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Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1)

 HNF1B_RAT               Reviewed;         557 AA.
P23899;
01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
01-NOV-1991, sequence version 1.
27-SEP-2017, entry version 138.
RecName: Full=Hepatocyte nuclear factor 1-beta;
Short=HNF-1-beta;
Short=HNF-1B;
AltName: Full=Transcription factor 2;
Short=TCF-2;
AltName: Full=Variant hepatic nuclear factor 1;
Short=vHNF1;
Name=Hnf1b; Synonyms=Hnf-1b, Tcf2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Liver;
PubMed=1673926;
Rey-Campos J., Chouard T., Yaniv M., Cereghini S.;
"vHNF1 is a homeoprotein that activates transcription and forms
heterodimers with HNF1.";
EMBO J. 10:1445-1457(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=16641100; DOI=10.1073/pnas.0600895103;
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
regulation of aquaporin-2 phosphorylation at two sites.";
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-75 AND SER-80,
AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Transcription factor, probably binds to the inverted
palindrome 5'-GTTAATNATTAAC-3'.
-!- SUBUNIT: Binds DNA as a dimer. Can form homodimer or heterodimer
with HNF1-alpha.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=VHNF1-A;
IsoId=P23899-1; Sequence=Displayed;
Name=2; Synonyms=VHNF1-B;
IsoId=P23899-2; Sequence=VSP_002257;
-!- TISSUE SPECIFICITY: Liver, kidney and intestine.
-!- SIMILARITY: Belongs to the HNF1 homeobox family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X56546; CAA39886.1; -; mRNA.
EMBL; BC081826; AAH81826.1; -; mRNA.
PIR; S15342; S15342.
RefSeq; NP_037235.1; NM_013103.2. [P23899-1]
UniGene; Rn.11342; -.
ProteinModelPortal; P23899; -.
SMR; P23899; -.
iPTMnet; P23899; -.
PhosphoSitePlus; P23899; -.
Ensembl; ENSRNOT00000047427; ENSRNOP00000046025; ENSRNOG00000002598. [P23899-1]
GeneID; 25640; -.
KEGG; rno:25640; -.
CTD; 6928; -.
RGD; 3830; Hnf1b.
GeneTree; ENSGT00860000133745; -.
HOVERGEN; HBG005980; -.
InParanoid; P23899; -.
KO; K08034; -.
OMA; QQPFMAT; -.
OrthoDB; EOG091G052F; -.
PhylomeDB; P23899; -.
PRO; PR:P23899; -.
Proteomes; UP000002494; Chromosome 10.
Bgee; ENSRNOG00000002598; -.
ExpressionAtlas; P23899; baseline and differential.
Genevisible; P23899; RN.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0001159; F:core promoter proximal region DNA binding; IDA:RGD.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0032403; F:protein complex binding; IDA:RGD.
GO; GO:0046982; F:protein heterodimerization activity; IDA:RGD.
GO; GO:0042803; F:protein homodimerization activity; IDA:RGD.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:RGD.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
GO; GO:0032922; P:circadian regulation of gene expression; IDA:RGD.
GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0048598; P:embryonic morphogenesis; IDA:RGD.
GO; GO:0031018; P:endocrine pancreas development; ISS:UniProtKB.
GO; GO:0001714; P:endodermal cell fate specification; IEA:Ensembl.
GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO; GO:0048806; P:genitalia development; ISS:UniProtKB.
GO; GO:0061017; P:hepatoblast differentiation; IEA:Ensembl.
GO; GO:0070365; P:hepatocyte differentiation; IEP:RGD.
GO; GO:0030902; P:hindbrain development; IEA:Ensembl.
GO; GO:0001826; P:inner cell mass cell differentiation; IEA:Ensembl.
GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
GO; GO:0001822; P:kidney development; ISS:UniProtKB.
GO; GO:0072181; P:mesonephric duct formation; IEA:Ensembl.
GO; GO:0061296; P:negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis; IEA:Ensembl.
GO; GO:1900212; P:negative regulation of mesenchymal cell apoptotic process involved in metanephros development; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD.
GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0039020; P:pronephric nephron tubule development; IEA:Ensembl.
GO; GO:0065004; P:protein-DNA complex assembly; IMP:RGD.
GO; GO:0072095; P:regulation of branch elongation involved in ureteric bud branching; IEA:Ensembl.
GO; GO:0042663; P:regulation of endodermal cell fate specification; IEA:Ensembl.
GO; GO:0035565; P:regulation of pronephros size; IEA:Ensembl.
GO; GO:0030111; P:regulation of Wnt signaling pathway; IEA:Ensembl.
GO; GO:0009743; P:response to carbohydrate; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0060677; P:ureteric bud elongation; IEA:Ensembl.
CDD; cd00086; homeodomain; 1.
InterPro; IPR006899; HNF-1_N.
InterPro; IPR023219; HNF1_dimer_dom.
InterPro; IPR006897; HNF1b_C.
InterPro; IPR009057; Homeobox-like.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR010982; Lambda_DNA-bd_dom.
Pfam; PF04814; HNF-1_N; 1.
Pfam; PF04812; HNF-1B_C; 1.
Pfam; PF00046; Homeobox; 1.
SMART; SM00389; HOX; 1.
SUPFAM; SSF100957; SSF100957; 1.
SUPFAM; SSF46689; SSF46689; 1.
SUPFAM; SSF47413; SSF47413; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Activator; Alternative splicing; Complete proteome; DNA-binding;
Homeobox; Nucleus; Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 557 Hepatocyte nuclear factor 1-beta.
/FTId=PRO_0000049124.
DNA_BIND 231 311 Homeobox; HNF1-type.
{ECO:0000255|PROSITE-ProRule:PRU00108}.
REGION 1 31 Dimerization. {ECO:0000250}.
MOD_RES 49 49 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 52 52 Phosphoserine.
{ECO:0000250|UniProtKB:P27889}.
MOD_RES 75 75 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 80 80 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
VAR_SEQ 183 208 Missing (in isoform 2).
{ECO:0000303|PubMed:1673926}.
/FTId=VSP_002257.
SEQUENCE 557 AA; 61371 MW; 7729E78C458B6DBC CRC64;
MVSKLTSLQQ ELLSALLSSG VTKEVLIQAL EELLPSPNFG VKLETLPLSP GSGADLDTKP
VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT EEAAEQRAEV DRMLSEDPWR
AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL SQHLNKGTPM KTQKRAALYT WYVRKQREIL
RQFNQTVQSS GNMTDKSSQD QLLFLFPEFS QQNQGPGQSE DACSEPTNKK MRRNRFKWGP
ASQQILYQAY DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF
ANRRKEEAFR QKLAMDAYSS NQTHNLNPLL THGSPHHQPS SSPPNKLSGV RYSQPGNNEV
TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHSLLSPDS KMISVSGGGL PPVSTLTNIH
SLSHHNPQQS QNLIMTPLSG VMAIAQSLNT SQAQGVPVIN SVASSLAALQ PVQFSQQLHS
PHQQPLMQQS PGSHMAQQPF MAAVTQLQNS HMYAHKQEPP QYSHTSRFPS AMVVTDTSSI
NTLTSMSSSK QCPLQAW


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