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Hemogen (Hemopoietic gene protein) (Negative differentiation regulator protein) (mNDR)

 HEMGN_MOUSE             Reviewed;         503 AA.
Q9ERZ0; B1AVH8; Q3TAE6; Q80YT2; Q8CF29;
11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
31-JAN-2018, entry version 97.
RecName: Full=Hemogen;
AltName: Full=Hemopoietic gene protein;
AltName: Full=Negative differentiation regulator protein;
Short=mNDR;
Name=Hemgn; Synonyms=Ndr;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE,
AND TISSUE SPECIFICITY.
TISSUE=Fetal heart;
PubMed=11404085; DOI=10.1016/S0925-4773(01)00376-8;
Yang L.V., Nicholson R.H., Kaplan J., Galy A., Li L.;
"Hemogen is a novel nuclear factor specifically expressed in mouse
hematopoietic development and its human homologue EDAG maps to
chromosome 9q22, a region containing breakpoints of hematological
neoplasms.";
Mech. Dev. 104:105-111(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Liu C.-C., Ch'ang L.-Y.;
"Effects of mNDR in spermatogenesis.";
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and NOD; TISSUE=Embryo, Spleen, and Testis;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=14648837; DOI=10.1002/dvdy.10399;
Yang L.V., Heng H.H., Wan J., Southwood C.M., Gow A., Li L.;
"Alternative promoters and polyadenylation regulate tissue-specific
expression of Hemogen isoforms during hematopoiesis and
spermatogenesis.";
Dev. Dyn. 228:606-616(2003).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103; SER-153; SER-158;
SER-171; SER-213; SER-223; SER-241; SER-269; THR-286 AND SER-387, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Lung, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Regulates the proliferation and differentiation of
hematopoietic cells. Overexpression block the TPA-induced
megakaryocytic differentiation in the K562 cell model. May also
prevent cell apoptosis through the activation of the nuclear
factor-kappa B (NF-kB) (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11404085}.
-!- TISSUE SPECIFICITY: Expressed in hematopoietic precursor cells.
Highly expressed in bone marrow, the red pulp of the spleen and
round spermatids. Weakly expressed in peripheral blood cells.
{ECO:0000269|PubMed:11404085, ECO:0000269|PubMed:14648837}.
-!- DEVELOPMENTAL STAGE: Expressed at E8.5 in the blood islands of the
yolk sac and in the circulating primitive blood cells. Expressed
in the circulating blood cells at E9.5 and E10.5. Detected in the
developing hepatic primordia at E10.5. From E11.5 to E14.5,
exclusively expressed in the fetal liver.
{ECO:0000269|PubMed:11404085, ECO:0000269|PubMed:14648837}.
-----------------------------------------------------------------------
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EMBL; AF269248; AAG33367.1; -; mRNA.
EMBL; AY699986; AAT94243.1; -; mRNA.
EMBL; AK006588; BAC25148.2; -; mRNA.
EMBL; AK077692; BAC36959.1; -; mRNA.
EMBL; AK156536; BAE33747.1; -; mRNA.
EMBL; AK171890; BAE42722.1; -; mRNA.
EMBL; AL683884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC050798; AAH50798.1; -; mRNA.
CCDS; CCDS18150.1; -.
RefSeq; NP_444379.1; NM_053149.2.
UniGene; Mm.25793; -.
ProteinModelPortal; Q9ERZ0; -.
STRING; 10090.ENSMUSP00000066383; -.
iPTMnet; Q9ERZ0; -.
PhosphoSitePlus; Q9ERZ0; -.
EPD; Q9ERZ0; -.
MaxQB; Q9ERZ0; -.
PaxDb; Q9ERZ0; -.
PeptideAtlas; Q9ERZ0; -.
PRIDE; Q9ERZ0; -.
Ensembl; ENSMUST00000071096; ENSMUSP00000066383; ENSMUSG00000028332.
Ensembl; ENSMUST00000107764; ENSMUSP00000103393; ENSMUSG00000028332.
GeneID; 93966; -.
KEGG; mmu:93966; -.
UCSC; uc008str.1; mouse.
CTD; 55363; -.
MGI; MGI:2136910; Hemgn.
eggNOG; ENOG410IXJU; Eukaryota.
eggNOG; ENOG411096P; LUCA.
GeneTree; ENSGT00390000004522; -.
HOGENOM; HOG000049208; -.
HOVERGEN; HBG080273; -.
InParanoid; Q9ERZ0; -.
OMA; PEIYQET; -.
OrthoDB; EOG091G0D5Q; -.
PhylomeDB; Q9ERZ0; -.
TreeFam; TF338654; -.
PRO; PR:Q9ERZ0; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000028332; -.
CleanEx; MM_HEMGN; -.
Genevisible; Q9ERZ0; MM.
GO; GO:0005654; C:nucleoplasm; IDA:MGI.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0045667; P:regulation of osteoblast differentiation; IBA:GO_Central.
InterPro; IPR033272; Hemogen.
PANTHER; PTHR15993:SF6; PTHR15993:SF6; 2.
1: Evidence at protein level;
Complete proteome; Developmental protein; Differentiation; Nucleus;
Phosphoprotein; Reference proteome.
CHAIN 1 503 Hemogen.
/FTId=PRO_0000245362.
REGION 7 87 Necessary for nuclear localization.
{ECO:0000250}.
MOD_RES 90 90 Phosphoserine.
{ECO:0000250|UniProtKB:Q6AZ54}.
MOD_RES 103 103 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 124 124 Phosphoserine.
{ECO:0000250|UniProtKB:Q9BXL5}.
MOD_RES 153 153 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 158 158 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 171 171 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 213 213 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 223 223 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 228 228 Phosphoserine.
{ECO:0000250|UniProtKB:Q9BXL5}.
MOD_RES 241 241 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 269 269 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 286 286 Phosphothreonine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 387 387 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 394 394 Phosphoserine.
{ECO:0000250|UniProtKB:Q6AZ54}.
CONFLICT 472 472 E -> G (in Ref. 5; AAH50798).
{ECO:0000305}.
SEQUENCE 503 AA; 55043 MW; B1027B81B55BB08D CRC64;
MDMGKGRPRL KLPQMPEAHP QKSCAPDIIG SWSLRNREQL RKRKAEAQGR QTSQWLLGEQ
KKRKYQRTGK GNKRGRKRQG NVEQKAEPWS QTERERVQEV LVSAEEETEH PGNSATEALP
LVPSPTKAVP ADQCSEAHQE SIQCQERAIQ NHSQTHLSPT TCQGIAVLQH SPKMCQDMAE
PEVFSPNMCQ ETAVPQTYPP KALEEMAAAE PLSPKMCQET TVSPNHSSKV PQDMAGPEAL
SPNMCQEPTV PQEHTLKMCH DVARPEVLSP KTHQEMAVPK AFPCVTPGDA AGLEGCAPKA
LPQSDVAEGC PLDTTPTSVT PEQTTSDPDL GMAVTEGFFS EARECTVSEG VSTKTHQEAV
EPEFISHETY KEFTVPIVSS QKTIQESPEP EQYSPETCQP IPGPENYSLE TCHEMSGPED
LSIKTCQDRE EPKHSLPEGA QKVGGAQGQD ADAQDSENAG AFSQDFTEME EENKADQDPE
APASPQGSQE TCPENGIYSS ALF


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