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Hemagglutinin (Fragment)

 Q1MVB4_9INFA            Unreviewed;       379 AA.
Q1MVB4;
30-MAY-2006, integrated into UniProtKB/TrEMBL.
30-MAY-2006, sequence version 1.
23-MAY-2018, entry version 72.
RecName: Full=Hemagglutinin {ECO:0000256|SAAS:SAAS00070811};
Flags: Fragment;
Name=H6 {ECO:0000313|EMBL:CAG27345.1};
Influenza A virus (A/Pekin Duck/France/M-92/00(H6N2)).
Viruses; ssRNA viruses; ssRNA negative-strand viruses;
Orthomyxoviridae; Alphainfluenzavirus.
NCBI_TaxID=273366 {ECO:0000313|EMBL:CAG27345.1};
[1] {ECO:0000313|EMBL:CAG27345.1}
NUCLEOTIDE SEQUENCE.
Rousset J., Louboutin K., Hars J., Jestin V.;
"Characterization of avian influenza viruses isolated from wild birds
and sentinel ducks during the winter seasons 2000-2001 and 2001-2002
in France.";
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Binds to sialic acid-containing receptors on the cell
surface, bringing about the attachment of the virus particle to
the cell. This attachment induces virion internalization either
through clathrin-dependent endocytosis or through clathrin- and
caveolin-independent pathway. Plays a major role in the
determination of host range restriction and virulence. Class I
viral fusion protein. Responsible for penetration of the virus
into the cell cytoplasm by mediating the fusion of the membrane of
the endocytosed virus particle with the endosomal membrane. Low pH
in endosomes induces an irreversible conformational change in HA2,
releasing the fusion hydrophobic peptide. Several trimers are
required to form a competent fusion pore.
{ECO:0000256|SAAS:SAAS01039674}.
-!- FUNCTION: Binds to sialic acid-containing receptors on the cell
surface, bringing about the attachment of the virus particle to
the cell. This attachment induces virion internalization of about
two third of the virus particles through clathrin-dependent
endocytosis and about one third through a clathrin- and caveolin-
independent pathway. Plays a major role in the determination of
host range restriction and virulence. Class I viral fusion
protein. Responsible for penetration of the virus into the cell
cytoplasm by mediating the fusion of the membrane of the
endocytosed virus particle with the endosomal membrane. Low pH in
endosomes induces an irreversible conformational change in HA2,
releasing the fusion hydrophobic peptide. Several trimers are
required to form a competent fusion pore.
{ECO:0000256|RuleBase:RU003324}.
-!- SUBUNIT: Homotrimer of disulfide-linked HA1-HA2.
{ECO:0000256|RuleBase:RU003324, ECO:0000256|SAAS:SAAS00070616}.
-!- SUBCELLULAR LOCATION: Host apical cell membrane
{ECO:0000256|SAAS:SAAS00554492}; Single-pass type I membrane
protein {ECO:0000256|SAAS:SAAS00554492}. Virion membrane
{ECO:0000256|SAAS:SAAS00554193}; Single-pass type I membrane
protein {ECO:0000256|SAAS:SAAS00554193}.
-!- SIMILARITY: Belongs to the influenza viruses hemagglutinin family.
{ECO:0000256|RuleBase:RU003324, ECO:0000256|SAAS:SAAS00554639}.
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EMBL; AJ697869; CAG27345.1; -; Genomic_RNA.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
Gene3D; 3.90.209.20; -; 1.
InterPro; IPR008980; Capsid_hemagglutn.
InterPro; IPR013828; Hemagglutn_HA1_a/b_dom_sf.
InterPro; IPR000149; Hemagglutn_influenz_A.
InterPro; IPR001364; Hemagglutn_influenz_A/B.
Pfam; PF00509; Hemagglutinin; 1.
PRINTS; PR00330; HEMAGGLUTN1.
PRINTS; PR00329; HEMAGGLUTN12.
SUPFAM; SSF49818; SSF49818; 1.
3: Inferred from homology;
Clathrin- and caveolin-independent endocytosis of virus by host
{ECO:0000256|SAAS:SAAS01039667};
Clathrin-mediated endocytosis of virus by host
{ECO:0000256|SAAS:SAAS01039644};
Disulfide bond {ECO:0000256|SAAS:SAAS00442250};
Fusion of virus membrane with host endosomal membrane
{ECO:0000256|SAAS:SAAS00046943};
Fusion of virus membrane with host membrane
{ECO:0000256|SAAS:SAAS00046943};
Hemagglutinin {ECO:0000256|RuleBase:RU003324,
ECO:0000256|SAAS:SAAS00046890};
Host cell membrane {ECO:0000256|SAAS:SAAS00047107};
Host membrane {ECO:0000256|SAAS:SAAS00047107};
Host-virus interaction {ECO:0000256|SAAS:SAAS00441705};
Membrane {ECO:0000256|SAAS:SAAS00047107,
ECO:0000256|SAAS:SAAS00441560};
Transmembrane {ECO:0000256|SAAS:SAAS00441560};
Transmembrane helix {ECO:0000256|SAAS:SAAS00441560};
Viral attachment to host cell {ECO:0000256|SAAS:SAAS00441705};
Viral envelope protein {ECO:0000256|RuleBase:RU003324,
ECO:0000256|SAAS:SAAS00046987};
Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00046943,
ECO:0000256|SAAS:SAAS01039644, ECO:0000256|SAAS:SAAS01039667};
Virion {ECO:0000256|RuleBase:RU003324, ECO:0000256|SAAS:SAAS00046987,
ECO:0000256|SAAS:SAAS00441705};
Virus endocytosis by host {ECO:0000256|SAAS:SAAS01039644,
ECO:0000256|SAAS:SAAS01039667};
Virus entry into host cell {ECO:0000256|SAAS:SAAS00046943,
ECO:0000256|SAAS:SAAS00441705, ECO:0000256|SAAS:SAAS01039644,
ECO:0000256|SAAS:SAAS01039667}.
NON_TER 379 379 {ECO:0000313|EMBL:CAG27345.1}.
SEQUENCE 379 AA; 41889 MW; 6B1F7A00A8741FC3 CRC64;
MIAIIVIAIL AAAGKSDKIC IGYHANNSTT QVDTILEKNV TVTHSVELLE NKKEERFCKI
LNKAPLDLRG CTIEGWILGN PQCDLLLGDQ SWSYIVERPT AQNGICYPGV LNEVEELKAL
IGSGERVERF EMFPKSTWAG VDTSSGVTKA CPYNSGSSFY RNLLWIIKTK SAAYPVIKGT
YNNTGNQPIL YFWGVHHPPD TNEQNTLYGS GDRYVRMGTE SMNFAKSPEI AARPAVNGQR
GRIDYYWSVL KPGETLNVES NGNLIAPWYA YRFVSTNNKG AVFKSNLPIE NCDATCQTIA
GVLRTNKTFQ NVSPLWIGEC PKYVKSESLR LATGLRNVPQ VETRGLFGAI AGFIEGGWTG
MIDGWYGYHH ENSQGSGYA


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