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Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)

 HAND2_DANRE             Reviewed;         208 AA.
P57102;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 1.
25-OCT-2017, entry version 96.
RecName: Full=Heart- and neural crest derivatives-expressed protein 2;
AltName: Full=Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2;
Short=dHAND;
Name=hand2; Synonyms=dhand;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Embryo;
PubMed=10906469; DOI=10.1016/S0925-4773(00)00334-8;
Angelo S., Lohr J., Lee K.H., Ticho B.S., Breitbart R.E., Hill S.,
Yost H.J., Srivastava D.;
"Conservation of sequence and expression of Xenopus and zebrafish
dHAND during cardiac, branchial arch and lateral mesoderm
development.";
Mech. Dev. 95:231-237(2000).
[2]
FUNCTION.
PubMed=10821756;
Yelon D., Ticho B.S., Halpern M.E., Ruvinsky I., Ho R.K., Silver L.M.,
Stainier D.Y.R.;
"The bHLH transcription factor hand2 plays parallel roles in zebrafish
heart and pectoral fin development.";
Development 127:2573-2582(2000).
-!- FUNCTION: Essential for myocardial and pectoral fin
differentiation, patterning and morphogenesis.
{ECO:0000269|PubMed:10821756}.
-!- SUBUNIT: Efficient DNA binding requires dimerization with another
bHLH protein.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00981}.
-!- DEVELOPMENTAL STAGE: Expression first detected at 8 hours post
fertilization (hpf) in a circumferential pattern in the lateral
mesoderm. At 12 hpf, still expressed in the anterior and posterior
lateral plate mesoderm which is partly detached from the yolk at
this stage. By 18-20 hpf, expressed in the cardiac ring and in a
layer of lateral mesoderm surrounding the cardiac region, as well
as in the posterior lateral mesoderm. At 24 hpf, expressed
throughout the nascent cardiac tube and in bilaterally symmetric
clusters of ventrolateral cells that condense to form branchial
arch mesoderm which gives rise to jaw and pharyngeal bones.
Expression continues bilaterally in the posterior lateral
mesoderm. At 36-48 hpf, expressed in defined branchial arch
mesoderm populations. At 48 hpf, strong expression throughout the
heart tube.
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EMBL; AF228334; AAF67130.1; -; mRNA.
UniGene; Dr.81423; -.
ProteinModelPortal; P57102; -.
SMR; P57102; -.
STRING; 7955.ENSDARP00000022921; -.
PaxDb; P57102; -.
PRIDE; P57102; -.
ZFIN; ZDB-GENE-000511-1; hand2.
eggNOG; KOG4029; Eukaryota.
eggNOG; ENOG411227D; LUCA.
HOGENOM; HOG000232082; -.
HOVERGEN; HBG051880; -.
InParanoid; P57102; -.
PRO; PR:P57102; -.
Proteomes; UP000000437; Unplaced.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0055007; P:cardiac muscle cell differentiation; IMP:ZFIN.
GO; GO:0010002; P:cardioblast differentiation; IMP:ZFIN.
GO; GO:0035051; P:cardiocyte differentiation; IMP:ZFIN.
GO; GO:0003142; P:cardiogenic plate morphogenesis; IMP:ZFIN.
GO; GO:0071908; P:determination of intestine left/right asymmetry; IMP:ZFIN.
GO; GO:0003144; P:embryonic heart tube formation; IMP:ZFIN.
GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IMP:ZFIN.
GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:ZFIN.
GO; GO:0060047; P:heart contraction; IMP:ZFIN.
GO; GO:0001947; P:heart looping; IGI:ZFIN.
GO; GO:0003007; P:heart morphogenesis; IMP:ZFIN.
GO; GO:0003357; P:noradrenergic neuron differentiation; IMP:ZFIN.
GO; GO:0030859; P:polarized epithelial cell differentiation; IMP:ZFIN.
GO; GO:0003342; P:proepicardium development; IMP:ZFIN.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0048485; P:sympathetic nervous system development; IMP:ZFIN.
GO; GO:0030878; P:thyroid gland development; IMP:ZFIN.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; DNA-binding; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 208 Heart- and neural crest derivatives-
expressed protein 2.
/FTId=PRO_0000127194.
DOMAIN 90 142 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
COMPBIAS 21 26 Poly-Ala.
SEQUENCE 208 AA; 23167 MW; F0E63A9329AC6E06 CRC64;
MSLVGGFPHH PVMHHDGYSF AAAAAASRCH EEPPYFHGWL ISHPEMSPPD YTMAPSYSPE
YSTGAPGLDH SHYGGVPGAG AVGMGPRTVK RRPTANRKER RRTQSINSAF AELRECIPNV
PADTKLSKIK TLRLATSYIA YLMDILDKDE QNGETEAFKA EFKKTDAKEE RRKKEMNDVL
KSSGSSNDKK TKGRTGWPQH VWALELKQ


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