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High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha)

 FCERA_MOUSE             Reviewed;         250 AA.
P20489; E9QLR4;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 2.
10-MAY-2017, entry version 145.
RecName: Full=High affinity immunoglobulin epsilon receptor subunit alpha;
AltName: Full=Fc-epsilon RI-alpha;
Short=FcERI;
AltName: Full=IgE Fc receptor subunit alpha;
Flags: Precursor;
Name=Fcer1a; Synonyms=Fce1a;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2527850;
Ra C., Jouvin M.H.E., Kinet J.-P.;
"Complete structure of the mouse mast cell receptor for IgE (Fc
epsilon RI) and surface expression of chimeric receptors (rat-mouse-
human) on transfected cells.";
J. Biol. Chem. 264:15323-15327(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 125-194.
PubMed=1839735;
Robertson M.W., Mehl V.S., Richards M.L., Liu F.T.;
"mRNA variants encoding multiple forms of the high-affinity IgE
receptor alpha subunit in transformed and nontransformed mast cells.";
Int. Arch. Allergy Appl. Immunol. 96:289-295(1991).
[4]
TISSUE SPECIFICITY, AND INDUCTION.
PubMed=17728245; DOI=10.1074/jbc.M705950200;
Ganguly S., Grodzki C., Sugden D., Moller M., Odom S., Gaildrat P.,
Gery I., Siraganian R.P., Rivera J., Klein D.C.;
"Neural adrenergic/cyclic AMP regulation of the immunoglobulin E
receptor alpha-subunit expression in the mammalian pinealocyte: a
neuroendocrine/immune response link?";
J. Biol. Chem. 282:32758-32764(2007).
-!- FUNCTION: Binds to the Fc region of immunoglobulins epsilon. High
affinity receptor. Responsible for initiating the allergic
response. Binding of allergen to receptor-bound IgE leads to cell
activation and the release of mediators (such as histamine)
responsible for the manifestations of allergy. The same receptor
also induces the secretion of important lymphokines.
-!- SUBUNIT: Tetramer of an alpha chain, a beta chain, and two
disulfide linked gamma chains.
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein.
-!- TISSUE SPECIFICITY: Expressed in bone marrow mast cells, as well
as in the pineal gland at night. {ECO:0000269|PubMed:17728245}.
-!- INDUCTION: Exhibits night/day variations with an increased
expression at night in the pineal gland.
{ECO:0000269|PubMed:17728245}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; J05018; AAA37600.1; -; mRNA.
EMBL; AC125268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS35788.1; -.
PIR; A34342; A34342.
RefSeq; NP_034314.2; NM_010184.2.
UniGene; Mm.5266; -.
ProteinModelPortal; P20489; -.
SMR; P20489; -.
STRING; 10090.ENSMUSP00000056882; -.
iPTMnet; P20489; -.
PhosphoSitePlus; P20489; -.
PaxDb; P20489; -.
PRIDE; P20489; -.
Ensembl; ENSMUST00000049706; ENSMUSP00000056882; ENSMUSG00000005339.
GeneID; 14125; -.
KEGG; mmu:14125; -.
UCSC; uc007dre.2; mouse.
CTD; 2205; -.
MGI; MGI:95494; Fcer1a.
eggNOG; ENOG410IJME; Eukaryota.
eggNOG; ENOG410ZPGM; LUCA.
GeneTree; ENSGT00760000119130; -.
HOGENOM; HOG000251632; -.
HOVERGEN; HBG051602; -.
InParanoid; P20489; -.
KO; K08089; -.
OMA; YENHNIS; -.
OrthoDB; EOG091G0ETN; -.
TreeFam; TF335097; -.
Reactome; R-MMU-2454202; Fc epsilon receptor (FCERI) signaling.
Reactome; R-MMU-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
Reactome; R-MMU-2871796; FCERI mediated MAPK activation.
Reactome; R-MMU-2871809; FCERI mediated Ca+2 mobilization.
Reactome; R-MMU-2871837; FCERI mediated NF-kB activation.
PRO; PR:P20489; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000005339; -.
ExpressionAtlas; P20489; baseline and differential.
Genevisible; P20489; MM.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0045121; C:membrane raft; TAS:MGI.
GO; GO:0019863; F:IgE binding; IDA:MGI.
GO; GO:0019767; F:IgE receptor activity; IDA:MGI.
GO; GO:0007257; P:activation of JUN kinase activity; IDA:MGI.
GO; GO:0000187; P:activation of MAPK activity; IDA:MGI.
GO; GO:0007166; P:cell surface receptor signaling pathway; IDA:MGI.
GO; GO:0019370; P:leukotriene biosynthetic process; IDA:MGI.
GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IDA:MGI.
GO; GO:0045425; P:positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; IDA:MGI.
GO; GO:0045401; P:positive regulation of interleukin-3 biosynthetic process; IDA:MGI.
GO; GO:0043306; P:positive regulation of mast cell degranulation; IDA:MGI.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI.
GO; GO:0001812; P:positive regulation of type I hypersensitivity; IMP:MGI.
GO; GO:0001820; P:serotonin secretion; IDA:MGI.
GO; GO:0007165; P:signal transduction; IDA:MGI.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
Pfam; PF13895; Ig_2; 1.
SMART; SM00409; IG; 2.
SUPFAM; SSF48726; SSF48726; 2.
PROSITE; PS50835; IG_LIKE; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
IgE-binding protein; Immunoglobulin domain; Membrane; Receptor;
Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 23
CHAIN 24 250 High affinity immunoglobulin epsilon
receptor subunit alpha.
/FTId=PRO_0000015162.
TOPO_DOM 24 204 Extracellular. {ECO:0000255}.
TRANSMEM 205 223 Helical. {ECO:0000255}.
TOPO_DOM 224 250 Cytoplasmic. {ECO:0000255}.
DOMAIN 28 104 Ig-like 1.
DOMAIN 114 181 Ig-like 2.
CARBOHYD 58 58 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 66 66 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 73 73 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 106 106 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 152 152 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 167 167 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 49 92 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 131 174 {ECO:0000255|PROSITE-ProRule:PRU00114}.
CONFLICT 121 121 V -> I (in Ref. 1; AAA37600).
{ECO:0000305}.
CONFLICT 182 182 K -> E (in Ref. 1; AAA37600).
{ECO:0000305}.
SEQUENCE 250 AA; 28657 MW; DDC9E2AD2CF42C54 CRC64;
MVTGRSAQLC LALLFMSLDV ILTATEKSVL TLDPPWIRIF TGEKVTLSCY GNNHLQMNST
TKWIHNGTVS EVNSSHLVIV SATVQDSGKY ICQKQGLFKS KPVYLNVTQD WLLLQTSADM
VLVHGSFDIR CHGWKNWNVR KVIYYRNDHA FNYSYESPVS IREATLNDSG TYHCKGYLRQ
VKYESDKFRI AVVKAYKCKY YWLQLIFPLL VAILFAVDTG LLLSTEEQFK SVLEIQKTGK
YKKVETELLT


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