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Hedgehog protein
F1P3J4_CHICK Unreviewed; 425 AA.
F1P3J4;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
03-MAY-2011, sequence version 1.
28-MAR-2018, entry version 61.
RecName: Full=Hedgehog protein {ECO:0000256|RuleBase:RU280812};
Name=SHH {ECO:0000313|Ensembl:ENSGALP00000010292};
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000010292, ECO:0000313|Proteomes:UP000000539};
[1] {ECO:0000313|Ensembl:ENSGALP00000010292, ECO:0000313|Proteomes:UP000000539}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000010292,
ECO:0000313|Proteomes:UP000000539};
PubMed=15592404; DOI=10.1038/nature03154;
International Chicken Genome Sequencing Consortium;
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
Mardis E.R., Wilson R.K.;
"Sequence and comparative analysis of the chicken genome provide
unique perspectives on vertebrate evolution.";
Nature 432:695-716(2004).
[2] {ECO:0000313|Ensembl:ENSGALP00000010292}
IDENTIFICATION.
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000010292};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- FUNCTION: Intercellular signal essential for a variety of
patterning events during development.
{ECO:0000256|RuleBase:RU280812}.
-!- SIMILARITY: Belongs to the hedgehog family.
{ECO:0000256|RuleBase:RU280812}.
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EMBL; AADN04000102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
SMR; F1P3J4; -.
Ensembl; ENSGALT00000010306; ENSGALP00000010292; ENSGALG00000006379.
eggNOG; KOG3638; Eukaryota.
eggNOG; ENOG410XQA3; LUCA.
GeneTree; ENSGT00390000001117; -.
OMA; EHSWAHR; -.
OrthoDB; EOG091G0N90; -.
PhylomeDB; F1P3J4; -.
TreeFam; TF106458; -.
Reactome; R-GGA-5358346; Hedgehog ligand biogenesis.
Reactome; R-GGA-5362798; Release of Hh-Np from the secreting cell.
Reactome; R-GGA-5632681; Ligand-receptor interactions.
Reactome; R-GGA-5635838; Activation of SMO.
Proteomes; UP000000539; Chromosome 2.
Bgee; ENSGALG00000006379; -.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IDA:AgBase.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
GO; GO:0005539; F:glycosaminoglycan binding; IEA:Ensembl.
GO; GO:0043237; F:laminin-1 binding; IEA:Ensembl.
GO; GO:0005113; F:patched binding; IEA:Ensembl.
GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
GO; GO:0008209; P:androgen metabolic process; IEA:Ensembl.
GO; GO:0048645; P:animal organ formation; IEA:Ensembl.
GO; GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0060840; P:artery development; IEA:Ensembl.
GO; GO:0060020; P:Bergmann glial cell differentiation; IEA:Ensembl.
GO; GO:0007596; P:blood coagulation; IEA:Ensembl.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0060447; P:bud outgrowth involved in lung branching; IEA:Ensembl.
GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0043369; P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; IEA:Ensembl.
GO; GO:0001709; P:cell fate determination; NAS:AgBase.
GO; GO:0060573; P:cell fate specification involved in pattern specification; NAS:AgBase.
GO; GO:0071285; P:cellular response to lithium ion; IEA:Ensembl.
GO; GO:0021930; P:cerebellar granule cell precursor proliferation; IEA:Ensembl.
GO; GO:0060591; P:chondroblast differentiation; IMP:AgBase.
GO; GO:0071679; P:commissural neuron axon guidance; IMP:AgBase.
GO; GO:0003140; P:determination of left/right asymmetry in lateral mesoderm; IEA:Ensembl.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0007398; P:ectoderm development; IEA:Ensembl.
GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0048617; P:embryonic foregut morphogenesis; IEA:Ensembl.
GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0009880; P:embryonic pattern specification; IMP:AgBase.
GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IMP:AgBase.
GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
GO; GO:0006897; P:endocytosis; IEA:Ensembl.
GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IEA:Ensembl.
GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
GO; GO:0090269; P:fibroblast growth factor production; IDA:AgBase.
GO; GO:0021508; P:floor plate formation; IMP:AgBase.
GO; GO:0048859; P:formation of anatomical boundary; IEA:Ensembl.
GO; GO:0003430; P:growth plate cartilage chondrocyte growth; IMP:AgBase.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0007442; P:hindgut morphogenesis; IEA:Ensembl.
GO; GO:0048877; P:homeostasis of number of retina cells; IMP:AgBase.
GO; GO:0048839; P:inner ear development; IEA:Ensembl.
GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
GO; GO:0045109; P:intermediate filament organization; IEA:Ensembl.
GO; GO:0060459; P:left lung development; IEA:Ensembl.
GO; GO:0060174; P:limb bud formation; IEA:Ensembl.
GO; GO:0060428; P:lung epithelium development; IEA:Ensembl.
GO; GO:0060463; P:lung lobe morphogenesis; IEA:Ensembl.
GO; GO:0060484; P:lung-associated mesenchyme development; IEA:Ensembl.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; IEA:Ensembl.
GO; GO:0030539; P:male genitalia development; IEA:Ensembl.
GO; GO:0060916; P:mesenchymal cell proliferation involved in lung development; IEA:Ensembl.
GO; GO:0060783; P:mesenchymal smoothened signaling pathway involved in prostate gland development; IEA:Ensembl.
GO; GO:0072136; P:metanephric mesenchymal cell proliferation involved in metanephros development; IEA:Ensembl.
GO; GO:0030901; P:midbrain development; IEA:Ensembl.
GO; GO:0045445; P:myoblast differentiation; IEA:Ensembl.
GO; GO:0014902; P:myotube differentiation; IEA:Ensembl.
GO; GO:0046639; P:negative regulation of alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IMP:AgBase.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
GO; GO:0090370; P:negative regulation of cholesterol efflux; IEA:Ensembl.
GO; GO:1904339; P:negative regulation of dopaminergic neuron differentiation; IEA:Ensembl.
GO; GO:2000357; P:negative regulation of kidney smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:2001054; P:negative regulation of mesenchymal cell apoptotic process; IEA:Ensembl.
GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO; GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:2000062; P:negative regulation of ureter smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0045060; P:negative thymic T cell selection; IEA:Ensembl.
GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
GO; GO:0014003; P:oligodendrocyte development; IEA:Ensembl.
GO; GO:0003408; P:optic cup formation involved in camera-type eye development; IMP:AgBase.
GO; GO:0021631; P:optic nerve morphogenesis; IMP:AgBase.
GO; GO:0002076; P:osteoblast development; IEA:Ensembl.
GO; GO:0060021; P:palate development; IEA:Ensembl.
GO; GO:0031016; P:pancreas development; IEA:Ensembl.
GO; GO:0009949; P:polarity specification of anterior/posterior axis; IEA:Ensembl.
GO; GO:0009951; P:polarity specification of dorsal/ventral axis; NAS:AgBase.
GO; GO:0010694; P:positive regulation of alkaline phosphatase activity; IDA:AgBase.
GO; GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0051781; P:positive regulation of cell division; IEA:Ensembl.
GO; GO:0010770; P:positive regulation of cell morphogenesis involved in differentiation; IMP:AgBase.
GO; GO:0060769; P:positive regulation of epithelial cell proliferation involved in prostate gland development; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IMP:AgBase.
GO; GO:0007228; P:positive regulation of hh target transcription factor activity; IEA:Ensembl.
GO; GO:0033092; P:positive regulation of immature T cell proliferation in thymus; IEA:Ensembl.
GO; GO:2000358; P:positive regulation of kidney smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:2000729; P:positive regulation of mesenchymal cell proliferation involved in ureter development; IEA:Ensembl.
GO; GO:0061075; P:positive regulation of neural retina development; IMP:AgBase.
GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IDA:AgBase.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0061189; P:positive regulation of sclerotome development; IEA:Ensembl.
GO; GO:0014858; P:positive regulation of skeletal muscle cell proliferation; IEA:Ensembl.
GO; GO:0048643; P:positive regulation of skeletal muscle tissue development; IEA:Ensembl.
GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0051155; P:positive regulation of striated muscle cell differentiation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:2000063; P:positive regulation of ureter smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IEA:Ensembl.
GO; GO:0045059; P:positive thymic T cell selection; IEA:Ensembl.
GO; GO:0060516; P:primary prostatic bud elongation; IEA:Ensembl.
GO; GO:0060523; P:prostate epithelial cord elongation; IEA:Ensembl.
GO; GO:0034504; P:protein localization to nucleus; IEA:Ensembl.
GO; GO:0030166; P:proteoglycan biosynthetic process; IMP:AgBase.
GO; GO:0060785; P:regulation of apoptosis involved in tissue homeostasis; IMP:AgBase.
GO; GO:0060786; P:regulation of cell differentiation involved in tissue homeostasis; TAS:AgBase.
GO; GO:0010468; P:regulation of gene expression; IMP:AgBase.
GO; GO:0060782; P:regulation of mesenchymal cell proliferation involved in prostate gland development; IEA:Ensembl.
GO; GO:2000177; P:regulation of neural precursor cell proliferation; IMP:AgBase.
GO; GO:0042481; P:regulation of odontogenesis; IEA:Ensembl.
GO; GO:0060685; P:regulation of prostatic bud formation; IEA:Ensembl.
GO; GO:0001895; P:retina homeostasis; IMP:AgBase.
GO; GO:0003406; P:retinal pigment epithelium development; IMP:AgBase.
GO; GO:0060458; P:right lung development; IEA:Ensembl.
GO; GO:0060662; P:salivary gland cavitation; IEA:Ensembl.
GO; GO:0097264; P:self proteolysis; IDA:AgBase.
GO; GO:0043588; P:skin development; IEA:Ensembl.
GO; GO:0021938; P:smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; IEA:Ensembl.
GO; GO:0061053; P:somite development; IEA:Ensembl.
GO; GO:0021513; P:spinal cord dorsal/ventral patterning; IMP:AgBase.
GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
GO; GO:0014706; P:striated muscle tissue development; IEA:Ensembl.
GO; GO:0021978; P:telencephalon regionalization; IEA:Ensembl.
GO; GO:0021794; P:thalamus development; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
GO; GO:0009888; P:tissue development; IMP:AgBase.
GO; GO:0060439; P:trachea morphogenesis; IEA:Ensembl.
GO; GO:1905327; P:tracheoesophageal septum formation; IEA:Ensembl.
GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
Gene3D; 3.30.1380.10; -; 1.
InterPro; IPR001657; Hedgehog.
InterPro; IPR009045; Hedgehog_sig/DD-Pept_Zn-bd_sf.
InterPro; IPR000320; Hedgehog_signalling_dom.
InterPro; IPR001767; Hint_dom.
InterPro; IPR003586; Hint_dom_C.
InterPro; IPR003587; Hint_dom_N.
InterPro; IPR036844; Hint_dom_sf.
InterPro; IPR006141; Intein_N.
Pfam; PF01085; HH_signal; 1.
Pfam; PF01079; Hint; 1.
PIRSF; PIRSF009400; Peptidase_C46; 1.
PRINTS; PR00632; SONICHHOG.
SMART; SM00305; HintC; 1.
SMART; SM00306; HintN; 1.
SUPFAM; SSF51294; SSF51294; 1.
SUPFAM; SSF55166; SSF55166; 1.
PROSITE; PS50817; INTEIN_N_TER; 1.
3: Inferred from homology;
Autocatalytic cleavage {ECO:0000256|RuleBase:RU280812};
Calcium {ECO:0000256|PIRSR:PIRSR009400-2};
Cell membrane {ECO:0000256|RuleBase:RU280812};
Complete proteome {ECO:0000313|Proteomes:UP000000539};
Developmental protein {ECO:0000256|RuleBase:RU280812};
Hydrolase {ECO:0000256|RuleBase:RU280812};
Membrane {ECO:0000256|RuleBase:RU280812};
Metal-binding {ECO:0000256|PIRSR:PIRSR009400-2};
Protease {ECO:0000256|RuleBase:RU280812};
Reference proteome {ECO:0000313|Proteomes:UP000000539};
Signal {ECO:0000256|RuleBase:RU280812, ECO:0000256|SAM:SignalP};
Zinc {ECO:0000256|PIRSR:PIRSR009400-2}.
SIGNAL 1 26 {ECO:0000256|SAM:SignalP}.
CHAIN 27 425 Hedgehog protein.
{ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003268621.
DOMAIN 199 310 HintN. {ECO:0000259|SMART:SM00306}.
DOMAIN 313 358 HintC. {ECO:0000259|SMART:SM00305}.
METAL 92 92 Calcium 1.
{ECO:0000256|PIRSR:PIRSR009400-2}.
METAL 93 93 Calcium 1.
{ECO:0000256|PIRSR:PIRSR009400-2}.
METAL 93 93 Calcium 2.
{ECO:0000256|PIRSR:PIRSR009400-2}.
METAL 98 98 Calcium 1.
{ECO:0000256|PIRSR:PIRSR009400-2}.
METAL 128 128 Calcium 1; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR009400-2}.
METAL 129 129 Calcium 1.
{ECO:0000256|PIRSR:PIRSR009400-2}.
METAL 129 129 Calcium 2.
{ECO:0000256|PIRSR:PIRSR009400-2}.
METAL 132 132 Calcium 2.
{ECO:0000256|PIRSR:PIRSR009400-2}.
METAL 134 134 Calcium 2.
{ECO:0000256|PIRSR:PIRSR009400-2}.
METAL 143 143 Zinc. {ECO:0000256|PIRSR:PIRSR009400-2}.
METAL 150 150 Zinc. {ECO:0000256|PIRSR:PIRSR009400-2}.
METAL 185 185 Zinc. {ECO:0000256|PIRSR:PIRSR009400-2}.
SITE 200 201 Cleavage; by autolysis.
{ECO:0000256|PIRSR:PIRSR009400-1}.
SITE 246 246 Involved in cholesterol transfer.
{ECO:0000256|PIRSR:PIRSR009400-1}.
SITE 270 270 Involved in auto-cleavage.
{ECO:0000256|PIRSR:PIRSR009400-1}.
SITE 273 273 Essential for auto-cleavage.
{ECO:0000256|PIRSR:PIRSR009400-1}.
SEQUENCE 425 AA; 46488 MW; 144948CDC12FF8EC CRC64;
MDEMLLLTRI LLVGFICALL VSSGLTCGPG RGIGKRRHPK KLTPLAYKQF IPNVAEKTLG
ASGRYEGKIT RNSERFKELT PNYNPDIIFK DEENTGADRL MTQRCKDKLN ALAISVMNQW
PGVKLRVTEG WDEDGHHSEE SLHYEGRAVD ITTSDRDRSK YGMLARLAVE AGFDWVYYES
KAHIHCSVKA ENSVAAKSGG CFPGSATVHL EHGGTKLVKD LSPGDRVLAA DADGRLLYSD
FLTFLDREDS SRKLFYVIET RQPRARLLLT AAHLLFVAPQ HNQSEATGST SGQALFASNV
KPGQRVYVLG EGGQQLLPAS VHSVSLREEA SGAYAPLTAQ GTILINRVLA SCYAVIEEHS
WAHWAFAPFR LAQGLLAALC PDGAIPTAAT TTTGIHWYSR LLYRIGSWVL DGDALHPLGM
VAPAS
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Pathways :
WP1022: Hedgehog Signaling Pathway
WP1032: NLR proteins
WP1049: G Protein Signaling Pathways
WP1071: Cytoplasmic Ribosomal Proteins
WP1141: Hedgehog Signaling Pathway
WP116: Hedgehog Signaling Pathway
WP1165: G Protein Signaling Pathways
WP1187: Cytoplasmic Ribosomal Proteins
WP1239: Cytoplasmic Ribosomal Proteins
WP1256: NLR proteins
WP1294: NLR proteins
WP1353: Hedgehog Signaling Pathway
WP1360: NLR proteins
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1497: Hedgehog-related genes
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP163: Cytoplasmic Ribosomal Proteins
Related Genes :
[shhb twhh] Tiggy-winkle hedgehog protein (TWHH) (Sonic hedgehog protein B) (SHHB) [Cleaved into: Tiggy-winkle hedgehog protein N-product; Tiggy-winkle hedgehog protein C-product]
[Shh Hhg1] Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp) (Sonic hedgehog protein 19 kDa product)]
[hh CG4637] Protein hedgehog [Cleaved into: Protein hedgehog N-product (Hh-Np) (N-Hh); Protein hedgehog C-product (Hh-Cp) (C-Hh)]
[IHH] Indian hedgehog protein (IHH) (HHG-2) [Cleaved into: Indian hedgehog protein N-product; Indian hedgehog protein C-product]
[shha shh vhh1] Sonic hedgehog protein A (SHHA) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) (VHH-1) [Cleaved into: Sonic hedgehog protein A N-product (Shh N-terminal processed signaling domains) (ShhNp) (Sonic hedgehog protein N-product) (ShhN)]
[DHH] Desert hedgehog protein (DHH) (HHG-3) [Cleaved into: Desert hedgehog protein N-product; Desert hedgehog protein C-product]
[hh GH23852] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GD18403] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GE23980] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GF18029] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GL23598] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GJ22641] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GG12458] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GI24573] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GM23589] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GK12833] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[Ihh] Indian hedgehog protein (IHH) (HHG-2) [Cleaved into: Indian hedgehog protein N-product; Indian hedgehog protein C-product]
[Dhh] Desert hedgehog protein (DHH) (HHG-3) [Cleaved into: Desert hedgehog protein N-product; Desert hedgehog protein C-product]
[IHH] Indian hedgehog protein (IHH) [Cleaved into: Indian hedgehog protein N-product; Indian hedgehog protein C-product]
[SHH] Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[SHH] Sonic hedgehog protein (SHH) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[Shh Vhh-1] Sonic hedgehog protein (SHH) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[ihhb ehh ihh] Indian hedgehog B protein (IHHB) (Echidna hedgehog protein) (EHH) [Cleaved into: Indian hedgehog B protein N-product; Indian hedgehog B protein C-product]
[shh] Sonic hedgehog protein (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) (VHH-1) (X-SHH) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[HHAT MART2 SKI1] Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Melanoma antigen recognized by T-cells 2) (MART-2) (Skinny hedgehog protein 1)
[Hhat Skn] Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Skinny hedgehog protein)
[ihh bhh] Indian hedgehog protein (IHH) (Banded hedgehog protein) (X-BHH) [Cleaved into: Indian hedgehog protein N-product; Indian hedgehog protein C-product]
[dhh-a chh] Desert hedgehog protein A (Cephalic hedgehog protein) (Desert hedgehog protein 1) (DHH-1) (X-CHH) [Cleaved into: Desert hedgehog protein A N-product; Desert hedgehog protein A C-product]
[hh-1 GA18321; hh-2 GA29124] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[HHIP HIP UNQ5825/PRO19644] Hedgehog-interacting protein (HHIP) (HIP)
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