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Hepatitis A virus cellular receptor 1 homolog (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (T-cell immunoglobulin mucin receptor 1) (TIM-1)

 HAVR1_MOUSE             Reviewed;         305 AA.
Q5QNS5; Q7TPU2; Q8VIM1; Q8VIM2;
30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
30-AUG-2005, sequence version 2.
18-JUL-2018, entry version 101.
RecName: Full=Hepatitis A virus cellular receptor 1 homolog;
Short=HAVcr-1;
AltName: Full=Kidney injury molecule 1;
Short=KIM-1;
AltName: Full=T cell immunoglobulin and mucin domain-containing protein 1;
Short=TIMD-1;
AltName: Full=T cell membrane protein 1;
AltName: Full=T-cell immunoglobulin mucin receptor 1;
Short=TIM-1;
Flags: Precursor;
Name=Havcr1; Synonyms=Kim1, Tim1, Timd1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), POLYMORPHISM, VARIANTS
HBA, AND TISSUE SPECIFICITY.
STRAIN=BALB/cJ; TISSUE=Spleen;
PubMed=11725301; DOI=10.1038/ni739;
McIntire J.J., Umetsu S.E., Akbari O., Potter M., Kuchroo V.K.,
Barsh G.S., Freeman G.J., Umetsu D.T., DeKruyff R.H.;
"Identification of Tapr (an airway hyperreactivity regulatory locus)
and the linked Tim gene family.";
Nat. Immunol. 2:1109-1116(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=C57BL/6J; TISSUE=Blastocyst;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION AS A RECEPTOR FOR TIMD4.
PubMed=15793576; DOI=10.1038/ni1185;
Meyers J.H., Chakravarti S., Schlesinger D., Illes Z., Waldner H.,
Umetsu S.E., Kenny J., Zheng X.X., Umetsu D.T., DeKruyff R.H.,
Strom T.B., Kuchroo V.K.;
"TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction
regulates T cell proliferation.";
Nat. Immunol. 6:455-464(2005).
[5]
X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 20-130, AND DISULFIDE BONDS.
PubMed=17363299; DOI=10.1016/j.immuni.2007.01.014;
Santiago C., Ballesteros A., Tami C., Martinez-Munoz L., Kaplan G.G.,
Casasnovas J.M.;
"Structures of T Cell immunoglobulin mucin receptors 1 and 2 reveal
mechanisms for regulation of immune responses by the TIM receptor
family.";
Immunity 26:299-310(2007).
-!- FUNCTION: May play a role in T-helper cell development and the
regulation of asthma and allergic diseases. Receptor for TIMD4.
May play a role in kidney injury and repair (By similarity).
{ECO:0000250, ECO:0000269|PubMed:15793576}.
-!- INTERACTION:
Q6U7R4:Timd4; NbExp=4; IntAct=EBI-20217708, EBI-16764486;
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
membrane protein {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q5QNS5-1; Sequence=Displayed;
Name=2;
IsoId=Q5QNS5-2; Sequence=VSP_015224;
-!- TISSUE SPECIFICITY: Expressed by stimulated T-cells. Expressed
during primary antigen stimulation. {ECO:0000269|PubMed:11725301}.
-!- POLYMORPHISM: Highly polymorphic. Depending on the alleles,
expression is associated with an increase and early (BALB/c
allele) or decrease (HBA allele) of T-helper type 2 cytokine
expression. Associated with asthma susceptibility.
{ECO:0000269|PubMed:11725301}.
-!- MISCELLANEOUS: Belongs to the T-cell and airway phenotype
regulator (Tapr) locus, a single chromosomal region that confers
reduced T-helper type 2 responsiveness and protects against airway
hyperactivity (AHR), the hallmark of human asthma.
-!- SIMILARITY: Belongs to the immunoglobulin superfamily. TIM family.
{ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF399829; AAL35774.1; -; mRNA.
EMBL; AF399830; AAL35775.1; -; mRNA.
EMBL; AL669892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC053400; AAH53400.1; -; mRNA.
CCDS; CCDS24583.1; -. [Q5QNS5-1]
CCDS; CCDS48778.1; -. [Q5QNS5-2]
RefSeq; NP_001160103.1; NM_001166631.1.
RefSeq; NP_001160104.1; NM_001166632.1.
RefSeq; NP_599009.2; NM_134248.2.
UniGene; Mm.17771; -.
PDB; 2OR8; X-ray; 2.50 A; A/B=20-130.
PDBsum; 2OR8; -.
ProteinModelPortal; Q5QNS5; -.
SMR; Q5QNS5; -.
IntAct; Q5QNS5; 1.
STRING; 10090.ENSMUSP00000043827; -.
iPTMnet; Q5QNS5; -.
PhosphoSitePlus; Q5QNS5; -.
PaxDb; Q5QNS5; -.
PRIDE; Q5QNS5; -.
GeneID; 171283; -.
KEGG; mmu:171283; -.
CTD; 26762; -.
MGI; MGI:2159680; Havcr1.
eggNOG; ENOG410IYS0; Eukaryota.
eggNOG; ENOG4111VB0; LUCA.
HOVERGEN; HBG073424; -.
InParanoid; Q5QNS5; -.
KO; K20413; -.
PhylomeDB; Q5QNS5; -.
TreeFam; TF336163; -.
EvolutionaryTrace; Q5QNS5; -.
PRO; PR:Q5QNS5; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_HAVCR1; -.
GO; GO:0009986; C:cell surface; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0001786; F:phosphatidylserine binding; IDA:MGI.
GO; GO:0033005; P:positive regulation of mast cell activation; IDA:MGI.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS50835; IG_LIKE; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Complete proteome; Disulfide bond;
Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism;
Reference proteome; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 305 Hepatitis A virus cellular receptor 1
homolog.
/FTId=PRO_0000014982.
TOPO_DOM 22 237 Extracellular. {ECO:0000255}.
TRANSMEM 238 258 Helical. {ECO:0000255}.
TOPO_DOM 259 305 Cytoplasmic. {ECO:0000255}.
DOMAIN 22 122 Ig-like V-type.
COMPBIAS 140 222 Thr-rich.
CARBOHYD 208 208 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 37 108 {ECO:0000244|PDB:2OR8,
ECO:0000255|PROSITE-ProRule:PRU00114,
ECO:0000269|PubMed:17363299}.
DISULFID 49 60 {ECO:0000244|PDB:2OR8,
ECO:0000269|PubMed:17363299}.
DISULFID 55 107 {ECO:0000244|PDB:2OR8,
ECO:0000269|PubMed:17363299}.
VAR_SEQ 183 205 Missing (in isoform 2).
{ECO:0000303|PubMed:11725301,
ECO:0000303|PubMed:15489334}.
/FTId=VSP_015224.
VARIANT 18 18 A -> T (in strain: HBA).
VARIANT 137 137 T -> R (in strain: HBA).
VARIANT 164 164 I -> T (in strain: HBA).
VARIANT 190 204 Missing (in strain: HBA).
CONFLICT 152 152 T -> A (in Ref. 3; AAH53400).
{ECO:0000305}.
STRAND 23 28 {ECO:0000244|PDB:2OR8}.
STRAND 33 35 {ECO:0000244|PDB:2OR8}.
STRAND 48 53 {ECO:0000244|PDB:2OR8}.
STRAND 57 59 {ECO:0000244|PDB:2OR8}.
STRAND 63 67 {ECO:0000244|PDB:2OR8}.
STRAND 69 77 {ECO:0000244|PDB:2OR8}.
HELIX 86 88 {ECO:0000244|PDB:2OR8}.
STRAND 93 97 {ECO:0000244|PDB:2OR8}.
HELIX 100 102 {ECO:0000244|PDB:2OR8}.
STRAND 104 110 {ECO:0000244|PDB:2OR8}.
STRAND 119 128 {ECO:0000244|PDB:2OR8}.
SEQUENCE 305 AA; 33361 MW; F995C93A9125E4FE CRC64;
MNQIQVFISG LILLLPGAVD SYVEVKGVVG HPVTLPCTYS TYRGITTTCW GRGQCPSSAC
QNTLIWTNGH RVTYQKSSRY NLKGHISEGD VSLTIENSVE SDSGLYCCRV EIPGWFNDQK
VTFSLQVKPE IPTRPPTRPT TTRPTATGRP TTISTRSTHV PTSIRVSTST PPTSTHTWTH
KPEPTTFCPH ETTAEVTGIP SHTPTDWNGT VTSSGDTWSN HTEAIPPGKP QKNPTKGFYV
GICIAALLLL LLVSTVAITR YILMKRKSAS LSVVAFRVSK IEALQNAAVV HSRAEDNIYI
VEDRP


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