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Histone H2A

 H2A_CAEEL               Reviewed;         127 AA.
P09588; Q7JKF5;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
23-MAY-2018, entry version 168.
RecName: Full=Histone H2A;
Name=his-3; ORFNames=T10C6.12;
Name=his-7; ORFNames=F45F2.4;
Name=his-12; ORFNames=ZK131.6;
Name=his-16; ORFNames=ZK131.10;
Name=his-19; ORFNames=K06C4.11;
Name=his-21; ORFNames=K06C4.3;
Name=his-30; ORFNames=F35H10.1;
Name=his-33; ORFNames=F17E9.13;
Name=his-43; ORFNames=F08G2.2;
Name=his-47; ORFNames=B0035.7;
Name=his-51; ORFNames=F07B7.10;
Name=his-53; ORFNames=F07B7.3;
Name=his-57; ORFNames=F54E12.5;
Name=his-61; ORFNames=F55G1.10;
Name=his-65; ORFNames=H02I12.7;
Name=his-68; ORFNames=T23D8.6;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
PubMed=2544730; DOI=10.1016/0022-2836(89)90566-4;
Roberts S.B., Emmons S.W., Childs G.;
"Nucleotide sequences of Caenorhabditis elegans core histone genes.
Genes for different histone classes share common flanking sequence
J. Mol. Biol. 206:567-577(1989).
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
PubMed=3606579; DOI=10.1042/bj2430297;
Vanfleteren J.R., van Bun S.M., van Beeumen J.J.;
"The primary structure of histone H2A from the nematode Caenorhabditis
Biochem. J. 243:297-300(1987).
PubMed=15133681; DOI=10.1007/s00412-004-0281-9;
Barber C.M., Turner F.B., Wang Y., Hagstrom K., Taverna S.D.,
Mollah S., Ueberheide B., Meyer B.J., Hunt D.F., Cheung P.,
Allis C.D.;
"The enhancement of histone H4 and H2A serine 1 phosphorylation during
mitosis and S-phase is evolutionarily conserved.";
Chromosoma 112:360-371(2004).
PubMed=15525528; DOI=10.1016/j.devcel.2004.10.005;
de Napoles M., Mermoud J.E., Wakao R., Tang Y.A., Endoh M.,
Appanah R., Nesterova T.B., Silva J., Otte A.P., Vidal M., Koseki H.,
Brockdorff N.;
"Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A
to heritable gene silencing and X inactivation.";
Dev. Cell 7:663-676(2004).
-!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and
compact DNA into chromatin, limiting DNA accessibility to the
cellular machineries which require DNA as a template. Histones
thereby play a central role in transcription regulation, DNA
repair, DNA replication and chromosomal stability. DNA
accessibility is regulated via a complex set of post-translational
modifications of histones, also called histone code, and
nucleosome remodeling.
-!- SUBUNIT: The nucleosome is a histone octamer containing two
molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4
heterotetramer and two H2A-H2B heterodimers. The octamer wraps
approximately 147 bp of DNA.
-!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
-!- PTM: Monoubiquitination of Lys-121 gives a specific tag for
epigenetic transcriptional repression. {ECO:0000305}.
-!- PTM: Phosphorylation on Ser-2 is enhanced during mitosis.
Phosphorylation on Ser-2 directly represses transcription (By
similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
EMBL; X15633; CAA33641.1; -; Genomic_DNA.
EMBL; FO081169; CCD69634.1; -; Genomic_DNA.
EMBL; FO081135; CCD69397.1; -; Genomic_DNA.
EMBL; FO081551; CCD72371.1; -; Genomic_DNA.
EMBL; FO081551; CCD72361.1; -; Genomic_DNA.
EMBL; FO081223; CCD70021.1; -; Genomic_DNA.
EMBL; Z73102; CAA97414.1; -; Genomic_DNA.
EMBL; Z81128; CAB03399.1; -; Genomic_DNA.
EMBL; Z81495; CAB04056.1; -; Genomic_DNA.
EMBL; Z82271; CAB05212.1; -; Genomic_DNA.
EMBL; Z83245; CAB05836.1; -; Genomic_DNA.
EMBL; Z83245; CAB05838.1; -; Genomic_DNA.
EMBL; Z92789; CAB07221.1; -; Genomic_DNA.
EMBL; Z93388; CAB07656.1; -; Genomic_DNA.
EMBL; FO081059; CCD68872.1; -; Genomic_DNA.
EMBL; FO081059; CCD68866.1; -; Genomic_DNA.
EMBL; FO081018; CCD68534.1; -; Genomic_DNA.
PIR; S04238; HSKW2A.
RefSeq; NP_492642.1; NM_060241.4.
RefSeq; NP_496887.1; NM_064486.3.
RefSeq; NP_496891.1; NM_064490.1.
RefSeq; NP_496898.1; NM_064497.1.
RefSeq; NP_501201.1; NM_068800.3.
RefSeq; NP_501404.1; NM_069003.1.
RefSeq; NP_501408.1; NM_069007.1.
RefSeq; NP_502131.1; NM_069730.4.
RefSeq; NP_502141.1; NM_069740.1.
RefSeq; NP_502150.1; NM_069749.1.
RefSeq; NP_505198.1; NM_072797.1.
RefSeq; NP_505277.1; NM_072876.1.
RefSeq; NP_505280.1; NM_072879.1.
RefSeq; NP_505293.1; NM_072892.1.
RefSeq; NP_505296.1; NM_072895.1.
RefSeq; NP_507032.1; NM_074631.3.
UniGene; Cel.12763; -.
UniGene; Cel.14855; -.
UniGene; Cel.16705; -.
UniGene; Cel.21396; -.
UniGene; Cel.21446; -.
UniGene; Cel.21869; -.
UniGene; Cel.28727; -.
UniGene; Cel.28728; -.
UniGene; Cel.3208; -.
UniGene; Cel.32608; -.
UniGene; Cel.32622; -.
UniGene; Cel.32841; -.
UniGene; Cel.32966; -.
ProteinModelPortal; P09588; -.
SMR; P09588; -.
BioGrid; 38282; 1.
BioGrid; 42639; 1.
BioGrid; 45064; 2.
BioGrid; 51394; 1.
BioGrid; 56170; 1.
BioGrid; 56178; 1.
STRING; 6239.ZK131.6; -.
iPTMnet; P09588; -.
EPD; P09588; -.
PaxDb; P09588; -.
PRIDE; P09588; -.
EnsemblMetazoa; B0035.7; B0035.7; WBGene00001921.
EnsemblMetazoa; F07B7.10; F07B7.10; WBGene00001925.
EnsemblMetazoa; F07B7.3; F07B7.3; WBGene00001927.
EnsemblMetazoa; F08G2.2; F08G2.2; WBGene00001917.
EnsemblMetazoa; F17E9.13; F17E9.13; WBGene00001907.
EnsemblMetazoa; F35H10.1; F35H10.1; WBGene00001904.
EnsemblMetazoa; F45F2.4; F45F2.4; WBGene00001881.
EnsemblMetazoa; F54E12.5a; F54E12.5a; WBGene00001931.
EnsemblMetazoa; F55G1.10; F55G1.10; WBGene00001935.
EnsemblMetazoa; H02I12.7; H02I12.7; WBGene00001939.
EnsemblMetazoa; K06C4.11; K06C4.11; WBGene00001893.
EnsemblMetazoa; K06C4.3; K06C4.3; WBGene00001895.
EnsemblMetazoa; T10C6.12; T10C6.12; WBGene00001877.
EnsemblMetazoa; T23D8.6; T23D8.6; WBGene00001942.
EnsemblMetazoa; ZK131.10; ZK131.10; WBGene00001890.
EnsemblMetazoa; ZK131.6; ZK131.6; WBGene00001886.
GeneID; 172860; -.
GeneID; 175025; -.
GeneID; 175028; -.
GeneID; 175034; -.
GeneID; 177521; -.
GeneID; 178048; -.
GeneID; 178056; -.
GeneID; 179261; -.
GeneID; 179265; -.
GeneID; 180073; -.
GeneID; 184112; -.
GeneID; 186671; -.
GeneID; 191669; -.
GeneID; 191676; -.
GeneID; 191678; -.
GeneID; 259800; -.
KEGG; cel:CELE_B0035.7; -.
KEGG; cel:CELE_F07B7.10; -.
KEGG; cel:CELE_F07B7.3; -.
KEGG; cel:CELE_F08G2.2; -.
KEGG; cel:CELE_F17E9.13; -.
KEGG; cel:CELE_F35H10.1; -.
KEGG; cel:CELE_F45F2.4; -.
KEGG; cel:CELE_F55G1.10; -.
KEGG; cel:CELE_H02I12.7; -.
KEGG; cel:CELE_K06C4.11; -.
KEGG; cel:CELE_K06C4.3; -.
KEGG; cel:CELE_T10C6.12; -.
KEGG; cel:CELE_T23D8.6; -.
KEGG; cel:CELE_ZK131.10; -.
KEGG; cel:CELE_ZK131.6; -.
UCSC; T23D8.6; c. elegans.
CTD; 172860; -.
CTD; 175025; -.
CTD; 175028; -.
CTD; 175034; -.
CTD; 177521; -.
CTD; 178048; -.
CTD; 178056; -.
CTD; 179261; -.
CTD; 179265; -.
CTD; 180073; -.
CTD; 184112; -.
CTD; 186671; -.
CTD; 191669; -.
CTD; 191676; -.
CTD; 191678; -.
CTD; 259800; -.
WormBase; B0035.7; CE04501; WBGene00001921; his-47.
WormBase; F07B7.10; CE04501; WBGene00001925; his-51.
WormBase; F07B7.3; CE04501; WBGene00001927; his-53.
WormBase; F08G2.2; CE04501; WBGene00001917; his-43.
WormBase; F17E9.13; CE04501; WBGene00001907; his-33.
WormBase; F35H10.1; CE04501; WBGene00001904; his-30.
WormBase; F45F2.4; CE04501; WBGene00001881; his-7.
WormBase; F54E12.5; CE04501; WBGene00001931; his-57.
WormBase; F55G1.10; CE04501; WBGene00001935; his-61.
WormBase; H02I12.7; CE04501; WBGene00001939; his-65.
WormBase; K06C4.11; CE04501; WBGene00001893; his-19.
WormBase; K06C4.3; CE04501; WBGene00001895; his-21.
WormBase; T10C6.12; CE04501; WBGene00001877; his-3.
WormBase; T23D8.6; CE04501; WBGene00001942; his-68.
WormBase; ZK131.10; CE04501; WBGene00001890; his-16.
WormBase; ZK131.6; CE04501; WBGene00001886; his-12.
eggNOG; KOG1756; Eukaryota.
eggNOG; COG5262; LUCA.
GeneTree; ENSGT00910000143981; -.
HOGENOM; HOG000234652; -.
InParanoid; P09588; -.
KO; K11251; -.
OrthoDB; EOG091G0XGD; -.
PhylomeDB; P09588; -.
Reactome; R-CEL-212300; PRC2 methylates histones and DNA.
Reactome; R-CEL-2299718; Condensation of Prophase Chromosomes.
Reactome; R-CEL-2559580; Oxidative Stress Induced Senescence.
Reactome; R-CEL-3214815; HDACs deacetylate histones.
Reactome; R-CEL-3214858; RMTs methylate histone arginines.
Reactome; R-CEL-427359; SIRT1 negatively regulates rRNA expression.
Reactome; R-CEL-5578749; Transcriptional regulation by small RNAs.
Reactome; R-CEL-5625886; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
Reactome; R-CEL-5689880; Ub-specific processing proteases.
Reactome; R-CEL-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
Reactome; R-CEL-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
Reactome; R-CEL-9018519; Estrogen-dependent gene expression.
PRO; PR:P09588; -.
Proteomes; UP000001940; Chromosome I.
Proteomes; UP000001940; Chromosome II.
Proteomes; UP000001940; Chromosome IV.
Proteomes; UP000001940; Chromosome V.
Bgee; WBGene00001877; -.
ExpressionAtlas; P09588; baseline.
GO; GO:0000790; C:nuclear chromatin; IBA:GO_Central.
GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IBA:GO_Central.
GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
GO; GO:0006342; P:chromatin silencing; IBA:GO_Central.
GO; GO:0006281; P:DNA repair; NAS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
CDD; cd00074; H2A; 1.
Gene3D;; -; 1.
InterPro; IPR009072; Histone-fold.
InterPro; IPR002119; Histone_H2A.
InterPro; IPR007125; Histone_H2A/H2B/H3.
InterPro; IPR032454; Histone_H2A_C.
InterPro; IPR032458; Histone_H2A_CS.
Pfam; PF00125; Histone; 1.
Pfam; PF16211; Histone_H2A_C; 1.
SMART; SM00414; H2A; 1.
SUPFAM; SSF47113; SSF47113; 1.
1: Evidence at protein level;
Acetylation; Chromosome; Complete proteome; Direct protein sequencing;
DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus;
Phosphoprotein; Reference proteome; Ubl conjugation.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:3606579}.
CHAIN 2 127 Histone H2A.
MOD_RES 2 2 N-acetylserine.
MOD_RES 2 2 Phosphoserine.
MOD_RES 6 6 N6-acetyllysine; partial.
MOD_RES 9 9 N6-acetyllysine; partial.
MOD_RES 11 11 N6-acetyllysine; partial.
MOD_RES 106 106 N5-methylglutamine. {ECO:0000250}.
CROSSLNK 121 121 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
SEQUENCE 127 AA; 13405 MW; FBF085558F1BD340 CRC64;

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