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Hemagglutinin-neuraminidase (EC 3.2.1.18)

 HN_PI3B                 Reviewed;         572 AA.
P06167;
01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
01-JAN-1988, sequence version 1.
23-MAY-2018, entry version 106.
RecName: Full=Hemagglutinin-neuraminidase;
EC=3.2.1.18;
Name=HN;
Bovine parainfluenza 3 virus (BPIV-3).
Viruses; ssRNA viruses; ssRNA negative-strand viruses;
Mononegavirales; Paramyxoviridae; Respirovirus.
NCBI_TaxID=11215;
NCBI_TaxID=9913; Bos taurus (Bovine).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=910N;
PubMed=3031615; DOI=10.1093/nar/15.7.2945;
Suzu S., Sakai Y., Shioda T., Shibuta H.;
"Nucleotide sequence of the bovine parainfluenza 3 virus genome: the
genes of the F and HN glycoproteins.";
Nucleic Acids Res. 15:2945-2958(1987).
-!- FUNCTION: Attaches the virus to sialic acid-containing cell
receptors and thereby initiating infection. Binding of HN protein
to the receptor induces a conformational change that allows the F
protein to trigger virion/cell membranes fusion (By similarity).
{ECO:0000250}.
-!- FUNCTION: Neuraminidase activity ensures the efficient spread of
the virus by dissociating the mature virions from the neuraminic
acid containing glycoproteins. {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-,
alpha-(2->8)- glycosidic linkages of terminal sialic acid residues
in oligosaccharides, glycoproteins, glycolipids, colominic acid
and synthetic substrates.
-!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
type II membrane protein {ECO:0000305}. Host cell membrane
{ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
-!- SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-
neuraminidase family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; Y00114; CAA68298.1; -; Genomic_RNA.
EMBL; D84095; BAA12218.1; -; Genomic_RNA.
ProteinModelPortal; P06167; -.
SMR; P06167; -.
CAZy; GH83; Glycoside Hydrolase Family 83.
Proteomes; UP000133413; Genome.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
InterPro; IPR016285; Hemagglutn-neuramid.
InterPro; IPR000665; Hemagglutn/HN.
InterPro; IPR036278; Sialidase_sf.
Pfam; PF00423; HN; 1.
PIRSF; PIRSF001072; Hemagglut-neuramid_paramyxoV; 1.
SUPFAM; SSF50939; SSF50939; 1.
3: Inferred from homology;
Complete proteome; Glycoprotein; Hemagglutinin; Host cell membrane;
Host membrane; Host-virus interaction; Hydrolase; Membrane;
Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix;
Viral attachment to host cell; Viral envelope protein; Virion;
Virus entry into host cell.
CHAIN 1 572 Hemagglutinin-neuraminidase.
/FTId=PRO_0000142624.
TOPO_DOM 1 30 Intravirion. {ECO:0000255}.
TRANSMEM 31 51 Helical. {ECO:0000255}.
TOPO_DOM 52 572 Virion surface. {ECO:0000255}.
CARBOHYD 308 308 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 351 351 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 448 448 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 523 523 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
SEQUENCE 572 AA; 64590 MW; DDF84E90C4EC87B4 CRC64;
MEYWKHTNST KDTNNELGTT RDRHSSKATN IIMYIFWTTT STILSVIFIM ILINLIQENN
HNKLMLQEIR KEFAAIDTKI QKTSDDIGTS IQSGINTRLL TIQSHVQNYI PLSLTQQMSD
LRKFINDLTT KREHQEVPIQ RMTHDSGIEP LNPDKFWRCT SGNPSLTSSP KIRLIPGPGL
LATSTTVNGC IRLPSLAINN LIYAYTSNLI TQGCQDIGKS YQVLQIGIIT INSDLVPDLN
PRVTHTFNID DNRKSCSLAL LNTDVYQLCS TPKVDERSDY ASTGIEDIVL DIVTSNGLII
TTRFTNNNIT FDKPYAALYP SVGPGIYYKD KVIFLGYGGL EHEENGDVIC NTTGCPGKTQ
RDCNQASYSP WFSNRRMVNS IIVVDKGIDT TFSLRVWTIP MRQNYWGSEG RLLLLGDRIY
IYTRSTSWHS KLQLGVIDIS DFNNIRINWT WHNVLSRPGN DECPWGHSCP DGCITGVYTD
AYPLNPSGSI VSSVILDSQK SRENPIITYS TATNRVNELA IYNRTLPAAY TTTNCITHYD
KGYCFHIVEI NHRSLNTFQP MLFKTEVPKN CS


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