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High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (FcRgamma) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (FceRI gamma)

 FCERG_PIG               Reviewed;          86 AA.
Q9XSZ6;
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
25-OCT-2017, entry version 99.
RecName: Full=High affinity immunoglobulin epsilon receptor subunit gamma;
AltName: Full=Fc receptor gamma-chain;
Short=FcRgamma;
AltName: Full=Fc-epsilon RI-gamma;
AltName: Full=IgE Fc receptor subunit gamma;
Short=FceRI gamma;
Flags: Precursor;
Name=FCER1G;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Minnesota miniature;
Yim D., Kim Y.B.;
"Molecular cloning of porcine Fc epsilon receptor gamma chain.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Associates with a variety of FcR alpha chains to form a
functional signaling complex. Regulates several aspects of the
immune response. The gamma subunit has a critical role in allowing
the IgE Fc receptor to reach the cell surface. Also involved in
collagen-mediated platelet activation and in neutrophil activation
mediated by integrin (By similarity). {ECO:0000250}.
-!- SUBUNIT: IgE Fc receptor is a tetramer of an alpha chain, a beta
chain, and two disulfide linked gamma chains. The gamma chain from
Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A.
Associated with CLEC6A. Interacts with CLEC4E. Interacts (via ITAM
domain) with SYK (via SH2 domains); activates SYK, enabling
integrin-mediated activation of neutrophils and macrophages.
Interacts with CD300LH; the interaction may be indirect. Interacts
with CD300LD. Interacts with TARM1. {ECO:0000250|UniProtKB:P20491,
ECO:0000250|UniProtKB:P30273}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the CD3Z/FCER1G family. {ECO:0000305}.
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EMBL; AF148221; AAD38022.1; -; mRNA.
RefSeq; NP_001001265.1; NM_001001265.1.
UniGene; Ssc.71807; -.
ProteinModelPortal; Q9XSZ6; -.
SMR; Q9XSZ6; -.
STRING; 9823.ENSSSCP00000006776; -.
PaxDb; Q9XSZ6; -.
PeptideAtlas; Q9XSZ6; -.
PRIDE; Q9XSZ6; -.
Ensembl; ENSSSCT00000006966; ENSSSCP00000006776; ENSSSCG00000006357.
GeneID; 397406; -.
KEGG; ssc:397406; -.
CTD; 2207; -.
eggNOG; ENOG410J5TQ; Eukaryota.
eggNOG; ENOG410Z3W0; LUCA.
GeneTree; ENSGT00390000003894; -.
HOGENOM; HOG000293158; -.
HOVERGEN; HBG051601; -.
InParanoid; Q9XSZ6; -.
KO; K07983; -.
OMA; LYCRLKL; -.
OrthoDB; EOG091G15OK; -.
TreeFam; TF330937; -.
Reactome; R-SSC-114604; GPVI-mediated activation cascade.
Reactome; R-SSC-2454202; Fc epsilon receptor (FCERI) signaling.
Reactome; R-SSC-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
Reactome; R-SSC-2871796; FCERI mediated MAPK activation.
Reactome; R-SSC-2871809; FCERI mediated Ca+2 mobilization.
Reactome; R-SSC-2871837; FCERI mediated NF-kB activation.
Reactome; R-SSC-6798695; Neutrophil degranulation.
Reactome; R-SSC-75892; Platelet Adhesion to exposed collagen.
Proteomes; UP000008227; Chromosome 4.
Bgee; ENSSSCG00000006357; -.
ExpressionAtlas; Q9XSZ6; differential.
Genevisible; Q9XSZ6; SS.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0032998; C:Fc-epsilon receptor I complex; IBA:GO_Central.
GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO; GO:0019863; F:IgE binding; IBA:GO_Central.
GO; GO:0019767; F:IgE receptor activity; IBA:GO_Central.
GO; GO:0019864; F:IgG binding; IBA:GO_Central.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IBA:GO_Central.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; ISS:UniProtKB.
GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
GO; GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; IBA:GO_Central.
GO; GO:0038094; P:Fc-gamma receptor signaling pathway; IBA:GO_Central.
GO; GO:0016064; P:immunoglobulin mediated immune response; IBA:GO_Central.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0045576; P:mast cell activation; IEA:Ensembl.
GO; GO:0033026; P:negative regulation of mast cell apoptotic process; IEA:Ensembl.
GO; GO:0002283; P:neutrophil activation involved in immune response; IBA:GO_Central.
GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0006911; P:phagocytosis, engulfment; IEA:Ensembl.
GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0032765; P:positive regulation of mast cell cytokine production; IEA:Ensembl.
GO; GO:0043306; P:positive regulation of mast cell degranulation; IEA:Ensembl.
GO; GO:0050766; P:positive regulation of phagocytosis; IBA:GO_Central.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0001812; P:positive regulation of type I hypersensitivity; IEA:Ensembl.
GO; GO:0001798; P:positive regulation of type IIa hypersensitivity; IEA:Ensembl.
GO; GO:0001805; P:positive regulation of type III hypersensitivity; IEA:Ensembl.
GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; ISS:UniProtKB.
GO; GO:0010543; P:regulation of platelet activation; IBA:GO_Central.
GO; GO:0002554; P:serotonin secretion by platelet; IEA:Ensembl.
GO; GO:0002292; P:T cell differentiation involved in immune response; IBA:GO_Central.
InterPro; IPR021663; CD3_zeta/IgE_Fc_rcpt_gamma.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
Pfam; PF02189; ITAM; 1.
Pfam; PF11628; TCR_zetazeta; 1.
SMART; SM00077; ITAM; 1.
PROSITE; PS51055; ITAM_1; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; Disulfide bond; IgE-binding protein;
Membrane; Phosphoprotein; Receptor; Reference proteome; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 86 High affinity immunoglobulin epsilon
receptor subunit gamma.
/FTId=PRO_0000016504.
TOPO_DOM 19 23 Extracellular. {ECO:0000255}.
TRANSMEM 24 44 Helical. {ECO:0000255}.
TOPO_DOM 45 86 Cytoplasmic. {ECO:0000255}.
DOMAIN 54 82 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
MOD_RES 65 65 Phosphotyrosine.
{ECO:0000250|UniProtKB:P20491,
ECO:0000255|PROSITE-ProRule:PRU00379}.
MOD_RES 69 69 Phosphoserine.
{ECO:0000250|UniProtKB:P30273}.
MOD_RES 76 76 Phosphotyrosine.
{ECO:0000250|UniProtKB:P20491,
ECO:0000255|PROSITE-ProRule:PRU00379}.
MOD_RES 78 78 Phosphothreonine.
{ECO:0000250|UniProtKB:P20491}.
DISULFID 25 25 Interchain. {ECO:0000250}.
SEQUENCE 86 AA; 9681 MW; 756D7536513D7763 CRC64;
MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKLQV RKAAIDSYEK
SDGVYTGLST RNQETYETLK HEKPPQ


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