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High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (FcRgamma) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (FceRI gamma)

 FCERG_MOUSE             Reviewed;          86 AA.
P20491;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 1.
22-NOV-2017, entry version 147.
RecName: Full=High affinity immunoglobulin epsilon receptor subunit gamma;
AltName: Full=Fc receptor gamma-chain;
Short=FcRgamma;
AltName: Full=Fc-epsilon RI-gamma;
AltName: Full=IgE Fc receptor subunit gamma;
Short=FceRI gamma;
Flags: Precursor;
Name=Fcer1g; Synonyms=Fce1g;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2527850;
Ra C., Jouvin M.H.E., Kinet J.-P.;
"Complete structure of the mouse mast cell receptor for IgE (Fc
epsilon RI) and surface expression of chimeric receptors (rat-mouse-
human) on transfected cells.";
J. Biol. Chem. 264:15323-15327(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
FUNCTION IN ACTIVATION OF PLATELETS BY COLLAGEN, AND FUNCTION IN PLCG2
PHOSPHORYLATION.
PubMed=9171347; DOI=10.1093/emboj/16.9.2333;
Poole A., Gibbins J.M., Turner M., van Vugt M.J., van de Winkel J.G.,
Saito T., Tybulewicz V.L., Watson S.P.;
"The Fc receptor gamma-chain and the tyrosine kinase Syk are essential
for activation of mouse platelets by collagen.";
EMBO J. 16:2333-2341(1997).
[4]
INTERACTION WITH CLEC6A.
PubMed=17050534; DOI=10.1074/jbc.M606542200;
Sato K., Yang X.L., Yudate T., Chung J.S., Wu J., Luby-Phelps K.,
Kimberly R.P., Underhill D., Cruz P.D. Jr., Ariizumi K.;
"Dectin-2 is a pattern recognition receptor for fungi that couples
with the Fc receptor gamma chain to induce innate immune responses.";
J. Biol. Chem. 281:38854-38866(2006).
[5]
FUNCTION IN INTEGRIN-MEDIATED NEUTROPHIL ACTIVATION, AND INTERACTION
WITH SYK.
PubMed=17086186; DOI=10.1038/ni1407;
Mocsai A., Abram C.L., Jakus Z., Hu Y., Lanier L.L., Lowell C.A.;
"Integrin signaling in neutrophils and macrophages uses adaptors
containing immunoreceptor tyrosine-based activation motifs.";
Nat. Immunol. 7:1326-1333(2006).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-65; TYR-76 AND THR-78,
AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Mast cell;
PubMed=17947660; DOI=10.4049/jimmunol.179.9.5864;
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
Kawakami T., Salomon A.R.;
"Quantitative time-resolved phosphoproteomic analysis of mast cell
signaling.";
J. Immunol. 179:5864-5876(2007).
[7]
INTERACTION WITH CLEC4E.
PubMed=18776906; DOI=10.1038/ni.1651;
Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T.;
"Mincle is an ITAM-coupled activating receptor that senses damaged
cells.";
Nat. Immunol. 9:1179-1188(2008).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-65 AND TYR-76, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[9]
INTERACTION WITH CD300LH AND CD300LD.
PubMed=20817736; DOI=10.1074/jbc.M110.137166;
Enomoto Y., Yamanishi Y., Izawa K., Kaitani A., Takahashi M.,
Maehara A., Oki T., Takamatsu R., Kajikawa M., Takai T., Kitamura T.,
Kitaura J.;
"Characterization of leukocyte mono-immunoglobulin-like receptor 7
(LMIR7)/CLM-3 as an activating receptor: its similarities to and
differences from LMIR4/CLM-5.";
J. Biol. Chem. 285:35274-35283(2010).
-!- FUNCTION: Associates with a variety of FcR alpha chains to form a
functional signaling complex. Regulates several aspects of the
immune response. The gamma subunit has a critical role in allowing
the IgE Fc receptor to reach the cell surface. Also involved in
collagen-mediated platelet activation and in neutrophil activation
mediated by integrin. {ECO:0000269|PubMed:17086186,
ECO:0000269|PubMed:9171347}.
-!- SUBUNIT: IgE Fc receptor is a tetramer of an alpha chain, a beta
chain, and two disulfide linked gamma chains. The gamma chain from
Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A
(By similarity). Associated with CLEC6A (PubMed:17050534).
Interacts with CLEC4E (PubMed:18776906). Interacts (via ITAM
domain) with SYK (via SH2 domains); activates SYK, enabling
integrin-mediated activation of neutrophils and macrophages
(PubMed:17086186). Interacts with CD300LH; the interaction may be
indirect (PubMed:20817736). Interacts with CD300LD
(PubMed:20817736). Interacts with TARM1 (By similarity).
{ECO:0000250|UniProtKB:P30273, ECO:0000269|PubMed:17050534,
ECO:0000269|PubMed:17086186, ECO:0000269|PubMed:18776906,
ECO:0000269|PubMed:20817736}.
-!- INTERACTION:
Q62120:Jak2; NbExp=2; IntAct=EBI-9306159, EBI-646604;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the CD3Z/FCER1G family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; J05020; AAA37602.1; -; mRNA.
EMBL; BC034163; AAH34163.1; -; mRNA.
CCDS; CCDS15483.1; -.
RefSeq; NP_034315.1; NM_010185.4.
UniGene; Mm.22673; -.
ProteinModelPortal; P20491; -.
SMR; P20491; -.
BioGrid; 199616; 2.
IntAct; P20491; 1.
STRING; 10090.ENSMUSP00000078875; -.
iPTMnet; P20491; -.
PhosphoSitePlus; P20491; -.
SwissPalm; P20491; -.
MaxQB; P20491; -.
PaxDb; P20491; -.
PeptideAtlas; P20491; -.
PRIDE; P20491; -.
Ensembl; ENSMUST00000079957; ENSMUSP00000078875; ENSMUSG00000058715.
GeneID; 14127; -.
KEGG; mmu:14127; -.
UCSC; uc007dnl.1; mouse.
CTD; 2207; -.
MGI; MGI:95496; Fcer1g.
eggNOG; ENOG410J5TQ; Eukaryota.
eggNOG; ENOG410Z3W0; LUCA.
GeneTree; ENSGT00390000003894; -.
HOGENOM; HOG000293158; -.
HOVERGEN; HBG051601; -.
InParanoid; P20491; -.
KO; K07983; -.
OMA; LYCRLKL; -.
PhylomeDB; P20491; -.
TreeFam; TF330937; -.
Reactome; R-MMU-114604; GPVI-mediated activation cascade.
Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
Reactome; R-MMU-2454202; Fc epsilon receptor (FCERI) signaling.
Reactome; R-MMU-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
Reactome; R-MMU-2871796; FCERI mediated MAPK activation.
Reactome; R-MMU-2871809; FCERI mediated Ca+2 mobilization.
Reactome; R-MMU-2871837; FCERI mediated NF-kB activation.
Reactome; R-MMU-6798695; Neutrophil degranulation.
Reactome; R-MMU-75892; Platelet Adhesion to exposed collagen.
PRO; PR:P20491; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000058715; -.
ExpressionAtlas; P20491; baseline and differential.
Genevisible; P20491; MM.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0032998; C:Fc-epsilon receptor I complex; IMP:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
GO; GO:0045121; C:membrane raft; TAS:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0019863; F:IgE binding; IDA:MGI.
GO; GO:0019767; F:IgE receptor activity; IDA:MGI.
GO; GO:0019864; F:IgG binding; IMP:MGI.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IMP:MGI.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IMP:MGI.
GO; GO:0007166; P:cell surface receptor signaling pathway; IDA:MGI.
GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IDA:UniProtKB.
GO; GO:0042742; P:defense response to bacterium; IMP:MGI.
GO; GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; IMP:MGI.
GO; GO:0038095; P:Fc-epsilon receptor signaling pathway; ISO:MGI.
GO; GO:0038094; P:Fc-gamma receptor signaling pathway; IDA:MGI.
GO; GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.
GO; GO:0045087; P:innate immune response; IMP:MGI.
GO; GO:0007229; P:integrin-mediated signaling pathway; IMP:UniProtKB.
GO; GO:0045576; P:mast cell activation; IDA:MGI.
GO; GO:0033026; P:negative regulation of mast cell apoptotic process; IDA:MGI.
GO; GO:0002283; P:neutrophil activation involved in immune response; IMP:UniProtKB.
GO; GO:0030593; P:neutrophil chemotaxis; IMP:MGI.
GO; GO:0006911; P:phagocytosis, engulfment; IMP:MGI.
GO; GO:0050778; P:positive regulation of immune response; IMP:MGI.
GO; GO:0032733; P:positive regulation of interleukin-10 production; IMP:MGI.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IDA:MGI.
GO; GO:0032765; P:positive regulation of mast cell cytokine production; IDA:MGI.
GO; GO:0043306; P:positive regulation of mast cell degranulation; IDA:MGI.
GO; GO:0050766; P:positive regulation of phagocytosis; IMP:MGI.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:MGI.
GO; GO:0001812; P:positive regulation of type I hypersensitivity; IMP:MGI.
GO; GO:0001798; P:positive regulation of type IIa hypersensitivity; IMP:MGI.
GO; GO:0001805; P:positive regulation of type III hypersensitivity; IMP:MGI.
GO; GO:0051260; P:protein homooligomerization; ISO:MGI.
GO; GO:0072659; P:protein localization to plasma membrane; IDA:MGI.
GO; GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO; GO:0050776; P:regulation of immune response; IMP:MGI.
GO; GO:0010543; P:regulation of platelet activation; IMP:UniProtKB.
GO; GO:0002554; P:serotonin secretion by platelet; IMP:UniProtKB.
GO; GO:0007165; P:signal transduction; IDA:MGI.
GO; GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome.
GO; GO:0002292; P:T cell differentiation involved in immune response; IMP:MGI.
InterPro; IPR021663; CD3_zeta/IgE_Fc_rcpt_gamma.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
Pfam; PF02189; ITAM; 1.
Pfam; PF11628; TCR_zetazeta; 1.
SMART; SM00077; ITAM; 1.
PROSITE; PS51055; ITAM_1; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond; IgE-binding protein;
Membrane; Phosphoprotein; Receptor; Reference proteome; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 86 High affinity immunoglobulin epsilon
receptor subunit gamma.
/FTId=PRO_0000016503.
TOPO_DOM 19 23 Extracellular. {ECO:0000255}.
TRANSMEM 24 44 Helical. {ECO:0000255}.
TOPO_DOM 45 86 Cytoplasmic. {ECO:0000255}.
DOMAIN 54 82 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
MOD_RES 65 65 Phosphotyrosine.
{ECO:0000244|PubMed:17947660,
ECO:0000244|PubMed:19144319}.
MOD_RES 76 76 Phosphotyrosine.
{ECO:0000244|PubMed:17947660,
ECO:0000244|PubMed:19144319}.
MOD_RES 78 78 Phosphothreonine.
{ECO:0000244|PubMed:17947660}.
DISULFID 25 25 Interchain. {ECO:0000250}.
SEQUENCE 86 AA; 9652 MW; 83184DE22FCC9ECB CRC64;
MISAVILFLL LLVEQAAALG EPQLCYILDA VLFLYGIVLT LLYCRLKIQV RKAAIASREK
ADAVYTGLNT RSQETYETLK HEKPPQ


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