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Hemoglobin-binding protein A

 HGBA_HAEIF              Reviewed;        1013 AA.
Q9KIV2;
29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
25-OCT-2017, entry version 71.
RecName: Full=Hemoglobin-binding protein A;
Flags: Precursor;
Name=hgbA;
Haemophilus influenzae.
Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
Pasteurellaceae; Haemophilus.
NCBI_TaxID=727;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=NTHi N182;
PubMed=10858226; DOI=10.1128/IAI.68.7.4092-4101.2000;
Cope L.D., Hrkal Z., Hansen E.J.;
"Detection of phase variation in expression of proteins involved in
hemoglobin and hemoglobin-haptoglobin binding by nontypeable
Haemophilus influenzae.";
Infect. Immun. 68:4092-4101(2000).
-!- FUNCTION: Acts as a receptor for hemoglobin of the human host and
is required for heme uptake.
-!- SUBCELLULAR LOCATION: Cell outer membrane.
-!- MISCELLANEOUS: This protein is subject to phase-variable
expression associated with alteration in the length of the CCAA
repeat region. This mechanism is called slipped-strand mispairing.
Addition or loss of CCAA repeat units would change the reading
frame and result in introduction of stop codons downstream of the
repeat region. This may be a mechanism of regulation and a way to
avoid the immunological response of the host.
-!- SIMILARITY: Belongs to the TonB-dependent receptor family.
Hemoglobin/haptoglobin binding protein subfamily. {ECO:0000305}.
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EMBL; AF221059; AAF80176.1; -; Genomic_DNA.
ProteinModelPortal; Q9KIV2; -.
GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0004872; F:receptor activity; IEA:InterPro.
GO; GO:0005215; F:transporter activity; IEA:InterPro.
Gene3D; 2.170.130.10; -; 1.
Gene3D; 2.40.170.20; -; 1.
InterPro; IPR012910; Plug_dom.
InterPro; IPR037066; Plug_dom_sf.
InterPro; IPR006970; PT.
InterPro; IPR000531; TonB-dep_rcpt_b-brl.
InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
InterPro; IPR036942; TonB_rcpt_b-brl_sf.
InterPro; IPR010917; TonB_rcpt_CS.
Pfam; PF07715; Plug; 1.
Pfam; PF04886; PT; 1.
Pfam; PF00593; TonB_dep_Rec; 1.
TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
3: Inferred from homology;
Cell outer membrane; Membrane; Receptor; Repeat; Signal; TonB box;
Transmembrane; Transmembrane beta strand; Transport.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 1013 Hemoglobin-binding protein A.
/FTId=PRO_0000034781.
REPEAT 26 29 1.
REPEAT 30 33 2.
REPEAT 34 37 3.
REPEAT 38 41 4.
REPEAT 42 45 5.
REPEAT 46 49 6.
REPEAT 50 53 7.
REPEAT 54 57 8.
REGION 26 57 8 X 4 AA tandem repeats of Q-P-T-N.
MOTIF 67 74 TonB box.
MOTIF 996 1013 TonB C-terminal box.
SEQUENCE 1013 AA; 116261 MW; 769964335A4ED3C1 CRC64;
MTNFKFSLLA CSIAFALNAS TAYAAQPTNQ PTNQPTNQPT NQPTNQPTNQ PTNQPTNQDS
NLSEQLEQIN VSGSTENSDS KTPPKIAETV KTAKTLEREQ ANNIKDIVKY ETGVTVVEAG
RFGQSGFAIR GVDENRVAIN IDGLRQAETL SSQGFKELFE GYGNFNNTRN GAEIETLKEV
NITKGANSIK SGSGSLGGSV IYKTKDARDY LLNKDYYVSY KKGYATENNQ SFNTLTLAGR
YKKFDVLVVT TSRNGHELEN YGYKNYNDKI QGKRREKADP YKIEQDSTLL KLSFNPTENH
RFTLAADLYE HRSRGQDLSY TLKYLKTLPD LPEVDSRHTN DKTKRHNISF SYENFSQTPF
WDTLKITFSK QKIKTRARTD EYCDAGVRYC EGTANPAGLK LKNGEITRRD GTPLQFKEIN
NTTTPNSNSN KDKTYDFSKL IDTNGKEIES GITRSNDTFW YDCSIFDCEN PGKMKVAEGK
TYYRYDGTWK NNVQLEKKVL NGKEFARINN GTRGKTFPIL PSSLGYLERL WQERDLDTNT
QQLNLDLTKD FKTWRVEHNL QYGSSYNTTM KRMVNRAGYD ATDVQWWAKR TLGTRFDFLK
NEEIVETCAT TFGWNAFLCP RVDPEFSYLL PIKTKEKSVY LFDNVVITDY LSFDLGYRYD
NIHYQPKYKH GVTPKLPDDI VKELFIPLKS GQNNNDAEVK KNVQENIDYI AKQNKKYKAH
SYSFVSTIDP TSFLRLQLKY SKGFRAPTSD EMYFTFKHPD FTILPNTHLK PEIAKTKEIA
FTLHHDDWGF ISTSLFKTNY RDFIDLVYKG EREFEVGNPN NRGKISFDTF QNINRDSAVV
KGIEINSKVF LGKMAKFMDG FNLSYKYTYQ KGRMDGNIPM NAIQPKTMVY GLGYDHPSQK
FGFNFYTTHV ASKNPEDTYD IYAKDKNQTN TSIKWRSKSY TILDLIGYVQ PIKNLTIRAG
VYNLTNRKYI TWDSARSIRS FGTSNVIDQK TGQGINRFYA PGRNYKMSVQ FEF


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