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Hepatocyte nuclear factor 1-alpha-A (HNF-1-alpha-A) (HNF-1A-A) (LFB1) (Transcription factor 1-A) (TCF-1-A) (XLFB1a)

 HNFAA_XENLA             Reviewed;         605 AA.
Q05041;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
22-NOV-2017, entry version 111.
RecName: Full=Hepatocyte nuclear factor 1-alpha-A;
Short=HNF-1-alpha-A;
Short=HNF-1A-A;
AltName: Full=LFB1;
AltName: Full=Transcription factor 1-A;
Short=TCF-1-A;
AltName: Full=XLFB1a;
Name=hnf1a-a; Synonyms=hnf1-a, lfb1a, tcf1-a;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8417340; DOI=10.1128/MCB.13.1.421;
Bartkowski S., Zapp D., Weber H., Eberle G., Zoidl C., Senkel S.,
Klein-Hitpass L., Ryffel G.U.;
"Developmental regulation and tissue distribution of the liver
transcription factor LFB1 (HNF1) in Xenopus laevis.";
Mol. Cell. Biol. 13:421-431(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8262383; DOI=10.1016/0378-1119(93)90102-9;
Zapp D., Bartkowski S., Zoidl C., Klein-Hitpass L., Ryffel G.U.;
"Genomic structure of the Xenopus laevis liver transcription factor
LFB1.";
Gene 134:251-256(1993).
[3]
FUNCTION.
PubMed=8735941;
Weber H., Pogge von Strandmann E., Holewa B., Bartkowski S., Zapp D.,
Zoidl C., Ryffel G.U.;
"Regulation and function of the tissue-specific transcription factor
HNF1 alpha (LFB1) during Xenopus development.";
Int. J. Dev. Biol. 40:297-304(1996).
-!- FUNCTION: Transcriptional activator that regulates the tissue
specific expression of multiple genes, especially in pancreas and
liver (By similarity). Binds to the hepatocyte specific promoter
element HP1. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
{ECO:0000250, ECO:0000269|PubMed:8735941}.
-!- SUBUNIT: Binds DNA as dimer. Forms a homodimer or heterodimer with
HNF1-alpha-B. Potentially also form a heterodimer with HNF1-beta.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Protein expressed in liver, stomach, small
intestine, colon and kidney. Not expressed in spleen, lung, blood,
heart muscle, skeletal muscle, testis and brain.
-!- DEVELOPMENTAL STAGE: Protein found in 2-day-old hatched larvae
(stage 35).
-!- SIMILARITY: Belongs to the HNF1 homeobox family. {ECO:0000305}.
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EMBL; X64759; CAA46007.1; -; mRNA.
PIR; A48115; A48115.
PIR; T01067; T01067.
RefSeq; NP_001095214.1; NM_001101744.1.
UniGene; Xl.1177; -.
ProteinModelPortal; Q05041; -.
SMR; Q05041; -.
GeneID; 378589; -.
KEGG; xla:378589; -.
CTD; 378589; -.
Xenbase; XB-GENE-865049; hnf1a.
HOVERGEN; HBG005980; -.
KO; K08036; -.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00086; homeodomain; 1.
InterPro; IPR006899; HNF-1_N.
InterPro; IPR023219; HNF1_dimer_N_dom_sf.
InterPro; IPR006898; HNF1a_C.
InterPro; IPR006897; HNF1b_C.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
Pfam; PF04814; HNF-1_N; 1.
Pfam; PF04813; HNF-1A_C; 1.
Pfam; PF04812; HNF-1B_C; 1.
Pfam; PF00046; Homeobox; 1.
SMART; SM00389; HOX; 1.
SUPFAM; SSF100957; SSF100957; 1.
SUPFAM; SSF46689; SSF46689; 1.
SUPFAM; SSF47413; SSF47413; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
2: Evidence at transcript level;
Activator; DNA-binding; Homeobox; Nucleus; Transcription;
Transcription regulation.
CHAIN 1 605 Hepatocyte nuclear factor 1-alpha-A.
/FTId=PRO_0000049119.
DNA_BIND 202 282 Homeobox; HNF1-type.
{ECO:0000255|PROSITE-ProRule:PRU00108}.
REGION 1 31 Dimerization. {ECO:0000250}.
REGION 128 130 Interaction with DNA. {ECO:0000250}.
REGION 141 147 Interaction with DNA. {ECO:0000250}.
REGION 153 156 Interaction with DNA. {ECO:0000250}.
REGION 206 209 Interaction with DNA. {ECO:0000250}.
REGION 266 268 Interaction with DNA. {ECO:0000250}.
REGION 273 276 Interaction with DNA. {ECO:0000250}.
REGION 448 453 Not present in other members of the HNF1
family.
MOTIF 200 208 Nuclear localization signal.
{ECO:0000255}.
COMPBIAS 69 78 Asp/Glu-rich (acidic; potential
involvement with transcription).
SEQUENCE 605 AA; 66577 MW; 946A5E873B9A686B CRC64;
MASQLSYLQR ELLQALLESG VTKEALKKAL ADGDDYTYPN VPLDDIRNLD EGENCVQLPN
GLGESHISED ESSDDGEDFT PPIMKELERL SPEEAAHQKA VVERLLQEDS WHVAKLVKSY
LQQHNIPQRE VVETTGLNQS HLSQHLNKGT PMKTQKRAAL YTWYVGKQRE IARLFTFTEF
THAGQGLITD DMSCDEVPTK KMRRNRFKWG PASQQILFQA YERQKNPSKE EREALVEECN
RAECLQRGVS PSQAQGLGSN LVTEVRVYNW FANRRKEEAF RHKLAMDTYN GQQNSAPTLS
AHDLPHGKTY GFRYIQDSST DRSAVMANSQ STPSPSALEP SHSLMNSDSK MIPVSGGSLP
PVSTLTALHN VDHSQHTLGQ TQNLIMASLP SVMTIGTDTA LGPAFSNPGS STLVIGLASQ
TQSVPVINSV GSSLTTLQSV QFSQQLHPSH QLHPSHQQPI VQQVQSHMAQ NPFMATMAQL
QSPHAIYSHK PDVAQYASAG FFPQTMVITD TSNLGTLTSL TPSKQVVPLH TTAHGDAPGS
QLQNQDSSIL HLPLCHRLSP IPTVSSASLV HYHNSSSPEN HSHLLSPSHN TIDSFISTQM
ASSSQ


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