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Histone H4

 H4_CAEEL                Reviewed;         103 AA.
P62784; O02619; P02306; P18678; Q7JNV2;
16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
12-SEP-2018, entry version 122.
RecName: Full=Histone H4;
Name=his-1; ORFNames=T10C6.14;
and
Name=his-5; ORFNames=F45F2.3;
and
Name=his-10; ORFNames=ZK131.4;
and
Name=his-14; ORFNames=ZK131.8;
and
Name=his-18; ORFNames=K06C4.10;
and
Name=his-26; ORFNames=ZK131.1;
and
Name=his-28; ORFNames=K06C4.2;
and
Name=his-31; ORFNames=F17E9.12;
and
Name=his-37; ORFNames=C50F4.7;
and
Name=his-38; ORFNames=K03A1.6;
and
Name=his-46; ORFNames=B0035.9;
and
Name=his-50; ORFNames=F07B7.9;
and
Name=his-56; ORFNames=F54E12.3;
and
Name=his-60; ORFNames=F55G1.11;
and
Name=his-64; ORFNames=F22B3.1;
and
Name=his-67; ORFNames=T23D8.5;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2544730; DOI=10.1016/0022-2836(89)90566-4;
Roberts S.B., Emmons S.W., Childs G.;
"Nucleotide sequences of Caenorhabditis elegans core histone genes.
Genes for different histone classes share common flanking sequence
elements.";
J. Mol. Biol. 206:567-577(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
PROTEIN SEQUENCE OF 2-103, ACETYLATION AT SER-2, AND METHYLATION AT
LYS-21.
PubMed=3665432;
Vanfleteren J.R., van Bun S.M., van Beeumen J.J.;
"The primary structure of histone H4 from the nematode Caenorhabditis
elegans.";
Comp. Biochem. Physiol. 87B:847-849(1987).
-!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and
compact DNA into chromatin, limiting DNA accessibility to the
cellular machineries which require DNA as a template. Histones
thereby play a central role in transcription regulation, DNA
repair, DNA replication and chromosomal stability. DNA
accessibility is regulated via a complex set of post-translational
modifications of histones, also called histone code, and
nucleosome remodeling.
-!- SUBUNIT: The nucleosome is a histone octamer containing two
molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4
heterotetramer and two H2A-H2B heterodimers. The octamer wraps
approximately 147 bp of DNA.
-!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
-!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X15634; CAA33643.1; -; Genomic_DNA.
EMBL; FO081018; CCD68533.1; -; Genomic_DNA.
EMBL; FO081059; CCD68871.1; -; Genomic_DNA.
EMBL; FO081135; CCD69398.1; -; Genomic_DNA.
EMBL; FO081223; CCD70020.1; -; Genomic_DNA.
EMBL; FO081551; CCD72360.1; -; Genomic_DNA.
EMBL; FO081551; CCD72370.1; -; Genomic_DNA.
EMBL; FO081579; CCD72542.1; -; Genomic_DNA.
EMBL; Z68336; CAA92734.1; -; Genomic_DNA.
EMBL; Z70750; CAA94742.1; -; Genomic_DNA.
EMBL; Z73102; CAA97407.1; -; Genomic_DNA.
EMBL; Z81128; CAB03396.1; -; Genomic_DNA.
EMBL; Z82271; CAB05210.1; -; Genomic_DNA.
EMBL; Z83245; CAB05835.4; -; Genomic_DNA.
EMBL; Z83245; CAB05837.1; -; Genomic_DNA.
EMBL; Z83245; CAB05839.1; -; Genomic_DNA.
EMBL; Z93388; CAB07657.1; -; Genomic_DNA.
PIR; JS0314; JS0314.
PIR; S04240; S04240.
PIR; T27741; T27741.
PIR; T29230; T29230.
RefSeq; NP_492641.1; NM_060240.4.
RefSeq; NP_496889.1; NM_064488.1.
RefSeq; NP_496893.1; NM_064492.1.
RefSeq; NP_496896.1; NM_064495.1.
RefSeq; NP_501203.2; NM_068802.5.
RefSeq; NP_501406.1; NM_069005.1.
RefSeq; NP_502133.1; NM_069732.1.
RefSeq; NP_502139.1; NM_069738.1.
RefSeq; NP_502154.1; NM_069753.3.
RefSeq; NP_505200.1; NM_072799.3.
RefSeq; NP_505275.1; NM_072874.1.
RefSeq; NP_505291.1; NM_072890.1.
RefSeq; NP_505298.1; NM_072897.4.
RefSeq; NP_505466.1; NM_073065.6.
RefSeq; NP_507034.1; NM_074633.1.
RefSeq; NP_509231.1; NM_076830.1.
UniGene; Cel.12858; -.
UniGene; Cel.12870; -.
UniGene; Cel.17998; -.
UniGene; Cel.21434; -.
UniGene; Cel.24406; -.
UniGene; Cel.24432; -.
UniGene; Cel.25563; -.
UniGene; Cel.28726; -.
UniGene; Cel.28998; -.
UniGene; Cel.29185; -.
UniGene; Cel.29404; -.
UniGene; Cel.32620; -.
UniGene; Cel.32860; -.
UniGene; Cel.33123; -.
UniGene; Cel.770; -.
ProteinModelPortal; P62784; -.
SMR; P62784; -.
BioGrid; 43149; 1.
BioGrid; 44273; 1.
BioGrid; 44379; 2.
BioGrid; 53446; 1.
BioGrid; 56168; 1.
BioGrid; 56177; 1.
IntAct; P62784; 2.
STRING; 6239.ZK131.8; -.
iPTMnet; P62784; -.
EPD; P62784; -.
PaxDb; P62784; -.
PeptideAtlas; P62784; -.
PRIDE; P62784; -.
EnsemblMetazoa; B0035.9; B0035.9; WBGene00001920.
EnsemblMetazoa; C50F4.7; C50F4.7; WBGene00001911.
EnsemblMetazoa; F07B7.9; F07B7.9; WBGene00001924.
EnsemblMetazoa; F17E9.12; F17E9.12; WBGene00001905.
EnsemblMetazoa; F22B3.1; F22B3.1; WBGene00001938.
EnsemblMetazoa; F45F2.3; F45F2.3; WBGene00001879.
EnsemblMetazoa; F54E12.3; F54E12.3; WBGene00001930.
EnsemblMetazoa; F55G1.11; F55G1.11; WBGene00001934.
EnsemblMetazoa; K03A1.6; K03A1.6; WBGene00001912.
EnsemblMetazoa; K06C4.10; K06C4.10; WBGene00001892.
EnsemblMetazoa; K06C4.2; K06C4.2; WBGene00001902.
EnsemblMetazoa; T10C6.14; T10C6.14; WBGene00001875.
EnsemblMetazoa; T23D8.5; T23D8.5; WBGene00001941.
EnsemblMetazoa; ZK131.1; ZK131.1; WBGene00001900.
EnsemblMetazoa; ZK131.4; ZK131.4; WBGene00001884.
EnsemblMetazoa; ZK131.8; ZK131.8; WBGene00001888.
GeneID; 175027; -.
GeneID; 175032; -.
GeneID; 177522; -.
GeneID; 178050; -.
GeneID; 178055; -.
GeneID; 178066; -.
GeneID; 179233; -.
GeneID; 179260; -.
GeneID; 179264; -.
GeneID; 179267; -.
GeneID; 179341; -.
GeneID; 188792; -.
GeneID; 191667; -.
GeneID; 191671; -.
GeneID; 191677; -.
GeneID; 191680; -.
KEGG; cel:CELE_B0035.9; -.
KEGG; cel:CELE_C50F4.7; -.
KEGG; cel:CELE_F07B7.9; -.
KEGG; cel:CELE_F17E9.12; -.
KEGG; cel:CELE_F22B3.1; -.
KEGG; cel:CELE_F45F2.3; -.
KEGG; cel:CELE_F54E12.3; -.
KEGG; cel:CELE_F55G1.11; -.
KEGG; cel:CELE_K03A1.6; -.
KEGG; cel:CELE_K06C4.10; -.
KEGG; cel:CELE_K06C4.2; -.
KEGG; cel:CELE_T10C6.14; -.
KEGG; cel:CELE_T23D8.5; -.
KEGG; cel:CELE_ZK131.1; -.
KEGG; cel:CELE_ZK131.4; -.
KEGG; cel:CELE_ZK131.8; -.
UCSC; T23D8.5; c. elegans.
CTD; 175027; -.
CTD; 175032; -.
CTD; 177522; -.
CTD; 178050; -.
CTD; 178055; -.
CTD; 178066; -.
CTD; 179233; -.
CTD; 179260; -.
CTD; 179264; -.
CTD; 179267; -.
CTD; 179341; -.
CTD; 188792; -.
CTD; 191667; -.
CTD; 191671; -.
CTD; 191677; -.
CTD; 191680; -.
WormBase; B0035.9; CE03252; WBGene00001920; his-46.
WormBase; C50F4.7; CE03252; WBGene00001911; his-37.
WormBase; F07B7.9; CE03252; WBGene00001924; his-50.
WormBase; F17E9.12; CE03252; WBGene00001905; his-31.
WormBase; F22B3.1; CE03252; WBGene00001938; his-64.
WormBase; F45F2.3; CE03252; WBGene00001879; his-5.
WormBase; F54E12.3; CE03252; WBGene00001930; his-56.
WormBase; F55G1.11; CE03252; WBGene00001934; his-60.
WormBase; K03A1.6; CE03252; WBGene00001912; his-38.
WormBase; K06C4.10; CE03252; WBGene00001892; his-18.
WormBase; K06C4.2; CE03252; WBGene00001902; his-28.
WormBase; T10C6.14; CE03252; WBGene00001875; his-1.
WormBase; T23D8.5; CE03252; WBGene00001941; his-67.
WormBase; ZK131.1; CE03252; WBGene00001900; his-26.
WormBase; ZK131.4; CE03252; WBGene00001884; his-10.
WormBase; ZK131.8; CE03252; WBGene00001888; his-14.
eggNOG; KOG3467; Eukaryota.
eggNOG; COG2036; LUCA.
GeneTree; ENSGT00760000119019; -.
HOGENOM; HOG000234654; -.
InParanoid; P62784; -.
KO; K11254; -.
OMA; HINGITK; -.
OrthoDB; EOG091G0XGD; -.
PhylomeDB; P62784; -.
Reactome; R-CEL-2299718; Condensation of Prophase Chromosomes.
Reactome; R-CEL-3214841; PKMTs methylate histone lysines.
Reactome; R-CEL-3214842; HDMs demethylate histones.
Reactome; R-CEL-3214847; HATs acetylate histones.
Reactome; R-CEL-3214858; RMTs methylate histone arginines.
Reactome; R-CEL-4551638; SUMOylation of chromatin organization proteins.
PRO; PR:P62784; -.
Proteomes; UP000001940; Chromosome I.
Proteomes; UP000001940; Chromosome II.
Proteomes; UP000001940; Chromosome IV.
Proteomes; UP000001940; Chromosome V.
Proteomes; UP000001940; Chromosome X.
Bgee; WBGene00001875; Expressed in 5 organ(s), highest expression level in material anatomical entity.
GO; GO:0000788; C:nuclear nucleosome; IBA:GO_Central.
GO; GO:0003677; F:DNA binding; IBA:GO_Central.
GO; GO:0042393; F:histone binding; IBA:GO_Central.
GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
CDD; cd00076; H4; 1.
Gene3D; 1.10.20.10; -; 1.
InterPro; IPR035425; CENP-T/H4_C.
InterPro; IPR009072; Histone-fold.
InterPro; IPR001951; Histone_H4.
InterPro; IPR019809; Histone_H4_CS.
Pfam; PF15511; CENP-T_C; 1.
PRINTS; PR00623; HISTONEH4.
SMART; SM00417; H4; 1.
SUPFAM; SSF47113; SSF47113; 1.
PROSITE; PS00047; HISTONE_H4; 1.
1: Evidence at protein level;
Acetylation; Chromosome; Complete proteome; Direct protein sequencing;
DNA-binding; Methylation; Nucleosome core; Nucleus;
Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:3665432}.
CHAIN 2 103 Histone H4.
/FTId=PRO_0000158290.
DNA_BIND 17 21
MOD_RES 2 2 N-acetylserine.
{ECO:0000269|PubMed:3665432}.
MOD_RES 17 17 N6-acetyllysine.
{ECO:0000250|UniProtKB:P62805}.
MOD_RES 21 21 N6-methyllysine.
{ECO:0000269|PubMed:3665432}.
CONFLICT 3 3 G -> E (in Ref. 3; AA sequence).
{ECO:0000305}.
CONFLICT 29 29 Missing (in Ref. 3; AA sequence).
{ECO:0000305}.
SEQUENCE 103 AA; 11369 MW; A9E5DFD3F8AF04FF CRC64;
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
VFLENVIRDA VTYCEHAKRK TVTAMDVVYA LKRQGRTLYG FGG


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