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High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1)

 HMGA1_CANLF             Reviewed;         107 AA.
Q6URC2;
26-APR-2005, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
23-MAY-2018, entry version 97.
RecName: Full=High mobility group protein HMG-I/HMG-Y;
Short=HMG-I(Y);
AltName: Full=High mobility group AT-hook protein 1;
Short=High mobility group protein A1;
Name=HMGA1; Synonyms=HMGIY;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HMG-I AND HMG-Y).
STRAIN=Alsatian, Bull terrier, Collie, Dachshund, Doberman pinscher,
German shorthaired pointer, Golden retriever, Jack Russel terrier,
Munsterland, and West Highland terrier;
PubMed=15087128; DOI=10.1016/j.gene.2004.01.009;
Murua Escobar H., Soller J.T., Richter A., Meyer B., Winkler S.,
Flohr A.M., Nolte I., Bullerdiek J.;
"The canine HMGA1.";
Gene 330:93-99(2004).
-!- FUNCTION: HMG-I/Y bind preferentially to the minor groove of A+T
rich regions in double-stranded DNA. It is suggested that these
proteins could function in nucleosome phasing and in the 3'-end
processing of mRNA transcripts. They are also involved in the
transcription regulation of genes containing, or in close
proximity to A+T-rich regions (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with HIPK2. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
{ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=HMG-I; Synonyms=HMGA1a;
IsoId=Q6URC2-1; Sequence=Displayed;
Name=HMG-Y; Synonyms=HMGA1b;
IsoId=Q6URC2-2; Sequence=VSP_013473;
-!- PTM: Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2.
Phosphorylation may modulate DNA-binding affinity (By similarity).
{ECO:0000250}.
-!- PTM: Methylation at Arg-58 is mutually exclusive with methylation
at Arg-60. {ECO:0000250}.
-!- SIMILARITY: Belongs to the HMGA family. {ECO:0000305}.
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EMBL; AY366390; AAR21596.1; -; mRNA.
EMBL; AY366391; AAR21597.1; -; mRNA.
EMBL; AY363599; AAR12011.1; -; mRNA.
EMBL; AY363600; AAR12012.1; -; mRNA.
EMBL; AY363601; AAR12013.1; -; mRNA.
EMBL; AY363602; AAR12014.1; -; mRNA.
EMBL; AY363603; AAR12015.1; -; mRNA.
EMBL; AY363604; AAR12016.1; -; mRNA.
EMBL; AY363605; AAR12017.1; -; mRNA.
EMBL; AY363606; AAR12018.1; -; mRNA.
EMBL; AY363607; AAR12019.1; -; mRNA.
EMBL; AY363608; AAR12020.1; -; mRNA.
EMBL; AY363609; AAR12021.1; -; mRNA.
EMBL; AY363610; AAR12022.1; -; mRNA.
RefSeq; NP_001003387.1; NM_001003387.1. [Q6URC2-1]
UniGene; Cfa.4558; -.
ProteinModelPortal; Q6URC2; -.
SMR; Q6URC2; -.
STRING; 9615.ENSCAFP00000001724; -.
PaxDb; Q6URC2; -.
PRIDE; Q6URC2; -.
GeneID; 442946; -.
KEGG; cfa:442946; -.
CTD; 3159; -.
eggNOG; ENOG410J4ZT; Eukaryota.
eggNOG; ENOG410Z566; LUCA.
HOGENOM; HOG000076308; -.
HOVERGEN; HBG063451; -.
InParanoid; Q6URC2; -.
KO; K09282; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0035985; C:senescence-associated heterochromatin focus; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0003700; F:DNA binding transcription factor activity; IBA:GO_Central.
GO; GO:0003906; F:DNA-(apurinic or apyrimidinic site) endonuclease activity; IBA:GO_Central.
GO; GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; ISS:UniProtKB.
GO; GO:0042975; F:peroxisome proliferator activated receptor binding; ISS:UniProtKB.
GO; GO:0042974; F:retinoic acid receptor binding; ISS:UniProtKB.
GO; GO:0046965; F:retinoid X receptor binding; ISS:UniProtKB.
GO; GO:0008134; F:transcription factor binding; ISS:UniProtKB.
GO; GO:0006284; P:base-excision repair; IBA:GO_Central.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0090402; P:oncogene-induced cell senescence; ISS:UniProtKB.
GO; GO:2000774; P:positive regulation of cellular senescence; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
GO; GO:0035986; P:senescence-associated heterochromatin focus assembly; ISS:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR017956; AT_hook_DNA-bd_motif.
InterPro; IPR000116; HMGA.
InterPro; IPR031079; HMGA1_mammal.
InterPro; IPR000637; HMGI/Y_DNA-bd_CS.
PANTHER; PTHR23341:SF1; PTHR23341:SF1; 1.
PRINTS; PR00929; ATHOOK.
PRINTS; PR00930; HIGHMOBLTYIY.
SMART; SM00384; AT_hook; 3.
PROSITE; PS00354; HMGI_Y; 3.
3: Inferred from homology;
Acetylation; ADP-ribosylation; Alternative splicing; Chromosome;
Complete proteome; DNA-binding; Isopeptide bond; Methylation; Nucleus;
Phosphoprotein; Reference proteome; Repeat; Transcription;
Transcription regulation; Ubl conjugation.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P17095}.
CHAIN 2 107 High mobility group protein HMG-I/HMG-Y.
/FTId=PRO_0000206706.
DNA_BIND 21 31 A.T hook 1.
DNA_BIND 53 63 A.T hook 2.
DNA_BIND 78 89 A.T hook 3.
REGION 53 77 Interaction with HIPK2. {ECO:0000250}.
COMPBIAS 91 106 Glu-rich (acidic).
MOD_RES 2 2 N-acetylserine.
{ECO:0000250|UniProtKB:P17095}.
MOD_RES 7 7 N6-acetyllysine.
{ECO:0000250|UniProtKB:P17095}.
MOD_RES 8 8 ADP-ribosylserine.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 9 9 ADP-ribosylserine; alternate.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 9 9 Phosphoserine; alternate.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 15 15 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 26 26 Asymmetric dimethylarginine; alternate.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 26 26 Omega-N-methylarginine; alternate.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 26 26 Symmetric dimethylarginine; alternate.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 36 36 Phosphoserine; by HIPK2 and CDC2.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 39 39 Phosphothreonine.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 44 44 Phosphoserine.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 49 49 Phosphoserine.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 53 53 Phosphothreonine; by HIPK2 and CDC2.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 58 58 Asymmetric dimethylarginine; by PRMT6;
alternate.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 58 58 Omega-N-methylarginine; by PRMT6;
alternate.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 60 60 Asymmetric dimethylarginine; by PRMT6;
alternate.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 60 60 Omega-N-methylarginine; by PRMT6;
alternate.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 78 78 Phosphothreonine; by HIPK2 and CDC2.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 99 99 Phosphoserine.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 102 102 Phosphoserine.
{ECO:0000250|UniProtKB:P17096}.
MOD_RES 103 103 Phosphoserine.
{ECO:0000250|UniProtKB:P17096}.
CROSSLNK 15 15 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2);
alternate.
{ECO:0000250|UniProtKB:P17096}.
VAR_SEQ 35 45 Missing (in isoform HMG-Y).
{ECO:0000303|PubMed:15087128}.
/FTId=VSP_013473.
SEQUENCE 107 AA; 11676 MW; E9C4E3F2200914B8 CRC64;
MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR
PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQ


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