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High affinity choline transporter 1 (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7)

 SC5A7_RAT               Reviewed;         580 AA.
Q9JMD7;
07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
22-NOV-2017, entry version 92.
RecName: Full=High affinity choline transporter 1;
AltName: Full=Hemicholinium-3-sensitive choline transporter;
Short=CHT;
AltName: Full=Solute carrier family 5 member 7;
Name=Slc5a7; Synonyms=Cht1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
STRAIN=Wistar; TISSUE=Spinal cord;
PubMed=10649566; DOI=10.1038/72059;
Okuda T., Haga T., Kanai Y., Endou H., Ishihara T., Katsura I.;
"Identification and characterization of the high-affinity choline
transporter.";
Nat. Neurosci. 3:120-125(2000).
[2]
INTERACTION WITH SEC14L1, AND REGION.
PubMed=17092608; DOI=10.1016/j.neuint.2006.09.010;
Ribeiro F.M., Ferreira L.T., Marion S., Fontes S., Gomez M.,
Ferguson S.S., Prado M.A., Prado V.F.;
"SEC14-like protein 1 interacts with cholinergic transporters.";
Neurochem. Int. 50:356-364(2007).
-!- FUNCTION: Transmembrane transporter that imports choline from the
extracellular space to the neuron with high affinity. Choline
uptake is the rate-limiting step in acetylcholine synthesis.
Sodium ion- and chloride ion-dependent.
{ECO:0000269|PubMed:10649566}.
-!- SUBUNIT: Homooligomerizes at cell surface (By similarity).
Interacts with SEC14L1; may regulate SLC5A7 (PubMed:17092608).
{ECO:0000250|UniProtKB:Q9GZV3, ECO:0000269|PubMed:17092608}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9GZV3};
Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9GZV3}. Cell
membrane {ECO:0000250|UniProtKB:Q9GZV3}. Cell junction, synapse
{ECO:0000250|UniProtKB:Q9GZV3}. Note=Localized at the
neuromuscular junction. {ECO:0000250|UniProtKB:Q9GZV3}.
-!- TISSUE SPECIFICITY: Expressed in basal forebrain, brain stem,
spinal chord, and striatum. Specific for cholinergic neurons.
{ECO:0000269|PubMed:10649566}.
-!- PTM: Phosphorylated. {ECO:0000250}.
-!- MISCELLANEOUS: Specifically inhibited by nanomolar concentrations
of hemicholinium 3.
-!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC
2.A.21) family. {ECO:0000305}.
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EMBL; AB030947; BAA90484.1; -; mRNA.
RefSeq; NP_445973.1; NM_053521.1.
UniGene; Rn.44872; -.
STRING; 10116.ENSRNOP00000014548; -.
BindingDB; Q9JMD7; -.
ChEMBL; CHEMBL5797; -.
TCDB; 2.A.21.8.1; the solute:sodium symporter (sss) family.
iPTMnet; Q9JMD7; -.
PhosphoSitePlus; Q9JMD7; -.
PaxDb; Q9JMD7; -.
PRIDE; Q9JMD7; -.
GeneID; 85426; -.
KEGG; rno:85426; -.
UCSC; RGD:69270; rat.
CTD; 60482; -.
RGD; 69270; Slc5a7.
eggNOG; KOG3761; Eukaryota.
eggNOG; COG0591; LUCA.
HOGENOM; HOG000016386; -.
HOVERGEN; HBG054160; -.
InParanoid; Q9JMD7; -.
KO; K14387; -.
PhylomeDB; Q9JMD7; -.
PRO; PR:Q9JMD7; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0045334; C:clathrin-coated endocytic vesicle; IDA:RGD.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0005769; C:early endosome; IDA:RGD.
GO; GO:0016021; C:integral component of membrane; ISO:RGD.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0031594; C:neuromuscular junction; ISO:RGD.
GO; GO:0043025; C:neuronal cell body; ISO:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0005886; C:plasma membrane; ISO:RGD.
GO; GO:0044853; C:plasma membrane raft; IDA:RGD.
GO; GO:0045202; C:synapse; IDA:RGD.
GO; GO:0008021; C:synaptic vesicle; IDA:RGD.
GO; GO:0033265; F:choline binding; ISO:RGD.
GO; GO:0015220; F:choline transmembrane transporter activity; IMP:UniProtKB.
GO; GO:0005307; F:choline:sodium symporter activity; ISO:RGD.
GO; GO:0008292; P:acetylcholine biosynthetic process; IMP:UniProtKB.
GO; GO:0015871; P:choline transport; ISO:RGD.
GO; GO:0007274; P:neuromuscular synaptic transmission; ISO:RGD.
GO; GO:0007271; P:synaptic transmission, cholinergic; ISO:RGD.
InterPro; IPR001734; Na/solute_symporter.
Pfam; PF00474; SSF; 1.
PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
1: Evidence at protein level;
Cell junction; Cell membrane; Complete proteome; Glycoprotein;
Ion transport; Membrane; Neurotransmitter biosynthesis;
Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport;
Synapse; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 580 High affinity choline transporter 1.
/FTId=PRO_0000105393.
TOPO_DOM 1 6 Extracellular. {ECO:0000255}.
TRANSMEM 7 27 Helical. {ECO:0000255}.
TOPO_DOM 28 48 Cytoplasmic. {ECO:0000255}.
TRANSMEM 49 69 Helical. {ECO:0000255}.
TOPO_DOM 70 81 Extracellular. {ECO:0000255}.
TRANSMEM 82 102 Helical. {ECO:0000255}.
TOPO_DOM 103 125 Cytoplasmic. {ECO:0000255}.
TRANSMEM 126 146 Helical. {ECO:0000255}.
TOPO_DOM 147 164 Extracellular. {ECO:0000255}.
TRANSMEM 165 185 Helical. {ECO:0000255}.
TOPO_DOM 186 191 Cytoplasmic. {ECO:0000255}.
TRANSMEM 192 212 Helical. {ECO:0000255}.
TOPO_DOM 213 237 Extracellular. {ECO:0000255}.
TRANSMEM 238 258 Helical. {ECO:0000255}.
TOPO_DOM 259 274 Cytoplasmic. {ECO:0000255}.
TRANSMEM 275 295 Helical. {ECO:0000255}.
TOPO_DOM 296 317 Extracellular. {ECO:0000255}.
TRANSMEM 318 338 Helical. {ECO:0000255}.
TOPO_DOM 339 376 Cytoplasmic. {ECO:0000255}.
TRANSMEM 377 397 Helical. {ECO:0000255}.
TOPO_DOM 398 406 Extracellular. {ECO:0000255}.
TRANSMEM 407 427 Helical. {ECO:0000255}.
TOPO_DOM 428 435 Cytoplasmic. {ECO:0000255}.
TRANSMEM 436 456 Helical. {ECO:0000255}.
TOPO_DOM 457 481 Extracellular. {ECO:0000255}.
TRANSMEM 482 502 Helical. {ECO:0000255}.
TOPO_DOM 503 580 Cytoplasmic. {ECO:0000255}.
REGION 502 580 Mediates interaction with SEC14L1.
{ECO:0000269|PubMed:17092608}.
CARBOHYD 301 301 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 580 AA; 63407 MW; B7CB73323DAD17A7 CRC64;
MPFHVEGLVA IILFYLLIFL VGIWAAWKTK NSGNAEERSE AIIVGGRDIG LLVGGFTMTA
TWVGGGYING TAEAVYGPGC GLAWAQAPIG YSLSLILGGL FFAKPMRSKG YVTMLDPFQQ
IYGKRMGGLL FIPALMGEMF WAAAIFSALG ATISVIIDVD VNISVIVSAL IAILYTLVGG
LYSVAYTDVV QLFCIFIGLW ISVPFALSHP AVTDIGFTAV HAKYQSPWLG TIESVEVYTW
LDNFLLLMLG GIPWQAYFQR VLSSSSATYA QVLSFLAAFG CLVMALPAIC IGAIGASTDW
NQTAYGFPDP KTKEEADMIL PIVLQYLCPV YISFFGLGAV SAAVMSSADS SILSASSMFA
RNIYQLSFRQ NASDKEIVWV MRITVFVFGA SATAMALLTK TVYGLWYLSS DLVYIIIFPQ
LLCVLFIKGT NTYGAVAGYI FGLFLRITGG EPYLYLQPLI FYPGYYPDKN GIYNQRFPFK
TLSMVTSFFT NICVSYLAKY LFESGTLPPK LDIFDAVVSR HSEENMDKTI LVRNENIKLN
ELAPVKPRQS LTLSSTFTNK EALLDVDSSP EGSGTEDNLQ


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SLC5A7 SLC5A7 Gene solute carrier family 5 (choline transporter), member 7


 

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