Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Histatin-1 (Histidine-rich protein 1) (Post-PB protein) (PPB) [Cleaved into: His1-(31-57)-peptide (His1 31/57) (His1-(12-38)-peptide) (His1 12/38) (Histatin-2)]

 HIS1_HUMAN              Reviewed;          57 AA.
P15515;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 2.
07-NOV-2018, entry version 143.
RecName: Full=Histatin-1;
AltName: Full=Histidine-rich protein 1;
AltName: Full=Post-PB protein;
Short=PPB;
Contains:
RecName: Full=His1-(31-57)-peptide;
Short=His1 31/57;
AltName: Full=His1-(12-38)-peptide;
Short=His1 12/38;
AltName: Full=Histatin-2;
Flags: Precursor;
Name=HTN1; Synonyms=HIS1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2719677; DOI=10.1016/0006-291X(89)92460-1;
Sabatini L.M., Azen E.A.;
"Histatins, a family of salivary histidine-rich proteins, are encoded
by at least two loci (HIS1 and HIS2).";
Biochem. Biophys. Res. Commun. 160:495-502(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8336540;
Chen Z.W.;
"Nucleotide sequence analysis of the human salivary protein genes HIS1
and HIS2, and evolution of the STATH/HIS gene family.";
Mol. Biol. Evol. 10:497-511(1993).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skeletal muscle;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PROTEIN SEQUENCE OF 20-57, AND PHOSPHORYLATION AT SER-21.
TISSUE=Parotid gland;
PubMed=3286634;
Oppenheim F.G., Xu T., McMillian F.M., Levitz S.M., Diamond R.D.,
Offner G.D., Troxler R.F.;
"Histatins, a novel family of histidine-rich proteins in human parotid
secretion. Isolation, characterization, primary structure, and
fungistatic effects on Candida albicans.";
J. Biol. Chem. 263:7472-7477(1988).
[5]
PROTEIN SEQUENCE OF 20-57.
TISSUE=Parotid gland;
PubMed=3944083;
Oppenheim F.G., Yang Y.C., Diamond R.D., Hyslop D., Offner G.D.,
Troxler R.F.;
"The primary structure and functional characterization of the neutral
histidine-rich polypeptide from human parotid secretion.";
J. Biol. Chem. 261:1177-1182(1986).
[6]
PROTEIN SEQUENCE OF 20-57.
TISSUE=Saliva;
PubMed=2372245; DOI=10.1016/0003-9969(90)90202-L;
Sugiyama K., Ogino T., Ogata K.;
"Rapid purification and characterization of histatins (histidine-rich
polypeptides) from human whole saliva.";
Arch. Oral Biol. 35:415-419(1990).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 14-57.
PubMed=2773933;
Vanderspek J.C., Wyandt H.E., Skare J.C., Milunsky A., Oppenheim F.G.,
Troxler R.F.;
"Localization of the genes for histatins to human chromosome 4q13 and
tissue distribution of the mRNAs.";
Am. J. Hum. Genet. 45:381-387(1989).
[8]
PHOSPHORYLATION, SULFATION AT TYR-46; TYR-49; TYR-53 AND TYR-55,
TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
PubMed=17503797; DOI=10.1021/pr0700706;
Cabras T., Fanali C., Monteiro J.A., Amado F., Inzitari R.,
Desiderio C., Scarano E., Giardina B., Castagnola M., Messana I.;
"Tyrosine polysulfation of human salivary histatin 1. A post-
translational modification specific of the submandibular gland.";
J. Proteome Res. 6:2472-2480(2007).
[9]
PEPTIDE NOMENCLATURE.
PubMed=20973643; DOI=10.1586/epr.10.48;
Amado F., Lobo M.J., Domingues P., Duarte J.A., Vitorino R.;
"Salivary peptidomics.";
Expert Rev. Proteomics 7:709-721(2010).
-!- FUNCTION: Histatins are salivary proteins that are considered to
be major precursors of the protective proteinaceous structure on
tooth surfaces (enamel pellicle). In addition, histatins exhibit
antibacterial and antifungal activities.
-!- INTERACTION:
Q8TAX7:MUC7; NbExp=2; IntAct=EBI-738638, EBI-738582;
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Submandibular and parotid glands.
{ECO:0000269|PubMed:17503797}.
-!- PTM: Depending on the authors, the form called histatin-2 is
alternatively a proteolytic product, or the non-phosphorylated
form of histatin-1. {ECO:0000269|PubMed:17503797,
ECO:0000269|PubMed:3286634}.
-!- MASS SPECTROMETRY: Mass=4848.2; Mass_error=0.5;
Method=Electrospray; Range=20-50; Note=Not post-translationally
modified.; Evidence={ECO:0000269|PubMed:17503797};
-!- MASS SPECTROMETRY: Mass=4928.2; Mass_error=0.5;
Method=Electrospray; Range=20-50; Note=with 1 phosphate group.;
Evidence={ECO:0000269|PubMed:17503797};
-!- MASS SPECTROMETRY: Mass=5008.6; Mass_error=0.5;
Method=Electrospray; Range=20-50; Note=with 1 phosphate group and
1 sulfate group.; Evidence={ECO:0000269|PubMed:17503797};
-!- MASS SPECTROMETRY: Mass=5088.4; Mass_error=0.5;
Method=Electrospray; Range=20-50; Note=with 1 phosphate group and
2 sulfate groups.; Evidence={ECO:0000269|PubMed:17503797};
-!- MASS SPECTROMETRY: Mass=5168.2; Mass_error=0.5;
Method=Electrospray; Range=20-50; Note=with 1 phosphate group and
3 sulfate groups.; Evidence={ECO:0000269|PubMed:17503797};
-!- MASS SPECTROMETRY: Mass=5247.7; Mass_error=0.5;
Method=Electrospray; Range=20-50; Note=with 1 phosphate group and
4 sulfate groups.; Evidence={ECO:0000269|PubMed:17503797};
-!- MISCELLANEOUS: The recommended nomenclature of salivary peptides
follows published guidelines (PubMed:20973643). In agreement with
the authors, it has been decided to indicate the boundaries of the
peptides according to the positions within the precursor, and not
in the mature protein, as has formerly been proposed.
{ECO:0000305|PubMed:20973643}.
-!- SIMILARITY: Belongs to the histatin/statherin family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; M26664; AAA58645.1; -; mRNA.
EMBL; L04132; AAA02745.1; -; Genomic_DNA.
EMBL; BC017835; AAH17835.1; -; mRNA.
CCDS; CCDS3534.1; -.
PIR; I57425; A32541.
RefSeq; NP_002150.1; NM_002159.3.
UniGene; Hs.250959; -.
ProteinModelPortal; P15515; -.
BioGrid; 109578; 2.
IntAct; P15515; 1.
STRING; 9606.ENSP00000246896; -.
iPTMnet; P15515; -.
PhosphoSitePlus; P15515; -.
BioMuta; HTN1; -.
PaxDb; P15515; -.
PeptideAtlas; P15515; -.
PRIDE; P15515; -.
ProteomicsDB; 53165; -.
TopDownProteomics; P15515; -.
Ensembl; ENST00000246896; ENSP00000246896; ENSG00000126550.
Ensembl; ENST00000511674; ENSP00000424501; ENSG00000126550.
Ensembl; ENST00000610341; ENSP00000482787; ENSG00000126550.
Ensembl; ENST00000634477; ENSP00000489510; ENSG00000283046.
Ensembl; ENST00000635327; ENSP00000489349; ENSG00000283046.
Ensembl; ENST00000635569; ENSP00000489198; ENSG00000283046.
GeneID; 3346; -.
KEGG; hsa:3346; -.
UCSC; uc003hex.4; human.
CTD; 3346; -.
DisGeNET; 3346; -.
EuPathDB; HostDB:ENSG00000126550.8; -.
GeneCards; HTN1; -.
HGNC; HGNC:5283; HTN1.
MIM; 142701; gene.
neXtProt; NX_P15515; -.
OpenTargets; ENSG00000126550; -.
PharmGKB; PA29546; -.
eggNOG; ENOG410KC71; Eukaryota.
eggNOG; ENOG4110P9N; LUCA.
GeneTree; ENSGT00390000006107; -.
HOGENOM; HOG000112905; -.
HOVERGEN; HBG005970; -.
InParanoid; P15515; -.
KO; K13913; -.
OMA; MKIFFFA; -.
OrthoDB; EOG091G16XM; -.
PhylomeDB; P15515; -.
TreeFam; TF341637; -.
Reactome; R-HSA-6803157; Antimicrobial peptides.
ChiTaRS; HTN1; human.
GeneWiki; HTN1; -.
GenomeRNAi; 3346; -.
PRO; PR:P15515; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000126550; Expressed in 35 organ(s), highest expression level in saliva-secreting gland.
CleanEx; HS_HTN1; -.
Genevisible; P15515; HS.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
GO; GO:0019730; P:antimicrobial humoral response; TAS:Reactome.
GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
GO; GO:0042742; P:defense response to bacterium; NAS:UniProtKB.
GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
GO; GO:0031640; P:killing of cells of other organism; IDA:UniProtKB.
InterPro; IPR030774; Histatin-1/3.
InterPro; IPR030773; Histatin/statherin.
PANTHER; PTHR15057; PTHR15057; 1.
PANTHER; PTHR15057:SF2; PTHR15057:SF2; 1.
1: Evidence at protein level;
Antibiotic; Antimicrobial; Biomineralization; Complete proteome;
Direct protein sequencing; Fungicide; Phosphoprotein;
Reference proteome; Secreted; Signal; Sulfation.
SIGNAL 1 19 {ECO:0000269|PubMed:2372245,
ECO:0000269|PubMed:3286634,
ECO:0000269|PubMed:3944083}.
PEPTIDE 20 57 Histatin-1.
/FTId=PRO_0000021416.
PEPTIDE 31 57 His1-(31-57)-peptide.
/FTId=PRO_0000021417.
MOD_RES 21 21 Phosphoserine.
{ECO:0000269|PubMed:3286634,
ECO:0000269|PubMed:3944083}.
MOD_RES 46 46 Sulfotyrosine; in submandibular gland
form. {ECO:0000269|PubMed:17503797}.
MOD_RES 49 49 Sulfotyrosine; in submandibular gland
form. {ECO:0000269|PubMed:17503797}.
MOD_RES 53 53 Sulfotyrosine; in submandibular gland
form. {ECO:0000269|PubMed:17503797}.
MOD_RES 55 55 Sulfotyrosine; in submandibular gland
form. {ECO:0000269|PubMed:17503797}.
SEQUENCE 57 AA; 6963 MW; F3532BD1DCE23D83 CRC64;
MKFFVFALVL ALMISMISAD SHEKRHHGYR RKFHEKHHSH REFPFYGDYG SNYLYDN


Related products :

Catalog number Product name Quantity
orb70174 [His1, Lys6]-GHRP-6 peptide This is [His1, Lys6]-GHRP-6 peptide. For research use only. 1 mg
orb71174 [Des-His1, Glu9]-Glucagon (1-29) peptide This is [Des-His1, Glu9]-Glucagon (1-29) peptide. For research use only. 1 mg
SP2708b Des His1, Glu8 Exendin-4 1 mg
SP2708a Des His1, Glu8 Exendin-4
SP2708a Des His1, Glu8 Exendin-4 0.5 mg
KP0029 [Des - His1, Glu8] - Exendin - 4 1 mg
SP3143a [Des-His1,Glu9] Glucagon 0.5 mg
SP3143b [Des-His1,Glu9] Glucagon 1 mg
SP2708b Des His1, Glu8 Exendin_4 1.0 mg
SP2708a Des His1, Glu8 Exendin_4 0.5 mg
SP3143b [Des-His1,Glu9] Glucagon
SP3143a [Des-His1,Glu9] Glucagon
RK-031-21 GHRP_6 _ GHRP [His1, Lys6] RIA Kit 125 RIA tubes
SP2708b Des His1, Glu8 Exendin-4
SP3686a [His1,Nle27] GHRF (1-32), amide, human 3
SP3686b [His1,Nle27] GHRF (1-32), amide, human 2
SP3686b [His1,Nle27] GHRF (1-32), amide, human 1 mg
SP3686a [His1,Nle27] GHRF (1-32), amide, human 0.5 mg
SP-82512-1 [Des-His1, Glu9] - Glucagon (1 - 29), amide [Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2; MW: 3358.72] 1 mg
SP3686b [His1,Nle27] GHRF (1_32), amide, human 1.0 mg
SP3686a [His1,Nle27] GHRF (1_32), amide, human 0.5 mg
H00010614-T01 HIS1 293T Cell Transient Overexpression Lysate(Denatured) 100 uL
031-21 Growth Hormone Releasing Factor_6 ([His1 _Lys6]_GHRP) _ 500ug 500 µg
55254 [His1, Lys6] _ GHRP, GHRP_ 6 Formula C46H56N12O6 Sequence His_D_Trp_Ala_Trp_D_Phe_Lys_NH2 5mg
FG-031-21A Growth Hormone Releasing Factor_6 ([His1 _Lys6]_GHRP) _ FAM Labeled _ 1 nmol 1 nmol


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur