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Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)

 MET_MOUSE               Reviewed;        1379 AA.
P16056; Q62125;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
01-APR-1990, sequence version 1.
22-NOV-2017, entry version 183.
RecName: Full=Hepatocyte growth factor receptor;
Short=HGF receptor;
EC=2.7.10.1;
AltName: Full=HGF/SF receptor;
AltName: Full=Proto-oncogene c-Met;
AltName: Full=Scatter factor receptor;
Short=SF receptor;
AltName: Full=Tyrosine-protein kinase Met;
Flags: Precursor;
Name=Met;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2838789;
Chan A.M.-L., King H.W.S., Deakin E.A., Tempest P.R., Hilkens J.,
Kroezen V., Edwards D.R., Wills A.J., Brookes P., Cooper C.S.;
"Characterization of the mouse met proto-oncogene.";
Oncogene 2:593-599(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 1199-1270.
PubMed=2482828; DOI=10.1016/0378-1119(89)90465-4;
Wilks A.F., Kurban R.R., Hovens C.M., Ralph S.J.;
"The application of the polymerase chain reaction to cloning members
of the protein tyrosine kinase family.";
Gene 85:67-74(1989).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 924-935.
PubMed=8384622; DOI=10.1083/jcb.121.1.145;
Weidner K.M., Sachs M., Birchmeier W.;
"The Met receptor tyrosine kinase transduces motility, proliferation,
and morphogenic signals of scatter factor/hepatocyte growth factor in
epithelial cells.";
J. Cell Biol. 121:145-154(1993).
[4]
FUNCTION IN DEVELOPMENT.
PubMed=7651534; DOI=10.1038/376768a0;
Bladt F., Riethmacher D., Isenmann S., Aguzzi A., Birchmeier C.;
"Essential role for the c-met receptor in the migration of myogenic
precursor cells into the limb bud.";
Nature 376:768-771(1995).
[5]
INTERACTION WITH INPP5D.
PubMed=11896575; DOI=10.1038/sj.onc.1205224;
Mancini A., Koch A., Wilms R., Tamura T.;
"The SH2-containing inositol 5-phosphatase (SHIP)-1 is implicated in
the control of cell-cell junction and induces dissociation and
dispersion of MDCK cells.";
Oncogene 21:1477-1484(2002).
[6]
INTERACTION WITH MUC20.
PubMed=15314156; DOI=10.1128/MCB.24.17.7456-7468.2004;
Higuchi T., Orita T., Katsuya K., Yamasaki Y., Akiyama K., Li H.,
Yamamoto T., Saito Y., Nakamura M.;
"MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras
pathway by binding to a multifunctional docking site of met.";
Mol. Cell. Biol. 24:7456-7468(2004).
[7]
INTERACTION WITH SPSB1; SPSB2 AND SPSB4.
PubMed=16369487; DOI=10.1038/nsmb1034;
Masters S.L., Yao S., Willson T.A., Zhang J.-G., Palmer K.R.,
Smith B.J., Babon J.J., Nicola N.A., Norton R.S., Nicholson S.E.;
"The SPRY domain of SSB-2 adopts a novel fold that presents conserved
Par-4-binding residues.";
Nat. Struct. Mol. Biol. 13:77-84(2006).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney, and Liver;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[9]
FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=26637977; DOI=10.1016/j.ajhg.2015.11.001;
Gray M.J., Kannu P., Sharma S., Neyt C., Zhang D., Paria N.,
Daniel P.B., Whetstone H., Sprenger H.G., Hammerschmidt P., Weng A.,
Dupuis L., Jobling R., Mendoza-Londono R., Dray M., Su P.,
Wilson M.J., Kapur R.P., McCarthy E.F., Alman B.A., Howard A.,
Somers G.R., Marshall C.R., Manners S., Flanagan A.M., Rathjen K.E.,
Karol L.A., Crawford H., Markie D.M., Rios J.J., Wise C.A.,
Robertson S.P.;
"Mutations preventing regulated exon skipping in MET cause
osteofibrous dysplasia.";
Am. J. Hum. Genet. 97:837-847(2015).
-!- FUNCTION: Receptor tyrosine kinase that transduces signals from
the extracellular matrix into the cytoplasm by binding to
hepatocyte growth factor/HGF ligand. Regulates many physiological
processes including proliferation, scattering, morphogenesis and
survival. Ligand binding at the cell surface induces
autophosphorylation of MET on its intracellular domain that
provides docking sites for downstream signaling molecules.
Following activation by ligand, interacts with the PI3-kinase
subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.
Recruitment of these downstream effectors by MET leads to the
activation of several signaling cascades including the RAS-ERK,
PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is
associated with the morphogenetic effects while PI3K/AKT
coordinates prosurvival effects. During embryonic development, MET
signaling plays a role in gastrulation, development and migration
of muscles and neuronal precursors, angiogenesis and kidney
formation. In adults, participates in wound healing as well as
organ regeneration and tissue remodeling. Promotes also
differentiation and proliferation of hematopoietic cells (By
similarity). May regulate cortical bone osteogenesis
(PubMed:26637977). {ECO:0000250, ECO:0000269|PubMed:26637977,
ECO:0000269|PubMed:7651534}.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-
ProRule:PRU10028}.
-!- ENZYME REGULATION: In its inactive state, the C-terminal tail
interacts with the catalytic domain and inhibits the kinase
activity. Upon ligand binding, the C-terminal tail is displaced
and becomes phosphorylated, thus increasing the kinase activity
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Heterodimer made of an alpha chain (50 kDa) and a beta
chain (145 kDa) which are disulfide linked (By similarity). Binds
PLXNB1 (By similarity). Interacts when phosphorylated with
downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and
GAB1 (By similarity). When phosphorylated at Tyr-1354, interacts
with INPPL1/SHIP2 (By similarity). Interacts with RANBP9 and
RANBP10 (By similarity). Interacts with INPP5D/SHIP1
(PubMed:11896575). Interacts with SPSB1, SPSB2, SPSB4 and probably
SPSB3. SPSB1 binding occurs in the presence and in the absence of
HGF, however HGF treatment has a positive effect on this
interaction (PubMed:16369487). Interacts with MUC20; prevents
interaction with GRB2 and suppresses hepatocyte growth factor-
induced cell proliferation (PubMed:15314156). Interacts with GRB10
(By similarity). Interacts with PTPN1 and PTPN2. Interacts with
HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase
activity (By similarity). {ECO:0000250|UniProtKB:P08581,
ECO:0000269|PubMed:11896575, ECO:0000269|PubMed:15314156,
ECO:0000269|PubMed:16369487}.
-!- INTERACTION:
P22682:Cbl; NbExp=2; IntAct=EBI-1798780, EBI-640919;
P14210:HGF (xeno); NbExp=2; IntAct=EBI-1798780, EBI-1039104;
P35918:Kdr; NbExp=3; IntAct=EBI-1798780, EBI-1555005;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- DEVELOPMENTAL STAGE: Low though detectable expression at 10 dpc.
From 15 dpc at least until 17 dpc, expression strongly increases.
Down-regulated in the adult. {ECO:0000269|PubMed:26637977}.
-!- DOMAIN: The kinase domain is involved in SPSB1 binding.
{ECO:0000250}.
-!- DOMAIN: The beta-propeller Sema domain mediates binding to HGF.
{ECO:0000250}.
-!- PTM: Autophosphorylated in response to ligand binding on Tyr-1232
and Tyr-1233 in the kinase domain leading to further
phosphorylation of Tyr-1347 and Tyr-1354 in the C-terminal
multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-
1347 and Tyr-1363 (By similarity). Dephosphorylated by PTPN1 and
PTPN2 (By similarity). {ECO:0000250}.
-!- PTM: Ubiquitinated. Ubiquitination by CBL regulates MET
endocytosis, resulting in decreasing plasma membrane receptor
abundance, and in endosomal degradation and/or recycling of
internalized receptors. {ECO:0000250|UniProtKB:P08581}.
-!- DISEASE: Note=Activation of Met after rearrangement with the TPR
(translocated promoter) locus of chromosome 1 produces an
oncogenic protein.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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EMBL; Y00671; CAA68680.1; -; mRNA.
EMBL; M33424; AAA40015.1; -; mRNA.
CCDS; CCDS19925.1; -.
PIR; S01254; S01254.
UniGene; Mm.86844; -.
ProteinModelPortal; P16056; -.
SMR; P16056; -.
IntAct; P16056; 4.
MINT; MINT-137318; -.
STRING; 10090.ENSMUSP00000079324; -.
BindingDB; P16056; -.
ChEMBL; CHEMBL5585; -.
iPTMnet; P16056; -.
PhosphoSitePlus; P16056; -.
SwissPalm; P16056; -.
MaxQB; P16056; -.
PaxDb; P16056; -.
PeptideAtlas; P16056; -.
PRIDE; P16056; -.
MGI; MGI:96969; Met.
eggNOG; KOG1095; Eukaryota.
eggNOG; KOG3610; Eukaryota.
eggNOG; COG0515; LUCA.
HOGENOM; HOG000220900; -.
HOVERGEN; HBG006348; -.
InParanoid; P16056; -.
PhylomeDB; P16056; -.
BRENDA; 2.7.10.1; 3474.
ChiTaRS; Met; mouse.
PMAP-CutDB; P16056; -.
PRO; PR:P16056; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_MET; -.
GO; GO:0009925; C:basal plasma membrane; ISO:MGI.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IDA:MGI.
GO; GO:0098794; C:postsynapse; IEA:GOC.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0005008; F:hepatocyte growth factor-activated receptor activity; IDA:MGI.
GO; GO:0004672; F:protein kinase activity; IDA:MGI.
GO; GO:0019903; F:protein phosphatase binding; ISO:MGI.
GO; GO:0000187; P:activation of MAPK activity; IPI:MGI.
GO; GO:0030534; P:adult behavior; IMP:MGI.
GO; GO:0007420; P:brain development; IMP:MGI.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; ISO:MGI.
GO; GO:0055013; P:cardiac muscle cell development; IMP:MGI.
GO; GO:0060048; P:cardiac muscle contraction; IMP:MGI.
GO; GO:0007268; P:chemical synaptic transmission; IMP:CACAO.
GO; GO:0001886; P:endothelial cell morphogenesis; ISO:MGI.
GO; GO:0061436; P:establishment of skin barrier; ISO:MGI.
GO; GO:0060079; P:excitatory postsynaptic potential; IMP:BHF-UCL.
GO; GO:0042593; P:glucose homeostasis; IMP:MGI.
GO; GO:0048012; P:hepatocyte growth factor receptor signaling pathway; IDA:MGI.
GO; GO:0001889; P:liver development; IMP:MGI.
GO; GO:0050804; P:modulation of chemical synaptic transmission; IMP:BHF-UCL.
GO; GO:0014812; P:muscle cell migration; IMP:MGI.
GO; GO:0007517; P:muscle organ development; IMP:MGI.
GO; GO:0051450; P:myoblast proliferation; IMP:MGI.
GO; GO:0014902; P:myotube differentiation; IMP:MGI.
GO; GO:0010629; P:negative regulation of gene expression; IMP:MGI.
GO; GO:1905098; P:negative regulation of guanyl-nucleotide exchange factor activity; ISO:MGI.
GO; GO:1901299; P:negative regulation of hydrogen peroxide-mediated programmed cell death; ISO:MGI.
GO; GO:0035024; P:negative regulation of Rho protein signal transduction; ISO:MGI.
GO; GO:0051497; P:negative regulation of stress fiber assembly; ISO:MGI.
GO; GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; ISO:MGI.
GO; GO:0071635; P:negative regulation of transforming growth factor beta production; IMP:MGI.
GO; GO:0001890; P:placenta development; IMP:MGI.
GO; GO:0050918; P:positive chemotaxis; IMP:UniProtKB.
GO; GO:2001028; P:positive regulation of endothelial cell chemotaxis; ISS:UniProtKB.
GO; GO:0010828; P:positive regulation of glucose transport; IMP:MGI.
GO; GO:0031116; P:positive regulation of microtubule polymerization; ISO:MGI.
GO; GO:1900745; P:positive regulation of p38MAPK cascade; IMP:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI.
GO; GO:0046777; P:protein autophosphorylation; IDA:MGI.
GO; GO:0072593; P:reactive oxygen species metabolic process; IMP:MGI.
GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IMP:MGI.
GO; GO:1900407; P:regulation of cellular response to oxidative stress; IMP:MGI.
GO; GO:0032675; P:regulation of interleukin-6 production; IMP:MGI.
GO; GO:0071526; P:semaphorin-plexin signaling pathway; IMP:UniProtKB.
GO; GO:0007519; P:skeletal muscle tissue development; IMP:MGI.
Gene3D; 2.130.10.10; -; 1.
Gene3D; 2.60.40.10; -; 4.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR002909; IPT.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR002165; Plexin_repeat.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR016201; PSI.
InterPro; IPR001627; Semap_dom.
InterPro; IPR036352; Semap_dom_sf.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR016244; Tyr_kinase_HGF/MSP_rcpt.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF01437; PSI; 1.
Pfam; PF01403; Sema; 1.
Pfam; PF01833; TIG; 3.
PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM00429; IPT; 4.
SMART; SM00423; PSI; 1.
SMART; SM00630; Sema; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF101912; SSF101912; 1.
SUPFAM; SSF56112; SSF56112; 1.
SUPFAM; SSF81296; SSF81296; 3.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS51004; SEMA; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase;
Membrane; Nucleotide-binding; Phosphoprotein; Proto-oncogene;
Receptor; Reference proteome; Repeat; Signal; Transferase;
Transmembrane; Transmembrane helix; Tyrosine-protein kinase;
Ubl conjugation.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 1379 Hepatocyte growth factor receptor.
/FTId=PRO_0000024441.
TOPO_DOM 25 931 Extracellular. {ECO:0000255}.
TRANSMEM 932 954 Helical. {ECO:0000255}.
TOPO_DOM 955 1379 Cytoplasmic. {ECO:0000255}.
DOMAIN 27 514 Sema. {ECO:0000255|PROSITE-
ProRule:PRU00352}.
DOMAIN 562 654 IPT/TIG 1.
DOMAIN 656 738 IPT/TIG 2.
DOMAIN 741 835 IPT/TIG 3.
DOMAIN 1076 1343 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 1082 1090 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 1210 1379 Interaction with RANBP9. {ECO:0000250}.
REGION 1318 1357 Interaction with MUC20. {ECO:0000250}.
ACT_SITE 1202 1202 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10028}.
BINDING 1108 1108 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
SITE 306 307 Cleavage. {ECO:0000255}.
SITE 1001 1001 Required for ligand-induced CBL-mediated
ubiquitination.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 964 964 Phosphoserine.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 975 975 Phosphothreonine.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 988 988 Phosphoserine.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 995 995 Phosphoserine.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 998 998 Phosphoserine.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 1001 1001 Phosphotyrosine.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 1228 1228 Phosphotyrosine.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 1232 1232 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 1233 1233 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 1287 1287 Phosphothreonine.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 1347 1347 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 1354 1354 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P08581}.
MOD_RES 1363 1363 Phosphotyrosine.
{ECO:0000250|UniProtKB:P08581}.
CARBOHYD 45 45 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 106 106 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 201 201 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 357 357 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 398 398 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 404 404 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 606 606 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 634 634 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 784 784 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 878 878 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 95 101 {ECO:0000255|PROSITE-ProRule:PRU00352}.
DISULFID 98 160 {ECO:0000255|PROSITE-ProRule:PRU00352}.
DISULFID 133 141 {ECO:0000255|PROSITE-ProRule:PRU00352}.
DISULFID 171 174 {ECO:0000255|PROSITE-ProRule:PRU00352}.
DISULFID 297 362 {ECO:0000255|PROSITE-ProRule:PRU00352}.
DISULFID 384 396 {ECO:0000255|PROSITE-ProRule:PRU00352}.
DISULFID 519 537 {ECO:0000255|PROSITE-ProRule:PRU00352}.
DISULFID 525 560 {ECO:0000255|PROSITE-ProRule:PRU00352}.
DISULFID 528 544 {ECO:0000255|PROSITE-ProRule:PRU00352}.
DISULFID 540 550 {ECO:0000255|PROSITE-ProRule:PRU00352}.
CONFLICT 1199 1199 V -> I (in Ref. 2; AAA40015).
{ECO:0000305}.
CONFLICT 1255 1255 T -> R (in Ref. 2; AAA40015).
{ECO:0000305}.
CONFLICT 1261 1261 K -> T (in Ref. 2; AAA40015).
{ECO:0000305}.
CONFLICT 1269 1270 VL -> IP (in Ref. 2). {ECO:0000305}.
SEQUENCE 1379 AA; 153549 MW; FC5CC87FDD8ADED8 CRC64;
MKAPTVLAPG ILVLLLSLVQ RSHGECKEAL VKSEMNVNMK YQLPNFTAET PIQNVVLHGH
HIYLGATNYI YVLNDKDLQK VSEFKTGPVL EHPDCLPCRD CSSKANSSGG VWKDNINMAL
LVDTYYDDQL ISCGSVNRGT CQRHVLPPDN SADIQSEVHC MFSPEEESGQ CPDCVVSALG
AKVLLSEKDR FINFFVGNTI NSSYPPGYSL HSISVRRLKE TQDGFKFLTD QSYIDVLPEF
LDSYPIKYIH AFESNHFIYF LTVQKETLDA QTFHTRIIRF CSVDSGLHSY MEMPLECILT
EKRRKRSTRE EVFNILQAAY VSKPGANLAK QIGASPSDDI LFGVFAQSKP DSAEPVNRSA
VCAFPIKYVN DFFNKIVNKN NVRCLQHFYG PNHEHCFNRT LLRNSSGCEA RSDEYRTEFT
TALQRVDLFM GRLNQVLLTS ISTFIKGDLT IANLGTSEGR FMQVVLSRTA HLTPHVNFLL
DSHPVSPEVI VEHPSNQNGY TLVVTGKKIT KIPLNGLGCG HFQSCSQCLS APYFIQCGWC
HNQCVRFDEC PSGTWTQEIC LPAVYKVFPT SAPLEGGTVL TICGWDFGFR KNNKFDLRKT
KVLLGNESCT LTLSESTTNT LKCTVGPAMS EHFNVSVIIS NSRETTQYSA FSYVDPVITS
ISPRYGPQAG GTLLTLTGKY LNSGNSRHIS IGGKTCTLKS VSDSILECYT PAQTTSDEFP
VKLKIDLANR ETSSFSYRED PVVYEIHPTK SFISGGSTIT GIGKTLNSVS LPKLVIDVHE
VGVNYTVACQ HRSNSEIICC TTPSLKQLGL QLPLKTKAFF LLDGILSKHF DLTYVHNPVF
EPFEKPVMIS MGNENVVEIK GNNIDPEAVK GEVLKVGNQS CESLHWHSGA VLCTVPSDLL
KLNSELNIEW KQAVSSTVLG KVIVQPDQNF AGLIIGAVSI SVVVLLLSGL FLWMRKRKHK
DLGSELVRYD ARVHTPHLDR LVSARSVSPT TEMVSNESVD YRATFPEDQF PNSSQNGACR
QVQYPLTDLS PILTSGDSDI SSPLLQNTVH IDLSALNPEL VQAVQHVVIG PSSLIVHFNE
VIGRGHFGCV YHGTLLDNDG KKIHCAVKSL NRITDIEEVS QFLTEGIIMK DFSHPNVLSL
LGICLRSEGS PLVVLPYMKH GDLRNFIRNE THNPTVKDLI GFGLQVAKGM KYLASKKFVH
RDLAARNCML DEKFTVKVAD FGLARDMYDK EYYSVHNKTG AKLPVKWMAL ESLQTQKFTT
KSDVWSFGVL LWELMTRGAP PYPDVNTFDI TIYLLQGRRL LQPEYCPDAL YEVMLKCWHP
KAEMRPSFSE LVSRISSIFS TFIGEHYVHV NATYVNVKCV APYPSLLPSQ DNIDGEGNT


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18-785-210280 Met (Ab-1349) - EC 2.7.10.1; HGF receptor; Scatter factor receptor; SF receptor; HGF_SF receptor; Met proto-oncogene tyrosine kinase; c-Met Polyclonal 0.1 mg
18-785-210277 Met (Phospho-Tyr1234) - EC 2.7.10.1; HGF receptor; Scatter factor receptor; SF receptor; HGF_SF receptor; Met proto-oncogene tyrosine kinase; c-Met Polyclonal 0.05 mg
18-785-210278 Met (Phospho-Tyr1349) - EC 2.7.10.1; HGF receptor; Scatter factor receptor; SF receptor; HGF_SF receptor; Met proto-oncogene tyrosine kinase; c-Met Polyclonal 0.1 mg
18-785-210277 Met (Phospho-Tyr1234) - EC 2.7.10.1; HGF receptor; Scatter factor receptor; SF receptor; HGF_SF receptor; Met proto-oncogene tyrosine kinase; c-Met Polyclonal 0.1 mg
18-785-210278 Met (Phospho-Tyr1349) - EC 2.7.10.1; HGF receptor; Scatter factor receptor; SF receptor; HGF_SF receptor; Met proto-oncogene tyrosine kinase; c-Met Polyclonal 0.05 mg
18-272-196210 Met ( c - Met ) - Rabbit polyclonal to Met ( c - Met ); EC 2.7.10.1; HGF receptor; Scatter factor receptor; SF receptor; HGF_SF receptor; Met proto-oncogene tyrosine kinase; c-Met Polyclonal 0.05 mg
18-272-195200 Met (c-Met) - Goat polyclonal to Met (c-Met); EC 2.7.10.1; HGF receptor; Scatter factor receptor; SF receptor; HGF_SF receptor; Met proto-oncogene tyrosine kinase; c-Met Polyclonal 0.025 mg
U0978r CLIA Epidermal growth factor receptor-related protein,Erbb2,Neu,p185erbB2,p185neu,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Rat,Rattus norvegicus,Receptor tyrosine-protein kinase erbB-2 96T
E0978r ELISA Epidermal growth factor receptor-related protein,Erbb2,Neu,p185erbB2,p185neu,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Rat,Rattus norvegicus,Receptor tyrosine-protein kinase erbB-2 96T
E0978r ELISA kit Epidermal growth factor receptor-related protein,Erbb2,Neu,p185erbB2,p185neu,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Rat,Rattus norvegicus,Receptor tyrosine-protein kinase erbB-2 96T
20-272-191078 Met ( c - Met ) ( phospho Y1234 ) - Mouse monoclonal [3i20] to Met ( c - Met ) ( phospho Y1234 ); EC 2.7.10.1; HGF receptor; Scatter factor receptor; SF receptor; HGF_SF receptor; Met proto-oncogene t 0.05 ml
U0757h CLIA EGFR,Epidermal growth factor receptor,ERBB1,Homo sapiens,Human,Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 96T
E0757h ELISA EGFR,Epidermal growth factor receptor,ERBB1,Homo sapiens,Human,Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 96T
E0757h ELISA kit EGFR,Epidermal growth factor receptor,ERBB1,Homo sapiens,Human,Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 96T
EIAAB13163 Erbb3,Glial growth factor receptor,Mouse,Mus musculus,Proto-oncogene-like protein c-ErbB-3,Receptor tyrosine-protein kinase erbB-3
U0147m CLIA Embryonic receptor kinase 2,Emrk2,Flt,Flt1,FLT-1,Fms-like tyrosine kinase 1,Mouse,Mus musculus,Tyrosine-protein kinase receptor FLT,Vascular endothelial growth factor receptor 1,VEGFR-1 96T
E0147m ELISA Embryonic receptor kinase 2,Emrk2,Flt,Flt1,FLT-1,Fms-like tyrosine kinase 1,Mouse,Mus musculus,Tyrosine-protein kinase receptor FLT,Vascular endothelial growth factor receptor 1,VEGFR-1 96T
E0147m ELISA kit Embryonic receptor kinase 2,Emrk2,Flt,Flt1,FLT-1,Fms-like tyrosine kinase 1,Mouse,Mus musculus,Tyrosine-protein kinase receptor FLT,Vascular endothelial growth factor receptor 1,VEGFR-1 96T
18-783-75623 RABBIT ANTI HUMAN EGF RECEPTOR - EPIDERMAL GROWTH FACTOR RECEPTOR; EC 2.7.10.1; Receptor tyrosine-protein kinase ErbB-1 Polyclonal 0.05 mg
15-288-21181 Vascular endothelial growth factor receptor 2 - EC 2.7.10.1; VEGFR-2; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; CD309 antigen Polyclonal 0.1 mg
15-288-21181 Vascular endothelial growth factor receptor 2 - EC 2.7.10.1; VEGFR-2; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; CD309 antigen Polyclonal 0.05 mg


 

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