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Hepatic leukemia factor

 HLF_MOUSE               Reviewed;         295 AA.
Q8BW74; Q6PF83;
16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
25-OCT-2017, entry version 116.
RecName: Full=Hepatic leukemia factor;
Name=Hlf;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Diencephalon, and Oviduct;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain, and Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
INVOLVEMENT IN EPILEPSY.
PubMed=15175240; DOI=10.1101/gad.301404;
Gachon F., Fonjallaz P., Damiola F., Gos P., Kodama T., Zakany J.,
Duboule D., Petit B., Tafti M., Schibler U.;
"The loss of circadian PAR bZip transcription factors results in
epilepsy.";
Genes Dev. 18:1397-1412(2004).
-!- SUBUNIT: Binds DNA specifically as homodimer or heterodimer with
other PAR factors. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- INDUCTION: Accumulates according to a robust circadian rhythm.
Displays only a moderate amplitude in the liver (1.6-fold) and
none in the brain.
-!- MISCELLANEOUS: Mice deficient for all three PAR bZIP proteins
(DBP, HLF and TEF) display a dramatically shortened life span and
are highly susceptible to generalized spontaneous and audiogenic
epilepsies (due for example to the noise of a vacuum cleaner) that
are frequently lethal. The down-regulation of pyridoxal kinase
(Pdxk) expression in these mice may participate in this seizure
phenotype.
-!- SIMILARITY: Belongs to the bZIP family. PAR subfamily.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH57693.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AK054062; BAC35642.1; -; mRNA.
EMBL; BC057693; AAH57693.1; ALT_INIT; mRNA.
EMBL; BC058705; AAH58705.1; -; mRNA.
CCDS; CCDS25241.1; -.
RefSeq; NP_766151.1; NM_172563.3.
RefSeq; XP_006533068.1; XM_006533005.3.
RefSeq; XP_006533069.1; XM_006533006.1.
UniGene; Mm.158903; -.
ProteinModelPortal; Q8BW74; -.
SMR; Q8BW74; -.
BioGrid; 229842; 3.
IntAct; Q8BW74; 2.
STRING; 10090.ENSMUSP00000004051; -.
iPTMnet; Q8BW74; -.
PhosphoSitePlus; Q8BW74; -.
PaxDb; Q8BW74; -.
PRIDE; Q8BW74; -.
DNASU; 217082; -.
Ensembl; ENSMUST00000004051; ENSMUSP00000004051; ENSMUSG00000003949.
GeneID; 217082; -.
KEGG; mmu:217082; -.
UCSC; uc007kwr.1; mouse.
CTD; 3131; -.
MGI; MGI:96108; Hlf.
eggNOG; KOG3119; Eukaryota.
eggNOG; ENOG410YJ8G; LUCA.
GeneTree; ENSGT00440000039070; -.
HOGENOM; HOG000234383; -.
HOVERGEN; HBG004983; -.
InParanoid; Q8BW74; -.
KO; K09057; -.
OMA; MEKMSRQ; -.
OrthoDB; EOG091G0EO0; -.
TreeFam; TF315869; -.
ChiTaRS; Hlf; mouse.
PRO; PR:Q8BW74; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000003949; -.
CleanEx; MM_HLF; -.
ExpressionAtlas; Q8BW74; baseline and differential.
Genevisible; Q8BW74; MM.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI.
GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
InterPro; IPR004827; bZIP.
InterPro; IPR029829; HLF.
PANTHER; PTHR11988:SF28; PTHR11988:SF28; 1.
Pfam; PF07716; bZIP_2; 1.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
2: Evidence at transcript level;
Biological rhythms; Complete proteome; DNA-binding; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 295 Hepatic leukemia factor.
/FTId=PRO_0000076511.
DOMAIN 225 288 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 227 247 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 248 255 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
COMPBIAS 158 209 Pro-rich (proline/acidic region (PAR)).
CONFLICT 27 38 ENPLKLPLHPED -> KKQSSPFPFSSS (in Ref. 2;
AAH57693). {ECO:0000305}.
CONFLICT 224 224 K -> KQ (in Ref. 2; AAH57693).
{ECO:0000305}.
SEQUENCE 295 AA; 33149 MW; D57CAB8601A954B4 CRC64;
MEKMSRQLPL NPTFIPPPYG VLRSLLENPL KLPLHPEDAF SKEKDKGKKL DDESSSPTVP
QSAFLGPTLW DKTLPYDGDT FQLEYMDLEE FLSENGIPPS PSQHDHSPHP PGLQPASSTA
PSVMDLSSRA TAPLHPGIPS PNCMQSPIRP GQLLPANRNT PSPIDPDTIQ VPVGYEPDPA
DLALSSIPGQ EMFDPRKRKF SEEELKPQPM IKKARKVFIP DDLKDDKYWA RRRKNNMAAK
RSRDARRLKE NQIAIRASFL EKENSALRQE VADLRKELGK CKNILAKYEA RHGPL


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