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Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)

 HAND2_RAT               Reviewed;         217 AA.
P61295; O95300; O95301; P97833;
10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
10-MAY-2004, sequence version 1.
23-MAY-2018, entry version 97.
RecName: Full=Heart- and neural crest derivatives-expressed protein 2;
AltName: Full=Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2;
Short=dHAND;
Name=Hand2; Synonyms=Dhand;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Aorta;
Kemp P., Grainger D., Metcalfe J.;
"Expression of helix-loop-helix proteins in vascular smooth muscle.";
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Essential for cardiac morphogenesis, particularly for
the formation of the right ventricle and of the aortic arch
arteries. Required for vascular development and regulation of
angiogenesis, possibly through a VEGF signaling pathway. Plays
also an important role in limb development, particularly in the
establishment of anterior-posterior polarization, acting as an
upstream regulator of sonic hedgehog (SHH) induction in the limb
bud. Is involved in the development of branchial arches, which
give rise to unique structures in the head and neck. Binds DNA on
E-box consensus sequence 5'-CANNTG-3' (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Efficient DNA binding requires dimerization with another
bHLH protein. Forms homodimers and heterodimers with TCF3 gene
products E12 and E47, HAND1 and HEY1, HEY2 and HEYL (hairy-related
transcription factors) (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00981}.
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EMBL; Y08138; CAA69332.1; -; mRNA.
RefSeq; NP_073187.1; NM_022696.1.
UniGene; Rn.41057; -.
ProteinModelPortal; P61295; -.
SMR; P61295; -.
STRING; 10116.ENSRNOP00000033513; -.
PaxDb; P61295; -.
PRIDE; P61295; -.
GeneID; 64637; -.
KEGG; rno:64637; -.
CTD; 9464; -.
RGD; 621207; Hand2.
eggNOG; KOG4029; Eukaryota.
eggNOG; ENOG411227D; LUCA.
HOGENOM; HOG000232082; -.
HOVERGEN; HBG051880; -.
InParanoid; P61295; -.
KO; K18486; -.
PhylomeDB; P61295; -.
PRO; PR:P61295; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0033613; F:activating transcription factor binding; IPI:BHF-UCL.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0003713; F:transcription coactivator activity; IMP:BHF-UCL.
GO; GO:0008134; F:transcription factor binding; IPI:BHF-UCL.
GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.
GO; GO:0071300; P:cellular response to retinoic acid; IEP:RGD.
GO; GO:0007507; P:heart development; IEP:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
2: Evidence at transcript level;
Angiogenesis; Complete proteome; Developmental protein;
Differentiation; DNA-binding; Nucleus; Reference proteome;
Transcription; Transcription regulation.
CHAIN 1 217 Heart- and neural crest derivatives-
expressed protein 2.
/FTId=PRO_0000127193.
DOMAIN 99 151 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
COMPBIAS 21 32 Poly-Ala.
SEQUENCE 217 AA; 23666 MW; 528F541BB2173F1E CRC64;
MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH PEMSPPDYSM
ALSYSPEYAS GAAGLDHSHY GGVPPGAGPP GLGGPRPVKR RGTANRKERR RTQSINSAFA
ELRECIPNVP ADTKLSKIKT LRLATSYIAY LMDLLAKDDQ NGEAEAFKAE IKKTDVKEEK
RKKELNEILK STVSSNDKKT KGRTGWPQHV WALELKQ


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