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Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)

 HBA_EQUAS               Reviewed;         142 AA.
P01959; P82988;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
25-APR-2018, entry version 106.
RecName: Full=Hemoglobin subunit alpha;
AltName: Full=Alpha-globin;
AltName: Full=Hemoglobin alpha chain;
Name=HBA1;
and
Name=HBA2;
Equus asinus (Donkey) (Equus africanus asinus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9793;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HBA1 AND HBA2).
PubMed=9847419; DOI=10.1007/PL00006436;
Oakenfull E.A., Clegg J.B.;
"Phylogenetic relationships within the genus Equus and the evolution
of alpha and theta globin genes.";
J. Mol. Evol. 47:772-783(1998).
[2]
PROTEIN SEQUENCE OF 2-142.
PubMed=6030605; DOI=10.1038/213269a0;
Kilmartin J.V., Clegg J.B.;
"Amino-acid replacements in horse haemoglobin.";
Nature 213:269-271(1967).
[3]
X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
PubMed=16488065; DOI=10.1016/j.biochi.2006.01.001;
Balasundaresan D., Saraboji K., Ponnuswamy M.N.;
"Crystal structure of haemoglobin from donkey (Equus asinus) at 3A
resolution.";
Biochimie 88:719-723(2006).
-!- FUNCTION: Involved in oxygen transport from the lung to the
various peripheral tissues.
-!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
-!- TISSUE SPECIFICITY: Red blood cells.
-!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
ProRule:PRU00238}.
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EMBL; U69894; AAD13640.1; -; Genomic_DNA.
EMBL; U69895; AAD13641.1; -; Genomic_DNA.
PIR; A02282; HAHOD.
PDB; 1S0H; X-ray; 3.00 A; A=2-142.
PDBsum; 1S0H; -.
ProteinModelPortal; P01959; -.
SMR; P01959; -.
PeptideAtlas; P01959; -.
PRIDE; P01959; -.
HOVERGEN; HBG009709; -.
EvolutionaryTrace; P01959; -.
GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0019825; F:oxygen binding; IEA:InterPro.
GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
CDD; cd08927; Hb-alpha_like; 1.
Gene3D; 1.10.490.10; -; 1.
InterPro; IPR000971; Globin.
InterPro; IPR009050; Globin-like_sf.
InterPro; IPR012292; Globin/Proto.
InterPro; IPR002338; Haemoglobin_a-typ.
InterPro; IPR002339; Haemoglobin_pi.
Pfam; PF00042; Globin; 1.
PRINTS; PR00612; ALPHAHAEM.
PRINTS; PR00815; PIHAEM.
SUPFAM; SSF46458; SSF46458; 1.
PROSITE; PS01033; GLOBIN; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Direct protein sequencing; Heme; Iron;
Metal-binding; Oxygen transport; Phosphoprotein; Transport.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:6030605}.
CHAIN 2 142 Hemoglobin subunit alpha.
/FTId=PRO_0000052624.
METAL 59 59 Iron (heme distal ligand).
METAL 88 88 Iron (heme proximal ligand).
MOD_RES 4 4 Phosphoserine.
{ECO:0000250|UniProtKB:P69905}.
MOD_RES 8 8 N6-succinyllysine.
{ECO:0000250|UniProtKB:P01942}.
MOD_RES 9 9 Phosphothreonine.
{ECO:0000250|UniProtKB:P69905}.
MOD_RES 12 12 N6-succinyllysine.
{ECO:0000250|UniProtKB:P01942}.
MOD_RES 17 17 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:P69905}.
MOD_RES 17 17 N6-succinyllysine; alternate.
{ECO:0000250|UniProtKB:P01942}.
MOD_RES 41 41 N6-succinyllysine.
{ECO:0000250|UniProtKB:P01942}.
MOD_RES 50 50 Phosphoserine.
{ECO:0000250|UniProtKB:P69905}.
MOD_RES 103 103 Phosphoserine.
{ECO:0000250|UniProtKB:P01942}.
MOD_RES 109 109 Phosphothreonine.
{ECO:0000250|UniProtKB:P01942}.
MOD_RES 125 125 Phosphoserine.
{ECO:0000250|UniProtKB:P01942}.
MOD_RES 135 135 Phosphothreonine.
{ECO:0000250|UniProtKB:P01942}.
MOD_RES 138 138 Phosphothreonine.
{ECO:0000250|UniProtKB:P01942}.
MOD_RES 139 139 Phosphoserine.
{ECO:0000250|UniProtKB:P01942}.
CONFLICT 132 132 T -> S (in Ref. 2; AA sequence).
{ECO:0000305}.
HELIX 5 18 {ECO:0000244|PDB:1S0H}.
HELIX 19 21 {ECO:0000244|PDB:1S0H}.
HELIX 22 36 {ECO:0000244|PDB:1S0H}.
HELIX 38 43 {ECO:0000244|PDB:1S0H}.
HELIX 54 72 {ECO:0000244|PDB:1S0H}.
HELIX 74 76 {ECO:0000244|PDB:1S0H}.
HELIX 77 80 {ECO:0000244|PDB:1S0H}.
HELIX 82 88 {ECO:0000244|PDB:1S0H}.
TURN 89 92 {ECO:0000244|PDB:1S0H}.
HELIX 97 113 {ECO:0000244|PDB:1S0H}.
TURN 115 117 {ECO:0000244|PDB:1S0H}.
HELIX 120 136 {ECO:0000244|PDB:1S0H}.
TURN 137 141 {ECO:0000244|PDB:1S0H}.
SEQUENCE 142 AA; 15220 MW; 93B837BC15C1D175 CRC64;
MVLSAADKTN VKAAWSKVGG NAGEFGAEAL ERMFLGFPTT KTYFPHFDLS HGSAQVKAHG
KKVGDALTLA VGHLDDLPGA LSNLSDLHAH KLRVDPVNFK LLSHCLLSTL AVHLPNDFTP
AVHASLDKFL STVSTVLTSK YR


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