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Histone deacetylase (EC 3 5 1 98)

 H3AZX3_LATCH            Unreviewed;       484 AA.
H3AZX3;
18-APR-2012, integrated into UniProtKB/TrEMBL.
18-APR-2012, sequence version 1.
28-MAR-2018, entry version 41.
RecName: Full=Histone deacetylase {ECO:0000256|PIRNR:PIRNR037913, ECO:0000256|SAAS:SAAS00894283};
EC=3.5.1.98 {ECO:0000256|PIRNR:PIRNR037913, ECO:0000256|SAAS:SAAS00894283};
Name=HDAC1 {ECO:0000313|Ensembl:ENSLACP00000015194};
Latimeria chalumnae (West Indian ocean coelacanth).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Coelacanthiformes; Coelacanthidae; Latimeria.
NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000015194, ECO:0000313|Proteomes:UP000008672};
[1] {ECO:0000313|Ensembl:ENSLACP00000015194}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000015194};
PubMed=9215903;
Zardoya R., Meyer A.;
"The complete DNA sequence of the mitochondrial genome of a 'living
fossil,' the coelacanth (Latimeria chalumnae).";
Genetics 146:995-1010(1997).
[2] {ECO:0000313|Ensembl:ENSLACP00000015194}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
a histone to yield a deacetylated histone.
{ECO:0000256|PIRNR:PIRNR037913, ECO:0000256|SAAS:SAAS00894227}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR037913,
ECO:0000256|SAAS:SAAS00894298}.
-!- SIMILARITY: Belongs to the histone deacetylase family. HD Type 1
subfamily. {ECO:0000256|PIRNR:PIRNR037913}.
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EMBL; AFYH01139792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AFYH01139793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AFYH01139794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AFYH01139795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AFYH01139796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AFYH01139797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 7897.ENSLACP00000015194; -.
Ensembl; ENSLACT00000015300; ENSLACP00000015194; ENSLACG00000013376.
eggNOG; KOG1342; Eukaryota.
eggNOG; COG0123; LUCA.
GeneTree; ENSGT00910000144047; -.
InParanoid; H3AZX3; -.
OMA; MDTSKPK; -.
OrthoDB; EOG091G067J; -.
TreeFam; TF106171; -.
Proteomes; UP000008672; Unassembled WGS sequence.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
GO; GO:0060028; P:convergent extension involved in axis elongation; IEA:Ensembl.
GO; GO:0048263; P:determination of dorsal identity; IEA:Ensembl.
GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
GO; GO:0021754; P:facial nucleus development; IEA:Ensembl.
GO; GO:0031101; P:fin regeneration; IEA:Ensembl.
GO; GO:0060218; P:hematopoietic stem cell differentiation; IEA:Ensembl.
GO; GO:0001889; P:liver development; IEA:Ensembl.
GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0033687; P:osteoblast proliferation; IEA:Ensembl.
GO; GO:0048935; P:peripheral nervous system neuron development; IEA:Ensembl.
GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0060042; P:retina morphogenesis in camera-type eye; IEA:Ensembl.
GO; GO:0021903; P:rostrocaudal neural tube patterning; IEA:Ensembl.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
Gene3D; 3.40.800.20; -; 1.
InterPro; IPR000286; His_deacetylse.
InterPro; IPR003084; His_deacetylse_1.
InterPro; IPR023801; His_deacetylse_dom.
InterPro; IPR037138; His_deacetylse_dom_sf.
InterPro; IPR023696; Ureohydrolase_dom_sf.
PANTHER; PTHR10625; PTHR10625; 1.
Pfam; PF00850; Hist_deacetyl; 2.
PIRSF; PIRSF037913; His_deacetylse_1; 1.
PRINTS; PR01270; HDASUPER.
PRINTS; PR01271; HISDACETLASE.
SUPFAM; SSF52768; SSF52768; 1.
3: Inferred from homology;
Chromatin regulator {ECO:0000256|PIRNR:PIRNR037913,
ECO:0000256|SAAS:SAAS00894233}; Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000008672};
Hydrolase {ECO:0000256|PIRNR:PIRNR037913,
ECO:0000256|SAAS:SAAS00870288};
Metal-binding {ECO:0000256|PIRSR:PIRSR037913-3};
Nucleus {ECO:0000256|PIRNR:PIRNR037913,
ECO:0000256|SAAS:SAAS00894277};
Reference proteome {ECO:0000313|Proteomes:UP000008672};
Transcription {ECO:0000256|PIRNR:PIRNR037913,
ECO:0000256|SAAS:SAAS00894290};
Transcription regulation {ECO:0000256|PIRNR:PIRNR037913,
ECO:0000256|SAAS:SAAS00894290}.
DOMAIN 65 169 Hist_deacetyl.
{ECO:0000259|Pfam:PF00850}.
DOMAIN 207 321 Hist_deacetyl.
{ECO:0000259|Pfam:PF00850}.
COILED 444 464 {ECO:0000256|SAM:Coils}.
ACT_SITE 145 145 Proton acceptor.
{ECO:0000256|PIRSR:PIRSR037913-1}.
METAL 268 268 Divalent metal cation.
{ECO:0000256|PIRSR:PIRSR037913-3}.
SEQUENCE 484 AA; 54663 MW; 63C7EC2F16D69465 CRC64;
MALSQGTKKK VCYYYDGEIG LQFSYRFSHV FKKGRLKCTL KLDSMAQFGC FMGPKIFLHK
NSTFTLLIYH CHSYIGFLTS VKKRENIAIY SEPMQRVDAA FNEICEKSSL LARSWVVVGG
KTAGAVKLNK QQTDIAINWA GGLHHAKKSE ASGFCYVNDI VLAILELLKM EQECTGFKIG
GWAGEWKASR TNKRDSLLPC PGRKRSAFSP VTGNLQDIGA GKGKYYAVNY PLRDGIDDES
YEAIFKPIMC KVMEMYQPSA IVLQCGADSL SGDRLGCFNL TIKGHAKCVE FMKSFNLPLL
MLGGGGYTIR NVARCWTYET AVALDSEIPN ELPYNDYFEY FGPDFKLHIS PSNMTNQNTN
EYLEKIKQRL FENLRMLPHA PGVQMQAIPE DAVQEDSGDE DEEDPNKRIS IRASDKRIAC
DEEFSDSEDE GEGGRRNIAS YKKAKRVKTE EEKDSEEKKD VKEEDKTKED KAEVKGKKKK
NHSY


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