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Hippocalcin-like protein 1 (Protein Rem-1)

 HPCL1_CHICK             Reviewed;         193 AA.
P42324;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
12-SEP-2018, entry version 123.
RecName: Full=Hippocalcin-like protein 1;
AltName: Full=Protein Rem-1;
Name=HPCAL1; Synonyms=REM1;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
STRAIN=White leghorn;
PubMed=7700627;
Kraut N., Frampton J., Graf T.;
"Rem-1, a putative direct target gene of the Myb-Ets fusion
oncoprotein in haematopoietic progenitors, is a member of the
recoverin family.";
Oncogene 10:1027-1036(1995).
-!- INTERACTION:
Q8AYS8:KCNMA1; NbExp=3; IntAct=EBI-1636399, EBI-1635766;
-!- TISSUE SPECIFICITY: Expressed in hemopoietic cells, but also in
the fibroblasts, bone marrow, brain, eye and gut.
{ECO:0000269|PubMed:7700627}.
-!- INDUCTION: By the MYB-ETS fusion oncogene.
{ECO:0000269|PubMed:7700627}.
-!- MISCELLANEOUS: Probably binds two or three calcium ions.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the recoverin family. {ECO:0000305}.
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EMBL; X80875; CAA56843.1; -; mRNA.
PIR; I50676; I50676.
RefSeq; NP_990565.1; NM_205234.1.
RefSeq; XP_015131510.1; XM_015276024.1.
RefSeq; XP_015131512.1; XM_015276026.1.
RefSeq; XP_015131513.1; XM_015276027.1.
RefSeq; XP_015131514.1; XM_015276028.1.
UniGene; Gga.3776; -.
ProteinModelPortal; P42324; -.
SMR; P42324; -.
BioGrid; 676425; 1.
IntAct; P42324; 1.
STRING; 9031.ENSGALP00000036116; -.
PaxDb; P42324; -.
PRIDE; P42324; -.
Ensembl; ENSGALT00000036903; ENSGALP00000036116; ENSGALG00000016443.
Ensembl; ENSGALT00000063322; ENSGALP00000046009; ENSGALG00000016443.
GeneID; 396161; -.
KEGG; gga:396161; -.
CTD; 3241; -.
eggNOG; KOG0044; Eukaryota.
eggNOG; COG5126; LUCA.
GeneTree; ENSGT00760000118820; -.
HOGENOM; HOG000233019; -.
HOVERGEN; HBG108179; -.
InParanoid; P42324; -.
OMA; LEIVQXK; -.
OrthoDB; EOG091G11T4; -.
PhylomeDB; P42324; -.
TreeFam; TF300009; -.
PRO; PR:P42324; -.
Proteomes; UP000000539; Chromosome 3.
Bgee; ENSGALG00000016443; Expressed in 11 organ(s), highest expression level in brain.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
CDD; cd00051; EFh; 2.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR018247; EF_Hand_1_Ca_BS.
InterPro; IPR002048; EF_hand_dom.
Pfam; PF13499; EF-hand_7; 1.
Pfam; PF13833; EF-hand_8; 1.
SMART; SM00054; EFh; 3.
SUPFAM; SSF47473; SSF47473; 1.
PROSITE; PS00018; EF_HAND_1; 3.
PROSITE; PS50222; EF_HAND_2; 4.
1: Evidence at protein level;
Calcium; Complete proteome; Lipoprotein; Metal-binding; Myristate;
Reference proteome; Repeat.
INIT_MET 1 1 Removed. {ECO:0000250}.
CHAIN 2 193 Hippocalcin-like protein 1.
/FTId=PRO_0000073775.
DOMAIN 23 58 EF-hand 1. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 60 95 EF-hand 2. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 96 131 EF-hand 3. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 144 179 EF-hand 4. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
CA_BIND 73 84 1. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
CA_BIND 109 120 2. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
CA_BIND 157 168 3. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
LIPID 2 2 N-myristoyl glycine. {ECO:0000250}.
SEQUENCE 193 AA; 22269 MW; 1EDDE87C53DCC29C CRC64;
MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVEEFKK IYANFFPYGD
ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRGE
MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI KGAKSDPSIV
RLLQCDPSSA SQF


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