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Heparan-sulfate 6-O-sulfotransferase 1-A (HS 6-OST-1A) (HS6ST-1) (EC 2.8.2.-)

 H6S1A_DANRE             Reviewed;         413 AA.
Q56UJ5; A0MGZ4; Q503W9;
11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
05-MAY-2009, sequence version 2.
05-DEC-2018, entry version 79.
RecName: Full=Heparan-sulfate 6-O-sulfotransferase 1-A;
Short=HS 6-OST-1A;
Short=HS6ST-1;
EC=2.8.2.-;
Name=hs6st1a; Synonyms=hs6st1; ORFNames=zgc:110038;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE
SPECIFICITY.
PubMed=16009360; DOI=10.1016/j.ydbio.2005.05.032;
Chen E., Stringer S.E., Rusch M.A., Selleck S.B., Ekker S.C.;
"A unique role for 6-O sulfation modification in zebrafish vascular
development.";
Dev. Biol. 284:364-376(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Larva;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 9-413, DEVELOPMENTAL STAGE, AND TISSUE
SPECIFICITY.
PubMed=17075883; DOI=10.1002/dvdy.20990;
Cadwallader A.B., Yost H.J.;
"Combinatorial expression patterns of heparan sulfate
sulfotransferases in zebrafish: II. The 6-O-sulfotransferase family.";
Dev. Dyn. 235:3432-3437(2006).
-!- FUNCTION: 6-O-sulfation enzyme which catalyzes the transfer of
sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to
position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan
sulfate. {ECO:0000269|PubMed:16009360}.
-!- CATALYTIC ACTIVITY:
Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-
[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan
sulfate](n) + adenosine 3',5'-bisphosphate + H(+);
Xref=Rhea:RHEA:56604, Rhea:RHEA-COMP:9830, Rhea:RHEA-COMP:14621,
ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343,
ChEBI:CHEBI:58388, ChEBI:CHEBI:140604;
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
membrane protein {ECO:0000305}.
-!- TISSUE SPECIFICITY: During somitogenesis, first expressed in
polster and presumptive forebrain. During mid-somitogenesis,
expressed in eye, hindbrain and anterior spinal cord. During late
somitogenesis, strong expression in eye and hindbrain, decreased
levels in midbrain and anterior spinal cord. At 24 hours post-
fertilization (hpf), expressed in neural retina and lens, brain
and anterior spinal cord. At 36 hpf, retinal expression is
confined to the ciliary marginal zone and there is strong
expression in tectum, rhombomeres and otic vesicle. At 48 hpf,
expressed in retinal ganglion cells and in tectum, rhombomeres and
pectoral fin. Not detected in the vasculature during
embryogenesis. {ECO:0000269|PubMed:16009360,
ECO:0000269|PubMed:17075883}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Expression is lost before gastrulation and begins again during
somitogenesis. {ECO:0000269|PubMed:16009360,
ECO:0000269|PubMed:17075883}.
-!- SIMILARITY: Belongs to the sulfotransferase 6 family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH95149.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAT80869.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AY575770; AAT80869.1; ALT_INIT; mRNA.
EMBL; BC095149; AAH95149.1; ALT_INIT; mRNA.
EMBL; DQ812993; ABH11455.1; -; mRNA.
RefSeq; NP_001018344.2; NM_001020508.2.
UniGene; Dr.43052; -.
SMR; Q56UJ5; -.
STRING; 7955.ENSDARP00000071478; -.
PaxDb; Q56UJ5; -.
PRIDE; Q56UJ5; -.
Ensembl; ENSDART00000189011; ENSDARP00000145279; ENSDARG00000054754.
GeneID; 553162; -.
KEGG; dre:553162; -.
CTD; 553162; -.
ZFIN; ZDB-GENE-050524-1; hs6st1a.
GeneTree; ENSGT00940000154073; -.
HOVERGEN; HBG083012; -.
InParanoid; Q56UJ5; -.
KO; K02514; -.
PhylomeDB; Q56UJ5; -.
Reactome; R-DRE-2022928; HS-GAG biosynthesis.
PRO; PR:Q56UJ5; -.
Proteomes; UP000000437; Chromosome 2.
ExpressionAtlas; Q56UJ5; baseline.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0017095; F:heparan sulfate 6-O-sulfotransferase activity; IMP:ZFIN.
GO; GO:0015015; P:heparan sulfate proteoglycan biosynthetic process, enzymatic modification; IBA:GO_Central.
InterPro; IPR010635; Heparan_SO4-6-sulfoTrfase.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005331; Sulfotransferase.
PANTHER; PTHR12812; PTHR12812; 1.
Pfam; PF03567; Sulfotransfer_2; 1.
SUPFAM; SSF52540; SSF52540; 1.
2: Evidence at transcript level;
Complete proteome; Glycoprotein; Membrane; Reference proteome;
Signal-anchor; Transferase; Transmembrane; Transmembrane helix.
CHAIN 1 413 Heparan-sulfate 6-O-sulfotransferase 1-A.
/FTId=PRO_0000190804.
TOPO_DOM 9 15 Cytoplasmic. {ECO:0000255}.
TRANSMEM 16 36 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 37 413 Lumenal. {ECO:0000255}.
REGION 92 100 PAPS binding.
{ECO:0000250|UniProtKB:A0MGZ7}.
REGION 122 123 Substrate binding.
{ECO:0000250|UniProtKB:A0MGZ7}.
REGION 315 317 PAPS binding.
{ECO:0000250|UniProtKB:A0MGZ7}.
REGION 321 322 PAPS binding.
{ECO:0000250|UniProtKB:A0MGZ7}.
ACT_SITE 149 149 Proton acceptor.
{ECO:0000250|UniProtKB:A0MGZ7}.
BINDING 139 139 Substrate.
{ECO:0000250|UniProtKB:A0MGZ7}.
BINDING 144 144 Substrate.
{ECO:0000250|UniProtKB:A0MGZ7}.
BINDING 149 149 Substrate.
{ECO:0000250|UniProtKB:A0MGZ7}.
BINDING 183 183 PAPS. {ECO:0000250|UniProtKB:A0MGZ7}.
BINDING 191 191 PAPS. {ECO:0000250|UniProtKB:A0MGZ7}.
BINDING 195 195 Substrate.
{ECO:0000250|UniProtKB:A0MGZ7}.
BINDING 202 202 Substrate.
{ECO:0000250|UniProtKB:A0MGZ7}.
CARBOHYD 262 262 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 318 318 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 329 329 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 20 20 V -> A (in Ref. 2; AAH95149).
{ECO:0000305}.
CONFLICT 79 79 D -> H (in Ref. 3; ABH11455 and 2;
AAH95149). {ECO:0000305}.
CONFLICT 307 307 R -> H (in Ref. 3; ABH11455 and 2;
AAH95149). {ECO:0000305}.
CONFLICT 324 324 G -> D (in Ref. 2; AAH95149).
{ECO:0000305}.
SEQUENCE 413 AA; 48910 MW; B5A8195A0111BE32 CRC64;
MNLLTGRNMV ERSSKFLFIV VGSVLFMLIL YQYVAPGMMN FGSPHGYMLE DDADLFPTPD
PHYVKKFYFP IRDLERTVDF EIKGDDVIVF LHIQKTGGTT FGRHLVQNVR LEVPCDCRPG
QKKCTCYRPN RKETWLFSRF STGWSCGLHA DWTELTNCVP GVLNKKESRM KNQRKFYYIT
LLRDPVSRYL SEWRHVQRGA TWKTSLHMCD GRTPTPEELP PCYEGTDWSG CTLQQFMDCP
YNLANNRQVR MLADLSLVGC YNMSFIPEKK RAQVLLESAK KNLRDMAFFG LTEFQRKTQY
LFERTFRLKF IRPFMQYNST RAAGVDLDND TIQRIEELND LDMQLYDYAR DLFQQRYMYK
RQLERREQRL KNQPLFPFRR TSSSDSTFRD DAPESEGSRL PTEDYMNHII NRW


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