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Hemoglobin and hemoglobin-haptoglobin-binding protein

 HGBA_HAEDU              Reviewed;         972 AA.
Q47952; Q47957;
29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
09-SEP-2003, sequence version 2.
07-JUN-2017, entry version 105.
RecName: Full=Hemoglobin and hemoglobin-haptoglobin-binding protein {ECO:0000305};
Flags: Precursor;
Name=hgbA {ECO:0000303|PubMed:7890379};
Synonyms=hupA {ECO:0000303|PubMed:8613384};
OrderedLocusNames=HD_2025 {ECO:0000312|EMBL:AAP96732.1};
Haemophilus ducreyi (strain 35000HP / ATCC 700724).
Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
Pasteurellaceae; Haemophilus.
NCBI_TaxID=233412;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=35000HP / ATCC 700724;
PubMed=7768598;
Elkins C., Chen C.J., Thomas C.E.;
"Characterization of the hgbA locus encoding a hemoglobin receptor
from Haemophilus ducreyi.";
Infect. Immun. 63:2194-2200(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, FUNCTION,
SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
STRAIN=35000HP / ATCC 700724;
PubMed=8613384;
Stevens M.K., Porcella S.F., Klesney-Tait J., Lumbley S., Thomas S.E.,
Norgard M.V., Radolf J.R., Hansen E.J.;
"A hemoglobin-binding outer membrane protein is involved in virulence
expression by Haemophilus ducreyi in an animal model.";
Infect. Immun. 64:1724-1735(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=35000HP / ATCC 700724;
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R.,
Johnson L., Nguyen D., Wang J., Forst C., Hood L.;
"The complete genome sequence of Haemophilus ducreyi.";
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[4]
PROTEIN SEQUENCE OF 23-36, FUNCTION, AND SUBCELLULAR LOCATION.
STRAIN=35000HP / ATCC 700724;
PubMed=7890379;
Elkins C.;
"Identification and purification of a conserved heme-regulated
hemoglobin-binding outer membrane protein from Haemophilus ducreyi.";
Infect. Immun. 63:1241-1245(1995).
-!- FUNCTION: Acts as a receptor for hemoglobin or the
hemoglobin/haptoglobin complex of the host and is required for
heme uptake. May be involved in virulence.
{ECO:0000269|PubMed:7890379, ECO:0000269|PubMed:8613384}.
-!- SUBCELLULAR LOCATION: Cell outer membrane
{ECO:0000269|PubMed:7890379, ECO:0000269|PubMed:8613384}.
-!- DISRUPTION PHENOTYPE: Mutant cannot utilize hemoglobin as the sole
source of heme for growth. Mutation attenuates the virulence.
{ECO:0000269|PubMed:8613384}.
-!- SIMILARITY: Belongs to the TonB-dependent receptor family.
Hemoglobin/haptoglobin binding protein subfamily. {ECO:0000305}.
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EMBL; U17281; AAA75311.1; -; Genomic_DNA.
EMBL; U34048; AAC44054.1; -; Genomic_DNA.
EMBL; AE017143; AAP96732.1; -; Genomic_DNA.
RefSeq; WP_010945753.1; NC_002940.2.
ProteinModelPortal; Q47952; -.
STRING; 233412.HD2025; -.
EnsemblBacteria; AAP96732; AAP96732; HD_2025.
GeneID; 24944774; -.
KEGG; hdu:HD_2025; -.
eggNOG; COG1629; LUCA.
KO; K16087; -.
OMA; WDTLKIT; -.
OrthoDB; POG091H05DQ; -.
Proteomes; UP000001022; Chromosome.
GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0004872; F:receptor activity; IEA:InterPro.
GO; GO:0005215; F:transporter activity; IEA:InterPro.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
Gene3D; 2.170.130.10; -; 1.
Gene3D; 2.40.170.20; -; 1.
InterPro; IPR012910; Plug_dom.
InterPro; IPR000531; TonB-dep_rcpt_b-brl.
InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
Pfam; PF07715; Plug; 1.
Pfam; PF00593; TonB_dep_Rec; 1.
TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
1: Evidence at protein level;
Cell outer membrane; Complete proteome; Direct protein sequencing;
Membrane; Receptor; Reference proteome; Signal; TonB box;
Transmembrane; Transmembrane beta strand; Transport; Virulence.
SIGNAL 1 22 {ECO:0000269|PubMed:7890379,
ECO:0000303|PubMed:8613384}.
CHAIN 23 972 Hemoglobin and hemoglobin-haptoglobin-
binding protein.
/FTId=PRO_0000034789.
MOTIF 32 39 TonB box.
MOTIF 955 972 TonB C-terminal box.
CONFLICT 55 55 A -> S (in Ref. 1; AAA75311).
{ECO:0000305}.
CONFLICT 181 181 G -> V (in Ref. 2; AAC44054).
{ECO:0000305}.
SEQUENCE 972 AA; 110921 MW; 535A45288A97A792 CRC64;
MKANKLSAIT LCILGYAHTV YAESNMQTEK LETIVVSSED DSVHNKNVGE IKKNAKALSK
QQVQDSRDLV RYETGVTVVE KGRFGSSGYA IRGVDENRVA VVVDGLHQAE TISSQGFKEL
FEGYGNFNNT RNGVEVENLK QAVIQKGADA IRTGSGSLGG TVSFESKDAR DYLIDKNYHF
GYKTGYSSAD NQKLHSVTAA GRYSDFDLLA VHTQRHGNEL RNYGYRHYDG SVVRKEREKA
DPYKITKQSS LIKIGYQLND TNRFTLGYDD SRNTSRGTDW SNAFTSYNGG PFLKDVRHTN
DQSNRKNISF VYENFDTNDF WDTLKITHNH QKIKLKARLD EYCDVNGEID CPAIANPSGL
YINDKGIFLD KHDGEITHKK EGEFNNYFDS KGKEVRVKGF NVDSILINCD QYDCSKPMQL
LSSTNNGYGG SPNKYIYKTY ELFEKTMNNG NGKYAVLEIR SSGHEKFSRV YLPSEKGYVE
NQWKDRDLNT DTQQYNIDLT KSFKLKSVEH NATYGGLYSE VKKSMTNRAG YEAYNRQWWA
NIFFGKENNK PNKCQPYNGN SFTTLCSHED RLFSFLIPVK TKTGALYVTD KIKLNDKVNL
DVAYRYDRIK HDPKYIPGTT PKLPTDLILG RFIEFKPKNT YATQDEKNEN AEKNAVYLAS
KKTKFSANSY SATFSFDPMD FLKIQAKYAT GFRAPTSDEI YFVFQHPSFS IYPNLYLKAE
RSKNKEVAIT LHKQKSFLTV NLFQTDYKDF LDLAYLKKGS LPYGNGGSQL ETLLYQNVNR
DKARVKGLEV NSKLHLGDVW RTLDGFNLSY KLSLQKGRMS SKVGEEGKQR DTNKLDTPMN
AIQPQTHVVG VGYEHPQEKF GVDMYLTHAS AKKEKDTFNM FYDGKDQKDQ HIKWRSDRYT
LVDLIAYVKP VKNVTLRAGV YNLTNREYGT WDSIRSIRPF GTTNLINQET GKGIKRFNAP
GRNFRVNAEI TF


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