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Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (Lysine acetyltransferase 5)

 KAT5_PONAB              Reviewed;         461 AA.
Q5RBG4;
11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
30-AUG-2017, entry version 92.
RecName: Full=Histone acetyltransferase KAT5;
EC=2.3.1.48 {ECO:0000250|UniProtKB:Q92993};
AltName: Full=60 kDa Tat-interactive protein;
Short=Tip60;
AltName: Full=Histone acetyltransferase HTATIP;
AltName: Full=Lysine acetyltransferase 5;
Name=KAT5; Synonyms=HTATIP, TIP60;
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalytic subunit of the NuA4 histone acetyltransferase
complex which is involved in transcriptional activation of select
genes principally by acetylation of nucleosomal histones H4 and
H2A. This modification may both alter nucleosome - DNA
interactions and promote interaction of the modified histones with
other proteins which positively regulate transcription. This
complex may be required for the activation of transcriptional
programs associated with oncogene and proto-oncogene mediated
growth induction, tumor suppressor mediated growth arrest and
replicative senescence, apoptosis, and DNA repair. NuA4 may also
play a direct role in DNA repair when recruited to sites of DNA
damage. Directly acetylates and activates ATM. Relieves NR1D2-
mediated inhibition of APOC3 expression by acetylating NR1D2.
Component of a SWR1-like complex that specifically mediates the
removal of histone H2A.Z/H2AFZ from the nucleosome. Promotes FOXP3
acetylation and positively regulates its transcriptional repressor
activity. {ECO:0000250|UniProtKB:Q92993}.
-!- CATALYTIC ACTIVITY: Acetyl-CoA + [protein]-L-lysine = CoA +
[protein]-N(6)-acetyl-L-lysine. {ECO:0000250|UniProtKB:Q92993}.
-!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex
which contains the catalytic subunit KAT5/TIP60 and the subunits
EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49,
RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX,
MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. HTATTIP/TIP60, EPC1, and
ING3 together constitute a minimal HAT complex termed Piccolo
NuA4. The NuA4 complex interacts with MYC. Interacts with ATM.
Interacts with JADE1. Interacts with PLA2G4A/CPLA2, EDNRA and
HDAC7. Interacts with the cytoplasmic tail of APP and APBB1/FE65.
Interacts with TRIM24 and TRIM68. Forms a complex with SENP6 and
UBE2I in response to UV irradiation. Identified in a complex with
HINT1. Interacts with ATF2 and CUL3. Interacts with NR1D2 (via N-
terminus). Component of a SWR1-like complex. Interacts with FOXP3.
Interacts with ZBTB49 (By similarity).
{ECO:0000250|UniProtKB:Q92993, ECO:0000250|UniProtKB:Q99MK2}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92993}.
Nucleus, nucleolus {ECO:0000250|UniProtKB:Q92993}. Cytoplasm,
perinuclear region {ECO:0000250|UniProtKB:Q92993}. Note=Upon
stimulation with EDN1, it is exported from the nucleus to the
perinuclear region. {ECO:0000250|UniProtKB:Q92993}.
-!- PTM: Sumoylated by UBE2I at Lys-378 and Lys-399, leading to
increase of its histone acetyltransferase activity in UV-induced
DNA damage response, as well as its translocation to nuclear
bodies. {ECO:0000250}.
-!- PTM: Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M
phase. The phosphorylated form has a higher HAT activity.
{ECO:0000250|UniProtKB:Q9H7Z6}.
-!- PTM: Ubiquitinated by MDM2, leading to its proteasome-dependent
degradation. {ECO:0000250}.
-!- PTM: Autoacetylation at Lys-275 is required for proper function.
{ECO:0000250|UniProtKB:Q9H7Z6}.
-!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family. {ECO:0000305}.
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EMBL; CR858684; CAH90896.1; -; mRNA.
RefSeq; NP_001127347.1; NM_001133875.1.
UniGene; Pab.13524; -.
ProteinModelPortal; Q5RBG4; -.
SMR; Q5RBG4; -.
PRIDE; Q5RBG4; -.
GeneID; 100174410; -.
KEGG; pon:100174410; -.
CTD; 10524; -.
InParanoid; Q5RBG4; -.
KO; K11304; -.
Proteomes; UP000001595; Unplaced.
GO; GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:UniProtKB.
GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; ISS:UniProtKB.
GO; GO:0000812; C:Swr1 complex; ISS:UniProtKB.
GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR016181; Acyl_CoA_acyltransferase.
InterPro; IPR000953; Chromo/chromo_shadow_dom.
InterPro; IPR016197; Chromodomain-like.
InterPro; IPR002717; HAT_MYST-type.
InterPro; IPR025995; Tudor-knot.
Pfam; PF01853; MOZ_SAS; 1.
Pfam; PF11717; Tudor-knot; 1.
SMART; SM00298; CHROMO; 1.
SUPFAM; SSF54160; SSF54160; 1.
SUPFAM; SSF55729; SSF55729; 1.
PROSITE; PS51726; MYST_HAT; 1.
2: Evidence at transcript level;
Acetylation; Activator; Acyltransferase; Chromatin regulator;
Complete proteome; Cytoplasm; Growth regulation; Isopeptide bond;
Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
Transcription; Transcription regulation; Transferase; Ubl conjugation;
Zinc; Zinc-finger.
CHAIN 1 461 Histone acetyltransferase KAT5.
/FTId=PRO_0000245806.
DOMAIN 175 452 MYST-type HAT. {ECO:0000255|PROSITE-
ProRule:PRU01063}.
ZN_FING 208 233 C2HC MYST-type. {ECO:0000255|PROSITE-
ProRule:PRU01063}.
REGION 316 461 Interaction with ATF2. {ECO:0000250}.
REGION 318 320 Acetyl-CoA binding.
{ECO:0000250|UniProtKB:Q9H7Z6}.
REGION 325 331 Acetyl-CoA binding.
{ECO:0000250|UniProtKB:Q9H7Z6}.
ACT_SITE 351 351 Proton donor/acceptor.
{ECO:0000250|UniProtKB:Q9H7Z6}.
BINDING 355 355 Acetyl-CoA.
{ECO:0000250|UniProtKB:Q9H7Z6}.
BINDING 364 364 Acetyl-CoA.
{ECO:0000250|UniProtKB:Q9H7Z6}.
MOD_RES 52 52 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q92993}.
MOD_RES 86 86 Phosphoserine.
{ECO:0000250|UniProtKB:Q92993}.
MOD_RES 90 90 Phosphoserine.
{ECO:0000250|UniProtKB:Q92993}.
MOD_RES 147 147 Phosphoserine.
{ECO:0000250|UniProtKB:Q92993}.
MOD_RES 275 275 N6-acetyllysine; by autocatalysis.
{ECO:0000250|UniProtKB:Q92993}.
CROSSLNK 378 378 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
CROSSLNK 399 399 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
SEQUENCE 461 AA; 53077 MW; 5A0E9324550AF246 CRC64;
MAEVGEIIEG CRLPVLRRNQ DNEDEWPLAE ILSVKDISGR KLFYVHYIDF NKRLDEWVTH
ERLDLKKIQF PKKEAKTPTK NGLPGSRPGS PEREVKRKVE VVSPATPVPS ETAPASVFPQ
NGAARRAVAA QPGRKRKSNC LGTDEDSQDS SDGIPSAPRM TGSLVSDRSH DDIVTRMKNI
ECIELGRHRL KPWYFSPYPQ ELTTLPVLYL CEFCLKYGRS LKCLQRHLTK CDLRHPPGNE
IYRKGTISFF EIDGRKNKSY SQNLCLLAKC FLDHKTLYYD TDPFLFYVMT EYDCKGFHIV
GYFSKEKEST EDYNVACILT LPPYQRRGYG KLLIEFSYEL SKVEGKTGTP EKPLSDLGLL
SYRSYWSQTI LEILMGLKSE SGERPQITIN EISEITSIKK EDVISTLQYL NLINYYKGQY
ILTLSEDIVD GHERAMLKRL LRIDSKCLHF TPKDWSKRGK W


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