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Hematopoietic progenitor cell antigen CD34 (CD antigen CD34)

 CD34_MOUSE              Reviewed;         382 AA.
Q64314; Q62550; Q62551;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
12-SEP-2018, entry version 148.
RecName: Full=Hematopoietic progenitor cell antigen CD34;
AltName: CD_antigen=CD34;
Flags: Precursor;
Name=Cd34;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE (ISOFORM LONG).
STRAIN=129, and BALB/cJ; TISSUE=Bone marrow;
PubMed=1709048; DOI=10.1093/intimm/3.2.175;
Brown J., Greaves M.F., Molgaard H.V.;
"The gene encoding the stem cell antigen, CD34, is conserved in mouse
and expressed in haemopoietic progenitor cell lines, brain, and
embryonic fibroblasts.";
Int. Immunol. 3:175-184(1991).
[2]
NUCLEOTIDE SEQUENCE (ISOFORMS LONG AND SHORT).
PubMed=1373970;
Suda J., Sudo T., Ito M., Ohno N., Yamaguchi Y., Suda T.;
"Two types of murine CD34 mRNA generated by alternative splicing.";
Blood 79:2288-2295(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
STRAIN=FVB/N; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=15592455; DOI=10.1038/nbt1046;
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
Zha X.-M., Polakiewicz R.D., Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer
cells.";
Nat. Biotechnol. 23:94-101(2005).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-326 AND TYR-336, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Mast cell;
PubMed=17947660; DOI=10.4049/jimmunol.179.9.5864;
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
Kawakami T., Salomon A.R.;
"Quantitative time-resolved phosphoproteomic analysis of mast cell
signaling.";
J. Immunol. 179:5864-5876(2007).
[6]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-246.
TISSUE=Myoblast;
PubMed=19656770; DOI=10.1074/mcp.M900195-MCP200;
Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I.,
Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E.,
Wollscheid B.;
"The mouse C2C12 myoblast cell surface N-linked glycoproteome:
identification, glycosite occupancy, and membrane orientation.";
Mol. Cell. Proteomics 8:2555-2569(2009).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Heart, Kidney, Lung, Pancreas, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Possible adhesion molecule with a role in early
hematopoiesis by mediating the attachment of stem cells to the
bone marrow extracellular matrix or directly to stromal cells.
Could act as a scaffold for the attachment of lineage specific
glycans, allowing stem cells to bind to lectins expressed by
stromal cells or other marrow components. Presents carbohydrate
ligands to selectins (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Long;
IsoId=Q64314-1; Sequence=Displayed;
Name=Short;
IsoId=Q64314-2; Sequence=VSP_004161, VSP_004162;
-!- TISSUE SPECIFICITY: Highly expressed in hematopoietic progenitor
cell lines, brain and testis, and moderately in the thymus,
spleen, and bone marrow, but not in adult liver.
-!- PTM: Highly glycosylated. {ECO:0000250}.
-!- PTM: Phosphorylated on serine residues by PKC. {ECO:0000250}.
-!- SIMILARITY: Belongs to the CD34 family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; S69293; AAB19246.1; -; mRNA.
EMBL; S69302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; S69295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; S69299; AAB22108.1; ALT_SEQ; mRNA.
EMBL; S69301; AAB22109.1; -; mRNA.
EMBL; BC006607; AAH06607.1; -; mRNA.
CCDS; CCDS15640.1; -. [Q64314-1]
CCDS; CCDS48490.1; -. [Q64314-2]
PIR; I65354; I65354.
RefSeq; NP_598415.1; NM_133654.3. [Q64314-1]
UniGene; Mm.29798; -.
ProteinModelPortal; Q64314; -.
IntAct; Q64314; 1.
MINT; Q64314; -.
STRING; 10090.ENSMUSP00000016638; -.
iPTMnet; Q64314; -.
PhosphoSitePlus; Q64314; -.
PaxDb; Q64314; -.
PRIDE; Q64314; -.
Ensembl; ENSMUST00000016638; ENSMUSP00000016638; ENSMUSG00000016494. [Q64314-1]
Ensembl; ENSMUST00000110815; ENSMUSP00000106439; ENSMUSG00000016494. [Q64314-2]
GeneID; 12490; -.
KEGG; mmu:12490; -.
UCSC; uc007eeq.2; mouse. [Q64314-1]
CTD; 947; -.
MGI; MGI:88329; Cd34.
eggNOG; ENOG410IPJJ; Eukaryota.
eggNOG; ENOG410YPR6; LUCA.
GeneTree; ENSGT00390000008414; -.
HOGENOM; HOG000052513; -.
HOVERGEN; HBG003461; -.
InParanoid; Q64314; -.
KO; K06474; -.
OMA; GMPRGWT; -.
OrthoDB; EOG091G0K1S; -.
PhylomeDB; Q64314; -.
TreeFam; TF335795; -.
Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
ChiTaRS; Cd34; mouse.
PRO; PR:Q64314; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000016494; Expressed in 278 organ(s), highest expression level in skin of back.
CleanEx; MM_CD34; -.
ExpressionAtlas; Q64314; baseline and differential.
Genevisible; Q64314; MM.
GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO; GO:0009925; C:basal plasma membrane; ISS:UniProtKB.
GO; GO:0071944; C:cell periphery; IDA:MGI.
GO; GO:0009986; C:cell surface; IDA:UniProtKB.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005576; C:extracellular region; IDA:MGI.
GO; GO:0036053; C:glomerular endothelium fenestra; ISS:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0045171; C:intercellular bridge; ISS:UniProtKB.
GO; GO:0005764; C:lysosome; ISS:UniProtKB.
GO; GO:0016020; C:membrane; IDA:MGI.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0030246; F:carbohydrate binding; ISS:UniProtKB.
GO; GO:0043199; F:sulfate binding; IDA:MGI.
GO; GO:0008134; F:transcription factor binding; ISO:MGI.
GO; GO:0008283; P:cell proliferation; ISS:UniProtKB.
GO; GO:0098609; P:cell-cell adhesion; ISS:UniProtKB.
GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
GO; GO:0001935; P:endothelial cell proliferation; ISO:MGI.
GO; GO:0071971; P:extracellular exosome assembly; ISO:MGI.
GO; GO:0072011; P:glomerular endothelium development; IEA:Ensembl.
GO; GO:0003094; P:glomerular filtration; ISS:UniProtKB.
GO; GO:0071425; P:hematopoietic stem cell proliferation; ISO:MGI.
GO; GO:0030097; P:hemopoiesis; ISO:MGI.
GO; GO:0050900; P:leukocyte migration; IMP:MGI.
GO; GO:0035759; P:mesangial cell-matrix adhesion; ISS:UniProtKB.
GO; GO:0072254; P:metanephric glomerular mesangial cell differentiation; IEA:Ensembl.
GO; GO:0030195; P:negative regulation of blood coagulation; ISS:UniProtKB.
GO; GO:1900035; P:negative regulation of cellular response to heat; ISS:UniProtKB.
GO; GO:1900038; P:negative regulation of cellular response to hypoxia; ISS:UniProtKB.
GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
GO; GO:1900041; P:negative regulation of interleukin-2 secretion; ISO:MGI.
GO; GO:1901215; P:negative regulation of neuron death; ISS:UniProtKB.
GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; ISS:UniProtKB.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:UniProtKB.
GO; GO:0038001; P:paracrine signaling; ISO:MGI.
GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:1900168; P:positive regulation of glial cell-derived neurotrophic factor secretion; ISO:MGI.
GO; GO:0071657; P:positive regulation of granulocyte colony-stimulating factor production; ISO:MGI.
GO; GO:0032733; P:positive regulation of interleukin-10 production; ISS:UniProtKB.
GO; GO:0042482; P:positive regulation of odontogenesis; ISS:UniProtKB.
GO; GO:0071636; P:positive regulation of transforming growth factor beta production; ISS:UniProtKB.
GO; GO:2001214; P:positive regulation of vasculogenesis; ISS:UniProtKB.
GO; GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
GO; GO:0007165; P:signal transduction; IEA:Ensembl.
GO; GO:0001894; P:tissue homeostasis; ISS:UniProtKB.
GO; GO:0060290; P:transdifferentiation; IEA:Ensembl.
GO; GO:0061042; P:vascular wound healing; IEA:Ensembl.
InterPro; IPR008083; CD34.
InterPro; IPR013836; CD34/Podocalyxin.
PANTHER; PTHR16677; PTHR16677; 1.
Pfam; PF06365; CD34_antigen; 1.
PRINTS; PR01700; CD34ANTIGEN.
1: Evidence at protein level;
Alternative splicing; Cell adhesion; Complete proteome; Glycoprotein;
Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 34 {ECO:0000255}.
CHAIN 35 382 Hematopoietic progenitor cell antigen
CD34.
/FTId=PRO_0000020901.
TOPO_DOM 35 287 Extracellular. {ECO:0000255}.
TRANSMEM 288 308 Helical. {ECO:0000255}.
TOPO_DOM 309 382 Cytoplasmic. {ECO:0000255}.
MOD_RES 326 326 Phosphotyrosine.
{ECO:0000244|PubMed:17947660}.
MOD_RES 336 336 Phosphotyrosine.
{ECO:0000244|PubMed:17947660}.
MOD_RES 343 343 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
CARBOHYD 50 50 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 56 56 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 87 87 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 137 137 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 144 144 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 145 145 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 246 246 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:19656770}.
VAR_SEQ 322 325 GEDP -> ELEP (in isoform Short).
{ECO:0000305}.
/FTId=VSP_004161.
VAR_SEQ 326 382 Missing (in isoform Short).
{ECO:0000305}.
/FTId=VSP_004162.
SEQUENCE 382 AA; 40983 MW; EAE611ABE85C4957 CRC64;
MQVHRDTRAG LLLPWRWVAL CLMSLLHLNN LTSATTETST QGISPSVPTN ESVEENITSS
IPGSTSHYLI YQDSSKTTPA ISETMVNFTV TSGIPSGSGT PHTFSQPQTS PTGILPTTSD
SISTSEMTWK SSLPSINVSD YSPNNSSFEM TSPTEPYAYT SSSAPSAIKG EIKCSGIREV
RLAQGICLEL SEASSCEEFK KEKGEDLIQI LCEKEEAEAD AGASVCSLLL AQSEVRPECL
LMVLANSTEL PSKLQLMEKH QSDLRKLGIQ SFNKQDIGSH QSYSRKTLIA LVTSGVLLAI
LGTTGYFLMN RRSWSPTGER LGEDPYYTEN GGGQGYSSGP GASPETQGKA NVTRGAQENG
TGQATSRNGH SARQHVVADT EL


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