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Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1)

 ROA1_CAEEL              Reviewed;         346 AA.
Q22037; Q336L3; Q336L4; Q95X69;
25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
07-JUN-2017, entry version 121.
RecName: Full=Heterogeneous nuclear ribonucleoprotein A1;
Short=hnRNP A1;
Name=hrp-1 {ECO:0000312|WormBase:F42A6.7a};
Synonyms=rbp-1 {ECO:0000312|EMBL:BAA01645.1}; ORFNames=F42A6.7;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1] {ECO:0000305, ECO:0000312|EMBL:BAA01645.1}
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
STRAIN=Bristol N2 {ECO:0000312|EMBL:BAA01645.1};
PubMed=1354852; DOI=10.1093/nar/20.15.4001;
Iwasaki M., Okumura K., Kondo Y., Igarashi H., Tanaka T.;
"cDNA cloning of a novel heterogeneous nuclear ribonucleoprotein gene
homologue in Caenorhabditis elegans using hamster prion protein cDNA
as a hybridisation probe.";
Nucleic Acids Res. 20:4001-4007(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
SPLICING.
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3] {ECO:0000305}
PROTEIN SEQUENCE OF 8-61; 65-91; 116-136; 143-149; 156-175; 189-197
AND 217-235 (ISOFORM A), AND IDENTIFICATION BY MASS SPECTROMETRY.
Bienvenut W.V.;
Submitted (SEP-2005) to UniProtKB.
[4]
FUNCTION, AND TELOMERE-BINDING.
PubMed=15122256; DOI=10.1038/ng1356;
Joeng K.S., Song E.J., Lee K.-J., Lee J.;
"Long lifespan in worms with long telomeric DNA.";
Nat. Genet. 36:607-611(2004).
-!- FUNCTION: This protein is a component of ribonucleosomes.
Overexpression gradually increases telomere length, leading to
increase lifespan. {ECO:0000269|PubMed:15122256}.
-!- SUBCELLULAR LOCATION: Nucleus. Chromosome, telomere. Note=Binds to
telomeres.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=a {ECO:0000269|PubMed:1354852};
IsoId=Q22037-1; Sequence=Displayed;
Name=b {ECO:0000303|PubMed:9851916};
IsoId=Q22037-2; Sequence=VSP_051843, VSP_051844;
Note=No experimental confirmation available. {ECO:0000305};
Name=c;
IsoId=Q22037-3; Sequence=VSP_051843;
Note=No experimental confirmation available.;
Name=d;
IsoId=Q22037-4; Sequence=VSP_051844;
Note=No experimental confirmation available.;
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EMBL; D10877; BAA01645.1; -; mRNA.
EMBL; FO081370; CCD71134.1; -; Genomic_DNA.
EMBL; FO081370; CCD71135.1; -; Genomic_DNA.
EMBL; FO081370; CCD71136.1; -; Genomic_DNA.
EMBL; FO081370; CCD71137.1; -; Genomic_DNA.
PIR; S35500; S35500.
RefSeq; NP_001023199.1; NM_001028028.3. [Q22037-2]
RefSeq; NP_001040944.1; NM_001047479.3. [Q22037-3]
RefSeq; NP_001040945.1; NM_001047480.3. [Q22037-4]
RefSeq; NP_500326.2; NM_067925.8. [Q22037-1]
UniGene; Cel.7537; -.
ProteinModelPortal; Q22037; -.
SMR; Q22037; -.
IntAct; Q22037; 1.
STRING; 6239.F42A6.7d.1; -.
iPTMnet; Q22037; -.
EPD; Q22037; -.
PaxDb; Q22037; -.
PeptideAtlas; Q22037; -.
PRIDE; Q22037; -.
EnsemblMetazoa; F42A6.7a.1; F42A6.7a.1; WBGene00001999. [Q22037-1]
EnsemblMetazoa; F42A6.7a.2; F42A6.7a.2; WBGene00001999. [Q22037-1]
GeneID; 177101; -.
KEGG; cel:CELE_F42A6.7; -.
UCSC; F42A6.7a.1; c. elegans.
CTD; 177101; -.
WormBase; F42A6.7a; CE17059; WBGene00001999; hrp-1. [Q22037-1]
WormBase; F42A6.7b; CE31510; WBGene00001999; hrp-1. [Q22037-2]
WormBase; F42A6.7c; CE29317; WBGene00001999; hrp-1. [Q22037-3]
WormBase; F42A6.7d; CE39251; WBGene00001999; hrp-1. [Q22037-4]
eggNOG; KOG0118; Eukaryota.
eggNOG; COG0724; LUCA.
GeneTree; ENSGT00760000118873; -.
InParanoid; Q22037; -.
KO; K12741; -.
OMA; IMTDRNT; -.
PhylomeDB; Q22037; -.
PRO; PR:Q22037; -.
Proteomes; UP000001940; Chromosome IV.
Bgee; WBGene00001999; -.
GO; GO:0000781; C:chromosome, telomeric region; IDA:WormBase.
GO; GO:0030529; C:intracellular ribonucleoprotein complex; IEA:UniProtKB-KW.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003723; F:RNA binding; ISS:WormBase.
GO; GO:0031581; P:hemidesmosome assembly; IGI:WormBase.
GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:WormBase.
InterPro; IPR000504; RRM_dom.
Pfam; PF00076; RRM_1; 2.
SMART; SM00360; RRM; 2.
SUPFAM; SSF54928; SSF54928; 2.
PROSITE; PS50102; RRM; 2.
1: Evidence at protein level;
Alternative splicing; Chromosome; Complete proteome;
Direct protein sequencing; Nucleus; Reference proteome; Repeat;
Ribonucleoprotein; RNA-binding; Telomere.
CHAIN 1 346 Heterogeneous nuclear ribonucleoprotein
A1.
/FTId=PRO_0000081833.
DOMAIN 23 123 RRM 1. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
DOMAIN 114 191 RRM 2. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
COMPBIAS 208 342 Gln/Gly-rich. {ECO:0000255}.
VAR_SEQ 1 38 Missing (in isoform b and isoform c).
{ECO:0000305}.
/FTId=VSP_051843.
VAR_SEQ 255 255 D -> GN (in isoform b and isoform d).
{ECO:0000305}.
/FTId=VSP_051844.
SEQUENCE 346 AA; 36343 MW; 48B95818D8BB9A54 CRC64;
MTDVEIKAEN GSGDASLEPE NLRKIFVGGL TSNTTDDLMR EFYSQFGEIT DIIVMRDPTT
KRSRGFGFVT FSGKTEVDAA MKQRPHIIDG KTVDPKRAVP RDDKNRSESN VSTKRLYVSG
VREDHTEDML TEYFTKYGTV TKSEIILDKA TQKPRGFGFV TFDDHDSVDQ CVLQKSHMVN
GHRCDVRKGL SKDEMSKAQM NRDRETRGGR SRDGQRGGYN GGGGGGGGWG GPAQRGGPGA
YGGPGGGGQG GYGGDYGGGW GQQGGGGQGG WGGPQQQQGG GGWGQQGGGG QGGWGGPQQQ
QQGGWGGPQQ GGGGGGWGGQ GQQQGGWGGQ SGAQQWAHAQ GGNRNY


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