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Hemagglutinin glycoprotein

 HEMA_CDVO               Reviewed;         604 AA.
P24306;
01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
01-MAR-1992, sequence version 1.
25-OCT-2017, entry version 85.
RecName: Full=Hemagglutinin glycoprotein;
Name=H;
Canine distemper virus (strain Onderstepoort) (CDV).
Viruses; ssRNA viruses; ssRNA negative-strand viruses;
Mononegavirales; Paramyxoviridae; Morbillivirus.
NCBI_TaxID=11233;
NCBI_TaxID=9646; Ailuropoda melanoleuca (Giant panda).
NCBI_TaxID=9649; Ailurus fulgens (Lesser panda) (Red panda).
NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
NCBI_TaxID=9665; Mustela.
NCBI_TaxID=9689; Panthera leo (Lion).
NCBI_TaxID=9654; Procyon lotor (Raccoon).
NCBI_TaxID=9704; Zalophus californianus (California sealion).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=1993883; DOI=10.1099/0022-1317-72-2-443;
Curran M.D., Clarke D.K., Rima B.K.;
"The nucleotide sequence of the gene encoding the attachment protein H
of canine distemper virus.";
J. Gen. Virol. 72:443-447(1991).
[2]
INTERACTION WITH CANINE SLAMF1.
PubMed=11390585; DOI=10.1128/JVI.75.13.5842-5850.2001;
Tatsuo H., Ono N., Yanagi Y.;
"Morbilliviruses use signaling lymphocyte activation molecules (CD150)
as cellular receptors.";
J. Virol. 75:5842-5850(2001).
[3]
MUTAGENESIS OF PRO-483; GLY-488; ASN-489; TYR-491; PRO-493; TYR-525;
ASP-526; ILE-527; SER-528; ARG-529; SER-530; HIS-532; ALA-533;
ARG-543; ILE-545; TYR-547; THR-548; HIS-549; PRO-550; PHE-551; ARG-552
AND LEU-553.
PubMed=15827201; DOI=10.1128/JVI.79.9.5857-5862.2005;
von Messling V., Oezguen N., Zheng Q., Vongpunsawad S., Braun W.,
Cattaneo R.;
"Nearby clusters of hemagglutinin residues sustain SLAM-dependent
canine distemper virus entry in peripheral blood mononuclear cells.";
J. Virol. 79:5857-5862(2005).
-!- FUNCTION: Attaches the virus to cell receptors and thereby
initiating infection. Binding of H protein to the receptor induces
a conformational change that allows the F protein to trigger
virion/cell membranes fusion. The cellular receptor might be SLAM,
and may explain the lymphotropism of the virus.
-!- SUBUNIT: Binds canine SLAMF1 at the cell surface.
-!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
type II membrane protein {ECO:0000305}. Host cell membrane
{ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-
neuraminidase family. Non-sialidase subfamily. {ECO:0000305}.
-!- CAUTION: Morbiliviruses hemagglutinins have no neuraminidase
activity. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; D00758; BAA00654.1; -; Genomic_RNA.
PIR; A38480; HMNZCD.
RefSeq; NP_047206.1; NC_001921.1.
GeneID; 1489792; -.
KEGG; vg:1489792; -.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
InterPro; IPR000665; Hemagglutn/HN.
InterPro; IPR036278; Sialidase_sf.
Pfam; PF00423; HN; 1.
SUPFAM; SSF50939; SSF50939; 1.
1: Evidence at protein level;
Glycoprotein; Hemagglutinin; Host cell membrane; Host membrane;
Host-virus interaction; Membrane; Signal-anchor; Transmembrane;
Transmembrane helix; Viral attachment to host cell;
Viral envelope protein; Virion; Virus entry into host cell.
CHAIN 1 604 Hemagglutinin glycoprotein.
/FTId=PRO_0000142597.
TOPO_DOM 1 37 Intravirion. {ECO:0000255}.
TRANSMEM 38 58 Helical. {ECO:0000255}.
TOPO_DOM 59 604 Virion surface. {ECO:0000255}.
CARBOHYD 149 149 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 422 422 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 587 587 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
MUTAGEN 483 483 P->S: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 488 488 G->A: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 489 489 N->A: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 491 491 Y->A: Loss of fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 493 493 P->S: Complete loss of fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 525 525 Y->A: Complete loss of fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 526 526 D->A: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 527 527 I->A: Partial loss of fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 528 528 S->A: Partial loss of fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 529 529 R->A: Partial loss of fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 530 530 S->A: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 532 532 H->A: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 533 533 A->S: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 543 543 R->A: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 545 545 I->S: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 547 547 Y->A: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 548 548 T->A: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 549 549 H->A: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 550 550 P->S: No effect on fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 551 551 F->S: Complete loss of fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 552 552 R->A: Partial loss of fusion activity.
{ECO:0000269|PubMed:15827201}.
MUTAGEN 553 553 L->S: Complete loss of fusion activity.
{ECO:0000269|PubMed:15827201}.
SEQUENCE 604 AA; 67988 MW; 552429817EF3D2A8 CRC64;
MLPYQDKVGA FYKDNARANS TKLSLVTEGH GGRRPPYLLF VLLILLVGIL ALLAITGVRF
HQVSTSNMEF SRLLKEDMEK SEAVHHQVID VLTPLFKIIG DEIGLRLPQK LNEIKQFILQ
KTNFFNPNRE FDFRDLHWCI NPPSTVKVNF TNYCESIGIR KAIASAANPI LLSALSGGRG
DIFPPHRCSG ATTSVGKVFP LSVSLSMSLI SRTSEVINML TAISDGVYGK TYLLVPDDIE
REFDTREIRV FEIGFIKRWL NDMPLLQTTN YMVLPKNSKA KVCTIAVGEL TLASLCVEES
TVLLYHDSSG SQDGILVVTL GIFWATPMDH IEEVIPVAHP SMKKIHITNH RGFIKDSIAT
WMVPALASEK QEEQKGCLES ACQRKTYPMC NQASWEPFGG RQLPSYGRLT LPLDASVDLQ
LNISFTYGPV ILNGDGMDYY ESPLLNSGWL TIPPKDGTIS GLINKAGRGD QFTVLPHVLT
FAPRESSGNC YLPIQTSQIR DRDVLIESNI VVLPTQSIRY VIATYDISRS DHAIVYYVYD
PIRTISYTHP FRLTTKGRPD FLRIECFVWD DNLWCHQFYR FEADIANSTT SVENLVRIRF
SCNR


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