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HTH-type transcriptional regulator QacR

 QACR_STAHA              Reviewed;         188 AA.
P0A0N5; P23217;
01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2005, sequence version 1.
12-SEP-2018, entry version 61.
RecName: Full=HTH-type transcriptional regulator QacR;
Name=qacR;
Staphylococcus haemolyticus.
Plasmid pNVH97A.
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
Staphylococcus.
NCBI_TaxID=1283;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=NVH97A; PLASMID=pNVH97A;
PubMed=12384372; DOI=10.1128/AAC.46.11.3606-3612.2002;
Anthonisen I.-L., Sunde M., Steinum T.M., Sidhu M.S., Sorum H.;
"Organization of the antiseptic resistance gene qacA and Tn552-related
beta-lactamase genes in multidrug-resistant Staphylococcus
haemolyticus strains of animal and human origins.";
Antimicrob. Agents Chemother. 46:3606-3612(2002).
-!- FUNCTION: Transcriptional repressor of qacA. Binds to IR1, an
unusually long 28 bp operator, which is located downstream from
the qacA promoter and overlaps its transcription start site. QacR
is induced from its IR1 site by binding to one of many
structurally dissimilar cationic lipophilic compounds, which are
also substrates of QacA (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer. Binds cooperatively to DNA as a pair of dimers
(By similarity). {ECO:0000250}.
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EMBL; AJ400722; CAB94807.1; -; Genomic_DNA.
PDB; 2G0E; X-ray; 2.88 A; A/B/D/E=1-188.
PDBsum; 2G0E; -.
ProteinModelPortal; P0A0N5; -.
SMR; P0A0N5; -.
DrugBank; DB04115; Berberine.
DrugBank; DB04209; Dequadin.
DrugBank; DB03895; Malachite Green.
DrugBank; DB03825; Rhodamine 6G.
EvolutionaryTrace; P0A0N5; -.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001647; HTH_TetR.
InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
InterPro; IPR013571; Tscrpt_reg_QacR_C.
Pfam; PF08360; TetR_C_5; 1.
Pfam; PF00440; TetR_N; 1.
PRINTS; PR00455; HTHTETR.
SUPFAM; SSF46689; SSF46689; 1.
SUPFAM; SSF48498; SSF48498; 1.
PROSITE; PS01081; HTH_TETR_1; 1.
PROSITE; PS50977; HTH_TETR_2; 1.
1: Evidence at protein level;
3D-structure; DNA-binding; Plasmid; Repressor; Transcription;
Transcription regulation.
CHAIN 1 188 HTH-type transcriptional regulator QacR.
/FTId=PRO_0000070610.
DOMAIN 1 61 HTH tetR-type. {ECO:0000255|PROSITE-
ProRule:PRU00335}.
DNA_BIND 24 43 H-T-H motif. {ECO:0000255|PROSITE-
ProRule:PRU00335}.
HELIX 4 17 {ECO:0000244|PDB:2G0E}.
TURN 20 22 {ECO:0000244|PDB:2G0E}.
HELIX 25 30 {ECO:0000244|PDB:2G0E}.
TURN 31 33 {ECO:0000244|PDB:2G0E}.
HELIX 36 38 {ECO:0000244|PDB:2G0E}.
TURN 41 43 {ECO:0000244|PDB:2G0E}.
HELIX 46 66 {ECO:0000244|PDB:2G0E}.
HELIX 69 71 {ECO:0000244|PDB:2G0E}.
HELIX 75 88 {ECO:0000244|PDB:2G0E}.
STRAND 90 92 {ECO:0000244|PDB:2G0E}.
HELIX 93 95 {ECO:0000244|PDB:2G0E}.
HELIX 96 105 {ECO:0000244|PDB:2G0E}.
TURN 110 117 {ECO:0000244|PDB:2G0E}.
HELIX 118 136 {ECO:0000244|PDB:2G0E}.
HELIX 145 161 {ECO:0000244|PDB:2G0E}.
HELIX 168 186 {ECO:0000244|PDB:2G0E}.
SEQUENCE 188 AA; 22174 MW; 7B91E005C8D47322 CRC64;
MNLKDKILGV AKELFIKNGY NATTTGEIVK LSESSKGNLY YHFKTKENLF LEILNIEESK
WQEQWKKEQI KCKTNREKFY LYNELSLTTE YYYPLQNAII EFYTEYYKTN SINEKMNKLE
NKYIDAYHVI FKEGNLNGEW CINDVNAVSK IAANAVNGIV TFTHEQNINE RIKLMNKFSQ
IFLNGLSK


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