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Hemagglutinin glycoprotein

 HEMA_MEASE              Reviewed;         617 AA.
P08362;
01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
01-AUG-1988, sequence version 1.
22-NOV-2017, entry version 98.
RecName: Full=Hemagglutinin glycoprotein;
Name=H;
Measles virus (strain Edmonston) (MeV) (Subacute sclerose
panencephalitis virus).
Viruses; ssRNA viruses; ssRNA negative-strand viruses;
Mononegavirales; Paramyxoviridae; Morbillivirus.
NCBI_TaxID=11235;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=3008420; DOI=10.1016/0042-6822(86)90312-0;
Alkhatib G., Briedis D.J.;
"The predicted primary structure of the measles virus hemagglutinin.";
Virology 150:479-490(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=2596022; DOI=10.1016/0042-6822(89)90554-0;
Cattaneo R., Schmid A., Spielhofer P., Kaelin K., Baczko K.,
Meulen V., Pardowitz J., Flanagan S., Rima B.K., Udem S.A.;
"Mutated and hypermutated genes of persistent measles viruses which
caused lethal human brain diseases.";
Virology 173:415-425(1989).
[3]
INTERACTION WITH HUMAN MCP/CD46.
PubMed=8402913; DOI=10.1016/0092-8674(93)80071-L;
Doerig R.E., Marcil A., Chopra A., Richardson C.D.;
"The human CD46 molecule is a receptor for measles virus (Edmonston
strain).";
Cell 75:295-305(1993).
[4]
FUNCTION.
PubMed=9811778;
Galbraith S.E., Tiwari A., Baron M.D., Lund B.T., Barrett T.,
Cosby S.L.;
"Morbillivirus downregulation of CD46.";
J. Virol. 72:10292-10297(1998).
[5]
INTERACTION WITH HUMAN SLAMF1.
PubMed=10972291; DOI=10.1038/35022579;
Tatsuo H., Ono N., Tanaka K., Yanagi Y.;
"SLAM (CDw150) is a cellular receptor for measles virus.";
Nature 406:893-897(2000).
-!- FUNCTION: Attaches the virus to cell receptors and thereby
initiating infection. Binding of H protein to the receptor induces
a conformational change that allows the F protein to trigger
virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as
receptors for viral entry into the cell. The high degree of
interaction between H and MCP/CD46 results in down-regulation of
the latter from the surface of infected cells, rendering them more
sensitive to c3b-mediated complement lysis.
{ECO:0000269|PubMed:9811778}.
-!- SUBUNIT: Interacts with human NECTIN4; this interaction allows
virus infection of the respiratory epithelium (By similarity).
Interacts with human MCP/CD46 antigen and SLAMF1. {ECO:0000250,
ECO:0000269|PubMed:10972291, ECO:0000269|PubMed:8402913}.
-!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
type II membrane protein {ECO:0000305}. Host cell membrane
{ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-
neuraminidase family. Non-sialidase subfamily. {ECO:0000305}.
-!- CAUTION: Morbiliviruses hemagglutinins have no neuraminidase
activity. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M14877; AAA46424.1; -; Genomic_RNA.
EMBL; K01711; AAA75500.1; -; Genomic_RNA.
PIR; A27006; HMNZED.
PDB; 2RKC; X-ray; 2.70 A; A=156-617.
PDB; 2ZB5; X-ray; 3.00 A; A=149-617.
PDB; 2ZB6; X-ray; 2.60 A; A=149-617.
PDB; 3ALW; X-ray; 3.55 A; A=184-607.
PDB; 3ALX; X-ray; 3.15 A; A/B/C/D=184-607.
PDB; 3ALZ; X-ray; 4.52 A; A=149-617.
PDB; 3INB; X-ray; 3.10 A; A/B=179-617.
PDBsum; 2RKC; -.
PDBsum; 2ZB5; -.
PDBsum; 2ZB6; -.
PDBsum; 3ALW; -.
PDBsum; 3ALX; -.
PDBsum; 3ALZ; -.
PDBsum; 3INB; -.
ProteinModelPortal; P08362; -.
SMR; P08362; -.
DIP; DIP-59049N; -.
IntAct; P08362; 2.
OrthoDB; VOG0900004D; -.
EvolutionaryTrace; P08362; -.
Proteomes; UP000000833; Genome.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
InterPro; IPR000665; Hemagglutn/HN.
InterPro; IPR036278; Sialidase_sf.
Pfam; PF00423; HN; 1.
SUPFAM; SSF50939; SSF50939; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Glycoprotein; Hemagglutinin;
Host cell membrane; Host membrane; Host-virus interaction; Membrane;
Signal-anchor; Transmembrane; Transmembrane helix;
Viral attachment to host cell; Viral envelope protein; Virion;
Virus entry into host cell.
CHAIN 1 617 Hemagglutinin glycoprotein.
/FTId=PRO_0000142599.
TOPO_DOM 1 37 Intravirion. {ECO:0000255}.
TRANSMEM 38 58 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 59 617 Virion surface. {ECO:0000255}.
CARBOHYD 168 168 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 187 187 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 200 200 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 215 215 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 238 238 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
HELIX 159 163 {ECO:0000244|PDB:2ZB6}.
STRAND 189 198 {ECO:0000244|PDB:2ZB6}.
HELIX 205 211 {ECO:0000244|PDB:2ZB6}.
STRAND 215 224 {ECO:0000244|PDB:2ZB6}.
STRAND 227 236 {ECO:0000244|PDB:2ZB6}.
STRAND 250 261 {ECO:0000244|PDB:2ZB6}.
STRAND 264 267 {ECO:0000244|PDB:2ZB6}.
STRAND 269 279 {ECO:0000244|PDB:2ZB6}.
STRAND 281 283 {ECO:0000244|PDB:3INB}.
STRAND 286 292 {ECO:0000244|PDB:2ZB6}.
STRAND 295 307 {ECO:0000244|PDB:2ZB6}.
STRAND 313 315 {ECO:0000244|PDB:2ZB6}.
STRAND 318 327 {ECO:0000244|PDB:2ZB6}.
STRAND 333 339 {ECO:0000244|PDB:2ZB6}.
STRAND 344 350 {ECO:0000244|PDB:2ZB6}.
STRAND 355 359 {ECO:0000244|PDB:2ZB6}.
STRAND 362 371 {ECO:0000244|PDB:2ZB6}.
HELIX 374 385 {ECO:0000244|PDB:2ZB6}.
STRAND 387 389 {ECO:0000244|PDB:2ZB5}.
HELIX 391 395 {ECO:0000244|PDB:2ZB6}.
HELIX 400 403 {ECO:0000244|PDB:2ZB6}.
STRAND 409 418 {ECO:0000244|PDB:2ZB6}.
TURN 420 422 {ECO:0000244|PDB:2ZB5}.
STRAND 425 430 {ECO:0000244|PDB:2ZB6}.
STRAND 442 445 {ECO:0000244|PDB:2ZB6}.
STRAND 451 456 {ECO:0000244|PDB:2ZB6}.
TURN 460 462 {ECO:0000244|PDB:3INB}.
STRAND 466 471 {ECO:0000244|PDB:2ZB6}.
STRAND 473 475 {ECO:0000244|PDB:2ZB6}.
STRAND 477 486 {ECO:0000244|PDB:2ZB6}.
STRAND 488 493 {ECO:0000244|PDB:2ZB6}.
STRAND 495 497 {ECO:0000244|PDB:2ZB6}.
TURN 504 506 {ECO:0000244|PDB:3INB}.
STRAND 509 511 {ECO:0000244|PDB:2ZB6}.
STRAND 519 521 {ECO:0000244|PDB:2ZB6}.
STRAND 524 530 {ECO:0000244|PDB:2ZB6}.
STRAND 531 535 {ECO:0000244|PDB:3INB}.
STRAND 538 543 {ECO:0000244|PDB:2ZB6}.
STRAND 548 552 {ECO:0000244|PDB:2ZB6}.
STRAND 565 572 {ECO:0000244|PDB:2ZB6}.
STRAND 574 584 {ECO:0000244|PDB:2ZB6}.
TURN 588 590 {ECO:0000244|PDB:2ZB6}.
STRAND 595 606 {ECO:0000244|PDB:2ZB6}.
SEQUENCE 617 AA; 69250 MW; 0E5A05AEDA43D9C6 CRC64;
MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI GLLAIAGIRL
HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG DEVGLRTPQR FTDLVKFISD
KIKFLNPDRE YDFRDLTWCI NPPERIKLDY DQYCADVAAE ELMNALVNST LLETRTTNQF
LAVSKGNCSG PTTIRGQFSN MSLSLLDLYL GRGYNVSSIV TMTSQGMYGG TYLVEKPNLS
SKRSELSQLS MYRVFEVGVI RNPGLGAPVF HMTNYLEQPV SNDLSNCMVA LGELKLAALC
HGEDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMQSWVPLS TDDPVIDRLY LSSHRGVIAD
NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA PLKDNRIPSY GVLSVDLSLT
VELKIKIASG FGPLITHGSG MDLYKSNHNN VYWLTIPPMK NLALGVINTL EWIPRFKVSP
YLFNVPIKEA GEDCHAPTYL PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY
YVYSPSRSFS YFYPFRLPIK GVPIELQVEC FTWDQKLWCR HFCVLADSES GGHITHSGME
GMGVSCTVTR EDGTNRR


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