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Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)

 HEMA_CVBQ               Reviewed;         424 AA.
P59709; P24351; Q66166; Q66167; Q66168; Q77NC5; Q98VL2; Q9DGT1;
Q9DGT9; Q9DR84; Q9DRF4; Q9DRF5;
16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
16-JUN-2003, sequence version 1.
23-MAY-2018, entry version 85.
RecName: Full=Hemagglutinin-esterase {ECO:0000255|HAMAP-Rule:MF_04207};
Short=HE protein {ECO:0000255|HAMAP-Rule:MF_04207};
EC=3.1.1.53 {ECO:0000255|HAMAP-Rule:MF_04207};
AltName: Full=E3 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04207};
Flags: Precursor;
Name=HE {ECO:0000255|HAMAP-Rule:MF_04207}; ORFNames=2b;
Bovine coronavirus (strain Quebec) (BCoV) (BCV).
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Nidovirales; Coronaviridae; Coronavirinae; Betacoronavirus.
NCBI_TaxID=11133;
NCBI_TaxID=9913; Bos taurus (Bovine).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=2732684; DOI=10.1099/0022-1317-70-1-155;
Parker M.D., Cox G.J., Deregt D., Fitzpatrick D.R., Babiuk L.A.;
"Cloning and in vitro expression of the gene for the E3 haemagglutinin
glycoprotein of bovine coronavirus.";
J. Gen. Virol. 70:155-164(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate BCQ.2590, Isolate BCQ.3, and Isolate BCQ.571;
PubMed=7730812; DOI=10.1099/0022-1317-76-5-1263;
Dea S., Michaud L., Milane G.;
"Comparison of bovine coronavirus isolates associated with neonatal
calf diarrhoea and winter dysentery in adult dairy cattle in Quebec.";
J. Gen. Virol. 76:1263-1270(1995).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate BCQ.1523, Isolate BCQ.2590, Isolate BCQ.3994,
Isolate BCQ.571, and Isolate BCQ.7373;
PubMed=11774537;
Gelinas A.-M., Sasseville A.M.-J., Dea S.;
"Identification of specific variations within the HE, S1, and ORF4
genes of bovine coronaviruses associated with enteric and respiratory
diseases in dairy cattle.";
Adv. Exp. Med. Biol. 494:63-67(2001).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate BCQ.1523, Isolate BCQ.2439, Isolate BCQ.2442,
Isolate BCQ.2508, Isolate BCQ.3708, Isolate BCQ.376, Isolate BCQ.701,
and Isolate BCQ.7373;
PubMed=11504427; DOI=10.1007/s007050170117;
Kourtesis A.B., Gelinas A.-M., Dea S.;
"Genomic and antigenic variations of the HE glycoprotein of bovine
coronaviruses associated with neonatal calf diarrhea and winter
dysentery.";
Arch. Virol. 146:1219-1230(2001).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate BCQ.3994;
PubMed=11376845; DOI=10.1016/S0168-1702(01)00243-X;
Gelinas A.-M., Boutin M., Sasseville A.M.-J., Dea S.;
"Bovine coronaviruses associated with enteric and respiratory diseases
in Canadian dairy cattle display different reactivities to anti-HE
monoclonal antibodies and distinct amino acid changes in their HE, S
and ns4.9 protein.";
Virus Res. 76:43-57(2001).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=11774548;
Yoo D., Pei Y.;
"Full-length genomic sequence of bovine coronavirus (31 kb).
Completion of the open reading frame 1a/1b sequences.";
Adv. Exp. Med. Biol. 494:73-76(2001).
-!- FUNCTION: Structural protein that makes short spikes at the
surface of the virus. Contains receptor binding and receptor-
destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-
acetylneuraminic acid, which is probably the receptor determinant
recognized by the virus on the surface of erythrocytes and
susceptible cells. This receptor-destroying activity is important
for virus release as it probably helps preventing self-aggregation
and ensures the efficient spread of the progeny virus from cell to
cell. May serve as a secondary viral attachment protein for
initiating infection, the spike protein being the major one. May
become a target for both the humoral and the cellular branches of
the immune system. {ECO:0000255|HAMAP-Rule:MF_04207}.
-!- CATALYTIC ACTIVITY: N-acetyl-O-acetylneuraminate + H(2)O = N-
acetylneuraminate + acetate. {ECO:0000255|HAMAP-Rule:MF_04207}.
-!- SUBUNIT: Homodimer; disulfide-linked. Forms a complex with the M
protein in the pre-Golgi. Associates then with S-M complex to form
a ternary complex S-M-HE. {ECO:0000255|HAMAP-Rule:MF_04207}.
-!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
Rule:MF_04207}; Single-pass type I membrane protein
{ECO:0000255|HAMAP-Rule:MF_04207}. Host cell membrane
{ECO:0000255|HAMAP-Rule:MF_04207}; Single-pass type I membrane
protein {ECO:0000255|HAMAP-Rule:MF_04207}. Note=In infected cells
becomes incorporated into the envelope of virions during virus
assembly at the endoplasmic reticulum and cis Golgi. However, some
may escape incorporation into virions and subsequently migrate to
the cell surface. {ECO:0000255|HAMAP-Rule:MF_04207}.
-!- PTM: N-glycosylated in the RER.
-!- PTM: N-glycosylated in the host RER. {ECO:0000255|HAMAP-
Rule:MF_04207}.
-!- MISCELLANEOUS: The sequence shown is that of Quebec reference
strain.
-!- SIMILARITY: Belongs to the influenza type C/coronaviruses
hemagglutinin-esterase family. {ECO:0000255|HAMAP-Rule:MF_04207}.
-----------------------------------------------------------------------
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EMBL; L38962; AAA92989.1; -; Genomic_RNA.
EMBL; L38963; AAA92990.1; -; Genomic_RNA.
EMBL; U06093; AAA92991.1; -; Genomic_RNA.
EMBL; AF239306; AAG40594.1; -; Genomic_RNA.
EMBL; AF239307; AAG40600.1; -; Genomic_RNA.
EMBL; AF230523; AAG40588.1; -; Genomic_RNA.
EMBL; AF230524; AAG40589.1; -; Genomic_RNA.
EMBL; AF230525; AAG40590.1; -; Genomic_RNA.
EMBL; AF230526; AAG40591.1; -; Genomic_RNA.
EMBL; AF230527; AAG40592.1; -; Genomic_RNA.
EMBL; AF230528; AAG40593.1; -; Genomic_RNA.
EMBL; AF339836; AAK14397.1; -; Genomic_RNA.
EMBL; AF220295; AAL40399.1; -; Genomic_RNA.
PIR; A31684; HMIHBQ.
RefSeq; NP_150076.1; NC_003045.1.
ProteinModelPortal; P59709; -.
SMR; P59709; -.
GeneID; 921684; -.
KEGG; vg:921684; -.
KO; K19253; -.
OrthoDB; VOG0900009Y; -.
Proteomes; UP000008572; Genome.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
GO; GO:0001681; F:sialate O-acetylesterase activity; ISS:UniProtKB.
GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
HAMAP; MF_04207; BETA_CORONA_HE; 1.
InterPro; IPR008980; Capsid_hemagglutn.
InterPro; IPR007142; Hemagglutn-estrase_core.
InterPro; IPR003860; Hemagglutn-estrase_hemagglutn.
Pfam; PF03996; Hema_esterase; 1.
Pfam; PF02710; Hema_HEFG; 1.
SUPFAM; SSF49818; SSF49818; 1.
3: Inferred from homology;
Complete proteome; Disulfide bond; Glycoprotein; Hemagglutinin;
Host cell membrane; Host membrane; Hydrolase; Membrane; Signal;
Transmembrane; Transmembrane helix; Viral envelope protein; Virion.
SIGNAL 1 16 {ECO:0000255|HAMAP-Rule:MF_04207}.
CHAIN 17 424 Hemagglutinin-esterase.
{ECO:0000255|HAMAP-Rule:MF_04207}.
/FTId=PRO_0000037143.
TOPO_DOM 17 392 Virion surface. {ECO:0000255|HAMAP-
Rule:MF_04207}.
TRANSMEM 393 413 Helical. {ECO:0000255|HAMAP-
Rule:MF_04207}.
TOPO_DOM 414 424 Intravirion. {ECO:0000255|HAMAP-
Rule:MF_04207}.
REGION 7 127 Esterase domain 1. {ECO:0000255|HAMAP-
Rule:MF_04207}.
REGION 128 266 Receptor binding. {ECO:0000255|HAMAP-
Rule:MF_04207}.
REGION 267 379 Esterase domain 2. {ECO:0000255|HAMAP-
Rule:MF_04207}.
ACT_SITE 40 40 Nucleophile. {ECO:0000255|HAMAP-
Rule:MF_04207}.
ACT_SITE 326 326 Charge relay system. {ECO:0000255|HAMAP-
Rule:MF_04207}.
ACT_SITE 329 329 Charge relay system. {ECO:0000255|HAMAP-
Rule:MF_04207}.
CARBOHYD 54 54 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04207}.
CARBOHYD 89 89 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04207}.
CARBOHYD 153 153 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04207}.
CARBOHYD 236 236 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04207}.
CARBOHYD 301 301 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04207}.
CARBOHYD 316 316 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04207}.
CARBOHYD 358 358 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04207}.
CARBOHYD 417 417 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04207}.
DISULFID 44 65 {ECO:0000255|HAMAP-Rule:MF_04207}.
DISULFID 113 162 {ECO:0000255|HAMAP-Rule:MF_04207}.
DISULFID 197 276 {ECO:0000255|HAMAP-Rule:MF_04207}.
DISULFID 205 249 {ECO:0000255|HAMAP-Rule:MF_04207}.
DISULFID 307 312 {ECO:0000255|HAMAP-Rule:MF_04207}.
DISULFID 347 371 {ECO:0000255|HAMAP-Rule:MF_04207}.
VARIANT 5 5 L -> P (in strain: Isolate BCQ.3, Isolate
BCQ.1523, Isolate BCQ.2439, Isolate
BCQ.2442, Isolate BCQ.2508, Isolate
BCQ.2590, Isolate BCQ.3708, Isolate
BCQ.3994 and Isolate BCQ.7373).
VARIANT 8 8 V -> A (in strain: Isolate BCQ.2590).
VARIANT 11 11 S -> C (in strain: Isolate BCQ.1523,
Isolate BCQ.2442 and Isolate BCQ.2508).
VARIANT 49 49 N -> T (in strain: Isolate BCQ.376,
Isolate BCQ.701, Isolate BCQ.1523,
Isolate BCQ.2442, Isolate BCQ.2508,
Isolate BCQ.3708, Isolate BCQ.3994 and
Isolate BCQ.7373).
VARIANT 53 53 R -> P (in strain: Isolate BCQ.2590).
VARIANT 66 66 D -> G (in strain: Isolate BCQ.376,
Isolate BCQ.701, Isolate BCQ.3708 and
Isolate BCQ.3994).
VARIANT 103 103 L -> I (in strain: Isolate BCQ.2439).
VARIANT 103 103 L -> V (in strain: Isolate BCQ.3, Isolate
BCQ.376, Isolate BCQ.701, Isolate
BCQ.1523, Isolate BCQ.2442, Isolate
BCQ.2508, Isolate BCQ.2590, Isolate
BCQ.3708, Isolate BCQ.3994 and Isolate
BCQ.7373).
VARIANT 114 114 T -> I (in strain: Isolate BCQ.3708).
VARIANT 182 182 G -> R (in strain: Isolate BCQ.7373).
VARIANT 245 245 F -> L (in strain: Isolate BCQ.7373).
VARIANT 282 282 D -> G (in strain: Isolate BCQ.7373).
VARIANT 344 344 D -> A (in strain: Isolate BCQ.2590).
VARIANT 350 350 Q -> R (in strain: Isolate BCQ.2590).
VARIANT 367 367 S -> P (in strain: Isolate BCQ.376,
Isolate BCQ.701, Isolate BCQ.1523,
Isolate BCQ.2439, Isolate BCQ.2442,
Isolate BCQ.2508, Isolate BCQ.2590,
Isolate BCQ.3708, Isolate BCQ.3994 and
Isolate BCQ.7373).
VARIANT 392 392 L -> I (in strain: Isolate BCQ.3, Isolate
BCQ.376, Isolate BCQ.571, Isolate
BCQ.701, Isolate BCQ.1523, Isolate
BCQ.2439, Isolate BCQ.2442, Isolate
BCQ.2508, Isolate BCQ.3708, Isolate
BCQ.3994 and Isolate BCQ.7373).
SEQUENCE 424 AA; 47709 MW; F1CE076E4AA7B277 CRC64;
MFLLLRFVLV SCIIGSLGFD NPPTNVVSHL NGDWFLFGDS RSDCNHVVNT NPRNYSYMDL
NPALCDSGKI SSKAGNSIFR SFHFTDFYNY TGEGQQIIFY EGLNFTPYHA FKCTTSGSND
IWMQNKGLFY TQVYKNMAVY RSLTFVNVPY VYNGSAQSTA LCKSGSLVLN NPAYIAREAN
FGDYYYKVEA DFYLSGCDEY IVPLCIFNGK FLSNTKYYDD SQYYFNKDTG VIYGLNSTET
ITTGFDFNCH YLVLPSGNYL AISNELLLTV PTKAICLNKR KDFTPVQVVD SRWNNARQSD
NMTAVACQPP YCYFRNSTTN YVGVYDINHG DAGFTSILSG LLYDSPCFSQ QGVFRYDNVS
SVWPLYSYGR CPTAADINTP DVPICVYDPL PLILLGILLG VAVIIIVVLL LYFMVDNGTR
LHDA


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