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Hepatocyte nuclear factor 1-beta-B (HNF-1-beta-B) (HNF-1B-B) (Hepatocyte nuclear factor 1-beta-like) (Hepatocyte nuclear factor 1-gamma) (HNF1g)

 HN1BB_DANRE             Reviewed;         532 AA.
Q8UW00;
24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
27-SEP-2017, entry version 114.
RecName: Full=Hepatocyte nuclear factor 1-beta-B {ECO:0000250|UniProtKB:P35680};
Short=HNF-1-beta-B {ECO:0000250|UniProtKB:P35680};
Short=HNF-1B-B {ECO:0000250|UniProtKB:P35680};
AltName: Full=Hepatocyte nuclear factor 1-beta-like {ECO:0000303|PubMed:18945197};
AltName: Full=Hepatocyte nuclear factor 1-gamma {ECO:0000303|Ref.1};
Short=HNF1g {ECO:0000303|Ref.1};
Name=hnf1bb {ECO:0000312|ZFIN:ZDB-GENE-030131-3003};
Synonyms=hnf1bl {ECO:0000303|PubMed:18945197},
hnf1g {ECO:0000303|Ref.1};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1] {ECO:0000312|EMBL:AAL48194.1}
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Embryo {ECO:0000312|EMBL:AAL48194.1};
Gong H.-Y., Hu M.-C., Lin C.J.-F., Chen M.C., Chen M.H.-C., Weng C.F.,
Wu J.-L.;
"Developmental expression of HNF1g, a novel hepatocyte nuclear factor
1, and HNF1b homolog in zebrafish pronephros formation.";
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000305}
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=18945197; DOI=10.1089/zeb.2008.0534;
Choe S.-K., Hirsch N., Zhang X., Sagerstrom C.G.;
"hnf1b genes in zebrafish hindbrain development.";
Zebrafish 5:179-187(2008).
-!- FUNCTION: Transcription factor, probably binds to the inverted
palindrome 5'-GTTAATNATTAAC-3' (By similarity). Acts downstream of
hnf1ba but is not required for induction of rhombomere r5/r6 gene
expression in the hindbrain. {ECO:0000250|UniProtKB:P35680,
ECO:0000269|PubMed:18945197}.
-!- SUBUNIT: Binds DNA as a dimer. Can form homodimer or heterodimer
with HNF1-alpha (By similarity). {ECO:0000250|UniProtKB:P35680}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P35680,
ECO:0000255|PROSITE-ProRule:PRU00108}.
-!- TISSUE SPECIFICITY: First expressed at stage 10 in the
intermediate mesoderm. Expressed in rhombomere r5 by 14 hpf with
expression diminishing by 18 hpf. {ECO:0000269|PubMed:18945197}.
-!- SIMILARITY: Belongs to the HNF1 homeobox family. {ECO:0000255}.
-!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
{ECO:0000305}.
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EMBL; AF250352; AAL48194.1; -; mRNA.
RefSeq; NP_919353.1; NM_194372.2.
UniGene; Dr.15418; -.
ProteinModelPortal; Q8UW00; -.
SMR; Q8UW00; -.
STRING; 7955.ENSDARP00000038789; -.
PaxDb; Q8UW00; -.
PRIDE; Q8UW00; -.
Ensembl; ENSDART00000029465; ENSDARP00000038789; ENSDARG00000022295.
GeneID; 324283; -.
KEGG; dre:324283; -.
CTD; 324283; -.
ZFIN; ZDB-GENE-030131-3003; hnf1bb.
GeneTree; ENSGT00860000133745; -.
HOGENOM; HOG000015305; -.
HOVERGEN; HBG005980; -.
InParanoid; Q8UW00; -.
OMA; EILYQAY; -.
OrthoDB; EOG091G052F; -.
PhylomeDB; Q8UW00; -.
PRO; PR:Q8UW00; -.
Proteomes; UP000000437; Chromosome 21.
Bgee; ENSDARG00000022295; -.
ExpressionAtlas; Q8UW00; baseline and differential.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0034672; P:anterior/posterior pattern specification involved in pronephros development; IGI:ZFIN.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00086; homeodomain; 1.
InterPro; IPR006899; HNF-1_N.
InterPro; IPR023219; HNF1_dimer_dom.
InterPro; IPR006897; HNF1b_C.
InterPro; IPR009057; Homeobox-like.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR010982; Lambda_DNA-bd_dom.
Pfam; PF04814; HNF-1_N; 1.
Pfam; PF04812; HNF-1B_C; 1.
Pfam; PF00046; Homeobox; 1.
SMART; SM00389; HOX; 1.
SUPFAM; SSF100957; SSF100957; 1.
SUPFAM; SSF46689; SSF46689; 1.
SUPFAM; SSF47413; SSF47413; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
2: Evidence at transcript level;
Activator; Complete proteome; Developmental protein; DNA-binding;
Homeobox; Nucleus; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 532 Hepatocyte nuclear factor 1-beta-B.
/FTId=PRO_0000389524.
DNA_BIND 244 324 Homeobox; HNF1-type.
{ECO:0000255|PROSITE-ProRule:PRU00108}.
REGION 1 35 Dimerization.
{ECO:0000250|UniProtKB:P15257}.
COMPBIAS 416 430 His-rich. {ECO:0000255}.
SEQUENCE 532 AA; 58320 MW; 88045D5D6510A799 CRC64;
MFTDMVSKLT SLQQELLSAL LDSGVTKDVL VQALEDLCPC PAEFGIKIEK PLSPSSANGG
SDCGDSKPVF LTLTGAQGKG GKLSGDEGSE DGDDFDTPPI LRELQSLNTE EAAEQRAEVD
RMLSEDPWRV ARTIKGYMQQ HNIPQREVVD VTGLNQSHLS QHLNKGTPMK TAKRAALYTW
YVQKQREIDR QFDRVQGSDP SDSASQDQVL FFFPEFNHGG HSSGAAGGSG AAVGDEGEPG
SKRMRRNRFK WGPASQEILY QAYERQKNPS KEEREALVEE CNRAECVQRG VSPSKAHGLG
SNLVTEVRVY NWFANRRKEE AFRQKLAMDT YTPHMNPLLS HTASLSHHHS SESKLRYSQQ
AASEVTSSTT ISHPSVLQQV SPGGLDHCHG LLSTDAKMIS VSGGVLPPVS TLTNIHSLSQ
SSHHHHHHHH QQAQSLIMSL AAQSLTSPQS QSVPVINSVS GLTTLQPMQF PQSSSLTQLT
TAHISQQPFA QSHMYSPKQE AGQFSHPSRY STMDSSTITH LGSSKQCPLQ AW


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