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Histone chaperone ASF1 (Anti-silencing function protein 1 homolog)

 ASF1_CHICK              Reviewed;         204 AA.
Q3C1E9;
17-APR-2007, integrated into UniProtKB/Swiss-Prot.
22-NOV-2005, sequence version 1.
25-OCT-2017, entry version 75.
RecName: Full=Histone chaperone ASF1;
AltName: Full=Anti-silencing function protein 1 homolog;
Name=ASF1;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CHAF1B; HIRA;
HISTONE H3 AND HISTONE H4, SUBCELLULAR LOCATION, PHOSPHORYLATION, AND
MUTAGENESIS OF 36-GLU-ASP-37.
PubMed=16537536; DOI=10.1074/jbc.M511590200;
Sanematsu F., Takami Y., Barman H.K., Fukagawa T., Ono T.,
Shibahara K., Nakayama T.;
"Asf1 is required for viability and chromatin assembly during DNA
replication in vertebrate cells.";
J. Biol. Chem. 281:13817-13827(2006).
-!- FUNCTION: Histone chaperone that facilitates histone deposition
and histone exchange and removal during nucleosome assembly and
disassembly. Cooperates with chromatin assembly factor 1 (CAF-1)
to promote replication-dependent chromatin assembly. May also
cooperate with HIRA to promote replication-independent chromatin
assembly. {ECO:0000269|PubMed:16537536}.
-!- SUBUNIT: Interacts with CHAF1B, HIRA, histone H3 and histone H4.
{ECO:0000269|PubMed:16537536}.
-!- INTERACTION:
Q5R1S9:CHAF1B; NbExp=2; IntAct=EBI-996834, EBI-996875;
P79987:HIRA; NbExp=2; IntAct=EBI-996834, EBI-996848;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16537536}.
-!- PTM: Phosphorylated. {ECO:0000269|PubMed:16537536}.
-!- SIMILARITY: Belongs to the ASF1 family. {ECO:0000305}.
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EMBL; AB238225; BAE46789.1; -; mRNA.
RefSeq; NP_001038155.1; NM_001044690.1.
UniGene; Gga.1997; -.
ProteinModelPortal; Q3C1E9; -.
SMR; Q3C1E9; -.
BioGrid; 689056; 4.
IntAct; Q3C1E9; 4.
STRING; 9031.ENSGALP00000023972; -.
PaxDb; Q3C1E9; -.
Ensembl; ENSGALT00000073491; ENSGALP00000057957; ENSGALG00000014887.
GeneID; 723780; -.
KEGG; gga:723780; -.
CTD; 25842; -.
eggNOG; KOG3265; Eukaryota.
eggNOG; COG5137; LUCA.
GeneTree; ENSGT00390000004692; -.
HOGENOM; HOG000197425; -.
HOVERGEN; HBG105617; -.
InParanoid; Q3C1E9; -.
KO; K10753; -.
PhylomeDB; Q3C1E9; -.
Reactome; R-GGA-2559584; Formation of Senescence-Associated Heterochromatin Foci (SAHF).
PRO; PR:Q3C1E9; -.
Proteomes; UP000000539; Chromosome 3.
ExpressionAtlas; Q3C1E9; baseline and differential.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0043234; C:protein complex; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0042393; F:histone binding; IEA:Ensembl.
GO; GO:0016569; P:covalent chromatin modification; IEA:UniProtKB-KW.
GO; GO:0006281; P:DNA repair; IEA:Ensembl.
GO; GO:0006335; P:DNA replication-dependent nucleosome assembly; IEA:Ensembl.
GO; GO:0006336; P:DNA replication-independent nucleosome assembly; IEA:Ensembl.
GO; GO:0042692; P:muscle cell differentiation; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 2.60.40.1490; -; 1.
InterPro; IPR006818; ASF1-like.
InterPro; IPR036747; ASF1-like_sf.
PANTHER; PTHR12040; PTHR12040; 1.
Pfam; PF04729; ASF1_hist_chap; 1.
SUPFAM; SSF101546; SSF101546; 1.
1: Evidence at protein level;
Chaperone; Chromatin regulator; Complete proteome; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 204 Histone chaperone ASF1.
/FTId=PRO_0000284017.
REGION 1 155 Interaction with CHAF1B, HIRA, histone H3
and histone H4.
{ECO:0000269|PubMed:16537536}.
MUTAGEN 36 37 ED->AA: Abrogates interaction with CHAF1B
and HIRA. {ECO:0000269|PubMed:16537536}.
SEQUENCE 204 AA; 22969 MW; 9819D531D3A9FC68 CRC64;
MAKVQVNNVV VLDNPSPFYN PFQFEITFEC IEDLSEDLEW KIIYVGSAES EEYDQVLDSV
LVGPVPAGRH MFVFQADAPN PGLIPDADAV GVTVVLITCT YRGQEFIRVG YYVNNEYTET
ELRENPPVKP DFSKLQRNIL ASNPRVTRFH INWEDNTEKL EDAESSNPNL QSLLSTDALP
SASKGWSTSE NSLNVMLESH MDCM


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