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High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor) (Ecotropic retrovirus receptor) (ERR) (Solute carrier family 7 member 1) (System Y basic amino acid transporter)

 CTR1_MOUSE              Reviewed;         622 AA.
Q09143; P30824;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
12-SEP-2018, entry version 151.
RecName: Full=High affinity cationic amino acid transporter 1;
Short=CAT-1 {ECO:0000250|UniProtKB:P30825};
Short=CAT1;
AltName: Full=Ecotropic retroviral leukemia receptor;
AltName: Full=Ecotropic retrovirus receptor {ECO:0000303|PubMed:2541919};
Short=ERR;
AltName: Full=Solute carrier family 7 member 1 {ECO:0000312|MGI:MGI:88117};
AltName: Full=System Y+ basic amino acid transporter;
Name=Slc7a1 {ECO:0000312|MGI:MGI:88117}; Synonyms=Atrc1, Rec-1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION (MICROBIAL INFECTION).
TISSUE=Fibroblast;
PubMed=2541919; DOI=10.1016/0092-8674(89)90134-7;
Albritton L.M., Tseng L., Scadden D., Cunningham J.M.;
"A putative murine ecotropic retrovirus receptor gene encodes a
multiple membrane-spanning protein and confers susceptibility to virus
infection.";
Cell 57:659-666(1989).
[2]
FUNCTION.
PubMed=1652100; DOI=10.1038/352725a0;
Kim J.W., Closs E.I., Albritton L.M., Cunningham J.M.;
"Transport of cationic amino acids by the mouse ecotropic retrovirus
receptor.";
Nature 352:725-728(1991).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-616, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[5]
SUBCELLULAR LOCATION.
PubMed=25683716; DOI=10.1016/j.celrep.2015.01.019;
Hlynialuk C.J., Ling B., Baker Z.N., Cobine P.A., Yu L.D., Boulet A.,
Wai T., Hossain A., El Zawily A.M., McFie P.J., Stone S.J., Diaz F.,
Moraes C.T., Viswanathan D., Petris M.J., Leary S.C.;
"The mitochondrial metallochaperone SCO1 is required to sustain
expression of the high-affinity copper transporter CTR1 and preserve
copper homeostasis.";
Cell Rep. 10:933-943(2015).
[6]
SUBCELLULAR LOCATION.
PubMed=28973536; DOI=10.1093/hmg/ddx344;
Baker Z.N., Jett K., Boulet A., Hossain A., Cobine P.A., Kim B.E.,
El Zawily A.M., Lee L., Tibbits G.F., Petris M.J., Leary S.C.;
"The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma
membrane to preserve copper homeostasis in the murine heart.";
Hum. Mol. Genet. 26:4617-4628(2017).
-!- FUNCTION: High-affinity, low capacity permease involved in the
transport of the cationic amino acids (arginine, lysine and
ornithine) in non-hepatic tissues. {ECO:0000269|PubMed:1652100}.
-!- FUNCTION: (Microbial infection) Acts as a receptor for the
ecotropic murine retroviral leukemia virus.
{ECO:0000269|PubMed:2541919}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25683716,
ECO:0000269|PubMed:28973536}; Multi-pass membrane protein
{ECO:0000255}. Note=In the absence of SCO1 in cardiomyocytes a
mislocalization to the cytoplasm is seen.
{ECO:0000269|PubMed:28973536}.
-!- TISSUE SPECIFICITY: Highest levels found in the testis and bone
marrow. Not found in the liver.
-!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3)
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M26687; AAA37574.1; -; mRNA.
CCDS; CCDS19882.1; -.
PIR; A32742; A32742.
RefSeq; NP_001288353.1; NM_001301424.1.
RefSeq; NP_031539.3; NM_007513.4.
RefSeq; XP_006504859.1; XM_006504796.1.
UniGene; Mm.275489; -.
ProteinModelPortal; Q09143; -.
IntAct; Q09143; 1.
STRING; 10090.ENSMUSP00000046714; -.
TCDB; 2.A.3.3.1; the amino acid-polyamine-organocation (apc) family.
iPTMnet; Q09143; -.
PhosphoSitePlus; Q09143; -.
SwissPalm; Q09143; -.
EPD; Q09143; -.
PaxDb; Q09143; -.
PeptideAtlas; Q09143; -.
PRIDE; Q09143; -.
Ensembl; ENSMUST00000048116; ENSMUSP00000046714; ENSMUSG00000041313.
GeneID; 11987; -.
KEGG; mmu:11987; -.
UCSC; uc009aos.2; mouse.
CTD; 6541; -.
MGI; MGI:88117; Slc7a1.
eggNOG; KOG1286; Eukaryota.
eggNOG; COG0531; LUCA.
GeneTree; ENSGT00760000119151; -.
HOGENOM; HOG000250623; -.
HOVERGEN; HBG000280; -.
InParanoid; Q09143; -.
KO; K13863; -.
OMA; TAYEMAN; -.
OrthoDB; EOG091G05NM; -.
PhylomeDB; Q09143; -.
TreeFam; TF315212; -.
Reactome; R-MMU-352230; Amino acid transport across the plasma membrane.
ChiTaRS; Slc7a1; mouse.
PRO; PR:Q09143; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000041313; Expressed in 253 organ(s), highest expression level in brain blood vessel.
ExpressionAtlas; Q09143; baseline and differential.
Genevisible; Q09143; MM.
GO; GO:0016021; C:integral component of membrane; IC:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0015181; F:arginine transmembrane transporter activity; IDA:MGI.
GO; GO:0015809; P:arginine transport; IDA:MGI.
GO; GO:0032006; P:regulation of TOR signaling; ISO:MGI.
InterPro; IPR002293; AA/rel_permease1.
InterPro; IPR004755; Cat_AA_permease.
InterPro; IPR029485; CAT_C.
Pfam; PF13520; AA_permease_2; 1.
Pfam; PF13906; AA_permease_C; 1.
PIRSF; PIRSF006060; AA_transporter; 1.
TIGRFAMs; TIGR00906; 2A0303; 1.
1: Evidence at protein level;
Amino-acid transport; Cell membrane; Complete proteome; Glycoprotein;
Membrane; Phosphoprotein; Receptor; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 622 High affinity cationic amino acid
transporter 1.
/FTId=PRO_0000054262.
TOPO_DOM 1 35 Cytoplasmic. {ECO:0000255}.
TRANSMEM 36 57 Helical. {ECO:0000255}.
TOPO_DOM 58 61 Extracellular. {ECO:0000255}.
TRANSMEM 62 82 Helical. {ECO:0000255}.
TOPO_DOM 83 102 Cytoplasmic. {ECO:0000255}.
TRANSMEM 103 123 Helical. {ECO:0000255}.
TOPO_DOM 124 162 Extracellular. {ECO:0000255}.
TRANSMEM 163 183 Helical. {ECO:0000255}.
TOPO_DOM 184 191 Cytoplasmic. {ECO:0000255}.
TRANSMEM 192 212 Helical. {ECO:0000255}.
TOPO_DOM 213 239 Extracellular. {ECO:0000255}.
TRANSMEM 240 260 Helical. {ECO:0000255}.
TOPO_DOM 261 280 Cytoplasmic. {ECO:0000255}.
TRANSMEM 281 300 Helical. {ECO:0000255}.
TOPO_DOM 301 330 Extracellular. {ECO:0000255}.
TRANSMEM 331 351 Helical. {ECO:0000255}.
TOPO_DOM 352 377 Cytoplasmic. {ECO:0000255}.
TRANSMEM 378 398 Helical. {ECO:0000255}.
TOPO_DOM 399 401 Extracellular. {ECO:0000255}.
TRANSMEM 402 422 Helical. {ECO:0000255}.
TOPO_DOM 423 485 Cytoplasmic. {ECO:0000255}.
TRANSMEM 486 506 Helical. {ECO:0000255}.
TOPO_DOM 507 519 Extracellular. {ECO:0000255}.
TRANSMEM 520 544 Helical. {ECO:0000255}.
TOPO_DOM 545 552 Cytoplasmic. {ECO:0000255}.
TRANSMEM 553 573 Helical. {ECO:0000255}.
TOPO_DOM 574 577 Extracellular. {ECO:0000255}.
TRANSMEM 578 598 Helical. {ECO:0000255}.
TOPO_DOM 599 622 Cytoplasmic. {ECO:0000255}.
MOD_RES 616 616 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
CARBOHYD 223 223 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 229 229 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 622 AA; 67092 MW; 157EE960CE737B6E CRC64;
MGCKNLLGLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV YVLAGAVARE
NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS
YIIGTSSVAR AWSATFDELI GKPIGEFSRQ HMALNAPGVL AQTPDIFAVI IIIILTGLLT
LGVKESAMVN KIFTCINVLV LCFIVVSGFV KGSIKNWQLT EKNFSCNNND TNVKYGEGGF
MPFGFSGVLS GAATCFYAFV GFDCIATTGE EVKNPQKAIP VGIVASLLIC FIAYFGVSAA
LTLMMPYFCL DIDSPLPGAF KHQGWEEAKY AVAIGSLCAL STSLLGSMFP MPRVIYAMAE
DGLLFKFLAK INNRTKTPVI ATVTSGAIAA VMAFLFELKD LVDLMSIGTL LAYSLVAACV
LVLRYQPEQP NLVYQMARTT EELDRVDQNE LVSASESQTG FLPVAEKFSL KSILSPKNVE
PSKFSGLIVN ISAGLLAALI ITVCIVAVLG REALAEGTLW AVFVMTGSVL LCMLVTGIIW
RQPESKTKLS FKVPFVPVLP VLSIFVNIYL MMQLDQGTWV RFAVWMLIGF TIYFGYGIWH
SEEASLAAGQ AKTPDSNLDQ CK


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