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High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2)

 FCERB_RAT               Reviewed;         243 AA.
P13386;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
30-AUG-2017, entry version 133.
RecName: Full=High affinity immunoglobulin epsilon receptor subunit beta;
Short=FcERI;
AltName: Full=Fc epsilon receptor I beta-chain;
AltName: Full=IgE Fc receptor subunit beta;
AltName: Full=Membrane-spanning 4-domains subfamily A member 2;
Name=Ms4a2; Synonyms=Fce1b, Fcer1b;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 11-29; 37-43 AND
217-243.
PubMed=2970642; DOI=10.1073/pnas.85.17.6483;
Kinet J.-P., Blank U., Ra C., White K., Metzger H., Kochan J.;
"Isolation and characterization of cDNAs coding for the beta subunit
of the high-affinity receptor for immunoglobulin E.";
Proc. Natl. Acad. Sci. U.S.A. 85:6483-6487(1988).
[2]
INTERACTION WITH FGR, AND SUBCELLULAR LOCATION.
PubMed=21746961; DOI=10.4049/jimmunol.1100296;
Lee J.H., Kim J.W., Kim do K., Kim H.S., Park H.J., Park D.K.,
Kim A.R., Kim B., Beaven M.A., Park K.L., Kim Y.M., Choi W.S.;
"The Src family kinase Fgr is critical for activation of mast cells
and IgE-mediated anaphylaxis in mice.";
J. Immunol. 187:1807-1815(2011).
-!- FUNCTION: High affinity receptor that binds to the Fc region of
immunoglobulins epsilon. Aggregation of FCER1 by multivalent
antigens is required for the full mast cell response, including
the release of preformed mediators (such as histamine) by
degranulation and de novo production of lipid mediators and
cytokines. Also mediates the secretion of important lymphokines.
Binding of allergen to receptor-bound IgE leads to cell activation
and the release of mediators responsible for the manifestations of
allergy.
-!- SUBUNIT: Tetramer of an alpha chain, a beta chain, and two
disulfide linked gamma chains. Binds LILRB1. Interacts with
FES/FPS and LYN (By similarity). Interacts with FGR. {ECO:0000250,
ECO:0000269|PubMed:21746961}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:21746961};
Multi-pass membrane protein {ECO:0000269|PubMed:21746961}.
-!- PTM: Phosphorylated on tyrosine residues by LYN. {ECO:0000250}.
-!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M22923; AAA41149.1; -; mRNA.
PIR; A31231; A31231.
RefSeq; NP_036977.1; NM_012845.1.
UniGene; Rn.10922; -.
BioGrid; 247355; 4.
STRING; 10116.ENSRNOP00000028491; -.
iPTMnet; P13386; -.
PhosphoSitePlus; P13386; -.
PaxDb; P13386; -.
PRIDE; P13386; -.
GeneID; 25316; -.
KEGG; rno:25316; -.
UCSC; RGD:2598; rat.
CTD; 2206; -.
RGD; 2598; Ms4a2.
eggNOG; ENOG410J28C; Eukaryota.
eggNOG; ENOG4111DU9; LUCA.
HOGENOM; HOG000060211; -.
HOVERGEN; HBG051600; -.
InParanoid; P13386; -.
KO; K08090; -.
OrthoDB; EOG091G0IBB; -.
PhylomeDB; P13386; -.
TreeFam; TF335157; -.
PRO; PR:P13386; -.
Proteomes; UP000002494; Unplaced.
Genevisible; P13386; RN.
GO; GO:0005768; C:endosome; IDA:RGD.
GO; GO:0032998; C:Fc-epsilon receptor I complex; IEA:InterPro.
GO; GO:0005887; C:integral component of plasma membrane; IDA:RGD.
GO; GO:0045121; C:membrane raft; IDA:RGD.
GO; GO:0019863; F:IgE binding; IEA:UniProtKB-KW.
GO; GO:0051219; F:phosphoprotein binding; IPI:RGD.
GO; GO:0019901; F:protein kinase binding; IPI:RGD.
GO; GO:0042169; F:SH2 domain binding; IDA:RGD.
GO; GO:0007202; P:activation of phospholipase C activity; IDA:RGD.
GO; GO:0050663; P:cytokine secretion; IGI:RGD.
GO; GO:0038095; P:Fc-epsilon receptor signaling pathway; IEA:InterPro.
GO; GO:0006954; P:inflammatory response; IMP:RGD.
GO; GO:0043306; P:positive regulation of mast cell degranulation; IMP:RGD.
GO; GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IDA:RGD.
GO; GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; IGI:RGD.
GO; GO:0007165; P:signal transduction; IMP:RGD.
InterPro; IPR007237; CD20-like.
InterPro; IPR030417; MS4A.
InterPro; IPR030420; MS4A2.
PANTHER; PTHR23320; PTHR23320; 1.
PANTHER; PTHR23320:SF83; PTHR23320:SF83; 1.
Pfam; PF04103; CD20; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond;
IgE-binding protein; Membrane; Phosphoprotein; Receptor;
Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 243 High affinity immunoglobulin epsilon
receptor subunit beta.
/FTId=PRO_0000158631.
TOPO_DOM 1 59 Cytoplasmic. {ECO:0000255}.
TRANSMEM 60 79 Helical. {ECO:0000255}.
TOPO_DOM 80 97 Extracellular. {ECO:0000255}.
TRANSMEM 98 117 Helical. {ECO:0000255}.
TOPO_DOM 118 130 Cytoplasmic. {ECO:0000255}.
TRANSMEM 131 150 Helical. {ECO:0000255}.
TOPO_DOM 151 179 Extracellular. {ECO:0000255}.
TRANSMEM 180 199 Helical. {ECO:0000255}.
TOPO_DOM 200 243 Cytoplasmic. {ECO:0000255}.
MOD_RES 218 218 Phosphotyrosine.
{ECO:0000250|UniProtKB:P20490}.
MOD_RES 224 224 Phosphotyrosine.
{ECO:0000250|UniProtKB:P20490}.
MOD_RES 225 225 Phosphoserine.
{ECO:0000250|UniProtKB:P20490}.
MOD_RES 228 228 Phosphotyrosine.
{ECO:0000250|UniProtKB:P20490}.
SEQUENCE 243 AA; 26731 MW; 471DFA59B6688E5D CRC64;
MDTENKSRAD LALPNPQESP SAPDIELLEA SPPAKALPEK PASPPPQQTW QSFLKKELEF
LGVTQVLVGL ICLCFGTVVC STLQTSDFDD EVLLLYRAGY PFWGAVLFVL SGFLSIMSER
KNTLYLVRGS LGANIVSSIA AGLGIAILIL NLSNNSAYMN YCKDITEDDG CFVTSFITEL
VLMLLFLTIL AFCSAVLLII YRIGQEFERS KVPDDRLYEE LHVYSPIYSA LEDTREASAP
VVS


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