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Hepatoma-derived growth factor-related protein 3 (HRP-3)

 HDGR3_RAT               Reviewed;         202 AA.
Q923W4;
21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
30-AUG-2017, entry version 80.
RecName: Full=Hepatoma-derived growth factor-related protein 3;
Short=HRP-3;
Name=Hdgfl3; Synonyms=Hdgfrp3, Hrp3;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Yu L.;
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121; SER-122 AND
SER-161, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Enhances DNA synthesis and may play a role in cell
proliferation. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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EMBL; AF389347; AAK72965.1; -; mRNA.
RefSeq; NP_665728.1; NM_145785.1.
UniGene; Rn.17383; -.
ProteinModelPortal; Q923W4; -.
SMR; Q923W4; -.
BioGrid; 251682; 1.
STRING; 10116.ENSRNOP00000026754; -.
iPTMnet; Q923W4; -.
PhosphoSitePlus; Q923W4; -.
PaxDb; Q923W4; -.
Ensembl; ENSRNOT00000026754; ENSRNOP00000026754; ENSRNOG00000019740.
GeneID; 252941; -.
KEGG; rno:252941; -.
UCSC; RGD:628773; rat.
CTD; 50810; -.
RGD; 628773; Hdgfrp3.
eggNOG; ENOG410KCQ5; Eukaryota.
eggNOG; ENOG41127WD; LUCA.
GeneTree; ENSGT00530000063013; -.
HOGENOM; HOG000112874; -.
HOVERGEN; HBG010574; -.
InParanoid; Q923W4; -.
OMA; FTGYQAM; -.
OrthoDB; EOG091G045X; -.
PhylomeDB; Q923W4; -.
PRO; PR:Q923W4; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000019740; -.
Genevisible; Q923W4; RN.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
GO; GO:0046785; P:microtubule polymerization; ISS:UniProtKB.
GO; GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.
GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
CDD; cd05834; HDGF_related; 1.
InterPro; IPR035496; HDGF-rel_PWWP.
InterPro; IPR000313; PWWP_dom.
Pfam; PF00855; PWWP; 1.
SMART; SM00293; PWWP; 1.
PROSITE; PS50812; PWWP; 1.
1: Evidence at protein level;
Complete proteome; Growth factor; Nucleus; Phosphoprotein;
Reference proteome.
CHAIN 1 202 Hepatoma-derived growth factor-related
protein 3.
/FTId=PRO_0000191705.
DOMAIN 11 68 PWWP. {ECO:0000255|PROSITE-
ProRule:PRU00162}.
MOTIF 135 147 Nuclear localization signal.
{ECO:0000255}.
MOD_RES 110 110 Phosphothreonine.
{ECO:0000250|UniProtKB:Q9JMG7}.
MOD_RES 121 121 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 122 122 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 161 161 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
SEQUENCE 202 AA; 22447 MW; FCCDEBBD2BEAB8D6 CRC64;
MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG THETAFLGPK
DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ TIQQQSSSET EGEGGNTADA
SSEEEGDRVE DGKGKRKNEK GGSKRKKSYT SKKSSKQSRK SPGDEDDKDC KEEENKSSSE
GGDAGNDTRN TTSDLQKAGE GT


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