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Histone H2B 1

 H2B1_CAEEL              Reviewed;         122 AA.
P04255; O02656;
20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 4.
28-MAR-2018, entry version 151.
RecName: Full=Histone H2B 1;
Name=his-11; ORFNames=ZK131.5;
and
Name=his-15; ORFNames=ZK131.9;
and
Name=his-29; ORFNames=F35H10.11;
and
Name=his-34; ORFNames=F17E9.9;
and
Name=his-44; ORFNames=F08G2.1;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2544730; DOI=10.1016/0022-2836(89)90566-4;
Roberts S.B., Emmons S.W., Childs G.;
"Nucleotide sequences of Caenorhabditis elegans core histone genes.
Genes for different histone classes share common flanking sequence
elements.";
J. Mol. Biol. 206:567-577(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
PROTEIN SEQUENCE OF 2-122.
PubMed=3753445; DOI=10.1042/bj2350769;
Vanfleteren J.R., van Bun S.M., Delcambe L.L., van Beeumen J.J.;
"Multiple forms of histone H2B from the nematode Caenorhabditis
elegans.";
Biochem. J. 235:769-773(1986).
[4]
PARTIAL PROTEIN SEQUENCE.
PubMed=2583267; DOI=10.1016/0014-5793(89)81541-8;
Vanfleteren J.R., van Bun S.M., van Beeumen J.J.;
"The histones of Caenorhabditis elegans: no evidence of stage-specific
isoforms. An overview.";
FEBS Lett. 257:233-237(1989).
-!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and
compact DNA into chromatin, limiting DNA accessibility to the
cellular machineries which require DNA as a template. Histones
thereby play a central role in transcription regulation, DNA
repair, DNA replication and chromosomal stability. DNA
accessibility is regulated via a complex set of post-translational
modifications of histones, also called histone code, and
nucleosome remodeling.
-!- SUBUNIT: The nucleosome is a histone octamer containing two
molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4
heterotetramer and two H2A-H2B heterodimers. The octamer wraps
approximately 147 bp of DNA.
-!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
-!- PTM: Monoubiquitination of Lys-117 gives a specific tag for
epigenetic transcriptional activation and is also prerequisite for
histone H3 'Lys-4' and 'Lys-79' methylation. {ECO:0000250}.
-!- PTM: GlcNAcylation at Ser-109 promotes monoubiquitination of Lys-
117. It fluctuates in response to extracellular glucose, and
associates with transcribed genes (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the histone H2B family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X15633; CAA33642.1; -; Genomic_DNA.
EMBL; FO081169; CCD69642.1; -; Genomic_DNA.
EMBL; Z81495; CAB04061.1; -; Genomic_DNA.
EMBL; Z83245; CAB05830.1; -; Genomic_DNA.
EMBL; Z83245; CAB05832.1; -; Genomic_DNA.
EMBL; FO081018; CCD68530.1; -; Genomic_DNA.
PIR; D88357; D88357.
PIR; D88753; D88753.
RefSeq; NP_496888.1; NM_064487.1.
RefSeq; NP_496892.1; NM_064491.6.
RefSeq; NP_496897.1; NM_064496.1.
RefSeq; NP_501403.1; NM_069002.1.
RefSeq; NP_501409.1; NM_069008.1.
UniGene; Cel.14856; -.
UniGene; Cel.29184; -.
UniGene; Cel.32395; -.
UniGene; Cel.32675; -.
ProteinModelPortal; P04255; -.
SMR; P04255; -.
STRING; 6239.ZK131.9; -.
EPD; P04255; -.
PaxDb; P04255; -.
PeptideAtlas; P04255; -.
PRIDE; P04255; -.
EnsemblMetazoa; F08G2.1; F08G2.1; WBGene00001918.
EnsemblMetazoa; F17E9.9; F17E9.9; WBGene00001908.
EnsemblMetazoa; F35H10.11; F35H10.11; WBGene00001903.
EnsemblMetazoa; ZK131.5; ZK131.5; WBGene00001885.
EnsemblMetazoa; ZK131.9; ZK131.9; WBGene00001889.
GeneID; 175026; -.
GeneID; 175029; -.
GeneID; 175033; -.
GeneID; 185332; -.
GeneID; 191679; -.
KEGG; cel:CELE_F08G2.1; -.
KEGG; cel:CELE_F17E9.9; -.
KEGG; cel:CELE_F35H10.11; -.
KEGG; cel:CELE_ZK131.5; -.
KEGG; cel:CELE_ZK131.9; -.
UCSC; ZK131.9; c. elegans.
CTD; 175026; -.
CTD; 175029; -.
CTD; 175033; -.
CTD; 185332; -.
CTD; 191679; -.
WormBase; F08G2.1; CE07075; WBGene00001918; his-44.
WormBase; F17E9.9; CE07075; WBGene00001908; his-34.
WormBase; F35H10.11; CE07075; WBGene00001903; his-29.
WormBase; ZK131.5; CE07075; WBGene00001885; his-11.
WormBase; ZK131.9; CE07075; WBGene00001889; his-15.
eggNOG; KOG1744; Eukaryota.
eggNOG; ENOG4111NV5; LUCA.
GeneTree; ENSGT00760000118976; -.
HOGENOM; HOG000231213; -.
InParanoid; P04255; -.
KO; K11252; -.
OMA; RINKKFT; -.
OrthoDB; EOG091G0XGD; -.
PhylomeDB; P04255; -.
Reactome; R-CEL-212300; PRC2 methylates histones and DNA.
Reactome; R-CEL-2299718; Condensation of Prophase Chromosomes.
Reactome; R-CEL-2559580; Oxidative Stress Induced Senescence.
Reactome; R-CEL-3214815; HDACs deacetylate histones.
Reactome; R-CEL-3214847; HATs acetylate histones.
Reactome; R-CEL-427359; SIRT1 negatively regulates rRNA expression.
Reactome; R-CEL-5578749; Transcriptional regulation by small RNAs.
Reactome; R-CEL-5625886; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
Reactome; R-CEL-5689880; Ub-specific processing proteases.
Reactome; R-CEL-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
Reactome; R-CEL-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
PRO; PR:P04255; -.
Proteomes; UP000001940; Chromosome II.
Proteomes; UP000001940; Chromosome IV.
Bgee; WBGene00001885; -.
GO; GO:0000785; C:chromatin; IDA:WormBase.
GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IBA:GO_Central.
GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
Gene3D; 1.10.20.10; -; 1.
InterPro; IPR009072; Histone-fold.
InterPro; IPR007125; Histone_H2A/H2B/H3.
InterPro; IPR000558; Histone_H2B.
PANTHER; PTHR23428; PTHR23428; 1.
Pfam; PF00125; Histone; 1.
PRINTS; PR00621; HISTONEH2B.
SMART; SM00427; H2B; 1.
SUPFAM; SSF47113; SSF47113; 1.
PROSITE; PS00357; HISTONE_H2B; 1.
1: Evidence at protein level;
Chromosome; Complete proteome; Direct protein sequencing; DNA-binding;
Glycoprotein; Isopeptide bond; Nucleosome core; Nucleus;
Reference proteome; Ubl conjugation.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:3753445}.
CHAIN 2 122 Histone H2B 1.
/FTId=PRO_0000071867.
CARBOHYD 109 109 O-linked (GlcNAc) serine. {ECO:0000250}.
CROSSLNK 117 117 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000250}.
CONFLICT 27 28 RH -> KK (in Ref. 3; AA sequence and 4;
AA sequence). {ECO:0000305}.
SEQUENCE 122 AA; 13501 MW; C7D161DDEB329401 CRC64;
MPPKPSAKGA KKAAKTVTKP KDGKKRRHAR KESYSVYIYR VLKQVHPDTG VSSKAMSIMN
SFVNDVFERI AAEASRLAHY NKRSTISSRE IQTAVRLILP GELAKHAVSE GTKAVTKYTS
SK


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