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Homeobox protein CDX-2 (Caudal-type homeobox protein 2)

 CDX2_MOUSE              Reviewed;         311 AA.
P43241;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
07-JUN-2017, entry version 147.
RecName: Full=Homeobox protein CDX-2;
AltName: Full=Caudal-type homeobox protein 2;
Name=Cdx2; Synonyms=Cdx-2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE.
STRAIN=BALB/cJ;
PubMed=7910823;
James R.J., Erler T., Kazenwadel J.;
"Structure of the murine homeobox gene cdx-2. Expression in embryonic
and adult intestinal epithelium.";
J. Biol. Chem. 269:15229-15237(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Small intestine;
PubMed=7935448; DOI=10.1128/MCB.14.11.7340;
Suh E., Chen L., Taylor J., Traber P.G.;
"A homeodomain protein related to caudal regulates intestine-specific
gene transcription.";
Mol. Cell. Biol. 14:7340-7351(1994).
[3]
NUCLEOTIDE SEQUENCE OF 204-229.
PubMed=1671571;
James R.J., Kazenwadel J.;
"Homeobox gene expression in the intestinal epithelium of adult
mice.";
J. Biol. Chem. 266:3246-3251(1991).
[4]
PHOSPHORYLATION AT SER-60.
PubMed=11729123; DOI=10.1053/gast.2001.29618;
Rings E.H., Boudreau F., Taylor J.K., Moffett J., Suh E.R.,
Traber P.G.;
"Phosphorylation of the serine 60 residue within the Cdx2 activation
domain mediates its transactivation capacity.";
Gastroenterology 121:1437-1450(2001).
-!- FUNCTION: Involved in the transcriptional regulation of multiple
genes expressed in the intestinal epithelium. Important in broad
range of functions from early differentiation to maintenance of
the intestinal epithelial lining of both the small and large
intestine.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Intestine; expressed specifically in gut
epithelium where it is not restricted to a particular cell
lineage. Abundant expression is seen in the proximal colon with
slightly lower levels in distal colon. Expression in the proximal
colon is not restricted either to a particular cell lineage or
stage of differentiation while in the distal colon it is more
abundant in the differentiated cells towards the top of the crypt.
-!- PTM: Phosphorylation of Ser-60 mediates the transactivation
capacity. {ECO:0000269|PubMed:11729123}.
-!- SIMILARITY: Belongs to the Caudal homeobox family. {ECO:0000305}.
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EMBL; U00454; AAA19645.1; -; Unassigned_DNA.
EMBL; S74520; AAB32251.1; -; mRNA.
CCDS; CCDS19878.1; -.
PIR; A53808; A53808.
RefSeq; NP_031699.2; NM_007673.3.
UniGene; Mm.20358; -.
ProteinModelPortal; P43241; -.
SMR; P43241; -.
BioGrid; 198664; 6.
STRING; 10090.ENSMUSP00000031650; -.
iPTMnet; P43241; -.
PhosphoSitePlus; P43241; -.
PaxDb; P43241; -.
PeptideAtlas; P43241; -.
PRIDE; P43241; -.
Ensembl; ENSMUST00000031650; ENSMUSP00000031650; ENSMUSG00000029646.
GeneID; 12591; -.
KEGG; mmu:12591; -.
UCSC; uc009anz.1; mouse.
CTD; 1045; -.
MGI; MGI:88361; Cdx2.
eggNOG; KOG0848; Eukaryota.
eggNOG; ENOG4111W2J; LUCA.
GeneTree; ENSGT00530000063388; -.
HOGENOM; HOG000115975; -.
HOVERGEN; HBG005302; -.
InParanoid; P43241; -.
KO; K09312; -.
OMA; GPSWPSP; -.
OrthoDB; EOG091G0LXJ; -.
PhylomeDB; P43241; -.
TreeFam; TF351605; -.
PRO; PR:P43241; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000029646; -.
CleanEx; MM_CDX2; -.
ExpressionAtlas; P43241; baseline and differential.
Genevisible; P43241; MM.
GO; GO:0000794; C:condensed nuclear chromosome; IDA:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0043234; C:protein complex; IDA:MGI.
GO; GO:0017053; C:transcriptional repressor complex; IDA:MGI.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; ISO:MGI.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0003714; F:transcription corepressor activity; IDA:MGI.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding; ISO:MGI.
GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
GO; GO:0009948; P:anterior/posterior axis specification; IBA:GO_Central.
GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
GO; GO:0001824; P:blastocyst development; IMP:MGI.
GO; GO:0001568; P:blood vessel development; IGI:MGI.
GO; GO:0030154; P:cell differentiation; IMP:MGI.
GO; GO:0008333; P:endosome to lysosome transport; IMP:MGI.
GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IMP:MGI.
GO; GO:0060575; P:intestinal epithelial cell differentiation; IMP:UniProtKB.
GO; GO:0060711; P:labyrinthine layer development; IGI:MGI.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0007389; P:pattern specification process; IMP:MGI.
GO; GO:0001890; P:placenta development; IGI:MGI.
GO; GO:0045597; P:positive regulation of cell differentiation; IDA:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0014807; P:regulation of somitogenesis; IMP:UniProtKB.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0035019; P:somatic stem cell population maintenance; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0001829; P:trophectodermal cell differentiation; IDA:MGI.
InterPro; IPR006820; Caudal_activation_dom.
InterPro; IPR009057; Homeobox-like.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
InterPro; IPR000047; HTH_motif.
Pfam; PF04731; Caudal_act; 1.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
PRINTS; PR00031; HTHREPRESSR.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Activator; Complete proteome; Developmental protein; DNA-binding;
Homeobox; Nucleus; Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 311 Homeobox protein CDX-2.
/FTId=PRO_0000048851.
DNA_BIND 185 244 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 46 53 Poly-Ala.
COMPBIAS 85 92 Poly-Ala.
COMPBIAS 247 257 Poly-Gln.
MOD_RES 60 60 Phosphoserine.
{ECO:0000269|PubMed:11729123}.
CONFLICT 69 69 Y -> H (in Ref. 2; AAB32251).
{ECO:0000305}.
SEQUENCE 311 AA; 33476 MW; 71FFC4C263462FF3 CRC64;
MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA ATANLDSAQS
PGPSWPTAYG APLREDWNGY APGGAAAANA VAHGLNGGSP AAAMGYSSPA EYHAHHHPHH
HPHHPAASPS CASGLLQTLN LGPPGPAATA AAEQLSPSGQ RRNLCEWMRK PAQQSLGSQV
KTRTKDKYRV VYTDHQRLEL EKEFHFSRYI TIRRKSELAA TLGLSERQVK IWFQNRRAKE
RKIKKKQQQQ QQQQQQQPPQ PPPQPSQPQP GALRSVPEPL SPVTSLQGSV PGSVPGVLGP
AGGVLNSTVT Q


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