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Hemogen (Hemopoietic gene protein) (Protein RP59)

 HEMGN_RAT               Reviewed;         514 AA.
Q6AZ54; Q9ER23;
11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
13-SEP-2004, sequence version 1.
12-SEP-2018, entry version 77.
RecName: Full=Hemogen;
AltName: Full=Hemopoietic gene protein;
AltName: Full=Protein RP59;
Name=Hemgn; Synonyms=Rp59;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley; TISSUE=Bone marrow;
PubMed=11161722; DOI=10.1006/excr.2000.5114;
Wurtz T., Krueger A., Christersson C., Lundmark C.;
"A new protein expressed in bone marrow cells and osteoblasts with
implication in osteoblast recruitment.";
Exp. Cell Res. 263:236-242(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=11891990; DOI=10.1002/dvdy.10067;
Krueger A., Ellerstroem C., Lundmark C., Christersson C., Wurtz T.;
"RP59, a marker for osteoblast recruitment, is also detected in
primitive mesenchymal cells, erythroid cells, and megakaryocytes.";
Dev. Dyn. 223:414-418(2002).
[4]
TISSUE SPECIFICITY.
PubMed=15726423; DOI=10.1007/s00441-004-1043-y;
Krueger A., Somogyi E., Christersson C., Lundmark C., Hultenby K.,
Wurtz T.;
"Rat enamel contains RP59: a new context for a protein from osteogenic
and haematopoietic precursor cells.";
Cell Tissue Res. 320:141-148(2005).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-179; SER-207;
SER-221; SER-415 AND SER-422, AND IDENTIFICATION BY MASS SPECTROMETRY
[LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Regulates the proliferation and differentiation of
hematopoietic cells. Overexpression block the TPA-induced
megakaryocytic differentiation in the K562 cell model. May also
prevent cell apoptosis through the activation of the nuclear
factor-kappa B (NF-kB) (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed by bone marrow cells and
osteoblasts. Also expressed by ameloblasts in tooth enamel (at
protein level). Expressed in enamel organ, ameloblasts, spleen,
bone marrow cells and osteoblasts. {ECO:0000269|PubMed:11161722,
ECO:0000269|PubMed:11891990, ECO:0000269|PubMed:15726423}.
-!- DEVELOPMENTAL STAGE: At 9 dpc expressed in extraembryonic
mesodermal layers with its prospective blood islands. Expressed in
blood islands at day 12 dpc. Expressed by the intraembryonic
primary ectoderm including the primitive streak at day 9 dpc.
Expressed in the fetal liver and in circulating cells at 17 dpc,
the liver expression disappear around birth (at protein level).
{ECO:0000269|PubMed:11891990}.
-!- SEQUENCE CAUTION:
Sequence=CAC16090.1; Type=Erroneous termination; Positions=483; Note=Translated as Gly.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AJ302650; CAC16090.1; ALT_SEQ; mRNA.
EMBL; BC078739; AAH78739.1; -; mRNA.
RefSeq; NP_579828.1; NM_133294.1.
RefSeq; XP_008761915.1; XM_008763693.2.
RefSeq; XP_008761916.1; XM_008763694.2.
RefSeq; XP_017448603.1; XM_017593114.1.
UniGene; Rn.22633; -.
STRING; 10116.ENSRNOP00000042341; -.
iPTMnet; Q6AZ54; -.
PhosphoSitePlus; Q6AZ54; -.
PaxDb; Q6AZ54; -.
PRIDE; Q6AZ54; -.
Ensembl; ENSRNOT00000042649; ENSRNOP00000042341; ENSRNOG00000009436.
GeneID; 113882; -.
KEGG; rno:113882; -.
UCSC; RGD:621569; rat.
CTD; 55363; -.
RGD; 621569; Hemgn.
eggNOG; ENOG410IXJU; Eukaryota.
eggNOG; ENOG411096P; LUCA.
GeneTree; ENSGT00390000004522; -.
HOGENOM; HOG000049208; -.
HOVERGEN; HBG080273; -.
InParanoid; Q6AZ54; -.
OMA; PEIYQET; -.
OrthoDB; EOG091G0D5Q; -.
PhylomeDB; Q6AZ54; -.
TreeFam; TF338654; -.
PRO; PR:Q6AZ54; -.
Proteomes; UP000002494; Chromosome 5.
Bgee; ENSRNOG00000009436; Expressed in 9 organ(s), highest expression level in testis.
GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0045667; P:regulation of osteoblast differentiation; IDA:RGD.
InterPro; IPR033272; Hemogen.
PANTHER; PTHR15993:SF6; PTHR15993:SF6; 2.
1: Evidence at protein level;
Complete proteome; Developmental protein; Differentiation; Nucleus;
Phosphoprotein; Reference proteome.
CHAIN 1 514 Hemogen.
/FTId=PRO_0000245363.
REGION 7 87 Necessary for nuclear localization.
{ECO:0000250}.
MOD_RES 90 90 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 124 124 Phosphoserine.
{ECO:0000250|UniProtKB:Q9BXL5}.
MOD_RES 153 153 Phosphoserine.
{ECO:0000250|UniProtKB:Q9ERZ0}.
MOD_RES 166 166 Phosphoserine.
{ECO:0000250|UniProtKB:Q9ERZ0}.
MOD_RES 179 179 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 207 207 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 221 221 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 259 259 Phosphoserine.
{ECO:0000250|UniProtKB:Q9ERZ0}.
MOD_RES 264 264 Phosphoserine.
{ECO:0000250|UniProtKB:Q9BXL5}.
MOD_RES 277 277 Phosphoserine.
{ECO:0000250|UniProtKB:Q9BXL5}.
MOD_RES 305 305 Phosphoserine.
{ECO:0000250|UniProtKB:Q9ERZ0}.
MOD_RES 322 322 Phosphothreonine.
{ECO:0000250|UniProtKB:Q9ERZ0}.
MOD_RES 415 415 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 422 422 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
CONFLICT 431 431 G -> E (in Ref. 1; CAC16090).
{ECO:0000305}.
CONFLICT 503 503 C -> F (in Ref. 1; CAC16090).
{ECO:0000305}.
SEQUENCE 514 AA; 56573 MW; 45E9AE48ACFAEF52 CRC64;
MDVRKDQSHL TLNQTPEAHV EKSHAPDIIG SWSLRNREQL KKRKAEAQGR QTSQWQLGEQ
KKRKYQRTGK GNRRGRKRQG NVEQKAESWS QTENERVQEV LVPAEEETEY SGNTATQALP
LRASPTKAVP TEHCSEVPQE SLQCQEITIQ NHSQTHQRRD KAEALSPTTC QEIGVLQYSP
KMCQDMAEPE ARSPKMCQET AVPQTYSPKA HEDMAEYEAL SPKMCRETPV PQYHSSKIPQ
DMTGPEALAP DMCQETTVSQ NHSSKVPQDM AGPEALSLKM CQEPTVLQEH TLKICQDVAR
PDVLSSKTHQ EMTVPKALPC ITPGDAAGPE GCSPKTLPQS DVTPMSVTPG KNTSHPDLGT
AVAEGCFSEA GECIVSEDIS TKTHQEAVEP KFLSHKTYKE FTVPIVSSHK TIQESPGPEE
YSPGSRHEMS GPEDLSIKTC KNRDGPKHSL PEGAQEVGGA QRQDPDAQDI EDAGAFSQDL
EEGNKADQDP ETPAGPQGPQ KICPENDVHS SALF


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