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HTH-type transcriptional regulator TtgV (Toluene tolerance pump ttgGHI operon repressor)

 TTGV_PSEPT              Reviewed;         259 AA.
Q93PU6;
19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
25-OCT-2017, entry version 69.
RecName: Full=HTH-type transcriptional regulator TtgV;
AltName: Full=Toluene tolerance pump ttgGHI operon repressor;
Name=ttgV;
Pseudomonas putida (strain DOT-T1E).
Plasmid pGRT1.
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
Pseudomonadaceae; Pseudomonas.
NCBI_TaxID=1196325;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=DOT-T1E;
PubMed=11395460; DOI=10.1128/JB.183.13.3967-3973.2001;
Rojas A., Duque E., Mosqueda G., Golden G., Hurtado A., Ramos J.L.,
Segura A.;
"Three efflux pumps are required to provide efficient tolerance to
toluene in Pseudomonas putida DOT-T1E.";
J. Bacteriol. 183:3967-3973(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=DOT-T1E;
PubMed=21605303; DOI=10.1111/j.1462-2920.2011.02492.x;
Molina L., Duque E., Gomez M.J., Krell T., Lacal J., Garcia-Puente A.,
Garcia V., Matilla M.A., Ramos J.L., Segura A.;
"The pGRT1 plasmid of Pseudomonas putida DOT-T1E encodes functions
relevant for survival under harsh conditions in the environment.";
Environ. Microbiol. 13:2315-2327(2011).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=DOT-T1E;
PubMed=23815283; DOI=10.1111/1751-7915.12061;
Udaondo Z., Molina L., Daniels C., Gomez M.J., Molina-Henares M.A.,
Matilla M.A., Roca A., Fernandez M., Duque E., Segura A., Ramos J.L.;
"Metabolic potential of the organic-solvent tolerant Pseudomonas
putida DOT-T1E deduced from its annotated genome.";
Microb. Biotechnol. 6:598-611(2013).
[4]
OPERON ORGANIZATION, INDUCTION, AND CHARACTERIZATION.
STRAIN=DOT-T1E;
PubMed=12896994; DOI=10.1128/JB.185.16.4755-4763.2003;
Rojas A., Segura A., Guazzaroni M.E., Teran W., Hurtado A.,
Gallegos M.T., Ramos J.L.;
"In vivo and in vitro evidence that TtgV is the specific regulator of
the TtgGHI multidrug and solvent efflux pump of Pseudomonas putida.";
J. Bacteriol. 185:4755-4763(2003).
[5]
CHARACTERIZATION.
STRAIN=DOT-T1E;
PubMed=15126451; DOI=10.1128/JB.186.10.2921-2927.2004;
Guazzaroni M.E., Teran W., Zhang X., Gallegos M.T., Ramos J.L.;
"TtgV bound to a complex operator site represses transcription of the
promoter for the multidrug and solvent extrusion TtgGHI pump.";
J. Bacteriol. 186:2921-2927(2004).
-!- FUNCTION: Represses the expression of the ttgGHI and ttgVW
operons. Binds to the ttgGHI / ttgVW intergenic region, probably
preventing binding of RNA polymerase; ttgV dissociates from this
region in the presence of 1-hexanol.
-!- INDUCTION: The ttgVW operon is induced by toluene and styrene, but
not by the antibiotics carbenicillin, chloramphenicol, nalidixic
acid, tetracycline or gentamicin. {ECO:0000269|PubMed:12896994}.
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EMBL; HM626202; AAK69562.1; -; Genomic_DNA.
RefSeq; WP_014003968.1; NC_015855.1.
RefSeq; YP_004750622.1; NC_015855.1.
PDB; 2XRN; X-ray; 2.90 A; A/B=14-253.
PDB; 2XRO; X-ray; 3.40 A; A/B/E/F=14-253.
PDBsum; 2XRN; -.
PDBsum; 2XRO; -.
ProteinModelPortal; Q93PU6; -.
SMR; Q93PU6; -.
GeneID; 11001996; -.
EvolutionaryTrace; Q93PU6; -.
Proteomes; UP000006503; Plasmid pGRT1.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 3.30.450.40; -; 1.
InterPro; IPR029016; GAF_dom-like.
InterPro; IPR014757; Tscrpt_reg_IclR_C.
InterPro; IPR005471; Tscrpt_reg_IclR_N.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF09339; HTH_IclR; 1.
Pfam; PF01614; IclR; 1.
SMART; SM00346; HTH_ICLR; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF55781; SSF55781; 1.
PROSITE; PS51077; HTH_ICLR; 1.
PROSITE; PS51078; ICLR_ED; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; DNA-binding; Plasmid; Repressor;
Transcription; Transcription regulation.
CHAIN 1 259 HTH-type transcriptional regulator TtgV.
/FTId=PRO_0000201767.
DOMAIN 14 76 HTH iclR-type. {ECO:0000255|PROSITE-
ProRule:PRU00393}.
DOMAIN 89 253 IclR-ED. {ECO:0000255|PROSITE-
ProRule:PRU00394}.
DNA_BIND 36 59 H-T-H motif. {ECO:0000255|PROSITE-
ProRule:PRU00393}.
HELIX 16 28 {ECO:0000244|PDB:2XRN}.
HELIX 36 42 {ECO:0000244|PDB:2XRN}.
HELIX 47 58 {ECO:0000244|PDB:2XRN}.
TURN 59 61 {ECO:0000244|PDB:2XRN}.
STRAND 62 65 {ECO:0000244|PDB:2XRN}.
HELIX 67 69 {ECO:0000244|PDB:2XRN}.
STRAND 71 74 {ECO:0000244|PDB:2XRN}.
HELIX 77 104 {ECO:0000244|PDB:2XRN}.
STRAND 106 114 {ECO:0000244|PDB:2XRN}.
STRAND 117 124 {ECO:0000244|PDB:2XRN}.
STRAND 128 130 {ECO:0000244|PDB:2XRN}.
STRAND 139 141 {ECO:0000244|PDB:2XRN}.
HELIX 142 144 {ECO:0000244|PDB:2XRN}.
HELIX 146 154 {ECO:0000244|PDB:2XRN}.
HELIX 157 163 {ECO:0000244|PDB:2XRN}.
STRAND 172 174 {ECO:0000244|PDB:2XRN}.
HELIX 178 191 {ECO:0000244|PDB:2XRN}.
STRAND 193 201 {ECO:0000244|PDB:2XRN}.
STRAND 204 213 {ECO:0000244|PDB:2XRN}.
STRAND 216 225 {ECO:0000244|PDB:2XRN}.
HELIX 226 251 {ECO:0000244|PDB:2XRN}.
SEQUENCE 259 AA; 27411 MW; 1B2A580D89A85767 CRC64;
MNQSDENIGK AGGIQVIARA ASIMRALGSH PHGLSLAAIA QLVGLPRSTV QRIINALEEE
FLVEALGPAG GFRLGPALGQ LINQAQTDIL SLVKPYLRSL AEELDESVCL ASLAGDKIYV
LDRIVSEREL RVVFPIGINV PAAATAAGKV LLAALPDETL QAALGEQLPV LTSNTLGRKA
LVKQLSEVRQ SGVASDLDEH IDGVCSFATL LDTYLGYYSL AIVMPSSRAS KQSDLIKKAL
LQSKLNIERA IGRASKKAP


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