).
/FTId=VAR_062930.
VARIANT 86 86 A -> V (in allele DRB1*14:48).
/FTId=VAR_062931.
VARIANT 87 87 A -> E (in allele DRB1*14:11).
/FTId=VAR_062932.
VARIANT 89 89 H -> S (in allele DRB1*14:48 and allele
DRB1*14:64; requires 2 nucleotide
substitutions).
/FTId=VAR_062934.
VARIANT 89 89 H -> Y (in allele DRB1*14:02, allele
DRB1*14:03, allele DRB1*14:05, allele
DRB1*14:06, allele DRB1*14:09, allele
DRB1*14:11, allele DRB1*14:12, allele
DRB1*14:13, allele DRB1*14:14, allele
DRB1*14:15, allele DRB1*14:17, allele
DRB1*14:18, allele DRB1*14:19, allele
DRB1*14:20, allele DRB1*14:21, allele
DRB1*14:23, allele DRB1*14:24, allele
DRB1*14:27, allele DRB1*14:29, allele
DRB1*14:30, allele DRB1*14:33, allele
DRB1*14:36, allele DRB1*14:37, allele
DRB1*14:40, allele DRB1*14:41, allele
DRB1*14:42, allele DRB1*14:43, allele
DRB1*14:44, allele DRB1*14:45, allele
DRB1*14:46, allele DRB1*14:47, allele
DRB1*14:51, allele DRB1*14:52, allele
DRB1*14:56, allele DRB1*14:57, allele
DRB1*14:59, allele DRB1*14:63, allele
DRB1*14:65, allele DRB1*14:67, allele
DRB1*14:76, allele DRB1*14:77, allele
DRB1*14:78, allele DRB1*14:80, allele
DRB1*14:81, allele DRB1*14:83, allele
DRB1*14:84 and allele DRB1*14:85).
/FTId=VAR_062933.
VARIANT 96 96 L -> F (in allele DRB1*14:15, allele
DRB1*14:22, allele DRB1*14:25, allele
DRB1*14:27, allele DRB1*14:53 and allele
DRB1*14:73).
/FTId=VAR_062935.
VARIANT 96 96 L -> I (in allele DRB1*14:16, allele
DRB1*14:24, allele DRB1*14:37, allele
DRB1*14:45, allele DRB1*14:57, allele
DRB1*14:63, allele DRB1*14:67 and allele
DRB1*14:78).
/FTId=VAR_062936.
VARIANT 99 99 R -> D (in allele DRB1*14:03, allele
DRB1*14:12, allele DRB1*14:15, allele
DRB1*14:16, allele DRB1*14:22, allele
DRB1*14:25, allele DRB1*14:27, allele
DRB1*14:40, allele DRB1*14:53, allele
DRB1*14:57, allele DRB1*14:63, allele
DRB1*14:67, allele DRB1*14:69, allele
DRB1*14:73, allele DRB1*14:74, allele
DRB1*14:77, allele DRB1*14:78, allele
DRB1*14:84 and allele DRB1*14:85;
requires 2 nucleotide substitutions).
/FTId=VAR_062938.
VARIANT 99 99 R -> Q (in allele DRB1*14:02, allele
DRB1*14:06, allele DRB1*14:09, allele
DRB1*14:13, allele DRB1*14:17, allele
DRB1*14:19, allele DRB1*14:20, allele
DRB1*14:21, allele DRB1*14:24, allele
DRB1*14:29, allele DRB1*14:30, allele
DRB1*14:33, allele DRB1*14:37, allele
DRB1*14:41, allele DRB1*14:46, allele
DRB1*14:47, allele DRB1*14:48, allele
DRB1*14:49, allele DRB1*14:51, allele
DRB1*14:52, allele DRB1*14:76, allele
DRB1*14:79, allele DRB1*14:80 and allele
DRB1*14:83).
/FTId=VAR_062937.
VARIANT 100 100 R -> A (in allele DRB1*14:24 and allele
DRB1*14:37; requires 2 nucleotide
substitutions).
/FTId=VAR_062941.
VARIANT 100 100 R -> E (in allele DRB1*14:16 and allele
DRB1*14:57; requires 2 nucleotide
substitutions).
/FTId=VAR_062940.
VARIANT 100 100 R -> K (in allele DRB1*14:19, allele
DRB1*14:21, allele DRB1*14:76 and allele
DRB1*14:79).
/FTId=VAR_062939.
VARIANT 102 102 A -> G (in allele DRB1*14:76 and allele
DRB1*14:79).
/FTId=VAR_062943.
VARIANT 102 102 A -> S (in allele DRB1*14:56).
/FTId=VAR_062942.
VARIANT 103 103 E -> A (in allele DRB1*14:02, allele
DRB1*14:06, allele DRB1*14:09, allele
DRB1*14:13, allele DRB1*14:16, allele
DRB1*14:17, allele DRB1*14:19, allele
DRB1*14:20, allele DRB1*14:21, allele
DRB1*14:22, allele DRB1*14:24, allele
DRB1*14:25, allele DRB1*14:29, allele
DRB1*14:30, allele DRB1*14:31, allele
DRB1*14:32, allele DRB1*14:34, allele
DRB1*14:37, allele DRB1*14:41, allele
DRB1*14:46, allele DRB1*14:47, allele
DRB1*14:48, allele DRB1*14:49, allele
DRB1*14:52, allele DRB1*14:53, allele
DRB1*14:57, allele DRB1*14:65, allele
DRB1*14:69, allele DRB1*14:74, allele
DRB1*14:80, allele DRB1*14:81 and allele
DRB1*14:83).
/FTId=VAR_062944.
VARIANT 103 103 E -> L (in allele DRB1*14:03, allele
DRB1*14:12, allele DRB1*14:15, allele
DRB1*14:27, allele DRB1*14:40, allele
DRB1*14:55, allele DRB1*14:63, allele
DRB1*14:67, allele DRB1*14:77, allele
DRB1*14:78, allele DRB1*14:84 and allele
DRB1*14:85; requires 2 nucleotide
substitutions).
/FTId=VAR_062945.
VARIANT 103 103 E -> R (in allele DRB1*14:76 and allele
DRB1*14:79; requires 2 nucleotide
substitutions).
/FTId=VAR_062946.
VARIANT 106 106 T -> A (in allele DRB1*14:43).
/FTId=VAR_062948.
VARIANT 106 106 T -> N (in allele DRB1*14:38, allele
DRB1*14:47, allele DRB1*14:50, allele
DRB1*14:76 and allele DRB1*14:79).
/FTId=VAR_062947.
VARIANT 110 110 H -> Y (in allele DRB1*14:75).
/FTId=VAR_062949.
VARIANT 114 114 V -> A (in allele DRB1*14:28 and allele
DRB1*14:29).
/FTId=VAR_062950.
VARIANT 115 115 V -> G (in allele DRB1*14:02, allele
DRB1*14:03, allele DRB1*14:07, allele
DRB1*14:09, allele DRB1*14:13, allele
DRB1*14:14, allele DRB1*14:19, allele
DRB1*14:22, allele DRB1*14:24, allele
DRB1*14:25, allele DRB1*14:27, allele
DRB1*14:30, allele DRB1*14:36, allele
DRB1*14:40, allele DRB1*14:41, allele
DRB1*14:42, allele DRB1*14:44, allele
DRB1*14:46, allele DRB1*14:47, allele
DRB1*14:48, allele DRB1*14:49, allele
DRB1*14:51, allele DRB1*14:53, allele
DRB1*14:63, allele DRB1*14:67, allele
DRB1*14:68, allele DRB1*14:69, allele
DRB1*14:77 and allele DRB1*14:85).
/FTId=VAR_062951.
VARIANT 115 115 V -> M (in allele DRB1*14:71).
/FTId=VAR_062952.
VARIANT 141 141 Y -> H (in allele DRB1*14:02, allele
DRB1*14:03, allele DRB1*14:04, allele
DRB1*14:05, allele DRB1*14:06, allele
DRB1*14:07, allele DRB1*14:10, allele
DRB1*14:11, allele DRB1*14:13, allele
DRB1*14:14, allele DRB1*14:21, allele
DRB1*14:46, allele DRB1*14:54, allele
DRB1*14:57 and allele DRB1*14:82).
/FTId=VAR_062953.
CONFLICT 124 124 V -> G (in Ref. 10; BAH23562).
{ECO:0000305}.
SEQUENCE 266 AA; 30139 MW; FA4BE90DFAB4FA55 CRC64;
MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT ERVRFLDRYF
HNQEEFVRFD SDVGEYRAVT ELGRPAAEHW NSQKDLLERR RAEVDTYCRH NYGVVESFTV
QRRVHPKVTV YPSKTQPLQH YNLLVCSVSG FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG
DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL
FLGAGLFIYF RNQKGHSGLQ PRGFLS


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