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Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2)

 FOXA2_MOUSE             Reviewed;         459 AA.
P35583; A2AR89; Q60602;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
22-NOV-2017, entry version 161.
RecName: Full=Hepatocyte nuclear factor 3-beta;
Short=HNF-3-beta;
Short=HNF-3B;
AltName: Full=Forkhead box protein A2;
Name=Foxa2; Synonyms=Hnf3b, Tcf-3b, Tcf3b;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8034310; DOI=10.1006/geno.1994.1191;
Kaestner K., Hiemisch H., Luckow B., Schuetz G.;
"The HNF-3 gene family of transcription factors in mice: gene
structure, cDNA sequence, and mRNA distribution.";
Genomics 20:377-385(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8375339;
Sasaki H., Hogan B.L.;
"Differential expression of multiple fork head related genes during
gastrulation and axial pattern formation in the mouse embryo.";
Development 118:47-59(1993).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 201-459.
PubMed=8306889;
Ang S.-L., Wierda A., Wong D., Stevens K.A., Cascio S., Rossant J.,
Zaret K.S.;
"The formation and maintenance of the definitive endoderm lineage in
the mouse: involvement of HNF3/forkhead proteins.";
Development 119:1301-1315(1993).
[5]
DISRUPTION PHENOTYPE, AND FUNCTION IN NOTOCHORD FORMATION.
PubMed=8069909; DOI=10.1016/0092-8674(94)90522-3;
Ang S.L., Rossant J.;
"HNF-3 beta is essential for node and notochord formation in mouse
development.";
Cell 78:561-574(1994).
[6]
DISRUPTION PHENOTYPE, AND FUNCTION.
PubMed=11445544; DOI=10.1101/gad.901601;
Sund N.J., Vatamaniuk M.Z., Casey M., Ang S.L., Magnuson M.A.,
Stoffers D.A., Matschinsky F.M., Kaestner K.H.;
"Tissue-specific deletion of Foxa2 in pancreatic beta cells results in
hyperinsulinemic hypoglycemia.";
Genes Dev. 15:1706-1715(2001).
[7]
FUNCTION IN REGULATION OF GLUCOSE HOMEOSTASIS.
PubMed=11875061; DOI=10.1074/jbc.M111037200;
Wang H., Gauthier B.R., Hagenfeldt-Johansson K.A., Iezzi M.,
Wollheim C.B.;
"Foxa2 (HNF3beta) controls multiple genes implicated in metabolism-
secretion coupling of glucose-induced insulin release.";
J. Biol. Chem. 277:17564-17570(2002).
[8]
INTERACTION WITH AKT1.
PubMed=14500912; DOI=10.1073/pnas.1931483100;
Wolfrum C., Besser D., Luca E., Stoffel M.;
"Insulin regulates the activity of forkhead transcription factor Hnf-
3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic
localization.";
Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003).
[9]
PHOSPHORYLATION AT THR-156, SUBCELLULAR LOCATION, AND FUNCTION IN
REGULATION OF LIPID METABOLISM AND KETOGENESIS.
PubMed=15616563; DOI=10.1038/nature03047;
Wolfrum C., Asilmaz E., Luca E., Friedman J.M., Stoffel M.;
"Foxa2 regulates lipid metabolism and ketogenesis in the liver during
fasting and in diabetes.";
Nature 432:1027-1032(2004).
[10]
FUNCTION IN LUNG DEVELOPMENT.
PubMed=15668254; DOI=10.1074/jbc.M414122200;
Wan H., Dingle S., Xu Y., Besnard V., Kaestner K.H., Ang S.L.,
Wert S., Stahlman M.T., Whitsett J.A.;
"Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.";
J. Biol. Chem. 280:13809-13816(2005).
[11]
FUNCTION IN LIVER DEVELOPMENT.
PubMed=15959514; DOI=10.1038/nature03649;
Lee C.S., Friedman J.R., Fulmer J.T., Kaestner K.H.;
"The initiation of liver development is dependent on Foxa
transcription factors.";
Nature 435:944-947(2005).
[12]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=16740652; DOI=10.1210/me.2006-0008;
Yu X., Suzuki K., Wang Y., Gupta A., Jin R., Orgebin-Crist M.C.,
Matusik R.;
"The role of forkhead box A2 to restrict androgen-regulated gene
expression of lipocalin 5 in the mouse epididymis.";
Mol. Endocrinol. 20:2418-2431(2006).
[13]
FUNCTION IN NEURON DEVELOPMENT.
PubMed=17596284; DOI=10.1242/dev.000141;
Ferri A.L., Lin W., Mavromatakis Y.E., Wang J.C., Sasaki H.,
Whitsett J.A., Ang S.L.;
"Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic
neuron development in a dosage-dependent manner.";
Development 134:2761-2769(2007).
[14]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[15]
FUNCTION.
PubMed=18336786; DOI=10.1016/j.bbrc.2008.02.158;
van der Sluis M., Vincent A., Bouma J., Korteland-Van Male A.,
van Goudoever J.B., Renes I.B., Van Seuningen I.;
"Forkhead box transcription factors Foxa1 and Foxa2 are important
regulators of Muc2 mucin expression in intestinal epithelial cells.";
Biochem. Biophys. Res. Commun. 369:1108-1113(2008).
[16]
FUNCTION IN PANCREAS DEVELOPMENT.
PubMed=19141476; DOI=10.1101/gad.1752608;
Gao N., LeLay J., Vatamaniuk M.Z., Rieck S., Friedman J.R.,
Kaestner K.H.;
"Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential
for pancreas development.";
Genes Dev. 22:3435-3448(2008).
[17]
FUNCTION IN BILE DUCT DEVELOPMENT.
PubMed=19436110; DOI=10.1172/JCI38201;
Li Z., White P., Tuteja G., Rubins N., Sackett S., Kaestner K.H.;
"Foxa1 and Foxa2 regulate bile duct development in mice.";
J. Clin. Invest. 119:1537-1545(2009).
[18]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver, Lung, and Pancreas;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Transcription factor that is involved in embryonic
development, establishment of tissue-specific gene expression and
regulation of gene expression in differentiated tissues. Is
thought to act as a 'pioneer' factor opening the compacted
chromatin for other proteins through interactions with nucleosomal
core histones and thereby replacing linker histones at target
enhancer and/or promoter sites. Binds DNA with the consensus
sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity).
In embryonic development is required for notochord formation.
Involved in the development of multiple endoderm-derived organ
systems such as the liver, pancreas and lungs; Foxa1 and Foxa2
seem to have at least in part redundant roles. FOXA1 and FOXA2 are
essential for hepatic specification. FOXA1 and FOXA2 are required
for morphogenesis and cell differentiation during formation of the
lung. FOXA1 and FOXA2 are involved in bile duct formation; they
positively regulate the binding glucocorticoid receptor/NR3C1 to
the IL6 promoter. FOXA1 and FOXA2 regulate multiple phases of
midbrain dopaminergic neuron development; they regulate expression
of NEUROG2 at the beginning of mDA neurogenesis and of NR4A2 and
EN1 in immature mDA neurons. Modulates the transcriptional
activity of nuclear hormone receptors; inhibits AR-mediated
transcription from the LCN5 promoter. Binds to fibrinogen beta
promoter and is involved in IL6-induced fibrinogen beta
transcriptional activation. Originally described as a
transcription activator for a number of liver genes such as AFP,
albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the
cis-acting regulatory regions of these genes. Involved in glucose
homeostasis; regulates the expression of genes important for
glucose sensing in pancreatic beta-cells and glucose homeostasis.
In pancreatic beta cells activates transcription of potassium
channel subunits KCNJ11 and ABCC8. Involved in regulation of fat
metabolism; activates transcriptional programs of lipid metabolism
and ketogenesis at low insulin state. Involved in transcriptional
regulation of MUC2 in the intestine. {ECO:0000250,
ECO:0000269|PubMed:11445544, ECO:0000269|PubMed:11875061,
ECO:0000269|PubMed:15616563, ECO:0000269|PubMed:15668254,
ECO:0000269|PubMed:15959514, ECO:0000269|PubMed:16740652,
ECO:0000269|PubMed:17596284, ECO:0000269|PubMed:18336786,
ECO:0000269|PubMed:19141476, ECO:0000269|PubMed:19436110,
ECO:0000269|PubMed:8069909}.
-!- SUBUNIT: Binds DNA as a monomer. Binds TLE1. Interacts with FOXA1
and FOXA3. Interacts with PRKDC (By similarity). {ECO:0000250}.
-!- INTERACTION:
Q61221:Hif1a; NbExp=5; IntAct=EBI-2893341, EBI-298954;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00089, ECO:0000269|PubMed:15616563}. Cytoplasm
{ECO:0000269|PubMed:15616563}. Note=Shuttles between the nucleus
and cytoplasm in a CRM1-dependent manner; in response to insulin
signaling via AKT1 is exported from the nucleus.
-!- TISSUE SPECIFICITY: Restricted mainly to endoderm-derived tissues
(lung, liver, stomach, and small intestine). Expressed in
epididymis with region-specific expression pattern: no expression
is observed in initial segment, low expression in proximal caput,
gradiently higher levels of expression in middle and distal caput
and highest level in corpus and cauda (at protein level).
{ECO:0000269|PubMed:16740652}.
-!- DEVELOPMENTAL STAGE: Most abundant in midgestation embryos (day
9.5).
-!- PTM: Phosphorylation on Thr-156 abolishes binding to target
promoters and subsequent transcription activation upon insulin
stimulation. {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Embryonic lethal; absence of organized node
and notochord formation, which leads to secondary defects in
dorsal-ventral patterning of the neural tube. Mice deficient for
Fox1a and deficient for Foxa2 in the endoderm from E8.5 onwards do
not show hepatic bud formation. Mice deficient for Fox1a and
deficient for Foxa2 in the midbrain from E10.5 onwards show almost
complete loss of mDA neurons. Mice deficient for Fox1a and
deficient for Foxa2 in the embryonic liver show hyperplasia of the
biliary tree due to at least in part activation of IL-6
expression, a proliferative signal for cholangiocytes. Mice
deficient for Fox2a in pancreatic beta cell show hypoglycemia and
disorganized islets arrangements. {ECO:0000269|PubMed:11445544,
ECO:0000269|PubMed:8069909}.
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EMBL; X74937; CAA52891.1; -; mRNA.
EMBL; L10409; AAA03161.1; -; mRNA.
EMBL; AL845297; CAM17482.1; -; Genomic_DNA.
EMBL; U04197; AAA03606.1; -; mRNA.
CCDS; CCDS16836.1; -.
PIR; B54258; B54258.
RefSeq; NP_001277994.1; NM_001291065.1.
RefSeq; NP_034576.2; NM_010446.3.
UniGene; Mm.938; -.
ProteinModelPortal; P35583; -.
SMR; P35583; -.
IntAct; P35583; 7.
STRING; 10090.ENSMUSP00000045918; -.
iPTMnet; P35583; -.
PhosphoSitePlus; P35583; -.
MaxQB; P35583; -.
PaxDb; P35583; -.
PRIDE; P35583; -.
DNASU; 15376; -.
Ensembl; ENSMUST00000047315; ENSMUSP00000045918; ENSMUSG00000037025.
GeneID; 15376; -.
KEGG; mmu:15376; -.
UCSC; uc008mtb.2; mouse.
CTD; 3170; -.
MGI; MGI:1347476; Foxa2.
eggNOG; KOG3563; Eukaryota.
eggNOG; COG5025; LUCA.
GeneTree; ENSGT00760000118904; -.
HOGENOM; HOG000231817; -.
HOVERGEN; HBG006621; -.
InParanoid; P35583; -.
KO; K08035; -.
TreeFam; TF316127; -.
PRO; PR:P35583; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000037025; -.
CleanEx; MM_FOXA2; -.
ExpressionAtlas; P35583; baseline and differential.
Genevisible; P35583; MM.
GO; GO:0030054; C:cell junction; ISO:MGI.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; ISO:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:MGI.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:MGI.
GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
GO; GO:0044212; F:transcription regulatory region DNA binding; ISO:MGI.
GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:MGI.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; IDA:MGI.
GO; GO:0008344; P:adult locomotory behavior; IMP:MGI.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IGI:MGI.
GO; GO:0009653; P:anatomical structure morphogenesis; IGI:MGI.
GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
GO; GO:0048468; P:cell development; IMP:MGI.
GO; GO:0021533; P:cell differentiation in hindbrain; IMP:MGI.
GO; GO:0001708; P:cell fate specification; IDA:MGI.
GO; GO:0061448; P:connective tissue development; IGI:MGI.
GO; GO:0016569; P:covalent chromatin modification; IEA:UniProtKB-KW.
GO; GO:0071542; P:dopaminergic neuron differentiation; IMP:MGI.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IDA:MGI.
GO; GO:0009953; P:dorsal/ventral pattern formation; IGI:MGI.
GO; GO:0001705; P:ectoderm formation; IGI:MGI.
GO; GO:0031018; P:endocrine pancreas development; IMP:MGI.
GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IGI:MGI.
GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
GO; GO:0030324; P:lung development; IGI:MGI.
GO; GO:0060487; P:lung epithelial cell differentiation; IGI:MGI.
GO; GO:2000971; P:negative regulation of detection of glucose; IDA:BHF-UCL.
GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; ISO:MGI.
GO; GO:0033132; P:negative regulation of glucokinase activity; IDA:BHF-UCL.
GO; GO:0045665; P:negative regulation of neuron differentiation; IGI:MGI.
GO; GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISO:MGI.
GO; GO:0000433; P:negative regulation of transcription from RNA polymerase II promoter by glucose; IDA:BHF-UCL.
GO; GO:0048665; P:neuron fate specification; IMP:MGI.
GO; GO:0007219; P:Notch signaling pathway; IDA:MGI.
GO; GO:0007389; P:pattern specification process; IGI:MGI.
GO; GO:0040019; P:positive regulation of embryonic development; IMP:UniProtKB.
GO; GO:2000543; P:positive regulation of gastrulation; IMP:UniProtKB.
GO; GO:0045666; P:positive regulation of neuron differentiation; IMP:MGI.
GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IGI:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0000432; P:positive regulation of transcription from RNA polymerase II promoter by glucose; IDA:BHF-UCL.
GO; GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter; IMP:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
GO; GO:0090009; P:primitive streak formation; IMP:UniProtKB.
GO; GO:0030193; P:regulation of blood coagulation; ISO:MGI.
GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
GO; GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; IDA:BHF-UCL.
GO; GO:0019216; P:regulation of lipid metabolic process; IDA:MGI.
GO; GO:0019218; P:regulation of steroid metabolic process; IDA:MGI.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISO:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI.
GO; GO:0070741; P:response to interleukin-6; TAS:UniProtKB.
GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IDA:MGI.
GO; GO:0032525; P:somite rostral/caudal axis specification; IMP:MGI.
CDD; cd00059; FH; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR013638; Fork-head_N.
InterPro; IPR001766; Fork_head_dom.
InterPro; IPR018533; Forkhead_box_C.
InterPro; IPR018122; TF_fork_head_CS_1.
InterPro; IPR030456; TF_fork_head_CS_2.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00250; Forkhead; 1.
Pfam; PF08430; Forkhead_N; 1.
Pfam; PF09354; HNF_C; 1.
PRINTS; PR00053; FORKHEAD.
SMART; SM00339; FH; 1.
SUPFAM; SSF46785; SSF46785; 1.
PROSITE; PS00657; FORK_HEAD_1; 1.
PROSITE; PS00658; FORK_HEAD_2; 1.
PROSITE; PS50039; FORK_HEAD_3; 1.
1: Evidence at protein level;
Activator; Chromatin regulator; Complete proteome; Cytoplasm;
Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 459 Hepatocyte nuclear factor 3-beta.
/FTId=PRO_0000091796.
DNA_BIND 159 252 Fork-head. {ECO:0000255|PROSITE-
ProRule:PRU00089}.
REGION 14 93 Transactivation domain 1. {ECO:0000250}.
REGION 362 459 Transactivation domain 2. {ECO:0000250}.
MOTIF 106 113 Nuclear localization signal.
{ECO:0000250}.
MOD_RES 156 156 Phosphothreonine.
{ECO:0000269|PubMed:15616563}.
MOD_RES 212 212 Phosphoserine.
{ECO:0000250|UniProtKB:P32182}.
MOD_RES 284 284 Phosphoserine.
{ECO:0000250|UniProtKB:P32182}.
MOD_RES 302 302 Phosphothreonine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 304 304 Phosphoserine.
{ECO:0000250|UniProtKB:Q9Y261}.
MOD_RES 307 307 Phosphoserine.
{ECO:0000250|UniProtKB:P32182}.
MOD_RES 308 308 Phosphoserine.
{ECO:0000250|UniProtKB:P32182}.
MOD_RES 310 310 Phosphoserine.
{ECO:0000250|UniProtKB:Q9Y261}.
MOD_RES 438 438 Phosphoserine.
{ECO:0000250|UniProtKB:P32182}.
MOD_RES 459 459 Phosphoserine.
{ECO:0000250|UniProtKB:P32182}.
CONFLICT 10 10 H -> L (in Ref. 1; CAA52891).
{ECO:0000305}.
CONFLICT 434 434 G -> S (in Ref. 4; AAA03606).
{ECO:0000305}.
SEQUENCE 459 AA; 48498 MW; 2F20F15AB372F557 CRC64;
MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA MGGGSGNMSA
GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM SGSAGAAGVA GMGPHLSPSL SPLGGQAAGA
MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML
TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG
NMFENGCYLR RQKRFKCEKQ LALKEAAGAA SSGGKKTAPG SQASQAQLGE AAGSASETPA
GTESPHSSAS PCQEHKRGGL SELKGAPASA LSPPEPAPSP GQQQQAAAHL LGPPHHPGLP
PEAHLKPEHH YAFNHPFSIN NLMSSEQQHH HSHHHHQPHK MDLKAYEQVM HYPGGYGSPM
PGSLAMGPVT NKAGLDASPL AADTSYYQGV YSRPIMNSS


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U2150p CLIA kit FPCB,FPC-binding protein,Hepatocyte nuclear factor 1-beta,HNF1B,HNF-1B,HNF-1-beta,Pig,Sus scrofa,TCF2,TCF-2,Transcription factor 2 96T
E2150p ELISA FPCB,FPC-binding protein,Hepatocyte nuclear factor 1-beta,HNF1B,HNF-1B,HNF-1-beta,Pig,Sus scrofa,TCF2,TCF-2,Transcription factor 2 96T
E2150p ELISA kit FPCB,FPC-binding protein,Hepatocyte nuclear factor 1-beta,HNF1B,HNF-1B,HNF-1-beta,Pig,Sus scrofa,TCF2,TCF-2,Transcription factor 2 96T
18-003-43076 Forkhead box protein I1 - Forkhead-related protein FKHL10; Forkhead-related transcription factor 6; FREAC-6; Hepatocyte nuclear factor 3 forkhead homolog 3; HNF-3_fork-head homolog 3; HFH-3 Polyclonal 0.05 mg Aff Pur
18-003-43387 Forkhead box protein Q1 - Hepatocyte nuclear factor 3 forkhead homolog 1; HNF-3_forkhead-like protein 1; HFH-1 Polyclonal 0.1 mg Protein A
E2150m ELISA Hepatocyte nuclear factor 1-beta,Hnf1b,HNF-1B,Hnf-1b,HNF-1-beta,Homeoprotein LFB3,Mouse,Mus musculus,Tcf2,TCF-2,Transcription factor 2 96T
U2150m CLIA Hepatocyte nuclear factor 1-beta,Hnf1b,HNF-1B,Hnf-1b,HNF-1-beta,Homeoprotein LFB3,Mouse,Mus musculus,Tcf2,TCF-2,Transcription factor 2 96T
E2150m ELISA kit Hepatocyte nuclear factor 1-beta,Hnf1b,HNF-1B,Hnf-1b,HNF-1-beta,Homeoprotein LFB3,Mouse,Mus musculus,Tcf2,TCF-2,Transcription factor 2 96T
U2150m CLIA kit Hepatocyte nuclear factor 1-beta,Hnf1b,HNF-1B,Hnf-1b,HNF-1-beta,Homeoprotein LFB3,Mouse,Mus musculus,Tcf2,TCF-2,Transcription factor 2 96T
EIAAB28851 Hepatocyte nuclear factor 6-beta,HNF6B,HNF-6-beta,Homo sapiens,Human,OC-2,One cut domain family member 2,One cut homeobox 2,ONECUT2,Transcription factor ONECUT-2
18-003-42184 Hepatocyte nuclear factor 1-beta - HNF-1beta; HNF-1B; Variant hepatic nuclear factor 1; VHNF1; Homeoprotein LFB3; Transcription factor 2; TCF-2 Polyclonal 0.05 mg Aff Pur
18-003-42183 Hepatocyte nuclear factor 1-beta - HNF-1beta; HNF-1B; Variant hepatic nuclear factor 1; VHNF1; Homeoprotein LFB3; Transcription factor 2; TCF-2 Polyclonal 0.1 mg Protein A
18-003-42183 Hepatocyte nuclear factor 1-beta - HNF-1beta; HNF-1B; Variant hepatic nuclear factor 1; VHNF1; Homeoprotein LFB3; Transcription factor 2; TCF-2 Polyclonal 0.05 mg Aff Pur


 

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