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Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1) (One cut homeobox 1)

 HNF6_MOUSE              Reviewed;         465 AA.
O08755;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
22-NOV-2017, entry version 156.
RecName: Full=Hepatocyte nuclear factor 6;
Short=HNF-6;
AltName: Full=One cut domain family member 1;
AltName: Full=One cut homeobox 1;
Name=Onecut1; Synonyms=Hnf6, Hnf6a;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=9441664; DOI=10.1006/dbio.1997.8744;
Rausa F., Samadani U., Ye H., Lim L., Fletcher C.F., Jenkins N.A.,
Copeland N.G., Costa R.H.;
"The cut-homeodomain transcriptional activator HNF-6 is coexpressed
with its target gene HNF-3 beta in the developing murine liver and
pancreas.";
Dev. Biol. 192:228-246(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
FUNCTION.
PubMed=15381696; DOI=10.1074/jbc.M409038200;
Pierreux C.E., Vanhorenbeeck V., Jacquemin P., Lemaigre F.P.,
Rousseau G.G.;
"The transcription factor hepatocyte nuclear factor-6/Onecut-1
controls the expression of its paralog Onecut-3 in developing mouse
endoderm.";
J. Biol. Chem. 279:51298-51304(2004).
[4]
STRUCTURE BY NMR OF 291-437, AND SUBUNIT.
PubMed=15169783; DOI=10.1074/jbc.M403805200;
Sheng W., Yan H., Rausa F.M. III, Costa R.H., Liao X.;
"Structure of the hepatocyte nuclear factor 6alpha and its interaction
with DNA.";
J. Biol. Chem. 279:33928-33936(2004).
-!- FUNCTION: Transcriptional activator. Binds the consensus sequence
5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those
of HNF3B and TTR. Important for liver genes transcription.
Stimulates the expression of Onecut3 in the developing endoderm.
{ECO:0000269|PubMed:15381696}.
-!- SUBUNIT: Binds DNA as a monomer. {ECO:0000269|PubMed:15169783}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the CUT homeobox family. {ECO:0000305}.
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EMBL; U95945; AAB53863.1; -; mRNA.
EMBL; BC024053; AAH24053.1; -; mRNA.
CCDS; CCDS23339.1; -.
RefSeq; NP_032288.1; NM_008262.3.
UniGene; Mm.303355; -.
PDB; 1S7E; NMR; -; A=291-437.
PDBsum; 1S7E; -.
ProteinModelPortal; O08755; -.
SMR; O08755; -.
STRING; 10090.ENSMUSP00000058020; -.
ChEMBL; CHEMBL2176818; -.
PhosphoSitePlus; O08755; -.
MaxQB; O08755; -.
PaxDb; O08755; -.
PeptideAtlas; O08755; -.
PRIDE; O08755; -.
Ensembl; ENSMUST00000056006; ENSMUSP00000058020; ENSMUSG00000043013.
GeneID; 15379; -.
KEGG; mmu:15379; -.
UCSC; uc009qrh.1; mouse.
CTD; 3175; -.
MGI; MGI:1196423; Onecut1.
eggNOG; KOG2252; Eukaryota.
eggNOG; ENOG410YWY4; LUCA.
GeneTree; ENSGT00530000063019; -.
HOGENOM; HOG000232114; -.
HOVERGEN; HBG005981; -.
InParanoid; O08755; -.
KO; K08026; -.
OMA; QMEEVNT; -.
OrthoDB; EOG091G0E7H; -.
PhylomeDB; O08755; -.
TreeFam; TF318206; -.
EvolutionaryTrace; O08755; -.
PRO; PR:O08755; -.
Proteomes; UP000000589; Chromosome 9.
Bgee; ENSMUSG00000043013; -.
CleanEx; MM_ONECUT1; -.
Genevisible; O08755; MM.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:MGI.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; IDA:MGI.
GO; GO:0009653; P:anatomical structure morphogenesis; IMP:MGI.
GO; GO:0030183; P:B cell differentiation; IMP:MGI.
GO; GO:0030154; P:cell differentiation; IMP:MGI.
GO; GO:0045165; P:cell fate commitment; IGI:MGI.
GO; GO:0060271; P:cilium assembly; IMP:MGI.
GO; GO:0031018; P:endocrine pancreas development; IGI:MGI.
GO; GO:0007492; P:endoderm development; IMP:MGI.
GO; GO:0002064; P:epithelial cell development; IMP:MGI.
GO; GO:0006006; P:glucose metabolic process; IMP:MGI.
GO; GO:0001889; P:liver development; IGI:MGI.
GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IGI:MGI.
GO; GO:0007219; P:Notch signaling pathway; IDA:MGI.
GO; GO:0031016; P:pancreas development; IMP:MGI.
GO; GO:0030335; P:positive regulation of cell migration; IGI:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0001952; P:regulation of cell-matrix adhesion; IGI:MGI.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:MGI.
GO; GO:0048536; P:spleen development; IMP:MGI.
CDD; cd00086; homeodomain; 1.
InterPro; IPR003350; CUT_dom.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
Pfam; PF02376; CUT; 1.
Pfam; PF00046; Homeobox; 1.
SMART; SM01109; CUT; 1.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
SUPFAM; SSF47413; SSF47413; 1.
PROSITE; PS51042; CUT; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
3D-structure; Activator; Complete proteome; DNA-binding; Homeobox;
Nucleus; Reference proteome; Transcription; Transcription regulation.
CHAIN 1 465 Hepatocyte nuclear factor 6.
/FTId=PRO_0000202403.
DNA_BIND 283 369 CUT. {ECO:0000255|PROSITE-
ProRule:PRU00374}.
DNA_BIND 385 444 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 69 72 Poly-His.
COMPBIAS 124 138 Poly-His.
COMPBIAS 450 460 Poly-Ser.
HELIX 295 305 {ECO:0000244|PDB:1S7E}.
HELIX 312 318 {ECO:0000244|PDB:1S7E}.
STRAND 320 322 {ECO:0000244|PDB:1S7E}.
HELIX 326 330 {ECO:0000244|PDB:1S7E}.
HELIX 344 355 {ECO:0000244|PDB:1S7E}.
STRAND 378 380 {ECO:0000244|PDB:1S7E}.
HELIX 394 403 {ECO:0000244|PDB:1S7E}.
HELIX 412 419 {ECO:0000244|PDB:1S7E}.
STRAND 424 426 {ECO:0000244|PDB:1S7E}.
HELIX 427 435 {ECO:0000244|PDB:1S7E}.
SEQUENCE 465 AA; 50952 MW; A770D27DD5AAC896 CRC64;
MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVGH RGSHLPPAHP RSMGMASLLD
GGSGGSDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP TTYTTLTPLQ PLPPISTVSD
KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT LMRDERGLAS MNNLYTPYHK DVAGMGQSLS
PLSGSGLGSI HNSQQGLPHY AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG
MVPINGLPPH HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR
ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM WKWLQEPEFQ
RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL HAIFKENKRP SKELQITISQ
QLGLELSTVS NFFMNARRRS LDKWQDEGGS NSGSSSSSSS TCTKA


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