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Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma-derived growth factor 2) (HDGF-2)

 HDGR3_HUMAN             Reviewed;         203 AA.
Q9Y3E1;
21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
22-NOV-2017, entry version 132.
RecName: Full=Hepatoma-derived growth factor-related protein 3;
Short=HRP-3;
AltName: Full=Hepatoma-derived growth factor 2;
Short=HDGF-2;
Name=HDGFL3 {ECO:0000312|HGNC:HGNC:24937}; Synonyms=HDGF2, HDGFRP3;
ORFNames=CGI-142;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
TISSUE=Lymphocyte;
PubMed=10581169; DOI=10.1006/bbrc.1999.1733;
Ikegame K., Yamamoto M., Kishima Y., Enomoto H., Yoshida K.,
Suemura M., Kishimoto T., Nakamura H.;
"A new member of a hepatoma-derived growth factor gene family can
translocate to the nucleus.";
Biochem. Biophys. Res. Commun. 266:81-87(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Yu L., Fu Q., Tu Q.;
"Cloning of a novel human cDNA which is a homolog to mouse hepatoma-
derived growth factor (mHDGF) and termed hHDGF2.";
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=10810093; DOI=10.1101/gr.10.5.703;
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
"Identification of novel human genes evolutionarily conserved in
Caenorhabditis elegans by comparative proteomics.";
Genome Res. 10:703-713(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Teratocarcinoma;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Uterus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21406692; DOI=10.1126/scisignal.2001570;
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
Blagoev B.;
"System-wide temporal characterization of the proteome and
phosphoproteome of human embryonic stem cell differentiation.";
Sci. Signal. 4:RS3-RS3(2011).
-!- FUNCTION: Enhances DNA synthesis and may play a role in cell
proliferation. {ECO:0000269|PubMed:10581169}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10581169}.
-!- TISSUE SPECIFICITY: Detected in testis, heart, spinal cord and
brain. {ECO:0000269|PubMed:10581169}.
-!- SIMILARITY: Belongs to the HDGF family. {ECO:0000305}.
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EMBL; AB029156; BAA90477.1; -; mRNA.
EMBL; AF110642; AAM27001.1; -; mRNA.
EMBL; AF151900; AAD34137.1; -; mRNA.
EMBL; AK001280; BAA91597.1; -; mRNA.
EMBL; BC015483; AAH15483.1; -; mRNA.
CCDS; CCDS32314.1; -.
PIR; JC7163; JC7163.
RefSeq; NP_057157.1; NM_016073.3.
UniGene; Hs.513954; -.
ProteinModelPortal; Q9Y3E1; -.
SMR; Q9Y3E1; -.
BioGrid; 119129; 20.
IntAct; Q9Y3E1; 4.
iPTMnet; Q9Y3E1; -.
PhosphoSitePlus; Q9Y3E1; -.
BioMuta; HDGFRP3; -.
DMDM; 68052386; -.
EPD; Q9Y3E1; -.
MaxQB; Q9Y3E1; -.
PaxDb; Q9Y3E1; -.
PeptideAtlas; Q9Y3E1; -.
PRIDE; Q9Y3E1; -.
TopDownProteomics; Q9Y3E1; -.
DNASU; 50810; -.
Ensembl; ENST00000299633; ENSP00000299633; ENSG00000166503.
GeneID; 50810; -.
KEGG; hsa:50810; -.
UCSC; uc002bjs.3; human.
CTD; 50810; -.
DisGeNET; 50810; -.
EuPathDB; HostDB:ENSG00000166503.8; -.
GeneCards; HDGFL3; -.
HGNC; HGNC:24937; HDGFL3.
HPA; HPA040719; -.
neXtProt; NX_Q9Y3E1; -.
OpenTargets; ENSG00000166503; -.
eggNOG; ENOG410IMJ2; Eukaryota.
eggNOG; ENOG41127WD; LUCA.
GeneTree; ENSGT00530000063013; -.
HOGENOM; HOG000112874; -.
HOVERGEN; HBG010574; -.
InParanoid; Q9Y3E1; -.
OMA; FTGYQAM; -.
OrthoDB; EOG091G045X; -.
PhylomeDB; Q9Y3E1; -.
ChiTaRS; HDGFRP3; human.
GeneWiki; HDGFRP3; -.
GenomeRNAi; 50810; -.
PRO; PR:Q9Y3E1; -.
Proteomes; UP000005640; Chromosome 15.
Bgee; ENSG00000166503; -.
ExpressionAtlas; Q9Y3E1; baseline and differential.
Genevisible; Q9Y3E1; HS.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0005576; C:extracellular region; IDA:BHF-UCL.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
GO; GO:0008283; P:cell proliferation; NAS:UniProtKB.
GO; GO:0046785; P:microtubule polymerization; ISS:UniProtKB.
GO; GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.
GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
CDD; cd05834; HDGF_related; 1.
InterPro; IPR035496; HDGF-rel_PWWP.
InterPro; IPR000313; PWWP_dom.
Pfam; PF00855; PWWP; 1.
SMART; SM00293; PWWP; 1.
PROSITE; PS50812; PWWP; 1.
1: Evidence at protein level;
Complete proteome; Growth factor; Nucleus; Phosphoprotein;
Reference proteome.
CHAIN 1 203 Hepatoma-derived growth factor-related
protein 3.
/FTId=PRO_0000191703.
DOMAIN 11 68 PWWP. {ECO:0000255|PROSITE-
ProRule:PRU00162}.
MOTIF 136 148 Nuclear localization signal.
{ECO:0000255}.
MOD_RES 110 110 Phosphothreonine.
{ECO:0000250|UniProtKB:Q9JMG7}.
MOD_RES 121 121 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JMG7}.
MOD_RES 122 122 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JMG7}.
MOD_RES 162 162 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
SEQUENCE 203 AA; 22620 MW; 0B660D665F01659C CRC64;
MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG THETAFLGPK
DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ AIQQQSSSET EGEGGNTADA
SSEEEGDRVE EDGKGKRKNE KAGSKRKKSY TSKKSSKQSR KSPGDEDDKD CKEEENKSSS
EGGDAGNDTR NTTSDLQKTS EGT


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