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Histidine protein kinase SaeS (EC 2.7.13.3) (Sensor protein SaeS) (Staphylococcus exoprotein expression protein S)

 SAES_STAAC              Reviewed;         351 AA.
Q5HHW5;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
15-FEB-2005, sequence version 1.
27-SEP-2017, entry version 95.
RecName: Full=Histidine protein kinase SaeS;
EC=2.7.13.3;
AltName: Full=Sensor protein SaeS;
AltName: Full=Staphylococcus exoprotein expression protein S;
Name=saeS; OrderedLocusNames=SACOL0765;
Staphylococcus aureus (strain COL).
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
Staphylococcus.
NCBI_TaxID=93062;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=COL;
PubMed=15774886; DOI=10.1128/JB.187.7.2426-2438.2005;
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T.,
Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J.,
Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S.,
Haft D.H., Vamathevan J.J., Khouri H., Utterback T.R., Lee C.,
Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H.,
Hance I.R., Nelson K.E., Fraser C.M.;
"Insights on evolution of virulence and resistance from the complete
genome analysis of an early methicillin-resistant Staphylococcus
aureus strain and a biofilm-producing methicillin-resistant
Staphylococcus epidermidis strain.";
J. Bacteriol. 187:2426-2438(2005).
[2]
FUNCTION IN GLOBAL REGULATION.
PubMed=17079681; DOI=10.1128/JB.00555-06;
Rogasch K., Ruehmling V., Pane-Farre J., Hoeper D., Weinberg C.,
Fuchs S., Schmudde M., Broeker B.M., Wolz C., Hecker M., Engelmann S.;
"Influence of the two-component system saeRS on global gene expression
in two different Staphylococcus aureus strains.";
J. Bacteriol. 188:7742-7758(2006).
-!- FUNCTION: Member of the two-component regulatory system SaeR/SaeS
involved in the regulation of staphylococcal virulence factors in
a strain-dependent fashion. Probably functions as a membrane-
associated protein kinase that upon sensing the appropriate
signal, autophosphorylates and in turn activates the cytosolic
response regulator SaeR (By similarity). Modulates the expression
of several genes. {ECO:0000250, ECO:0000269|PubMed:17079681}.
-!- CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N-
phospho-L-histidine.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- PTM: Autophosphorylated. {ECO:0000250}.
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EMBL; CP000046; AAW37824.1; -; Genomic_DNA.
RefSeq; WP_000244412.1; NC_002951.2.
ProteinModelPortal; Q5HHW5; -.
SMR; Q5HHW5; -.
STRING; 93062.SACOL0765; -.
EnsemblBacteria; AAW37824; AAW37824; SACOL0765.
KEGG; sac:SACOL0765; -.
eggNOG; ENOG4108YBA; Bacteria.
eggNOG; COG0642; LUCA.
HOGENOM; HOG000279878; -.
KO; K10681; -.
OMA; QQRGRML; -.
Proteomes; UP000000530; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
CDD; cd00082; HisKA; 1.
Gene3D; 3.30.565.10; -; 1.
InterPro; IPR003660; HAMP_dom.
InterPro; IPR003594; HATPase_C.
InterPro; IPR005467; His_kinase_dom.
InterPro; IPR003661; HisK_dim/P.
InterPro; IPR004358; Sig_transdc_His_kin-like_C.
Pfam; PF02518; HATPase_c; 1.
Pfam; PF00512; HisKA; 1.
PRINTS; PR00344; BCTRLSENSOR.
SMART; SM00387; HATPase_c; 1.
SMART; SM00388; HisKA; 1.
SUPFAM; SSF47384; SSF47384; 1.
SUPFAM; SSF55874; SSF55874; 1.
PROSITE; PS50885; HAMP; 1.
PROSITE; PS50109; HIS_KIN; 1.
1: Evidence at protein level;
ATP-binding; Cell membrane; Complete proteome; Kinase; Membrane;
Nucleotide-binding; Phosphoprotein; Transferase; Transmembrane;
Transmembrane helix; Two-component regulatory system; Virulence.
CHAIN 1 351 Histidine protein kinase SaeS.
/FTId=PRO_0000295931.
TRANSMEM 9 29 Helical. {ECO:0000255}.
TRANSMEM 40 60 Helical. {ECO:0000255}.
DOMAIN 61 114 HAMP. {ECO:0000255|PROSITE-
ProRule:PRU00102}.
DOMAIN 129 348 Histidine kinase. {ECO:0000255|PROSITE-
ProRule:PRU00107}.
MOD_RES 132 132 Phosphohistidine; by autocatalysis.
{ECO:0000255|PROSITE-ProRule:PRU00107}.
SEQUENCE 351 AA; 39741 MW; 08CB447C472A1B47 CRC64;
MVLSIRSQII IGVVSSILLT STILAIAYIL MWFNGHMTLT LTLTTIITSC LTLLICSIFI
NPLIQKIKQF NIKTKQFANG NYASNDKTFN SPKEIYELNQ SFNKMASEIT QQMNQIKSEQ
QEKTELIQNL AHDLKTPLAS IISYSEGLRD GIITKDHEIK ESYDILIKQA NRLSTLFDDM
THIITLNTGK TYPPELIQLD QLLVSILQPY EQRIKHENRT LEVNFCNEID AFYQYRTPLE
RILTNLLDNA LKFSNVGSRI DINISENEDQ DTIDIAISDE GIGIIPELQE RIFERTFRVE
NSRNTKTGGS GLGLYIANEL AQQNNAKISV SSDIDVGTTM TVTLHKLDIT S


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