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Hemoglobin and hemoglobin-haptoglobin-binding protein B

 HGPB_HAEIF              Reviewed;         999 AA.
O87296;
29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
12-APR-2017, entry version 76.
RecName: Full=Hemoglobin and hemoglobin-haptoglobin-binding protein B;
Flags: Precursor;
Name=hgpB;
Haemophilus influenzae.
Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
Pasteurellaceae; Haemophilus.
NCBI_TaxID=727;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=HI689 / Serotype B;
PubMed=9746572;
Ren Z., Jin H., Morton D.J., Stull T.L.;
"hgpB, a gene encoding a second Haemophilus influenzae hemoglobin- and
hemoglobin-haptoglobin-binding protein.";
Infect. Immun. 66:4733-4741(1998).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=E1a / Serotype B;
Morton D.J., Stull T.L.;
"Conservation of hemoglobin/hemoglobin-haptoglobin binding proteins in
Haemophilus influenzae.";
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Acts as a receptor for hemoglobin or the
hemoglobin/haptoglobin complex of the human host and is required
for heme uptake.
-!- SUBCELLULAR LOCATION: Cell outer membrane.
-!- MISCELLANEOUS: This protein is subject to phase-variable
expression associated with alteration in the length of the CCAA
repeat region. This mechanism is called slipped-strand mispairing.
Addition or loss of CCAA repeat units would change the reading
frame and result in introduction of stop codons downstream of the
repeat region. This may be a mechanism of regulation and a way to
avoid the immunological response of the host.
-!- SIMILARITY: Belongs to the TonB-dependent receptor family.
Hemoglobin/haptoglobin binding protein subfamily. {ECO:0000305}.
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EMBL; AF022910; AAC60790.1; -; Genomic_DNA.
EMBL; AF259266; AAK51630.1; -; Genomic_DNA.
ProteinModelPortal; O87296; -.
GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0004872; F:receptor activity; IEA:InterPro.
GO; GO:0005215; F:transporter activity; IEA:InterPro.
Gene3D; 2.170.130.10; -; 1.
Gene3D; 2.40.170.20; -; 1.
InterPro; IPR012910; Plug_dom.
InterPro; IPR006970; PT.
InterPro; IPR000531; TonB-dep_rcpt_b-brl.
InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
InterPro; IPR010917; TonB_rcpt_CS.
Pfam; PF07715; Plug; 1.
Pfam; PF04886; PT; 1.
Pfam; PF00593; TonB_dep_Rec; 1.
TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
3: Inferred from homology;
Cell outer membrane; Membrane; Receptor; Repeat; Signal; TonB box;
Transmembrane; Transmembrane beta strand; Transport.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 999 Hemoglobin and hemoglobin-haptoglobin-
binding protein B.
/FTId=PRO_0000034779.
REPEAT 26 29 1.
REPEAT 30 33 2.
REPEAT 34 37 3.
REPEAT 38 41 4.
REPEAT 42 45 5.
REPEAT 46 49 6.
REPEAT 50 53 7.
REPEAT 54 57 8.
REGION 26 57 8 X 4 AA tandem repeats of P-T-N-Q.
MOTIF 66 73 TonB box.
MOTIF 982 999 TonB C-terminal box.
VARIANT 46 57 Missing (in strain: E1a).
VARIANT 85 85 I -> V (in strain: E1a).
VARIANT 101 101 D -> N (in strain: E1a).
VARIANT 108 108 T -> K (in strain: E1a).
VARIANT 121 122 LA -> FG (in strain: E1a).
VARIANT 151 151 T -> S (in strain: E1a).
VARIANT 304 304 G -> A (in strain: E1a).
VARIANT 560 560 N -> D (in strain: E1a).
VARIANT 633 633 L -> F (in strain: E1a).
VARIANT 658 658 R -> H (in strain: E1a).
VARIANT 689 689 K -> E (in strain: E1a).
VARIANT 755 755 A -> T (in strain: E1a).
VARIANT 782 782 S -> G (in strain: E1a).
SEQUENCE 999 AA; 114436 MW; 58F631FA5D2685B0 CRC64;
MTNFRLNVLA YSVMLGLTAS VAYAEPTNQP TNQPTNQPTN QPTNQPTNQP TNQPTNQNSN
ASEQLEQINV SGSTENTDTK APPKIAETVK TAKTLEREQA DNIKDIVTYE TGVTVVEAGR
LAQSGFAIRG VDENRVAINI DGLRQAETLS TQGFKELFEG YGNFNNTRNG AEIETLKEVN
ITKGADSIKN GSGSLGGSVI YKTKDARDYL INKDYYVSYK KGYATENNQS FNTLTLAGRY
KKFDVLVVTT SRNGHELENY GYKNYNDKIQ GKKREKADPY KIEQDSTLLK LSFNPTENHR
FTFGADLYEH RSRGQDLSYT LKYQKTDPNL AEVDSRHTND KTKRRNISFS YENFSQTPFW
DTLKITYSDQ RIKTRARTDE YCDAGVRHCE GTDNPTGLKV TDGKITRRDG SELQFEKKNN
TAHSNGETYD FKKFIDTDKK VIEDKLTLKN PNDTWYDCSI FNCENNAKIK VFEGNYSYGY
DGKWKEVDLE IKTLNGKKFA KIKDPTNKIK SILPSSPGYL ERLWQERDLD TNTQQLNLDL
TKDFKTWHIE HNLQYGGSYN TAMKRMVNRA GNDASDVQWW ATPTLGYNFY DQPYTCATAY
SWNANLCPRV DPEFSYLLPI KTTGKSVYLF DNLVITDYLS FDLGYRYDNI HYQPKYKRGI
TPKLPDDIVK GLFIPLPKNS NSKPDEVKKN VQQNIDYIAK QNKKYKAHSY SFVSTIDPTS
FLRLQLKYSK GFRTPTSDEM YFTFKHPDFT ILPNADLKPE IAKTKEIAFT LHNDDWGFIS
TSLFKTNYKN FIDLIFKGEK DFPLVSGGSS LPFSLYQNIN RDNASLKGIE INSKVFLGKM
AKFMDGFNLS YKYTYQKGRM NGNIPMNAIQ PRTMVYGLGY DHPNHKFGFD FYTTHVASKN
PEDTYDIYAK DKKQTDTSIK WRSKSYTILD LIGYVQPIKN LTIRAGVYNL TNRKYITWDS
ARSIRSFGTS NVIEQSTGLG INRFYAPGRN YKMSVQFEF


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