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Histone deacetylase (EC 3.5.1.98)

 G1MJ38_AILME            Unreviewed;      1111 AA.
G1MJ38;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
22-NOV-2017, entry version 40.
RecName: Full=Histone deacetylase {ECO:0000256|PIRNR:PIRNR037911, ECO:0000256|SAAS:SAAS00894283};
EC=3.5.1.98 {ECO:0000256|PIRNR:PIRNR037911, ECO:0000256|SAAS:SAAS00894283};
Name=HDAC5 {ECO:0000313|Ensembl:ENSAMEP00000019373};
Ailuropoda melanoleuca (Giant panda).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
Ailuropoda.
NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000019373, ECO:0000313|Proteomes:UP000008912};
[1] {ECO:0000313|Ensembl:ENSAMEP00000019373}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20010809; DOI=10.1038/nature08696;
Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
Wang J., Wang J.;
"The sequence and de novo assembly of the giant panda genome.";
Nature 463:311-317(2010).
[2] {ECO:0000313|Ensembl:ENSAMEP00000019373}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- FUNCTION: Responsible for the deacetylation of lysine residues on
the N-terminal part of the core histones (H2A, H2B, H3 and H4).
Histone deacetylation gives a tag for epigenetic repression and
plays an important role in transcriptional regulation, cell cycle
progression and developmental events.
{ECO:0000256|PIRNR:PIRNR037911}.
-!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
a histone to yield a deacetylated histone.
{ECO:0000256|PIRNR:PIRNR037911, ECO:0000256|SAAS:SAAS00894227}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR037911,
ECO:0000256|SAAS:SAAS00894298}.
-!- SIMILARITY: Belongs to the histone deacetylase family. HD type 2
subfamily. {ECO:0000256|PIRNR:PIRNR037911}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000019373}.
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EMBL; ACTA01058246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01066246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9646.ENSAMEP00000019373; -.
Ensembl; ENSAMET00000020140; ENSAMEP00000019373; ENSAMEG00000018326.
eggNOG; KOG1343; Eukaryota.
eggNOG; COG0123; LUCA.
GeneTree; ENSGT00530000062809; -.
InParanoid; G1MJ38; -.
OMA; LGPYDSR; -.
OrthoDB; EOG091G0EQO; -.
TreeFam; TF106174; -.
Proteomes; UP000008912; Unassembled WGS sequence.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0000118; C:histone deacetylase complex; IEA:UniProtKB-UniRule.
GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
GO; GO:0001047; F:core promoter binding; IEA:Ensembl.
GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
GO; GO:0005080; F:protein kinase C binding; IEA:Ensembl.
GO; GO:0070491; F:repressing transcription factor binding; IEA:Ensembl.
GO; GO:0001025; F:RNA polymerase III transcription factor binding; IEA:Ensembl.
GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0010832; P:negative regulation of myotube differentiation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0040029; P:regulation of gene expression, epigenetic; IEA:Ensembl.
GO; GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 2.130.10.10; -; 1.
Gene3D; 3.40.800.20; -; 1.
InterPro; IPR000286; His_deacetylse.
InterPro; IPR023801; His_deacetylse_dom.
InterPro; IPR037138; His_deacetylse_dom_sf.
InterPro; IPR024643; Hist_deacetylase_Gln_rich_N.
InterPro; IPR017320; Histone_deAcase_II_euk.
InterPro; IPR030703; Histone_deacetylase_5.
InterPro; IPR023696; Ureohydrolase_dom_sf.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
PANTHER; PTHR10625; PTHR10625; 1.
PANTHER; PTHR10625:SF57; PTHR10625:SF57; 1.
Pfam; PF12203; HDAC4_Gln; 1.
Pfam; PF00850; Hist_deacetyl; 1.
PIRSF; PIRSF037911; HDAC_II_euk; 1.
PRINTS; PR01270; HDASUPER.
SUPFAM; SSF52768; SSF52768; 1.
3: Inferred from homology;
Chromatin regulator {ECO:0000256|PIRNR:PIRNR037911,
ECO:0000256|SAAS:SAAS00894233}; Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000008912};
Hydrolase {ECO:0000256|PIRNR:PIRNR037911,
ECO:0000256|SAAS:SAAS00870288};
Metal-binding {ECO:0000256|PIRSR:PIRSR037911-2};
Nucleus {ECO:0000256|SAAS:SAAS00894277};
Reference proteome {ECO:0000313|Proteomes:UP000008912};
Repressor {ECO:0000256|PIRNR:PIRNR037911};
Transcription {ECO:0000256|PIRNR:PIRNR037911,
ECO:0000256|SAAS:SAAS00894290};
Transcription regulation {ECO:0000256|PIRNR:PIRNR037911,
ECO:0000256|SAAS:SAAS00894290};
Zinc {ECO:0000256|PIRSR:PIRSR037911-2}.
DOMAIN 68 122 HDAC4_Gln. {ECO:0000259|Pfam:PF12203}.
DOMAIN 694 1011 Hist_deacetyl.
{ECO:0000259|Pfam:PF00850}.
COILED 567 597 {ECO:0000256|SAM:Coils}.
ACT_SITE 823 823 {ECO:0000256|PIRSR:PIRSR037911-1}.
METAL 686 686 Zinc. {ECO:0000256|PIRSR:PIRSR037911-2}.
METAL 688 688 Zinc. {ECO:0000256|PIRSR:PIRSR037911-2}.
METAL 694 694 Zinc. {ECO:0000256|PIRSR:PIRSR037911-2}.
METAL 771 771 Zinc. {ECO:0000256|PIRSR:PIRSR037911-2}.
SITE 995 995 Contributes to catalysis.
{ECO:0000256|PIRSR:PIRSR037911-3}.
SEQUENCE 1111 AA; 120024 MW; 903A3D7321A1660A CRC64;
ETESCFSADG MSGREPSLEI LPRTPLHSIP VAVEVKPVLP GAMPSSMGGG GGGSPGPAEL
RGALAGPVDP ALREQQLQQE LLALKQQQQL QKQLLFAEFQ KQHDHLTRQH EVQLQKHLKV
SEGGAGGPPR PPTPARTWLK EELEKQRLEQ QLLILRNKEK SKESAIASTE VKLRLQEFLL
SKSKEPTPGG LNHSLPQHPK CWGAHHASLD QSSPPQSGPP GTPPSYKLPL LGPYDSRDDF
PLRKTASEPN LKVRSRLKQK VAERRSSPLL RRKDGTVIST FKKRAVEITG AGPGVSSVCN
SAPGSGPSSP NSSHSTIAEN GFTGSVPNIP TEMLPQHRAL PLDSSPNQFS LYTSPSLPNI
SLGLQATVTV TNSHLTASPK LSTQQEAERQ ALQSLRQGGA LTGKFMSTSS IPGCLLGVAL
EGDTSPHGHA SLLQHVLLLE QARQQSALIA VPLHGQSPLV TGERVATSMR TVGKLPRHRP
LSRTQSSPLP QSPQALQQLV MQQQHQQFLE KQKQQQLQLG KILTKTGELS RQPPTHPEET
EEELTEQQEA LLGEGALTIP REGSTESEST QGDLEEEEED EEEEEEEEED CIQVKDEEGE
SGTEEGPDLD ESSAGYKKVF SDAQQLQPLQ VYQAPLSLAT VPHQALGRTQ SSPAAPGGMK
SPPDQPAKHL FTTGVVYDTF MLKHQCTCGN THVHPEHAGR IQSIWSRLQE TGLLSKCERI
RGRKATLDEI QTVHSEYHTL LYGTSPLNRQ KLDSKKLLGP ISQKMYAMLP CGGIGVDSDT
VWNEMHSSSA VRMAVGCLVE LAFKVASGEL KNGFAIIRPP GHHAEESTAM GFCFFNSVAI
TTKLLQQKLN VGKVLIVDWD IHHGNGTQQA FYNDPSVLYI SLHRYDNGNF FPGSGAPEEV
GGGPGMGYNV NVAWTGGVDP PIGDVEYLTA FRTVVMPIAH EFSPDVVLVS AGFDAVEGHL
SPLGGYSVTA RFGHLTRQLM TLAGGRVVLA LEGGHDLTAI CDASEACVSA LLSVELQPLD
EAVLQQKPNI NAVATLEKVI EIQSKHWSCV QRFAAGLGRS LREAQAGETE EAETVSAMAL
LSVGAEQAQA AAAREHSPRP AEEPMEQEPA L


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