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Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1)

 HNF4A_XENLA             Reviewed;         464 AA.
Q91766; Q8AVK3;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
29-MAY-2007, sequence version 2.
22-NOV-2017, entry version 110.
RecName: Full=Hepatocyte nuclear factor 4-alpha;
Short=HNF-4-alpha;
AltName: Full=Nuclear receptor subfamily 2 group A member 1;
Name=hnf4a; Synonyms=hnf4, nr2a1;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8808405; DOI=10.1016/0925-4773(95)00460-2;
Holewa B., Pogge von Strandmann E., Zapp D., Lorenz P., Ryffel G.U.;
"Transcriptional hierarchy in Xenopus embryogenesis: HNF4 a maternal
factor involved in the developmental activation of the gene encoding
the tissue specific transcription factor HNF1 alpha (LFB1).";
Mech. Dev. 54:45-57(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Transcription factor; binds and activates the promoter
for the HNF1-alpha gene. Potential initiator of a transcriptional
cascade within a subset of cells committed to a specific
developmental program. Could be a determinant for asymmetry in
early development.
-!- SUBUNIT: Homodimerization is required for HNF4-alpha to bind to
its recognition site. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Expressed in liver and kidney.
-!- DEVELOPMENTAL STAGE: Maternal protein which is distributed within
an animal-to-vegetal gradient in the embryo. Present throughout
the entire development.
-!- MISCELLANEOUS: Binds fatty acids. {ECO:0000250}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAA85763.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; Z37526; CAA85763.1; ALT_INIT; mRNA.
EMBL; BC042224; AAH42224.1; -; mRNA.
RefSeq; NP_001080070.1; NM_001086601.1.
UniGene; Xl.1217; -.
ProteinModelPortal; Q91766; -.
SMR; Q91766; -.
GeneID; 379762; -.
KEGG; xla:379762; -.
CTD; 379762; -.
Xenbase; XB-GENE-864872; hnf4a.
HOVERGEN; HBG005606; -.
KO; K07292; -.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.565.10; -; 1.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR000003; Retinoid-X_rcpt/HNF4.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR00545; RETINOIDXR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
2: Evidence at transcript level;
Activator; DNA-binding; Metal-binding; Nucleus; Receptor;
Transcription; Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 464 Hepatocyte nuclear factor 4-alpha.
/FTId=PRO_0000053561.
DNA_BIND 57 132 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 60 80 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 96 120 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
CONFLICT 335 335 E -> D (in Ref. 2; AAH42224).
{ECO:0000305}.
SEQUENCE 464 AA; 51967 MW; B42ABD572989E484 CRC64;
MRLSKALIDM DMADYTEALD PAYTTLEFEN MQVLSIGTDT STSDVTSLSA SNSIGINSLC
AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR QCVVDKDKRN QCRYCRLKKC
FRAGMKKEAV QNERDRISTR RSSYEDSSLP SINVLIQAEV LSQQITSSVG VLNTDIRGKK
IACIIDVCDS MKQQLLVLVE WAKYIPAFCE LPLDDQVALL RAHAGEHLLL GATKRSMMFK
DILLLGNDRL IPRNCPELEV GRVAVRILDE LVLPFQELQI DDNEYACLKA IIFFDPDAKG
LSDPTKIKRM RYQVQVSLED YINDRQYDSR GRFGELLLLL PTLQSITWQM IEQIQFVKLF
GMAKIDNLLQ EMLLGGSANE ASHTHHHLHP HLVQDHLATN VIVANNTLPS QLHNGQMSTP
ETPQPSPPAG SGAEQYKIVH GTIASINKQP TSIPQSTITK QEAM


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